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“必选项目”体检、随访在恶性肿瘤筛查路径中的应用 被引量:9
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作者 沈振海 李凤 +5 位作者 祁华金 鲍艳英 宋文军 黄荣根 水克冬 陆昀 《中华老年医学杂志》 CAS CSCD 北大核心 2017年第10期1112-1115,共4页
目的探讨健康体检人群中早期发现恶性肿瘤性价比高的筛查路径。方法回顾性分析我院20122016年应用“必选项目”体检人群280477例。具体4个步骤,首先,各科医生对健康体检人群“必选项目”常规检查;第二,主检医生筛选出恶性肿瘤高危... 目的探讨健康体检人群中早期发现恶性肿瘤性价比高的筛查路径。方法回顾性分析我院20122016年应用“必选项目”体检人群280477例。具体4个步骤,首先,各科医生对健康体检人群“必选项目”常规检查;第二,主检医生筛选出恶性肿瘤高危病例,推荐专项筛查;第三,主检医生判断恶性肿瘤疑似病例、推荐专科进一步就诊和随访对象;第四,随访医生督促恶性肿瘤疑似病例专科就诊、记录结果,对随访对象定期健康教育、督促复查和专科就诊等。结果病理诊断恶性肿瘤517例,在健康体检人群中的检Ⅲ率184/100000(1.84‰),在随访人群中的检出率2023/100000(20.23‰);检出前5位依次为甲状腺癌140例(0.499‰)、肺癌120(0.428%。)、乳腺癌35例(0.374‰)。肾癌55例(0.196‰)和前列腺癌33例(0.177‰)。结论定期“必选项目”体检、专项筛查、专科就诊和随访是在健康体检人群中早期发现恶性肿瘤性价比高的筛查路径。 展开更多
关键词 体检 恶性肿瘤
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儿童严重急性高白细胞白血病致死性并发症诊治策略 被引量:5
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作者 裴瑜馨 李毓 +4 位作者 黄慧敏 徐玲玲 黄雪琼 李易娟 唐雯 《广东医学》 CAS 2019年第23期3250-3254,共5页
目的探讨儿童严重急性高白细胞白血病(外周血WBC>300×10^9·L^-1)早期致死性并发症的诊治及预后。方法回顾性分析儿科收治的严重急性高白细胞白血病患儿的临床表现、实验室检查、治疗方法及转归。结果 13例患儿确诊时年龄5... 目的探讨儿童严重急性高白细胞白血病(外周血WBC>300×10^9·L^-1)早期致死性并发症的诊治及预后。方法回顾性分析儿科收治的严重急性高白细胞白血病患儿的临床表现、实验室检查、治疗方法及转归。结果 13例患儿确诊时年龄5个月至13岁,初诊时外周血白细胞最高达(301~1 350)×10^9·L^-1,骨髓MICM分型确诊为急性白血病(其中急性淋巴细胞白血病11例,急性髓系白血病2例)。急性淋巴细胞白血病予泼尼松治疗(小剂量开始,逐渐加量),急性髓系白血病予羟基脲治疗,并予水化、别嘌醇降尿酸及对症治疗,7例合并颅内出血的患儿出现不同程度意识障碍,其中3例合并严重颅高压死亡,1例同时合并弥散性血管内凝血及肿瘤溶解综合征死亡;4例合并肿瘤溶解综合征,2例死亡;2例合并呼吸衰竭,1例死亡。结论儿童严重高白细胞白血病早期病死率高,迅速降低循环中白细胞数量,密切监测并防治早期致死性并发症可提高其生存率。 展开更多
关键词 高白细胞白血病 儿童 致死性并发症 治疗
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重组人内皮抑素联合放疗对小鼠胃癌移植瘤的生长抑制作用及机制的研究 被引量:5
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作者 谭叶 王效军 +1 位作者 李美玲 陆海军 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2017年第3期187-192,共6页
目的通过重组人内皮抑素(商品名:恩度)联合照射对小鼠胃癌移植瘤生长抑制情况及G蛋白信号调节因子5(regulator of G—protein signaling 5,RGS5)、血管内皮生长因子(vascular endothelia grouth factor,VEGF)和乏氧诱导因子-1α... 目的通过重组人内皮抑素(商品名:恩度)联合照射对小鼠胃癌移植瘤生长抑制情况及G蛋白信号调节因子5(regulator of G—protein signaling 5,RGS5)、血管内皮生长因子(vascular endothelia grouth factor,VEGF)和乏氧诱导因子-1α(hypoxia—induced factor HIF-1α)表达的影响,探讨抗血管生成治疗联合照射协同抑瘤作用的可能机制。方法制备32只胃癌移植瘤小鼠模型,将其按随机数字表法分为生理盐水对照组(Ns对照组)、恩度组、单纯照射组(RT组)、恩度联合照射组(恩度+RT组),共4组,每组8只。通过肿瘤生长曲线和抑瘤率两个指标比较4种治疗对小鼠移植瘤的生长抑制作用,应用免疫组织化学法,计算肿瘤组织中微血管密度(MVD)值及检测RGS5、VEGF、HIF-1α的表达情况差异及相关性分析。结果抑瘤作用RT组、恩度+RT组与NS对照组、恩度组比较差异有统计学意义(t=7.4、5.6,P〈0.05),其中,恩度+RT组抑瘤作用最强。恩度组、RT组及恩度+RT组的MVD值均降低,恩度+RT组最明显。恩度组、RT组及恩度+RT组HIF-1α表达比对照组减弱,其中联合组最明显,差异有统计学意义(t=6.5、8.2、13.1,P〈0.05)。与对照组相比,RT组VEGF、RGS5表达量升高,恩度组和联合组表达量降低,但恩度+RT组与恩度组表达差异无统计学意义(P〉0.05)。Pearson相关分析发现,RGS5、VEGF表达与HIF-1α的表达呈正相关(r=0.57、0.71,P〈0.05)。结论恩度联合照射可通过抑制肿瘤HIF-1α的表达,下调VEGF、RGS5的表达,抑制移植瘤血管生成,使肿瘤血管趋于正常化,改善乏氧抑瘤效果好。 展开更多
关键词 重组人内皮抑素 辐射 微血管密度 G蛋白信号调节因子5 乏氧诱导因子-1Α
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冲击毁伤载荷作用下新型舰船舱壁结构型式研究 被引量:4
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作者 尹群 李舒 王珂 《舰船科学技术》 北大核心 2017年第6期6-11,共6页
本文对高速破片与冲击波载荷联合作用下典型舰船舱壁结构的动态响应过程进行数值模拟研究。基于结构吸能和破片平均剩余速度的评判标准,对比分析3种新型夹芯板双层舱壁(I型、X型、V型)抗冲击毁伤特性。研究结果表明,在相同高速破片与冲... 本文对高速破片与冲击波载荷联合作用下典型舰船舱壁结构的动态响应过程进行数值模拟研究。基于结构吸能和破片平均剩余速度的评判标准,对比分析3种新型夹芯板双层舱壁(I型、X型、V型)抗冲击毁伤特性。研究结果表明,在相同高速破片与冲击波载荷联合作用下,破片穿透V型夹芯板双层舱壁结构的平均剩余速度最小,并且V型夹芯板结构吸能最多;3种新型夹芯板舱壁结构抗冲击性能均强于典型单层舱壁结构。 展开更多
关键词 联合作用 双层舱壁 动态响应 新型结构
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鼻咽癌肺转移相关基因的检测及筛选 被引量:1
