Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrin...Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride （EH） is a compound that is widely used in cardiovascular diseases, especially to treat hypotension caused by either anesthesia or overdose of antihypertensive drugs. In this study, we reported that EH also plays an important role in the control of the inflammatory response. EH increased IL-IO and decreased proinflammatory cytokine （IL-6, tumor-necrosis factor （TNF）-a, IL-12 and IL-11~） expression in primary peritoneal macrophages and Raw264.7 cells treated with peptidoglycan （PGN）, a Gram-positive cell wall component. The anti-inflammatory role of EH was also demonstrated in an experimental mouse model of peritonitis induced by intraperitoneal PGN injection. The phosphatidylinositol 3-kinase （PI3K）/Akt pathway was found to be responsible for the EH-mediated increase in IL-IO production and decrease in IL-6 expression. Therefore, our results illustrated that EH can help maintain immune equilibrium and diminish host damage by balancing the production of pro- and anti-inflammatory cytokines after PGN challenge. EH may be a new potential anti-inflammatory drug that can be useful for treating severe invasive Gram-positive bacterial infection.展开更多
To the Editor,A 48-year-old male patient presented to our hospital with abnormal liver function.The results of his liver function tests were as follows:alanine transaminase,118 U/L(normal range,5-35 U/L);aspartate tra...To the Editor,A 48-year-old male patient presented to our hospital with abnormal liver function.The results of his liver function tests were as follows:alanine transaminase,118 U/L(normal range,5-35 U/L);aspartate transaminase,86 U/L(8-40 U/L);alkaline phosphatase(ALP),246 U/L(40-150 U/L);andγglutamyl transferase(γ-GT),792 U/L(17-53 U/L).His immunoglobulin(Ig)G and IgM levels were 13.0 g/L(7.51-15.60 g/L)and 2.44 g/L(0.460-3.040 g/L),respectively,and his autoimmune antibody tests were positive for antinuclear antibodies and M2 subtype antimitochondrial antibodies.展开更多
Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a r...Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a rep-resentative Pas,insults hepatic sinusoidal endothelial cells and ensues congestion of hepatic sinusoids.However,little known about the impact of Pas on gut microbiota and intesti-nal barrier and inflammation in HSOS.Methods:Mice were gavaged with or without nonabsorbable antibiotics(ABX),followed by a single dose of RTS.The gut microbiota was examined by 16S rDNA sequencing.Results:ABX pretreat-ment significantly reversed RTS-induced liver damage.RTS altered gut microbiota composition,increasing Gram-nega-tive bacteria and resulting in a sharp elevation of circulating lipopolysaccharides(LPS)in HSOS mice.Gut decontamina-tion with ABX alleviated RTS-induced intestine inflamma-tion,protected against disruption of the intestinal epithelial barrier and gut vascular barrier(GVB),and suppressed he-patic LPS-NF-κB pathway activation in RTS-induced HSOS.Importantly,the LPS level was positively correlated with MELD score in patients with HSOS.Elevated LPS in patients with HSOS confirmed that Gram-negative bacteria were in-volved in the pathogenesis of HSOS.Conclusions:RTS,a PA,cooperated with gut dysbiosis to cause intestinal inflam-mation and gut barrier compromise that increased transport of gut-derived LPS into the liver through the portal vein,which contributed to the pathology of HSOS.Modulating the gut microbiota,protecting the intestinal barrier,and sup-pressing intestinal inflammation with prebiotics or antibiot-ics might be a useful pharmacologic intervention in HSOS.展开更多
Background and Aims:Although ursodeoxycholic acid(UDCA)treatment in primary biliary cholangitis is effective in many patients,there are still many people who respond poorly to it.Identifying and intervening these pati...Background and Aims:Although ursodeoxycholic acid(UDCA)treatment in primary biliary cholangitis is effective in many patients,there are still many people who respond poorly to it.Identifying and intervening these patients early is important.Therefore,exploring the risk factors and proposing a predictor index to predict the UDCA treatment nonresponse earlier among primary biliary cholangitis patients were the aims of this research.Methods:A total of 135 primary biliary cholangitis patients treated with UDCA(13–15 mg/kg/d)were enrolled in this retrospective study.The response to treatment was evaluated based on Paris I criteria.The univariate and logistic multivariate regression analyses were adopted to determine the independent risk factors and propose a predictor index.Receiver operating characteristic curve was used to evaluate the predictive ability of the predictor index.Results:Total bilirubin,albumin,globulin,immunoglobin M,and aspartate aminotransferase-to-platelet ratio index were the five independent risk factors associating with early biochemical nonresponse to UDCA treatment.Based on these factors,we established a predictor index with the predictive value being 0.886(sensitivity:82.80%,specificity:84.40%).Conclusions:We developed a predictor index that had an accurate prediction of the early biochemical nonresponse to UDCA treatment,which is expected to provide valuable information for the high-risk group before treatment begins.展开更多
