AIM:To estimate and compare the incidence and characteristics of rhegmatogenous retinal detachments(RRDs)in the Wenzhou area in 2015 to 2019.METHODS:All newly developed RRD cases among residents of the Wenzhou area,fr...AIM:To estimate and compare the incidence and characteristics of rhegmatogenous retinal detachments(RRDs)in the Wenzhou area in 2015 to 2019.METHODS:All newly developed RRD cases among residents of the Wenzhou area,from January 2015 to December 2019,were retrospectively retrieved from hospital records.Annual population data were extracted from the Wenzhou Statistical Yearbook.RESULTS:There were 3629 eligible cases.The average incidence of RRD was 7.79 cases per 100000 population(95%confidence interval,7.24-8.34),and the incidences were 7.99 and 7.56 for males and females,respectively.The annual incidence increased gradually from 7.26 cases per 100000 in 2015 to 10.00 cases per 100000 in 2019,with an overall increase of 37.74%.The highest rate of increase occurred in the age group from 60 to 69 years.Of 2750 eyes with axial length(AL)data,1675(60.91%)had an AL greater than 24 mm.CONCLUSION:A trend to increasing RRD incidence is observed in the Wenzhou area over the past 5-year period.展开更多
A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up ...A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up to 10-fold higher inhibition(IC5074.0±1.3μmol·L-1)than acarbose.The molecular docking revealed that compound 10 f could bind toα-glucosidase via the hydrophobic,π-πstacking,and hydrogen bonding interactions.The results may benefit further structural modifications to find new and potentα-glucosidase inhibitors.展开更多
基金Supported by Zhejiang Provincial Highlevel Health Talents Training Project(No.CZ-RC2022010)Wenzhou Basic Medical and Health Technology Project(No.Y20220779)。
文摘AIM:To estimate and compare the incidence and characteristics of rhegmatogenous retinal detachments(RRDs)in the Wenzhou area in 2015 to 2019.METHODS:All newly developed RRD cases among residents of the Wenzhou area,from January 2015 to December 2019,were retrospectively retrieved from hospital records.Annual population data were extracted from the Wenzhou Statistical Yearbook.RESULTS:There were 3629 eligible cases.The average incidence of RRD was 7.79 cases per 100000 population(95%confidence interval,7.24-8.34),and the incidences were 7.99 and 7.56 for males and females,respectively.The annual incidence increased gradually from 7.26 cases per 100000 in 2015 to 10.00 cases per 100000 in 2019,with an overall increase of 37.74%.The highest rate of increase occurred in the age group from 60 to 69 years.Of 2750 eyes with axial length(AL)data,1675(60.91%)had an AL greater than 24 mm.CONCLUSION:A trend to increasing RRD incidence is observed in the Wenzhou area over the past 5-year period.
基金the National Key R&D Program of China(No.2018YF-A0507602)the National Natural Science Foundation of China(Nos.81821004 and21738001)。
文摘A series of novel pyrano[2,3-d]trizaole compounds were synthesized and theirα-glucosidase inhibitory activities were evaluated by in vitro enzyme assay.The experimental data demonstrated that compound 10 f showed up to 10-fold higher inhibition(IC5074.0±1.3μmol·L-1)than acarbose.The molecular docking revealed that compound 10 f could bind toα-glucosidase via the hydrophobic,π-πstacking,and hydrogen bonding interactions.The results may benefit further structural modifications to find new and potentα-glucosidase inhibitors.
文摘黑画面的漏光是高级超维场开关显示模式(Advanced-Super Dimensional Switching,ADS)TFT-LCD中常见的一种不良,当液晶面板有形变或应力作用即容易发生漏光不良,窄长型ADS车载产品更容易受力形变。本文探讨漏光发生的机理并进行改善。研究发现,面板由于形变,内应力,液晶偏转发生异常,最终导致黑画面的漏光。本文以312.4mm(12.3in)寸窄长型车载ADS产品为例,首先对平坦度进行分析:从面板平坦度、背光源平坦度、背光源口子胶位置等方面分析。再从应力着手:从模组将集成电路压接在玻璃基板上的工艺(Chip on Glass,COG)、面板和背光源的组装精度进行漏光实验。实验结果表明,在面板平坦度提升、背光源平坦度管控、背光源口子胶设计为半口子胶并由长边固定变更为短边固定,COG绑定温度和压力进行实验设计、组装精度提升等方面改善后,黑画面漏光可从15%降低至0.1%以内。