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作者 徐唱 肖惠雯 +5 位作者 张凌浩 武鹏 方一 李大伟 李文峰 廖志苏 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2016年第12期891-895,共5页
目的 通过建立鼻咽癌(nasopharyngeal carcinoma,NPC)的肺转移动物模型,运用基因芯片技术检测及筛选肺转移最相关的10种差异基因.方法 采用鼻咽癌细胞株CNE,构建稳定表达荧光酶基因的CNE/Luc稳转细胞株,尾静脉注射CNE/Luc悬液到裸鼠中... 目的 通过建立鼻咽癌(nasopharyngeal carcinoma,NPC)的肺转移动物模型,运用基因芯片技术检测及筛选肺转移最相关的10种差异基因.方法 采用鼻咽癌细胞株CNE,构建稳定表达荧光酶基因的CNE/Luc稳转细胞株,尾静脉注射CNE/Luc悬液到裸鼠中,利用动物活体成像系统筛选得到肺转移裸鼠,分离肿瘤细胞,进行2次尾静脉注射筛选得到肺部转移的肿瘤细胞,运用荧光成像验证其组织特异性转移后,通过基因表达谱芯片技术,获得鼻咽癌肺转移相关的差异基因.通过文献检索筛选出相关性最高的10种基因进行分析.结果 本实验利用基因芯片技术,构建鼻咽癌原代细胞株CNE/Luc与鼻咽癌肺细胞转移相关亚群CNE/Luc-2的基因表达谱,通过软件分析,筛选出10个可能与鼻咽癌肺转移关系密切的基因,分别是TP53、PIK3CA、MET、KRAS、VEGFA、EDNRB、GSK3B、FOXO3、SOD2、BIRC3.结论 通过构建动物模型及基因芯片技术得出的10个基因对于鼻咽癌的肺转移有重要的调节作用,对下一步验证鼻咽癌肺转移相关通路有重要意义. 展开更多
关键词 鼻咽肿瘤 肿瘤转移 模型 动物 基因测定
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Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV 被引量:351
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作者 H.Agakishiev M.M.Aggarwal +140 位作者 Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger 《Chinese Physics C》 SCIE CAS CSCD 2021年第4期198-241,共44页
Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the tr... Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with exte 展开更多
关键词 relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane
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广泛耐药革兰阴性菌感染的实验诊断、抗菌治疗及医院感染控制:中国专家共识 被引量:296
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作者 王明贵 X.Guan +20 位作者 L.He B.Hu J.Hu X.Huang G.Lai y.li y.liu y.Ni H.Qiu Z.Shao y.Shi M.Wang R.Wang D.Wu C.Xie y.Xu F.yang K.yu y.yu J.Zhang C.Zhuo 《中国感染与化疗杂志》 CAS CSCD 北大核心 2017年第1期82-92,共11页
广泛耐药革兰阴性杆菌(XDR-GNB),是指除1~2类抗菌药物(主要指多黏菌素和替加环素)外,几乎对所有类别抗菌药物均不敏感的革兰阴性杆菌。XDR-GNB常见于肠杆菌科细菌、鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌等。近年来,中国XDR-GN... 广泛耐药革兰阴性杆菌(XDR-GNB),是指除1~2类抗菌药物(主要指多黏菌素和替加环素)外,几乎对所有类别抗菌药物均不敏感的革兰阴性杆菌。XDR-GNB常见于肠杆菌科细菌、鲍曼不动杆菌、铜绿假单胞菌和嗜麦芽窄食单胞菌等。近年来,中国XDR-GNB的发生率呈不断上升趋势,由于缺乏有效的治疗药物,XDR-GNB感染成为公共卫生安全的一大威胁。我国有关感染的临床、微生物学及临床药理学专家们就XDR-GNB感染的实验室诊断、临床诊疗和医院感染控制等问题深入讨论,形成此共识。其中细菌药敏试验的抗菌药物品种及结果判定标准遵循美国临床和实验室标准化协会(CLSI)、欧洲抗菌药物敏感性试验委员会(EUCAST)或美国食品与药物监督管理局(FDA)的指南。研究提示长疗程使用广谱抗菌药物是引发XDR-GNB感染最重要的危险因素。根据现有的临床研究和实验室数据,共识提供治疗各种XDRGNB感染的联合用药推荐方案,其中常用的抗菌药物有替加环素、多黏菌素、碳青霉烯类、氨基糖苷类和磷霉素等。同时建议实行严格的感染控制措施,包括手卫生、接触隔离、主动筛查、环境消毒、去定植和抗菌药物应用管理等遏制XDRGNB感染的传播。 展开更多
关键词 广泛耐药 肠杆菌科细菌 鲍曼不动杆菌 铜绿假单胞菌 嗜麦芽窄食单胞菌 抗菌治疗
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Study of BESIII trigger efficiencies with the 2018 J/ψ data 被引量:36
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作者 M.Ablikim M.N.Achasov +150 位作者 P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai y.Bai O.Bakina R.Baldini Ferroli I.Balossino y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov D.y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen y.B.Chen Z.J Chen W.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori y.Ding C.Dong J.Dong L.y.Dong M.y.Dong X.Dong S.X.Du y.L.Fan J.Fang S.S.Fang y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu y.Gao y.Gao y.Gao y.G.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu y.T.Gu C.y Guan A.Q.Guo L.B.Guo R.P.Guo y.P.Guo A.Guskov T.T.Han W.y.Han X.Q.Hao F.A.Harris H Hüsken K.L.He F.H.Heinsius C.H.Heinz T.Held y.K.Heng C.Herold M.Himmelreich T.Holtmann y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu y.Hu G.S.Huang L.Q.Huang X.T.Huang y.P.Huang Z.Huang T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.B.Jiang X.S.Jiang J.B.Jiao Z.Jiao S.Jin y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel 《Chinese Physics C》 SCIE CAS CSCD 2021年第2期48-55,共8页
Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,na... Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses. 展开更多
关键词 BESIII trigger efficiency Bhabha dimuon hadronic events
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Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction 被引量:24
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作者 O.Kochebina M.Kolpin +139 位作者 I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington y.li T.likhomanenko M.liles R.lindner C.linn F.lionetto B.liu X.liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C 《Chinese Physics C》 SCIE CAS CSCD 2016年第1期1-16,共16页
The product of the ∧0/b (-B/0) differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-(-B/0→ J/ψ-K*(892)0)is measured as a function of the beauty hadron transverse mome... The product of the ∧0/b (-B/0) differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-(-B/0→ J/ψ-K*(892)0)is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B(∧0/b→ J/ψ pK-)=(3.17±0.04±0.07±0.34+0.45/-0.28)×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K*(892)0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P+c(→ J/ψp)K-are determined. 展开更多
关键词 production cross-section branching fraction b hadrons proton-proton collisions
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Microstructure and mechanical properties of Mg-to-Al dissimilar welded joints with an Ag interlayer using ultrasonic spot welding 被引量:17
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作者 H.Peng D.L.Chen +3 位作者 X.F.Bai P.Q.Wang D.y.li X.Q.Jiang 《Journal of Magnesium and Alloys》 SCIE 2020年第2期552-563,共12页
Lightweight ZEK100-0 Mg alloy and A16022-T43 Al alloy with an Ag interlayer were joined via ultrasonic spot welding(USW),focusing on the microstructural change and tensile lap shear strength of the welded joints in re... Lightweight ZEK100-0 Mg alloy and A16022-T43 Al alloy with an Ag interlayer were joined via ultrasonic spot welding(USW),focusing on the microstructural change and tensile lap shear strength of the welded joints in relation to welding energy.Mg/Al interface was superseded by Mg/Ag and Al/Ag interfaces,and unfavorable Mg门A-intermetallic compound was eliminated.Ag foil was observed to be intact in the nugget center,while it was broken or dissolved at the nugget edge at high welding energy levels.The diffusion layer at the Mg/Ag interface consisted of two distinctive sub-layers:Mg3Ag intermetallic compound adjoining Ag foil,and Mg3Ag-l-Mg eutectic structure adjacent to Mg.Only a thin diffusion layer consisting mainly of Ag3Al occurred al lhe Al/Ag interface.The tensile lap shear strength first increased,reached its peak value,and then decreased with increasing welding energy.The shear strength achieved in the present study was〜31%higher than that of the joint without interlayer.Interfacial failure occurred at all energy levels,with Ag foil particles or fragments being stuck on both Mg and Al sides due to its intense interaction with Mg and Al via accelerated diffusion during USW.The results obtained pave the way for the challenging dissimilar welding between Mg and Al alloys. 展开更多