To investigate the regulation of tumor sup-pressor XAF1 gene expression in digestive system cancers,we studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines(human hepat...To investigate the regulation of tumor sup-pressor XAF1 gene expression in digestive system cancers,we studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines(human hepatoma cell line HepG2,human colon cancer cell line LoVo,and human gastric cancer cell line AGS)and nontumor cell lines(human embryonic liver cell line L02(L02 cells)and human embryonic kidney 293 cells[HEK293 cells])as controls.1395-bp-promoter fragment of XAF1 gene was amplified by polymerase chain reaction(PCR)and cloned into pGL3-basic vector and pEGFP-1 vector to assay its promoter transcription activity.The plasmids were transfected into a variety of cell lines by lipofectamine 2000.The promoter transcription activity was determined by dual-luciferase report assay,and enhanced greenfluorescent protein(EGFP)-positive cells were detected byfluorescence microscope.The expression of XAF1 mRNA in HEK293 and L02 were significantly higher than that in any of the three digestive system cancer cell lines.The dual-luciferase reporter assay showed that the promoter transcription activity in digestive system tumor cell lines transfected with pGL3-XAF1p promoter was apparently lower than that of both HEK293 and L02 cells.Expression of greenfluorescent protein(GFP)under the control of XAF1 promoter in the three digestive system cancer cell lines was lower than that of both HEK293 and L02 cells.The activities of pGL3-XAF1p in the three digestive system cancer cell lines after treatment with heat stress were significantly lower than those in the unstressed cells.The results suggested that remarkably down-regulated XAF1 mRNA expression in digestive system cancer cell lines may be due to loss of transcription activity of XAF1 promoter.展开更多
Virus tagged with greenfluorescent protein(GFP)contributes to the visualization and study of the virus in living cells.However,the hepatitis B virus(HBV)particle,which is a compact virion with limited internal space,ca...Virus tagged with greenfluorescent protein(GFP)contributes to the visualization and study of the virus in living cells.However,the hepatitis B virus(HBV)particle,which is a compact virion with limited internal space,cannot be incorporated with GFP tag as a large fragment.It was recently reported that protein genetically inserted with a smaller size tetracysteine(TC)tag could be specially labeled by a biarsenicalfluorescent dye in living cells.In this study,we constructed a recombinant HBV vector encoding TC-tagged core protein for biarsenical labeling of HBV virion.TC tag was genetically inserted near the immunodominant c/e1 site of HBV core protein by mutagenesis.Western blot and enzyme-linked immu-nosorbent assay(ELISA)analysis showed that the TC-tagged core protein,hepatitis B surface antigen(HBsAg)and hepatitis B e antigen(HBeAg)could be expressed in cells transfected with the recombinant HBV vector,which is similar to the cells transfected with wild-type HBV vector.Reverse transcription-polymerase chain reaction(RT-PCR)and Southern blot analysis showed that HBV virion formation was affected by the genetic insertion of TC tag into core protein in some degree,but cells transfected with the HBV vector could still produce HBV virions incorporated with TC-tagged core proteins.Taken together,the recombinant HBV vector can serve as a useful tool to produce HBV virions incorporated with TC-tagged core proteins to befluorescently labeled by biarsencial dye for visualizing and studying HBV in living cells.展开更多
In-beamγ-ray spectroscopic experiment for the deformed odd-A nucleus 179Pt has been performed via the 149Sm(35Cl, p4n) reaction at beam energy of 180 MeV. The 35Cl beam was provided by the tandem accelerator at the J...In-beamγ-ray spectroscopic experiment for the deformed odd-A nucleus 179Pt has been performed via the 149Sm(35Cl, p4n) reaction at beam energy of 180 MeV. The 35Cl beam was provided by the tandem accelerator at the Japan Atomic Energy Research Institute (JAERI). The target was an isotopic 149Sm foil of 1. 5 mg /cm2 thickness with a 5 me/cm2 Pb backing. Based on the measured results, three rotational展开更多
