INTRODUCTION Great changes have taken place in modern neurosurgery in the past decades.Contrasting models of management for complex neurosurgical patients have been developed in China as the specialty evolving,thus ar...INTRODUCTION Great changes have taken place in modern neurosurgery in the past decades.Contrasting models of management for complex neurosurgical patients have been developed in China as the specialty evolving,thus arise many controversies.Clinical demand calls for an expert consensus on neurosurgical inpatients management,especially for the subspecialty of neurosciences critical care （NCC）.展开更多
ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer cachexia.MethodsA mouse model of colon cancer(CT26)-induced cancer cach...ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer cachexia.MethodsA mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)groups.After successful modeling,the mice were administered by gavage for 11 d.The body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after implantation.The liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and weighed.The pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was calculated.The protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western blot.In addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle atrophy.In vitro experiments were divided into control,model,and JP serum groups.After 2-d administration,microscopic photographs were taken and myotube diameters were calculated.Western blot was performed to measure the protein expressions of STAT3 and E3 ubiquitinase.ResultsJP combined with MPA restored tumor-induced weight loss(P<0.05,vs.CC)and muscle fiber size(P<0.01,vs.CC).Mechanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(P<0.05,vs.CC).In addition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(P<0.05 or P<0.01 vs.model group)in C2C12 myotubes treated with dexamethasone in vitro.ConclusionsAdministration of JP combined with MPA restores tumor-induced cachexia co展开更多
目的探讨双支架错位重叠技术辅助弹簧圈栓塞治疗颈内动脉床突上段血泡样动脉瘤(BBAs)的可行性、有效性及预后。方法回顾性分析2014年7月至2018年6月采用双支架技术辅助弹簧圈栓塞治疗的9例BBAs的临床资料。结果 9例均成功实施双支架错...目的探讨双支架错位重叠技术辅助弹簧圈栓塞治疗颈内动脉床突上段血泡样动脉瘤(BBAs)的可行性、有效性及预后。方法回顾性分析2014年7月至2018年6月采用双支架技术辅助弹簧圈栓塞治疗的9例BBAs的临床资料。结果 9例均成功实施双支架错位重叠技术辅助弹簧圈栓塞治疗,术中即刻影像Raymond分级Ⅰ级5例,Ⅱ级1例,Ⅲ级3例。出院时改良Rankin量表(mRS)评分0分4例,3分2例,4分1例,死亡2例;术后90 d mRS评分0分5例,1分1例,3分1例。7例存活病人影像学随访1周～24个月,动脉瘤均完全闭塞,载流动脉无狭窄。结论双支架错位重叠技术辅助弹簧圈栓塞治疗颈内动脉床突上段BBAs是一种可行、有效的方法,可降低动脉瘤术后复发率,改善病人预后。展开更多
Acoustic neurinoma usually results in impairment of .facial nerve and hearing, and rarely leads to subarachnoid hemorrhage （SAH）. In 2002, we treated a patient with bilateral acoustic neurinomas presenting as SAH.
文摘INTRODUCTION Great changes have taken place in modern neurosurgery in the past decades.Contrasting models of management for complex neurosurgical patients have been developed in China as the specialty evolving,thus arise many controversies.Clinical demand calls for an expert consensus on neurosurgical inpatients management,especially for the subspecialty of neurosciences critical care （NCC）.
基金Supported by Guangdong Key Lab of Traditional Chinese Medicine Information Technology(No.2021B1212040007)“3030”Project of Shenzhen Hospital of Traditional Chinese Medicine in 2021。
文摘ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer cachexia.MethodsA mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)groups.After successful modeling,the mice were administered by gavage for 11 d.The body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after implantation.The liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and weighed.The pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was calculated.The protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western blot.In addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle atrophy.In vitro experiments were divided into control,model,and JP serum groups.After 2-d administration,microscopic photographs were taken and myotube diameters were calculated.Western blot was performed to measure the protein expressions of STAT3 and E3 ubiquitinase.ResultsJP combined with MPA restored tumor-induced weight loss(P<0.05,vs.CC)and muscle fiber size(P<0.01,vs.CC).Mechanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(P<0.05,vs.CC).In addition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(P<0.05 or P<0.01 vs.model group)in C2C12 myotubes treated with dexamethasone in vitro.ConclusionsAdministration of JP combined with MPA restores tumor-induced cachexia co
文摘目的探讨双支架错位重叠技术辅助弹簧圈栓塞治疗颈内动脉床突上段血泡样动脉瘤(BBAs)的可行性、有效性及预后。方法回顾性分析2014年7月至2018年6月采用双支架技术辅助弹簧圈栓塞治疗的9例BBAs的临床资料。结果 9例均成功实施双支架错位重叠技术辅助弹簧圈栓塞治疗,术中即刻影像Raymond分级Ⅰ级5例,Ⅱ级1例,Ⅲ级3例。出院时改良Rankin量表(mRS)评分0分4例,3分2例,4分1例,死亡2例;术后90 d mRS评分0分5例,1分1例,3分1例。7例存活病人影像学随访1周～24个月,动脉瘤均完全闭塞,载流动脉无狭窄。结论双支架错位重叠技术辅助弹簧圈栓塞治疗颈内动脉床突上段BBAs是一种可行、有效的方法,可降低动脉瘤术后复发率,改善病人预后。
基金This study was supported by a grant from the National Natural Science Foundation of China(No.30600204)
文摘Acoustic neurinoma usually results in impairment of .facial nerve and hearing, and rarely leads to subarachnoid hemorrhage （SAH）. In 2002, we treated a patient with bilateral acoustic neurinomas presenting as SAH.
