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Nutrition and metabolism in burn patients 被引量:28
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作者 Audra Clark Jonathan imran +1 位作者 Tarik Madni Steven E. Wolf 《Burns & Trauma》 2017年第2期95-106,共12页
Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increa... Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction,and susceptibility to infection. Adequate assessment and provision of nutritional needs is imperative to care for these patients. There is no consensus regarding the optimal timing, route, amount, and composition of nutritional support for burn patients, but most clinicians advocate for early enteral nutrition with highcarbohydrate formulas.Nutritional support must be individualized, monitored, and adjusted throughout recovery. Further investigation is needed regarding optimal nutritional support and accurate nutritional endpoints and goals. 展开更多
关键词 BURN NUTRITION METABOLISM CRITICAL CARE
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Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance 被引量:28
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作者 Hilal Ahmad Khan Muhammad Zishan Ahmad +1 位作者 Junaid Ali Khan Muhammad imran Arshad 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2017年第3期245-256,共12页
BACKGROUND: Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay ... BACKGROUND: Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic interventions.DATA SOURCES: The data of mouse hepatic models and rele- vant human liver diseases presented in this review are system- atically collected from PubMed, ScienceDirect and the Web of Science databases published in English. RESULTS: The hepatotoxic liver injury in mice induced by the metabolites of CC14, acetaminophen or alcohol represent ne- crotic cell death with activation of cytochrome pathway, for- mation of reactive oxygen species (ROS) and mitochondrial damage. The Fas or TNF-a induced apoptotic liver injury was dependent on activation of caspases, release of cytochrome c and apoptosome formation. The ConA-hepatitis demonstrat- ed the involvement of TRAIL-dependent necrotic/necroptotic cell death with activation of RIPK1/3. The a-GalCer-induced liver injury was mediated by TNF-a. The LPS-induced hepatitis involved TNF-a, Fas/FasL, and perforin/granzyme cell death pathways. The MHV3 or Poly(I:C) induced liver injury was mediated by natural killer cells and TNF-a signaling. The necrotic ischemia-reperfusion liver injury was mediated by hypoxia, ROS, and pro-inflammatory cytokines; however, necroptotic cell death was found in partial hepatectomy. The crucial role of immune ceils and cell death mediators in viral hepatitis (HBV, HCV), drug-induced liver injury, non-alcohol- ic fatty liver disease and alcoholic liver disease in human were discussed. CONCLUSIONS: The mouse animal models of hepatitis provide a parallel approach for the study of human 展开更多
关键词 liver immunobiology HEPATITIS THERAPY mode of cell death
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长期施肥对棕壤有机碳储量及固碳速率的影响 被引量:25
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作者 兰宇 Muhammad imran Asshraf +4 位作者 韩晓日 杨劲峰 吴正超 王月 李娜 《环境科学学报》 CAS CSCD 北大核心 2016年第1期264-270,共7页
利用棕壤肥料长期定位试验,研究了不同施肥条件下棕壤有机碳在0~60 cm土层的含量和储量特征以及土壤固碳速率.试验共设6个处理,即氮磷肥有机肥配施(M_2NP)、氮肥有机肥配施(M_2N)、单施有机肥(M_2)、单施氮肥(N)、氮磷肥配施(NP)和不施... 利用棕壤肥料长期定位试验,研究了不同施肥条件下棕壤有机碳在0~60 cm土层的含量和储量特征以及土壤固碳速率.试验共设6个处理,即氮磷肥有机肥配施(M_2NP)、氮肥有机肥配施(M_2N)、单施有机肥(M_2)、单施氮肥(N)、氮磷肥配施(NP)和不施肥处理(CK).结果表明:经过31年长期不同施肥,各处理土壤有机碳(SOC)含量和储量的剖面分布均呈现随土层深度增加而显著降低的规律.本试验条件下M_2NP、M_2N、M_2、NP、N、CK处理的耕层有机碳富集系数分别为0.465、0.455、0.407、0.48_2、0.393、0.471,表明耕层土壤对有机碳的保持强度最强.在0~60 cm土层土壤有机碳储量表现为M_2NP、M_2N>M_2、NP>N>CK,有机肥和化肥配施能够显著提高土壤有机碳含量和储量.与试验前相比,CK处理各土层土壤有机碳含量和储量均显著降低.各处理碳库管理指数(CPMI)表现为M_2NP>M_2N>M_2>N>NP>CK.分析不同施肥处理土壤固碳速率可知,与试验前相比,CK处理表现为碳的净释放,固碳速率达-401.4 kg·hm^(-_2)·a^(-1);固碳速率最高的为M_2NP,M_2N,分别达到489kg·hm^(-_2)·a^(-1)、440._2 kg·hm^(-_2)·a^(-1).综合结果表明,化肥、有机肥配施所产生交互效应更有利于棕壤有机碳储量的增加及固碳速率的提高. 展开更多
关键词 棕壤 长期定位施肥 土壤有机碳 有机碳储量 固碳速率
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Chemical composition and antioxidant activity of certain Morus species 被引量:16
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作者 Mohammad imran Hamayun KHAN +2 位作者 Mohibullah SHAH Rasool KHAN Faridullah KHAN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2010年第12期973-980,共8页