High-spin states in 190Tl have been studied via the 160Gd(35Cl, 5nγ) reaction. The level scheme, consisting of the π h9 /2 νi13/2 oblate band and a cascade with character of single particle excitations, has been es...High-spin states in 190Tl have been studied via the 160Gd(35Cl, 5nγ) reaction. The level scheme, consisting of the π h9 /2 νi13/2 oblate band and a cascade with character of single particle excitations, has been established. Spin values have been firmly assigned to the oblate band in 190Tl, resulting in low-spin signature inversion in the π h9 /2 νi13/2 oblate band for the first time. Based on the similarity of the level structure in doubly odd Tl nuclei, spin values for the oblate bands in 192―200Tl should be re-assigned, and a consistent low-spin signature inversion has occurred in these oblate deformed nuclei. The low-spin signature inversion phenomena can be interpreted qualitatively by using the 2-quasiparticle plus rotor model including p-n residual interactions.展开更多
The high-spin states of neutron-deficient doubly odd nucleus 190Tl have been investigated via the 160Gd (35Cl,5n)19Tl reaction at 167 and 175 MeV beam energies by using techniques of in-beamγ-ray spectroscopy. Measur...The high-spin states of neutron-deficient doubly odd nucleus 190Tl have been investigated via the 160Gd (35Cl,5n)19Tl reaction at 167 and 175 MeV beam energies by using techniques of in-beamγ-ray spectroscopy. Measurements of X-γandγ-γ-t coincidences were performed with 12 BGO(AC)HPGe detectors. The detailed results of the present work have been reported.With the configuration and spin-parity as-展开更多
Theβ+/EC decay of doubly odd 176Ir has been studied via the 146Nd(35Cl,5nγ) heavy ion fusion evaporation reaction at the Sector-Focusing Cyclotron (SFC) accelerator in the Institute of Modern Physics (IMP), Lanzhou....Theβ+/EC decay of doubly odd 176Ir has been studied via the 146Nd(35Cl,5nγ) heavy ion fusion evaporation reaction at the Sector-Focusing Cyclotron (SFC) accelerator in the Institute of Modern Physics (IMP), Lanzhou. A 210 MeV 35C1 beam from the cyclotron entered a helium-filed target chamber,展开更多
The high-spin states in 139Ce have been populated via the 130Te(12C, 3n) 139Ce reaction by using techniques of in-beamγ-ray spectroscopy. The 12C beam at 50 MeV energy was provided by the HI-13 tandem accelerator at ...The high-spin states in 139Ce have been populated via the 130Te(12C, 3n) 139Ce reaction by using techniques of in-beamγ-ray spectroscopy. The 12C beam at 50 MeV energy was provided by the HI-13 tandem accelerator at the China Institute of Atomic Energy, Beijing. The 130Te target is an enriched metallic foil of about 1. 4 mg/cm2 thickness with a 9 mg/cm2 197Au backing to stop the recoiling nuclei. 14 BGO(AC)展开更多
The high-spin states of 190Tl, populated via the 160Gd(35Cl, 5n)190Tl fusion-evaporation reaction at 167 and 175 MeV beam energies, have been investigated by in-beam γ-ray spectroscopy. Based on the experiment measur...The high-spin states of 190Tl, populated via the 160Gd(35Cl, 5n)190Tl fusion-evaporation reaction at 167 and 175 MeV beam energies, have been investigated by in-beam γ-ray spectroscopy. Based on the experiment measured results, together with references to the previous in-beam work and the studies of the 194Bi αdecay, the level scheme of 190Tl has been established as shown in Fig.1. Spins for the levels above the 300 keV 10-state were proposed from the measured DCO and γ-ray anisotropy results. It is the first time that spin展开更多
In order to provide an anti-Compton shield for N-type axially symmetric HPGe detector, we designed and made a new BGO counter. The structure of the axially symmetric BGO detector is shown in Fig.l. It consists mainly ...In order to provide an anti-Compton shield for N-type axially symmetric HPGe detector, we designed and made a new BGO counter. The structure of the axially symmetric BGO detector is shown in Fig.l. It consists mainly of a Pb collimator with 30 mm thickness, BGO crystals, Teflon reflectors, optical couplings, photo-multiplier tubes (PMT) and stainless steel photo shields. Signals from the photo-multiplier tubes were mixed before amplified. Applying a negative high voltage of 1 200 V to the PMTs, the maximum negative展开更多
基金This work was supported by grants from the National Key Basic Research Program of China （2010CB529901 and 2010CB530600）, the National Natural Science Foundation of China （31100619 and 30972705）, the China Postdoctoral Science Foundation （20110490186）, the Chen-guang Plan Project of Shanghai Educational Municipal Education Commission （11CG48 and szyl0004）, the Specialized Research Fund for the Doctoral Program of Higher Education （20113107120014） and the Leading Academic Discipline Project of Shanghai Municipal Education Commission （J50301） （Yuejuan Zheng, Shanghai University of T.C.M）.