关键词 Magnesium alloy Aluminum alloy Ultrasonic spot welding Ag interlayer Microstructure Tensile lap shear strength
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临床-影像组学列线图对于伴随中等大小肺结节的结直肠癌病人肺转移的术前预测 被引量:16
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作者 T.D.Hu S.P.Wang +5 位作者 L.Huang J.Z.Wang D.B.Shi y.li 李璐(译) 陈秀玉(校) 《国际医学放射学杂志》 北大核心 2019年第2期247-248,共2页
目的建立并验证临床-影像组学列线图,以期在术前预测伴随中等大小肺结节(IPN)结直肠癌(CRC)病人的肺转移。方法194例有肺结节的CRC病人被纳入研究(训练组136例,验证组58例)。
关键词 列线图 肺转移 结直肠癌 肺结节
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Why is it difficult to accurately predict the COVID-19 epidemic? 被引量:13
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作者 Weston C.Roda Marie B.Varughese +1 位作者 Donglin Han Michael y.li 《Infectious Disease Modelling》 2020年第1期271-281,共11页
Since the COVID-19 outbreak in Wuhan City in December of 2019,numerous model predictions on the COVID-19 epidemics in Wuhan and other parts of China have been reported.These model predictions have shown a wide range o... Since the COVID-19 outbreak in Wuhan City in December of 2019,numerous model predictions on the COVID-19 epidemics in Wuhan and other parts of China have been reported.These model predictions have shown a wide range of variations.In our study,we demonstrate that nonidentifiability in model calibrations using the confirmed-case data is the main reason for such wide variations.Using the Akaike Information Criterion(AIC)for model selection,we show that an SIR model performs much better than an SEIR model in representing the information contained in the confirmed-case data.This indicates that predictions using more complex models may not be more reliable compared to using a simpler model.We present our model predictions for the COVID-19 epidemic in Wuhan after the lockdown and quarantine of the city on January 23,2020.We also report our results of modeling the impacts of the strict quarantine measures undertaken in the city after February 7 on the time course of the epidemic,and modeling the potential of a second outbreak after the return-to-work in the city. 展开更多
关键词 COVID-19 epidemic in Wuhan SIR and SEIR models Bayesian inference Model selection Nonidentifiability QUARANTINE Peak time of epidemic
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Anisotropic NdFeB Magnet Fabricated by Single Stroke Hot Deformation 被引量:11
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作者 y.li (Chungnam National University, Taejon, Korea) y.B.Kim (Korea Research Institute of Standards and Science, Taejon, Korea) M.J.Kim, M.S.Song, J.H.yang, T.K.Kim and C.O.Kim (Chungnam National University, Taejon, Korea) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2000年第2期129-130,共2页
The general hot deformation process consists of two steps, hot pressing and die-upsetting in order to obtain the anisotropic NdFeB magnet. This is the first report that the high anisotropy NdFeB magnets can be fabrica... The general hot deformation process consists of two steps, hot pressing and die-upsetting in order to obtain the anisotropic NdFeB magnet. This is the first report that the high anisotropy NdFeB magnets can be fabricated by single stroke hot deforming the isotropic magnet. The magnetic properties of those materials are: coercivity iHc ~11 kOe, remanence Br ~12 kG, and the maximum energy product (BH)max ~28 MG.Oe. 展开更多