In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proxim... In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proximate composition,essential minerals,and antioxidant potentials.For this purpose,the ripe fruits were collected from the northern regions of Pakistan.The major nutritional components moisture,ash,lipids,proteins,fibres,carbohydrates,and total sugar) were found to be in the suitable range along with good computed energy.Total dry weight,pH,and titratable acidity (percent citric acid) were (17.60±1.94)–(21.97±2.34) mg/100 g,(3.20±0.07)–(4.78±0.15),and (0.84±0.40)%–(2.00±0.08)%,respectively.Low riboflavin (vitamin B2) and niacin (vitamin B3) contents were recorded in all the fruits,while ascorbic acid (vitamin C) was in the range from (15.20±1.25) to (17.03±1.71) mg/100 g fresh weight (FW).The mulberry fruits were rich with regard to the total phenol and alkaloid contents,having values of (880±7.20)–(1650±12.25) mg/100 g FW and (390±3.22)–(660±5.25) mg/100 g FW,respectively.Sufficient quantities of essential macro-(K,Ca,Mg,and Na) and micro-(Fe,Zn,and Ni) elements were found in all the fruits.K was the predominant element with concentration ranging from (1270±9.36) to (1731±11.50) mg/100 g,while Ca,Na,and Mg contents were (440±3.21)–(576±7.37),(260±3.86)–(280±3.50),and (240±3.51)–(360±4.20) mg/100 g,respectivly.The decreasing order of micro-minerals was Fe>Zn>Ni.The radical scavenging activity of methanolic extract of fruits was concentration-dependent and showed a correlation with total phenolic constituents of the respective fruits.Based on the results obtained,mulberry fruits were found to serve as a potential source of food diet and natural antioxidants. 展开更多
关键词 Mulberry fruits Chemical composition 2 2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging activity Nutritional value. Pakistan
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Numerical Simulation of Direct-contact Condensation from a Supersonic Steam Jet in Subcooled Water 被引量:16
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作者 Ajmal Shah imran Rafiq Chughtai Mansoor Hameed Inayat 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第4期577-587,共11页
The phenomenon of direct-contact condensation,used in steam driven jet injectors,nuclear reactor emergency core cooling systems and direct-contact heat exchangers,was investigated computationally by introducing a ther... The phenomenon of direct-contact condensation,used in steam driven jet injectors,nuclear reactor emergency core cooling systems and direct-contact heat exchangers,was investigated computationally by introducing a thermal equilibrium model for direct-contact condensation of steam in subcooled water.The condensation model presented was a two resistance model which takes care of the heat transfer process on both sides of the interface and uses a variable steam bubble diameter.The injection of supersonic steam jet in subcooled water tank was simulated using the Euler-Euler multiphase flow model of Fluent 6.3 code with the condensation model incorporated. The findings of the computational fluid dynamics(CFD) simulations were compared with the published experimental data and fairly good agreement was observed between the two,thus validating the condensation model.The results of CFD simulations for dimensionless penetration length of steam plume varies from 2.73-7.33,while the condensation heat transfer coefficient varies from 0.75-0.917 MW·(m ^2 ·K)^ -1 for water temperature in the range of 293-343 K. 展开更多
关键词 computational fluid dynamics condensation model direct-contact condensation heat transfer coefficient supersonic steam jet
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不同土壤水分调控技术对土壤含水量和鸭梨果实品质的影响 被引量:10
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作者 王国英 李宪松 +3 位作者 齐国辉 黄瑞虹 王立国 imran Hassan 《河北农业大学学报》 CAS CSCD 北大核心 2003年第1期24-27,共4页
以13、20和30年生鸭梨为试材,分别在辛集市新垒头、泊头市苗圃场和曲阳县寺南庄梨园,研究了覆膜、定期浇水和对照3种不同土壤水分调控技术对土壤含水量和鸭梨品质的影响。结果表明,土壤含水量以定期浇水最高,对照和覆膜较低;平均单果重... 以13、20和30年生鸭梨为试材,分别在辛集市新垒头、泊头市苗圃场和曲阳县寺南庄梨园,研究了覆膜、定期浇水和对照3种不同土壤水分调控技术对土壤含水量和鸭梨品质的影响。结果表明,土壤含水量以定期浇水最高,对照和覆膜较低;平均单果重以定期浇水最大,覆膜次之,对照最小;果肉硬度则正相反;可溶性固形物、总糖含量和糖酸比以对照最高,覆膜次之,定期浇水最低;可滴定酸含量以定期浇水最高,对照和覆膜较低;Vc含量以覆膜最高,对照次之,定期浇水最低;果实淀粉和果皮叶绿素含量均表现为对照>定期浇水>覆膜。 展开更多
关键词 土壤水分调控技术 鸭梨 土壤含水量 果实品质
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Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence 被引量:15