文摘Approaches for controlling inflammatory responses and reducing the mortality rate of septic patients remain clinically ineffective; new drugs need to be identified that can induce anti-inflammatory responses. Ephedrine hydrochloride （EH） is a compound that is widely used in cardiovascular diseases, especially to treat hypotension caused by either anesthesia or overdose of antihypertensive drugs. In this study, we reported that EH also plays an important role in the control of the inflammatory response. EH increased IL-IO and decreased proinflammatory cytokine （IL-6, tumor-necrosis factor （TNF）-a, IL-12 and IL-11~） expression in primary peritoneal macrophages and Raw264.7 cells treated with peptidoglycan （PGN）, a Gram-positive cell wall component. The anti-inflammatory role of EH was also demonstrated in an experimental mouse model of peritonitis induced by intraperitoneal PGN injection. The phosphatidylinositol 3-kinase （PI3K）/Akt pathway was found to be responsible for the EH-mediated increase in IL-IO production and decrease in IL-6 expression. Therefore, our results illustrated that EH can help maintain immune equilibrium and diminish host damage by balancing the production of pro- and anti-inflammatory cytokines after PGN challenge. EH may be a new potential anti-inflammatory drug that can be useful for treating severe invasive Gram-positive bacterial infection.
基金supported by the National Natural Science Foundation of China(No.82070631).
文摘To the Editor,A 48-year-old male patient presented to our hospital with abnormal liver function.The results of his liver function tests were as follows:alanine transaminase,118 U/L(normal range,5-35 U/L);aspartate transaminase,86 U/L(8-40 U/L);alkaline phosphatase(ALP),246 U/L(40-150 U/L);andγglutamyl transferase(γ-GT),792 U/L(17-53 U/L).His immunoglobulin(Ig)G and IgM levels were 13.0 g/L(7.51-15.60 g/L)and 2.44 g/L(0.460-3.040 g/L),respectively,and his autoimmune antibody tests were positive for antinuclear antibodies and M2 subtype antimitochondrial antibodies.
基金the National Natural Science Foundation of China(No.81974078,81570530,81370550 to LY,No.8190034336 to WW)Natural Science Founda-tion of Hubei Province(No.2019ACA133 to LY)。
文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a rep-resentative Pas,insults hepatic sinusoidal endothelial cells and ensues congestion of hepatic sinusoids.However,little known about the impact of Pas on gut microbiota and intesti-nal barrier and inflammation in HSOS.Methods:Mice were gavaged with or without nonabsorbable antibiotics(ABX),followed by a single dose of RTS.The gut microbiota was examined by 16S rDNA sequencing.Results:ABX pretreat-ment significantly reversed RTS-induced liver damage.RTS altered gut microbiota composition,increasing Gram-nega-tive bacteria and resulting in a sharp elevation of circulating lipopolysaccharides(LPS)in HSOS mice.Gut decontamina-tion with ABX alleviated RTS-induced intestine inflamma-tion,protected against disruption of the intestinal epithelial barrier and gut vascular barrier(GVB),and suppressed he-patic LPS-NF-κB pathway activation in RTS-induced HSOS.Importantly,the LPS level was positively correlated with MELD score in patients with HSOS.Elevated LPS in patients with HSOS confirmed that Gram-negative bacteria were in-volved in the pathogenesis of HSOS.Conclusions:RTS,a PA,cooperated with gut dysbiosis to cause intestinal inflam-mation and gut barrier compromise that increased transport of gut-derived LPS into the liver through the portal vein,which contributed to the pathology of HSOS.Modulating the gut microbiota,protecting the intestinal barrier,and sup-pressing intestinal inflammation with prebiotics or antibiot-ics might be a useful pharmacologic intervention in HSOS.