关键词 NDFEB Anisotropic NdFeB Magnet Fabricated by Single Stroke Hot Deformation
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Methods for a blind analysis of isobar data collected by the STAR collaboration 被引量:7
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作者 J.Adam L.Adamczyk +143 位作者 J.R.Adams J.K.Adkins G.Agakishiev M.M.Aggarwal Z.Ahammed I.Alekseev D.M.Anderson A.Aparin E.C.Aschenauer M.U.Ashraf F.G.Atetalla A.Attri G.S.Averichev V.Bairathi K.Barish A.Behera R.Bellwied A.Bhasin J.Bielcik J.Bielcikova L.C.Bland I.G.Bordyuzhin J.D.Brandenburg A.V.Brandin J.Butterworth H.Caines M.Calderon de la Barca Sanchez D.Cebra I.Chakaberia P.Chaloupka B.K.Chan F-H.Chang Z.Chang N.Chankova-Bunzarova A.Chatterjee D.Chen J.Chen J.H.Chen X.Chen Z.Chen J.Cheng M.Cherney M.Chevalier S.Choudhury W.Christie X.Chu H.J.Crawford M.Csanad M.Daugherity T.G.Dedovich I.M.Deppner A.A.Derevschikov L.Didenko X.Dong J.L.Drachenberg J.C.Dunlop T.Edmonds N.Elsey J.Engelage G.Eppley S.Esumi O.Evdokimov A.Ewigleben O.Eyser R.Fatemi S.Fazio P.Federic J.Fedorisin C.J.Feng y.Feng P.Filip E.Finch y.Fisyak A.Francisco L.Fulek C.A.Gagliardi T.Galatyuk F.Geurts A.Gibson K.Gopal X.Gou D.Grosnick W.Guryn A.I.Hamad A.Hamed S.Harabasz J.W.Harris S.He W.He X.H.He y.He S.Heppelmann S.Heppelmann N.Herrmann E.Hoffman L.Holub y.Hong S.Horvat y.Hu H.Z.Huang S.L.Huang T.Huang X.Huang T.J.Humanic P.Huo G.Igo D.Isenhower W.W.Jacobs C.Jena A.Jentsch y.Ji J.Jia K.Jiang S.Jowzaee X.Ju E.G.Judd S.Kabana M.L.Kabir S.Kagamaster D.Kalinkin K.Kang D.Kapukchyan K.Kauder H.W.Ke D.Keane A.Kechechyan M.Kelsey y.V.Khyzhniak D.P.Kikoła C.Kim B.Kimelman D.Kincses T.A.Kinghorn I.Kisel A.Kiselev M.Kocan L.Kochenda L.K.Kosarzewski L.Kramarik P.Kravtsov K.Krueger N.Kulathunga Mudiyanselage L.Kumar S.Kumar 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2021年第5期43-50,共8页
In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of nuclei.The isobar ... In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of nuclei.The isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr.In order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis procedure.Analysts are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run conditions.After tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking runs.For this sample,species-specific information is disguised,but individual output files contain data from a single isobar species.Only run-by-run corrections and code alteration subsequent to these corrections are allowed at this stage.Following these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind analysis.As a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in 2018.The Au+Au data were prepared in the same manner intended for the isobar blind data.The details of the blind analysis procedure and results from the mock data challenge are presented. 展开更多
关键词 Blind analysis Chiral magnetic effect Heavy-ion collisions
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STCF conceptual design report (Volume 1): Physics & detector 被引量:3
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作者 M.Achasov X.C.Ai +163 位作者 L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.li C.li D.y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X 《Frontiers of physics》 SCIE CSCD 2024年第1期1-154,共154页