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作者 Dezhi Wu Zhe Liang +23 位作者 Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang 《Molecular Plant》 SCIE CAS CSCD 2019年第1期30-43,共14页
Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underly... Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of "Darmor-bzh"and "Tapidor,"respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. 展开更多
关键词 Brassica NAPUS genome RESEQUENCING selective sweep ECOTYPE DIVERGENCE GWAS floweringtime trait
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Single-atom catalysts for electrochemical N_(2)reduction to NH_(3) 被引量:14
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作者 Muhammad Saqlain lqbal Zhi-Bo Yao +5 位作者 Yu-Kun Ruan Ramsha Iftikhar Lei-Duan Hao Alex WRobertson Syed Muhammad imran Zhen-Yu Sun 《Rare Metals》 SCIE EI CAS CSCD 2023年第4期1075-1097,共23页
The increasing demand for clean energy and growing concerns regarding environmental sustainability have led to greater attention devoted toward the production of clean fuels via green chemistry.In this respect,ammonia... The increasing demand for clean energy and growing concerns regarding environmental sustainability have led to greater attention devoted toward the production of clean fuels via green chemistry.In this respect,ammonia is a green alternative to fossil fuels and can serve as a clean energy source.There is now great interest in realizing the electrochemical reduction in atmospheric nitrogen(N_(2))for cheap,environmentally friendly and reliable ammonia(NH_(3))production worldwide.However,the robustness of the triple bond in N2 and the low efficiency of candidate catalysts limit the utility of this conversion.Single atom catalysts have been found to be more effective than nanoparticles due to their unique properties,and thus have been studied extensively for the nitrogen reduction reaction.In this review,we have covered the recent advances in design and synthesis of noble metal and non-noble metal single atom catalysts for the electrochemical reduction in nitrogen during the years 2018-2022.The catalyst efficiencies,with reference to coordination preferences and theoretical studies have been discussed.Moreover,we also provide insights into the current challenges and some considerations for further future studies. 展开更多
关键词 N_(2)reduction Single atom catalyst(SAC) ELECTROCATALYSIS NH_(3)
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Chemical composition, mechanism of antibacterial action and antioxidant activity of leaf essential oil of Forsythia koreana deciduous shrub 被引量:15
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作者 Xiao-Nan Yang imran Khan Sun Chul Kang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第9期682-688,共7页
Objective: To identify the chemical constituents of leaf essential oil of Forsythia koreana(F. koreana) and evaluate its ef ects on bacterial strains. Methods: The essential oil of leaf of F. koreana was extracted by ... Objective: To identify the chemical constituents of leaf essential oil of Forsythia koreana(F. koreana) and evaluate its ef ects on bacterial strains. Methods: The essential oil of leaf of F. koreana was extracted by using hydrodistillation process and the volatile components investigated with the help of gas chromatography coupled with mass spectrometry. The antibacterial study was carried out with the help of agar disc dif usion method, MIC, MBC and viable count. The mode of action was determined with help of potassium ion l ux, cellular material release and scanning electron microscopy. The antioxidant activity was determined with the help of 2, 3-diphenyl-2-picrylhydrazyl method, nitric oxide scavenging activity and superoxide anion radical scavenging assay. Results: Total ten compounds were identii ed as trans-phytol(42.73%), cis-3-hexenol(12.95%), 毬-linalool(10.68%), trans-2-hexenal(8.86%), trans-2-hexenol(8.86%), myrcenol(3.86%), 4-vinylphenyl acetate(3.86%),(4Z)-4,6-heptadien-1-ol(3.18%), lemonol(2.73%) and benzeneacetaldehyde(2.27%) by gas chromatography coupled with mass spectrometry. The antibacterial study was demonstrated that leaf essential oil of F. koreana act against foodborne and other pathogenic bacteria. The mode of action revealed that this essential oil acted on the cytoplasmic membrane, resulting in loss of integrity and increased permeability. In addition, leaf essential oil of F. koreana was shown to be rich in linalool, which contributes to improved antioxidant activity. Conclusions: These results show that leaf essential oil of F. koreana has great potential as a natural food preservative, antibacterial and antioxidant agent. 展开更多