基金This work was supported by the National Natural Science Foundation of China(grant number 81770582).
文摘Background and Aims:Although ursodeoxycholic acid(UDCA)treatment in primary biliary cholangitis is effective in many patients,there are still many people who respond poorly to it.Identifying and intervening these patients early is important.Therefore,exploring the risk factors and proposing a predictor index to predict the UDCA treatment nonresponse earlier among primary biliary cholangitis patients were the aims of this research.Methods:A total of 135 primary biliary cholangitis patients treated with UDCA(13–15 mg/kg/d)were enrolled in this retrospective study.The response to treatment was evaluated based on Paris I criteria.The univariate and logistic multivariate regression analyses were adopted to determine the independent risk factors and propose a predictor index.Receiver operating characteristic curve was used to evaluate the predictive ability of the predictor index.Results:Total bilirubin,albumin,globulin,immunoglobin M,and aspartate aminotransferase-to-platelet ratio index were the five independent risk factors associating with early biochemical nonresponse to UDCA treatment.Based on these factors,we established a predictor index with the predictive value being 0.886(sensitivity:82.80%,specificity:84.40%).Conclusions:We developed a predictor index that had an accurate prediction of the early biochemical nonresponse to UDCA treatment,which is expected to provide valuable information for the high-risk group before treatment begins.
基金supported by grants from the National Natural Sciences Foundation of China(Grant No.30872237)Research Fund for the Doctoral Program of Higher Education of China(No.20070487007)the National Program for Basic Research(973 project)of China(No.2007CB512900).
文摘To investigate the regulation of tumor sup-pressor XAF1 gene expression in digestive system cancers,we studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines(human hepatoma cell line HepG2,human colon cancer cell line LoVo,and human gastric cancer cell line AGS)and nontumor cell lines(human embryonic liver cell line L02(L02 cells)and human embryonic kidney 293 cells[HEK293 cells])as controls.1395-bp-promoter fragment of XAF1 gene was amplified by polymerase chain reaction(PCR)and cloned into pGL3-basic vector and pEGFP-1 vector to assay its promoter transcription activity.The plasmids were transfected into a variety of cell lines by lipofectamine 2000.The promoter transcription activity was determined by dual-luciferase report assay,and enhanced greenfluorescent protein(EGFP)-positive cells were detected byfluorescence microscope.The expression of XAF1 mRNA in HEK293 and L02 were significantly higher than that in any of the three digestive system cancer cell lines.The dual-luciferase reporter assay showed that the promoter transcription activity in digestive system tumor cell lines transfected with pGL3-XAF1p promoter was apparently lower than that of both HEK293 and L02 cells.Expression of greenfluorescent protein(GFP)under the control of XAF1 promoter in the three digestive system cancer cell lines was lower than that of both HEK293 and L02 cells.The activities of pGL3-XAF1p in the three digestive system cancer cell lines after treatment with heat stress were significantly lower than those in the unstressed cells.The results suggested that remarkably down-regulated XAF1 mRNA expression in digestive system cancer cell lines may be due to loss of transcription activity of XAF1 promoter.
基金supported in part by the National Natural Science Foundation of China(Grant Nos.30872237 and 30600277)National Key Basic Research Program of China(973 Program,No.2007CB512900)Doctoral Fund of Ministry of Education of China(No.20070487007).
文摘Virus tagged with greenfluorescent protein(GFP)contributes to the visualization and study of the virus in living cells.However,the hepatitis B virus(HBV)particle,which is a compact virion with limited internal space,cannot be incorporated with GFP tag as a large fragment.It was recently reported that protein genetically inserted with a smaller size tetracysteine(TC)tag could be specially labeled by a biarsenicalfluorescent dye in living cells.In this study,we constructed a recombinant HBV vector encoding TC-tagged core protein for biarsenical labeling of HBV virion.TC tag was genetically inserted near the immunodominant c/e1 site of HBV core protein by mutagenesis.Western blot and enzyme-linked immu-nosorbent assay(ELISA)analysis showed that the TC-tagged core protein,hepatitis B surface antigen(HBsAg)and hepatitis B e antigen(HBeAg)could be expressed in cells transfected with the recombinant HBV vector,which is similar to the cells transfected with wild-type HBV vector.Reverse transcription-polymerase chain reaction(RT-PCR)and Southern blot analysis showed that HBV virion formation was affected by the genetic insertion of TC tag into core protein in some degree,but cells transfected with the HBV vector could still produce HBV virions incorporated with TC-tagged core proteins.Taken together,the recombinant HBV vector can serve as a useful tool to produce HBV virions incorporated with TC-tagged core proteins to befluorescently labeled by biarsencial dye for visualizing and studying HBV in living cells.