The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics community.It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of... The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics community.It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or higher.The STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard Model.The STCF project in China is under development with an extensive R&D program.This document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies. 展开更多
关键词 electron–positron collider tau-charm region high luminosity STCF detector conceptual design
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用二阶矩两相湍流模型模拟鼓泡床内气泡-液体湍流两相流动 被引量:8
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作者 杨玟 周力行 +4 位作者 廉春英 李荣先 L.SFan y.li D.JLee 《空气动力学学报》 CSCD 北大核心 2001年第3期249-255,共7页
建立了二阶矩气液两相湍流模型 ,模拟了不同工况下二维矩形断面气液鼓泡床中气泡 液体湍流两相流动 ,给出了气泡和液体的速度场、气泡体积分数和两相雷诺应力分布 ,基本工况的模拟结果与美国俄亥俄州立大学PIV测量结果符合较好。文中研... 建立了二阶矩气液两相湍流模型 ,模拟了不同工况下二维矩形断面气液鼓泡床中气泡 液体湍流两相流动 ,给出了气泡和液体的速度场、气泡体积分数和两相雷诺应力分布 ,基本工况的模拟结果与美国俄亥俄州立大学PIV测量结果符合较好。文中研究了不同气体表观速度对两相流场的影响。模拟结果显示了鼓泡床内液体的回流流动和气泡的上升运动、各向异性的两相湍流 ,气泡湍流脉动比液体的强 。 展开更多
关键词 气液鼓泡床 气液两相湍流 数值模拟 二阶矩两相湍流模型 气体表观速度 气泡湍流脉动 气泡体积分数 两相湍流强度
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Recent development in the application of bulk metallic glasses 被引量:8
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作者 K.Gao X.G.Zhu +8 位作者 L.Chen W.H.li X.Xu B.T.Pan W.R.li W.H.Zhou L.li W.Huang y.li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第36期115-121,共7页
Over the past decades,considerable efforts have been made in the commercial application of bulk metallic glasses(BMGs).Despite great challenges faced by the industrial players,significant progress has been achieved,an... Over the past decades,considerable efforts have been made in the commercial application of bulk metallic glasses(BMGs).Despite great challenges faced by the industrial players,significant progress has been achieved,and millions of commercial products for various kinds of applications have been shipped around the world.Here in this paper,we shall present the alloys suitable for the actual products in the application and discuss the merits of the processing technique of BMGs over the existing processing techniques and materials.Most importantly we demonstrate the typical examples of products over the past few years.Finally,future directions of the industrialization of BMGs are also discussed. 展开更多
关键词 Bulk metallic glasses Commercial application Alloy design PRODUCTS
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Determination of the number ofψ(3686)events taken at BESⅢ
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作者 M.Ablikim M.N.Achasov +147 位作者 P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.Q.Chen Z.J.Chen Z.y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du y.y.Duan Z.H.Duan P.Egorov y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng y.T.Feng M.Fritsch C.D.Fu J.L.Fu y.W.Fu H.Gao X.B.Gao y.N.Gao yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu J.F.Hu S.L.Hu T.Hu y.Hu G. 《Chinese Physics C》 SCIE CAS CSCD 2024年第9期8-20,共13页
The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic events.The uncertainty is systematic and the ... The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic events.The uncertainty is systematic and the statistical uncertainty is negligible.Meanwhile,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,respectively.Both numbers are consistent with the previous measurements within one standard deviation.The total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6. 展开更多