关键词 ANTIBACTERIAL ACTIVITY Antioxidant ACTIVITY Cell material RELEASED Essential oil GC-MS Potassium ion flux
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Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis 被引量:14
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作者 Cho Naing Joon Wah Mak +1 位作者 Syed imran Ahmed Mala Maung 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第14期1642-1651,共10页
AIM:To investigate the association between hepatitis C infection and type 2 diabetes mellitus.METHODS:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were id... AIM:To investigate the association between hepatitis C infection and type 2 diabetes mellitus.METHODS:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand searches.Studies published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present analysis.Authors performed separate analyses for the comparisons between hepatitis C virus(HCV) infected and not infected,and HCV infected and hepatitis B virus infected.The included studies were further subgrouped according to the study design.Heterogenity was assessed using I2 statistics.The summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects model.The included studies were subgrouped according to the study design.To assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective studies.RESULTS:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final analysis.Based on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a higher risk of developing type 2 diabetes c 展开更多
关键词 Hepatitis C Type 2 diabetes mellitus Observational studies META-ANALYSIS
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Challenges against CO_(2) abatement strategies in cement industry: A review 被引量:11
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作者 Emad Benhelal Ezzatollah Shamsaei Muhammad imran Rashid 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第6期84-101,共18页
Cement industry is an intensive source of fuel consumption and greenhouse gases(GHGs) emissions. This industry is responsible for 5% of GHGs emissions and is among the top industrial sources of carbon dioxide(CO_(2)) ... Cement industry is an intensive source of fuel consumption and greenhouse gases(GHGs) emissions. This industry is responsible for 5% of GHGs emissions and is among the top industrial sources of carbon dioxide(CO_(2)) emissions. Therefore, CO_(2) emissions reduction from cement production process has been always an appealing subject for researches in universities and industry. Various efforts have been carried out to mitigate the huge mass of CO_(2) emissions from the cement industry. Although, majority of these strategies are technically viable, due to various barriers, the level of CO_(2) mitigation in cement industry is still not satisfactory. Among numerous researches on this topic, only a few have tried to answer why CO_(2) abatement strategies are not globally practiced yet. This work aims to highlight the challenges and barriers against widespread and effective implementation of CO_(2) mitigation strategies in the cement industry and to propose practical solutions to overcome such barriers. 展开更多
关键词 CO_(2)emissions CO_(2)mitigation Cement industry Challenges of CO_(2)reduction
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Blockchain-enabled resource management and sharing for 6G communications 被引量:11
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作者 Hao Xu Paulo Valente Klaine +3 位作者 Oluwakayode Onireti Bin Cao Muhammad imran Lei Zhang 《Digital Communications and Networks》 SCIE 2020年第3期261-269,共9页
The sixth-generation(6G)network must provide better performance than previous generations to meet the requirements of emerging services and applications,such as multi-gigabit transmission rate,higher reliability,and s... The sixth-generation(6G)network must provide better performance than previous generations to meet the requirements of emerging services and applications,such as multi-gigabit transmission rate,higher reliability,and sub-1 ms latency and ubiquitous connection for the Internet of Everything(IoE).However,with the scarcity of spectrum resources,efficient resource management and sharing are crucial to achieving all these ambitious requirements.One possible technology to achieve all this is the blockchain.Because of its inherent properties,the blockchain has recently gained an important position,which is of great significance to the 6G network and other networks.In particular,the integration of the blockchain in 6G will enable the network to monitor and manage resource utilization and sharing efficiently.Hence,in this paper,we discuss the potentials of the blockchain for resource management and sharing in 6G using multiple application scenarios,namely,Internet of things,deviceto-device communications,network slicing,and inter-domain blockchain ecosystems. 展开更多
