目的探讨早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及神经功能评分的影响。方法将60例高血压脑出血非手术治疗患者随机分为2组,每组30例。对照组给予常规降压方案,控制收缩压<160mmHg。观察组行早期控压联合镇静镇...目的探讨早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及神经功能评分的影响。方法将60例高血压脑出血非手术治疗患者随机分为2组,每组30例。对照组给予常规降压方案,控制收缩压<160mmHg。观察组行早期控压联合镇静镇痛治疗,控制收缩压120～140mmHg。观察2组0d,1d,14d血肿量和美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分,统计2组血肿量扩大率。结果 2组血肿量和NIHSS评分比较,治疗1d时略有增加,治疗14d时明显减少,但观察组减少更明显,2组组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.05)。2组血肿扩大率差异无统计学意义(P>0.05)。结论早期控压联合镇静镇痛可有效控制血肿量增多,该方案有利于血肿清除,并有利于改善神经功能。展开更多
Objective: To investigate the hemodynamic effect of Shen-Fu Injection(参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output(PICCO). Method...Objective: To investigate the hemodynamic effect of Shen-Fu Injection(参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output(PICCO). Methods: All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1 st, 2014 to December 31 th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group(33 cases) and control group(32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation, antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients, the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation, hemodynamic data of patients were recorded by PICCO monitor at 0, 12, and 24 h after the catheter implantation. Results: The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h(P>0.05). At 12 and 24 h, the hemodynamic indices of SFI group were significantly improved in comparison with the control group(P<0.05), including cardiac index(CI), global end diastolic volume index(GEDI), mean arterial pressure(MAP) and heart rate(HR). In addition, there was no significant change of extra-vascular lung water index between the two groups(P>0.05). Conclusion: SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients.展开更多
Large-volume liquid scintillator detectors with ultra-low background levels have been widely used to study neutrino physics and search for dark matter.Event vertex and event time are not only useful for event selectio...Large-volume liquid scintillator detectors with ultra-low background levels have been widely used to study neutrino physics and search for dark matter.Event vertex and event time are not only useful for event selection but also essential for the reconstruction of event energy.In this study,four event vertex and event time reconstruction algorithms using charge and time information collected by photomultiplier tubes were analyzed comprehensively.The effects of photomultiplier tube properties were also investigated.The results indicate that the transit time spread is the main effect degrading the vertex reconstruction,while the effect of dark noise is limited.In addition,when the event is close to the detector boundary,the charge information provides better performance for vertex reconstruction than the time information.展开更多
Detector and event visualization are essential parts of the software used in high-energy physics(HEP)experiments.Modern visualization techniques and multimedia production platforms such as Unity provide impressive dis...Detector and event visualization are essential parts of the software used in high-energy physics(HEP)experiments.Modern visualization techniques and multimedia production platforms such as Unity provide impressive display effects and professional extensions for visualization in HEP experiments.In this study,a method for automatic detector description transformation is presented,which can convert the complicated HEP detector geometry from GDML in offline software to 3D modeling in Unity.The method was successfully applied in the BESIII experiment and can be further developed into applications such as event displays,data monitoring,or virtual reality.It has great potential in detector design,offline software development,physics analysis,and outreach for next-generation HEP experiments as well as applications in nuclear techniques for the industry.展开更多
文摘目的探讨早期强化控压联合镇静镇痛策略对老年高血压脑出血患者血肿量及神经功能评分的影响。方法将60例高血压脑出血非手术治疗患者随机分为2组,每组30例。对照组给予常规降压方案,控制收缩压<160mmHg。观察组行早期控压联合镇静镇痛治疗,控制收缩压120～140mmHg。观察2组0d,1d,14d血肿量和美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分,统计2组血肿量扩大率。结果 2组血肿量和NIHSS评分比较,治疗1d时略有增加,治疗14d时明显减少,但观察组减少更明显,2组组间、时点间、组间·时点间交互作用差异均有统计学意义(P<0.05)。2组血肿扩大率差异无统计学意义(P>0.05)。结论早期控压联合镇静镇痛可有效控制血肿量增多,该方案有利于血肿清除,并有利于改善神经功能。
基金Supported by Science and Technology Development Plan of Shandong Province(No.2012YD19011)Medical and Health Technology Development Plan of Shandong Province(No.2013WS0250)+2 种基金National Natural Science Foundation of China(No.81503543)Traditional Chinese Medicine Science and Technology Development Plan of Shandong Province(No.2011-095 and 2013-080)Key Development Program of Shandong Province,China(No.2016GSF202029)
文摘Objective: To investigate the hemodynamic effect of Shen-Fu Injection(参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output(PICCO). Methods: All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1 st, 2014 to December 31 th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group(33 cases) and control group(32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation, antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients, the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation, hemodynamic data of patients were recorded by PICCO monitor at 0, 12, and 24 h after the catheter implantation. Results: The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h(P>0.05). At 12 and 24 h, the hemodynamic indices of SFI group were significantly improved in comparison with the control group(P<0.05), including cardiac index(CI), global end diastolic volume index(GEDI), mean arterial pressure(MAP) and heart rate(HR). In addition, there was no significant change of extra-vascular lung water index between the two groups(P>0.05). Conclusion: SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients.
基金supported by the National Natural Science Foundation of China(Nos.11805294 and 11975021)the China Postdoctoral Science Foundation(2018M631013),the Strategic Priority Research Program of Chinese Academy of Sciences(XDA10010900)+1 种基金the Fundamental Research Funds for the Central Universities,Sun Yatsen University(19lgpy268)in part by the CAS Center for Excellence in Particle Physics(CCEPP).
文摘Large-volume liquid scintillator detectors with ultra-low background levels have been widely used to study neutrino physics and search for dark matter.Event vertex and event time are not only useful for event selection but also essential for the reconstruction of event energy.In this study,four event vertex and event time reconstruction algorithms using charge and time information collected by photomultiplier tubes were analyzed comprehensively.The effects of photomultiplier tube properties were also investigated.The results indicate that the transit time spread is the main effect degrading the vertex reconstruction,while the effect of dark noise is limited.In addition,when the event is close to the detector boundary,the charge information provides better performance for vertex reconstruction than the time information.
基金supported by the National Natural Science Foundation of China (Nos. 11975021,12175321,11675275,U1832204,and U1932101)National Key Research and Development Program of China (Nos. 2020YFA0406300 and 2020YFA0406400)+6 种基金Guangdong Basic and Applied Basic Research Foundation (No.2021A1515012039)State Key Laboratory of Nuclear Physics and Technology,Peking University (Nos. NPT2020KFY04 and NPT2020KFY05)Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDA10010900)Chinese Academy of Sciences (CAS) Large-Scale Scientific Facility ProgramFundamental Research Funds for the Central UniversitiesSun Yat-sen University,National College Students Science and Technology Innovation ProjectUndergraduate Base Scientific Research Project of Sun Yat-sen University
文摘Detector and event visualization are essential parts of the software used in high-energy physics(HEP)experiments.Modern visualization techniques and multimedia production platforms such as Unity provide impressive display effects and professional extensions for visualization in HEP experiments.In this study,a method for automatic detector description transformation is presented,which can convert the complicated HEP detector geometry from GDML in offline software to 3D modeling in Unity.The method was successfully applied in the BESIII experiment and can be further developed into applications such as event displays,data monitoring,or virtual reality.It has great potential in detector design,offline software development,physics analysis,and outreach for next-generation HEP experiments as well as applications in nuclear techniques for the industry.