关键词 ψ(3686) inclusive process Hadronic events BESⅢdetector
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Hot Deformation and Work Hardening Behavior of an Extruded Mg–Zn–Mn–Y Alloy 被引量:8
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作者 N.Tahreen D.F.Zhang +3 位作者 F.S.Pan X.Q.Jiang D.y.li D.L.Chen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2015年第12期1161-1170,共10页
The aim of this study was to evaluate the strain hardening and hot deformation behavior of asextruded Mg-Zn-Mn (ZM31) magnesium alloy with varying Y contents (0.3, 3.2, and 6 wt%) via compression testing along the... The aim of this study was to evaluate the strain hardening and hot deformation behavior of asextruded Mg-Zn-Mn (ZM31) magnesium alloy with varying Y contents (0.3, 3.2, and 6 wt%) via compression testing along the extrusion direction at room temperature, 200℃ and 300 ℃. Texture and phases were identified by X-ray diffraction. Alloy ZM31 + 0.3Y consisted of a mixture of fine equiaxed grains and elon- gated grains with 1-phase (Mg3YZno); alloy ZM31 + 3.2Y contained 1-phase and W-phase (Mg3Y2Zn3); alloy ZM31 + 6Y had long-period stacking-ordered (LPSO) X-phase (Mg12YZn) and Mg24Y5 particles. With increasing Y content the basal texture became weakened significantly. While alloys ZM31 + 0.3Y and ZM31 + 3.2Y exhibited a skewed true stress-true stain curve with a three-stage strain hardening feature caused by the occurrence of {1072} extension twinning, the true stress-true stain curve of alloy ZM31 + 6Y was normal due to the dislocation slip during compression. With increasing temperature the extent of skewness decreased. While the compressive yield stress, ultimate compressive stress, strain hardening exponent, and hardening capacity all decreased as the temperature increased, the retention of the high- temperature deformation resistance increased with increasing Y content mainly due to the presence of thermally-stable LPSO X-ohase. 展开更多
关键词 Magnesium alloy Yttrium effect Temperature effect Strain hardening I and W-phase LPSO X-phase
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Search for the doubly charmed baryon ■ 被引量:3
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作者 R.Aaij C.Abellán Beteta +133 位作者 T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr S.Amato y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli J.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy R.Bernet D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese S.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci J.Cerasoli M.G.Chapm 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2020年第2期8-22,共15页
A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13... A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 TeV.The data correspond to a total integrated luminosity of 9 fb^-1.No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^2.Upper limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc baryons.The limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c. 展开更多
关键词 charmed baryons limits on production of particles charmed quarks experimental tests
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