关键词 6G Blockchain Resource management Network slicing Wireless blockchain
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Hepatitis B virus therapy:What's the future holding for us? 被引量:10
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作者 Sobia Manzoor Muhammad Saalim +2 位作者 Muhammad imran Saleha Resham Javed Ashraf 《World Journal of Gastroenterology》 SCIE CAS 2015年第44期12558-12575,共18页
Hepatitis B is one of the leading causes of liver cancer worldwide and unfortunately the number of people affected with hepatitis B virus(HBV) infection is still on the rise. Although the HBV has been known to cause f... Hepatitis B is one of the leading causes of liver cancer worldwide and unfortunately the number of people affected with hepatitis B virus(HBV) infection is still on the rise. Although the HBV has been known to cause fatal illness since decades but the population effected by this lethal virus have still only a few options for its management. The major treatment strategies include interferons and nucleos(t)ide analogues. These agents have so far produced unsatisfactory results in terms of complete virus eradication. Interferons cannot be used for long term therapy because of their potential side effects. Prolong treatment with nucleos(t)ide analogues has also been reported to cause serious side effects besides the increasing resistance by the virus. The need for new innovative solutions for treatment of HBV has been realized by global research institutes and pharmaceutical industry. Present review focuses in detail on the new ideas that are being transformed into therapeutic tools for use as future therapies in HBV infection. Modern drug designing and screening methods have made the drug discovery process shorter and more reliable. HBV therapeutics will take a new turn in coming years owing to these intelligent drug designing and screening methods. Future therapy of HBV is aiming to include the use of vaccines(both prophylactic and therapeutic), immunomodulators such as antibodies, non-nucleoside antivirals such as RNAi and inhibitors of viral life cycle. 展开更多
关键词 HEPATITIS B VIRUS treatment HEPATITIS B VIRUS vacc
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Delivery strategies of amphotericin B for invasive fungal infections 被引量:10
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作者 Xiaochun Wang imran Shair Mohammad +7 位作者 Lifang Fan Zongmin Zhao Md Nurunnabi Marwa A.Sallam Jun Wu Zhongjian Chen Lifang Yin Wei He 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第8期2585-2604,共20页
Invasive fungal infections(IFIs)represent a growing public concern for clinicians to manage in many medical settings,with substantial associated morbidities and mortalities.Among many current therapeutic options for t... Invasive fungal infections(IFIs)represent a growing public concern for clinicians to manage in many medical settings,with substantial associated morbidities and mortalities.Among many current therapeutic options for the treatment of IFIs,amphotericin B(AmB)is the most frequently used drug.AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance.In this review,we summarized the most promising research efforts on nanocarriers for AmB delivery and highlighted their efficacy and safety for treating IFIs.We have also discussed the mechanism of actions of AmB,rationale for treating IFIs,and recent advances in formulating AmB for clinical use.Finally,this review discusses some practical considerations and provides recommendations for future studies in applying AmB for combating IFIs. 展开更多
关键词 Invasive fungal infections Amphotericin B Poor water-solubility Drug delivery Topical administration NANOPARTICLES CONJUGATES TOXICITY