基金Supported by National Natural science Foundation of China (10005012)Major State Basic Research Development Program (G2000077400)
文摘In-beamγ-ray spectroscopic experiment for the deformed odd-A nucleus 179Pt has been performed via the 149Sm(35Cl, p4n) reaction at beam energy of 180 MeV. The 35Cl beam was provided by the tandem accelerator at the Japan Atomic Energy Research Institute (JAERI). The target was an isotopic 149Sm foil of 1. 5 mg /cm2 thickness with a 5 me/cm2 Pb backing. Based on the measured results, three rotational
基金supported by the National Natural Science Foundation of China(Grant Nos.10475097,10375077 and 10221003)the Major State Basic Research Development Program of China(Grant No.G2000077402)and the Chinese Academy of Sciences.
文摘High-spin states in 190Tl have been studied via the 160Gd(35Cl, 5nγ) reaction. The level scheme, consisting of the π h9 /2 νi13/2 oblate band and a cascade with character of single particle excitations, has been established. Spin values have been firmly assigned to the oblate band in 190Tl, resulting in low-spin signature inversion in the π h9 /2 νi13/2 oblate band for the first time. Based on the similarity of the level structure in doubly odd Tl nuclei, spin values for the oblate bands in 192―200Tl should be re-assigned, and a consistent low-spin signature inversion has occurred in these oblate deformed nuclei. The low-spin signature inversion phenomena can be interpreted qualitatively by using the 2-quasiparticle plus rotor model including p-n residual interactions.
文摘The high-spin states of neutron-deficient doubly odd nucleus 190Tl have been investigated via the 160Gd (35Cl,5n)19Tl reaction at 167 and 175 MeV beam energies by using techniques of in-beamγ-ray spectroscopy. Measurements of X-γandγ-γ-t coincidences were performed with 12 BGO(AC)HPGe detectors. The detailed results of the present work have been reported.With the configuration and spin-parity as-
基金Supported by National Natural science Foundation of China for Distinguished oung Scholar (1002525) , NSFC(10375077,10223003)Major Stale Basic Research Development Program(G2000077400)the Chinese Academy of Sciences
文摘Theβ+/EC decay of doubly odd 176Ir has been studied via the 146Nd(35Cl,5nγ) heavy ion fusion evaporation reaction at the Sector-Focusing Cyclotron (SFC) accelerator in the Institute of Modern Physics (IMP), Lanzhou. A 210 MeV 35C1 beam from the cyclotron entered a helium-filed target chamber,
文摘The high-spin states in 139Ce have been populated via the 130Te(12C, 3n) 139Ce reaction by using techniques of in-beamγ-ray spectroscopy. The 12C beam at 50 MeV energy was provided by the HI-13 tandem accelerator at the China Institute of Atomic Energy, Beijing. The 130Te target is an enriched metallic foil of about 1. 4 mg/cm2 thickness with a 9 mg/cm2 197Au backing to stop the recoiling nuclei. 14 BGO(AC)
基金Supported by NSFC(10375077 and 10221003)Major State Basic Research Development Program (TG2000077402).
文摘The high-spin states of 190Tl, populated via the 160Gd(35Cl, 5n)190Tl fusion-evaporation reaction at 167 and 175 MeV beam energies, have been investigated by in-beam γ-ray spectroscopy. Based on the experiment measured results, together with references to the previous in-beam work and the studies of the 194Bi αdecay, the level scheme of 190Tl has been established as shown in Fig.1. Spins for the levels above the 300 keV 10-state were proposed from the measured DCO and γ-ray anisotropy results. It is the first time that spin
文摘In order to provide an anti-Compton shield for N-type axially symmetric HPGe detector, we designed and made a new BGO counter. The structure of the axially symmetric BGO detector is shown in Fig.l. It consists mainly of a Pb collimator with 30 mm thickness, BGO crystals, Teflon reflectors, optical couplings, photo-multiplier tubes (PMT) and stainless steel photo shields. Signals from the photo-multiplier tubes were mixed before amplified. Applying a negative high voltage of 1 200 V to the PMTs, the maximum negative