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Enhanced stability and electrochemical properties of lanthanum and cerium co-modified LiVOPO_(4) cathode materials for Li-ion batteries 被引量:8
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作者 Zishan Ahsan Zhenfei Cai +7 位作者 Shuai Wang Haichuan Wang Yangzhou Ma Guangsheng Song Shihong Zhang Weidong Yang Muhammad imran Cuie Wen 《Journal of Rare Earths》 SCIE EI CAS CSCD 2023年第10期1590-1596,I0005,共8页
A facile and efficient ball-milling assisted sol-gel synthesis route was developed to prepare triclinic e-LiVOPO_(4)(LVOP)material with lanthanum(La)and cerium(Ce)modification individually as well as simultaneously.An... A facile and efficient ball-milling assisted sol-gel synthesis route was developed to prepare triclinic e-LiVOPO_(4)(LVOP)material with lanthanum(La)and cerium(Ce)modification individually as well as simultaneously.An LVOP/LaPO_(4)/CePO_(4)composite cathode material was successfully synthesized and results show that La and Ce co-modification noticeably improves the electrochemical performance by enhancing the high voltage capacity upon cycling,which indicates contributions from the good ionic conductors LaPO_(4)and CePO_(4).The simultaneous La and Ce modification improves the high voltage performance significantly with an increase of 50%in high voltage capacity after 20 cycles compared to pure LVOP.It also shows stabilized cycling perfo rmance with 91%capacity rete ntion after 50 cycles at 0.1 C rate,along with high-rate capability with a capacity of 83.1 mAh/g compared to the pristine sample showing the capacity of 51.6 mAh/g at a high rate of 5C.This can be attributed to the good conductivity of LaPO_(4)and CePO_(4).In addition,the LVOP/LaPO_(4)/CePO_(4)composite and the pristine LVOP give a charge transfer resistance of-105 and-212Ω,respectively,showing much lower impedance due to a combination of La and Ce addition. 展开更多
关键词 Li-ion bateries ε-LiVOP04 Cathode materials La Ce co-modification Enhanced stability Rare earths
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Reversible multiplexing for optical information recording, erasing, and reading-out in photochromic BaMgSiO4:Bi3+ luminescence ceramics 被引量:6
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作者 Youtao Ren Zhengwen Yang +6 位作者 Yuehui Wang Mingjun Li Jianbei Qiu Zhiguo Song Jie Yu Asad Ullah imran Khan 《Science China Materials》 SCIE EI CSCD 2020年第4期582-592,共11页
Optical data storage technology has many advantages over the traditional solid-state and magnetic storage technology,such as low cost,multi-dimensional storage,and rewritable capability.Therefore,the optical data stor... Optical data storage technology has many advantages over the traditional solid-state and magnetic storage technology,such as low cost,multi-dimensional storage,and rewritable capability.Therefore,the optical data storage technology has been in increasing demand for optical storage media.Herein,the photochromic and photoluminescence properties of BaMgSiO4:Bi^3+ceramics were investigated.The BaMgSiO4:Bi^3+ceramics showed reversible photochromism from gray to pink upon alternating the 254 nm ultraviolet light and 532 nm laser irradiation.This is caused by the electron trapping and de-trapping in the oxygen vacancies of the BaMgSiO4:Bi^3+host.This reversible behavior of photochromism was applied to fabricate different patterns on the surface of the BaMgSiO4:Bi^3+ceramics,which exhibited the reversible dual-mode optical information recording and erasing abilities.The photoluminescence reversible modulation of the BaMgSiO4:Bi^3+ceramics was obtained through the photochromic phenomenon.This modification behavior of luminescence could be applied to read-out the recording information in the BaMgSiO4:Bi^3+ceramics.The coloration and bleaching of BaMgSiO4:Bi^3+ceramics were dependent on the time of light stimulation,which facilitated multiplexing encoding.This photoluminescence and photochromism multiplexing of the BaMgSiO4:Bi^3+ceramics enhanced the optical data storage capability. 展开更多
关键词 BaMgSiO4:Bi3+ceramic PHOTOCHROMISM photoluminescence reversible modification
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Preparation and properties of graphene nanoplatelets reinforced aluminum composites 被引量:6
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作者 Zhong ZHENG Xiao-xia YANG +3 位作者 Jian-chao LI Xue-xi ZHANG imran MUHAMMAD Lin GENG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2021年第4期878-886,共9页
5.0 vol.% graphene nanoplatelets(GNPs) and aluminum powders were mixed to prepare GNPs/Al composites via high-energy ball milling(HEBM). The mixed powders were subjected to spark plasma sintering(SPS) and subsequent h... 5.0 vol.% graphene nanoplatelets(GNPs) and aluminum powders were mixed to prepare GNPs/Al composites via high-energy ball milling(HEBM). The mixed powders were subjected to spark plasma sintering(SPS) and subsequent hot extrusion. The microstructure and mechanical properties of extruded composites were investigated by X-ray photoelectron spectroscopy(XPS), transmission electron microscopy(TEM) and tensile tests. In the extruded composites, 5.0 vol.% GNPs were dispersed homogeneously and no serious GNP-Al interfacial reaction occurred. As a result, the yield strength and ultimate tensile strength of the extruded GNPs/Al composites reached 462 and 479 MPa, which were 62% and 60% higher than those of the extruded Al matrix, respectively. The enhanced mechanical properties were attributed to the effective load transfer capacity of dispersed GNPs. This demonstrated that it may be promising to introduce dispersed high-content GNPs via HEBM, SPS and hot extrusion techniques and GNP-Al interfacial reaction can be controlled. 展开更多
关键词 aluminum matrix composites graphene nano-platelets powder metallurgy interface microstructure mechanical properties
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Towards Collaborative Robotics in Top View Surveillance:A Framework for Multiple Object Tracking by Detection Using Deep Learning 被引量:8
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作者 imran Ahmed Sadia Din +2 位作者 Gwanggil Jeon Francesco Piccialli Giancarlo Fortino 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第7期1253-1270,共18页
Collaborative Robotics is one of the high-interest research topics in the area of academia and industry.It has been progressively utilized in numerous applications,particularly in intelligent surveillance systems.It a... Collaborative Robotics is one of the high-interest research topics in the area of academia and industry.It has been progressively utilized in numerous applications,particularly in intelligent surveillance systems.It allows the deployment of smart cameras or optical sensors with computer vision techniques,which may serve in several object detection and tracking tasks.These tasks have been considered challenging and high-level perceptual problems,frequently dominated by relative information about the environment,where main concerns such as occlusion,illumination,background,object deformation,and object class variations are commonplace.In order to show the importance of top view surveillance,a collaborative robotics framework has been presented.It can assist in the detection and tracking of multiple objects in top view surveillance.The framework consists of a smart robotic camera embedded with the visual processing unit.The existing pre-trained deep learning models named SSD and YOLO has been adopted for object detection and localization.The detection models are further combined with different tracking algorithms,including GOTURN,MEDIANFLOW,TLD,KCF,MIL,and BOOSTING.These algorithms,along with detection models,help to track and predict the trajectories of detected objects.The pre-trained models are employed;therefore,the generalization performance is also investigated through testing the models on various sequences of top view data set.The detection models achieved maximum True Detection Rate 93%to 90%with a maximum 0.6%False Detection Rate.The tracking results of different algorithms are nearly identical,with tracking accuracy ranging from 90%to 94%.Furthermore,a discussion has been carried out on output results along with future guidelines. 展开更多
关键词 Collaborative robotics deep learning object detection and tracking top view video surveillance
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Burden of care in caregivers of patients with alcohol use disorder and schizophrenia and its association with anxiety, depression and quality of life 被引量:8
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作者 Sneha Vadher Rishi Desai +4 位作者 Bharat Pancha Ashok Vala imran Jahangirali Ratnani Mihir P Rupani Kinjal Vasava 《General Psychiatry》 CSCD 2020年第4期209-217,共9页
Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care ... Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care and its association with depression,anxiety and quality of life among caregivers of patients with alcohol use disorder(AUD)and schizophrenia.Methods This was an observational,cross-sectional,single-centred study of 50 consecutive caregivers of patients with AUD and schizophrenia.Participants were recruited from the psychiatry outpatient department of a tertiary care hospital between January and June 2017.The caregivers were further assessed by demographic details,Hospital Anxiety Depression Scale for assessment of depression and anxiety,Zarit Burden Interview for assessment of caregiver burden and WHO Quality Of Life-BREF for assessment of quality of life.Statistical data were analysed using GraphPad InStat V.3.06(California).Multiple linear regression analysis was applied to identify the predictors of caregiver burden.Results Burden of care experienced by caregivers of patients with AUD is as high as that of caregivers of patients with schizophrenia(U=1142.5,p=0.46).Caregivers experiencing high burden of care are likely to have symptoms of anxiety(U=22,p<0.001),depression(U=32,p<0.001)and poor quality of life(U=84.5,p<0.001).Female caregivers are likely to experience higher burden of care(U=819.5,p=0.006).For caregivers of patients with schizophrenia,anxiety,environmental health,socioeconomic status and patients,occupation can predict burden of care,while for caregivers of patients with AUD,depression and environmental health can predict burden of care.Conclusion Our study suggests that caregivers of patients with AUD experience burden of care as high as that of caregivers of patients with schizophrenia.Caregivers with high burden of care are more likely to have depression,anxiety and poor quality of life.Trial registration number CTRI/2017/03/008224. 展开更多
关键词 alcohol LIKELY OCCUPATION
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Seedling-lump integrated non-destructive monitoring for automatic transplanting with Intel RealSense depth camera 被引量:8
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作者 Tabinda Naz Syed Liu Jizhan +4 位作者 Zhou Xin Zhao Shengyi Yuan Yan Sami Hassan Ahmed Mohamed imran Ali Lakhiar 《Artificial Intelligence in Agriculture》 2019年第3期18-32,共15页
Non-destructive plant growth parameters measurement is an important concern in automatic-seedling transplanting.Recently,several image-basedmonitoring approaches have been proposed and potentially developed for severa... Non-destructive plant growth parameters measurement is an important concern in automatic-seedling transplanting.Recently,several image-basedmonitoring approaches have been proposed and potentially developed for several agricultural applications.The presented study proposed and developed a RealSense-based machine vision system for the close-shot seedling-lump integrated monitoring.The strategy was based on the close-shot depth information.Further,the point cloud clustering and suitable algorithms were applied to obtain the segmentation of 3D seedling models.In addition,the data processing pipeline was developed to assess the differentmorphological parameter of 4 different seedling varieties.The experiments were carried out with 4 different seedling varieties(pepper,tomato,cucumber,and lettuce)and trained under different light conditions(light and dark).Moreover,analysis results showed that therewas not significantly different(p<0.05)found towards light and dark environments due to close-shot near-infrared detection.However,the results revealed that the stem diameter relationship between RealSense and the manual method was found for R^2=0.68 cucumber,R^2=0.54 tomato,R^2=0.35 pepper,and R^2=0.58 lettuce seedlings.Whereas,the seedling height relationship between RealSense and the manual methodwas found higher than R^2=0.99,0.99,0.99,and 0.99 for pepper,tomato,cucumber,and lettuce,respectively.Based on the experiment results,it was concluded that the RGB-D integrated monitoring system with the purposed method could be practiced for nursery seedlings most promisingly without high labour requirements in terms of ease of use.The system revealed a good sturdiness and relevance for plant growth monitoring.Additionally,it has the perspective for future practical value to real-time vision servo operations for transplanting robots. 展开更多
关键词 Machine vision RealSense SR300 Segmentation Seedlings transplanting
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