The myriad sensing nodes in the Internet of Things(IoT)are mainly powered by battery,which has limited the lifespan and increased the maintenance costs.Herein,a self-powered IoT sensing node based on triboelectric nan...The myriad sensing nodes in the Internet of Things(IoT)are mainly powered by battery,which has limited the lifespan and increased the maintenance costs.Herein,a self-powered IoT sensing node based on triboelectric nanogenerator(TENG)is proposed for the sustainable environmental monitoring.The wind powered TENG(W-TENG)is adopted in freestanding mode with the rabbit hair and six pairs of finger electrodes.With the energy management module,the weak electrical energy from WTENG can be converted into a stable direct current(DC)2.5 V voltage for the operation of the IoT sensing node.When the storage energy exceeds 4.4 V,the node can be activated,then the microprogrammed control unit(MCU)transmits the monitoring data.Thereafter,the monitoring data will be identified and relayed to the IoT cloud platform by narrowband IoT(NBIoT)module.At a wind speed of 8.4 m/s,the node can realize the wireless monitoring and data transmission for temperature and atmosphere pressure every 30 s.This work has provided a universal strategy for sustainable IoT sensing nodes powered by environmental micro-nano mechanical energy and exhibited potential applications in IoT,big data,and environmental monitoring.展开更多
Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-b...Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition.Dopamine is a crucial catecholaminergic neurotransmitter in the human body.Dopamine-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations.Howeve r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive impairment.This review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs.The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.展开更多
Objective:To observe the effects of Danggui Shaoyao powder(DSP)on hepatic lipid metabolism and further explore its mechanism of action by peroxisome proliferator-activated receptor(PPARγ)-liver X receptor(LXRα)-aden...Objective:To observe the effects of Danggui Shaoyao powder(DSP)on hepatic lipid metabolism and further explore its mechanism of action by peroxisome proliferator-activated receptor(PPARγ)-liver X receptor(LXRα)-adenosine triphosphate(ATP)-binding cassette transporter A1(ABCA1)pathway regulation.Methods: Eight C57BL/6J male mice were selected as the control group,and 24 ApoE^(−/−)male mice were randomly divided into the atherosclerosis model(AS)group,atorvastatin calcium(AC)group,and DSP group(n=8 each group).To establish an AS model,ApoE^(−/−)mice were fed a high-fat diet for 16 weeks.Pathologic changes in the aortic vasculature and liver were identified using Oil Red O staining.Triglyceride(TG),cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)levels were determined in the livers using a single-reagent GPO-PAP method.Fluorescence quantitative polymerase chain reaction and western blot were used to observe and evaluate the mRNA and protein expression of the PPARγ-LXRα-ABCA1 intermediates in the liver.Results: After 16 weeks of a high-fat diet,ApoE^(−/−)mice showed more Oil Red O staining in the aorta and liver compared to the CONT group.Compared to the AS group,the DSP and AC treatment reduced aortic plaque and hepatic lipid deposition to varying degrees.Furthermore,DSP significantly reduced the hepatic lipid area in ApoE^(−/−)mice(P<.001)and decreased the levels of TG,TC,and LDL-C in liver(P<.001,P=.027,P<.001,respectively).DSP also significantly increased the levels of PPARγ,LXRα,ABCA1,and ABCG1 mRNA expression,as well as the PPARγ,LXRα,ABCA1,and ABCG1 protein expression in liver.Conclusion: DSP improved hepatic lipid metabolism via PPARγ-LXRα-ABCA1 pathway modulation for AS treatment.展开更多
Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases.Although various studies and reviews have described developments and a...Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases.Although various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience.To identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years.First,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were identified.The hotspots in this field were also systematically identified.Subsequently,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively discussed.Towards that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.展开更多
In recent years,the rapid development of portable/wearable electronics has created an urgent need for the development of flexible energy storage devices.Flexible lithium-ion batteries(FLIBs)have emerged as the most at...In recent years,the rapid development of portable/wearable electronics has created an urgent need for the development of flexible energy storage devices.Flexible lithium-ion batteries(FLIBs)have emerged as the most attractive and versatile flexible electronic storage devices available.Carbon nanotubes(CNTs)are hollow-structured tubular nanomaterials with high electrical conductivity,large specific surface area,and excellent mechanical properties.Graphene(G)is to some extent comparable to CNTs,because both have unlimited value in flexible electrodes.Herein,a systematic summary of the application of CNT and G in FLIBs electrodes is presented,including different functional applications and services at different temperatures.Furthermore,the effects of electrode structures,including powder,wire-shaped,and film-shaped structures,on electrochemical properties is highlighted.The assembly structures of the FLIBs consisting of CNT and G-based flexible electrodes to realize different functions,including bendability,stretchability,foldability,self-healing,and self-detecting,are systematically reviewed.The current challenges and development prospects of flexible CNT and G-based flexible electrodes and corresponding FLIBs are discussed.展开更多
基金supported by the National Key Research&Development Project from Minister of Science and Technology(No.2021YFA1201604)the National Natural Science Foundation of China(Nos.52250112 and 51922023)Fundamental Research Funds for the Central Universities(No.E1EG6804).
文摘The myriad sensing nodes in the Internet of Things(IoT)are mainly powered by battery,which has limited the lifespan and increased the maintenance costs.Herein,a self-powered IoT sensing node based on triboelectric nanogenerator(TENG)is proposed for the sustainable environmental monitoring.The wind powered TENG(W-TENG)is adopted in freestanding mode with the rabbit hair and six pairs of finger electrodes.With the energy management module,the weak electrical energy from WTENG can be converted into a stable direct current(DC)2.5 V voltage for the operation of the IoT sensing node.When the storage energy exceeds 4.4 V,the node can be activated,then the microprogrammed control unit(MCU)transmits the monitoring data.Thereafter,the monitoring data will be identified and relayed to the IoT cloud platform by narrowband IoT(NBIoT)module.At a wind speed of 8.4 m/s,the node can realize the wireless monitoring and data transmission for temperature and atmosphere pressure every 30 s.This work has provided a universal strategy for sustainable IoT sensing nodes powered by environmental micro-nano mechanical energy and exhibited potential applications in IoT,big data,and environmental monitoring.
文摘Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition.Dopamine is a crucial catecholaminergic neurotransmitter in the human body.Dopamine-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations.Howeve r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive impairment.This review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs.The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.
基金supported by the National Natural Science Foundation of China(82074325).
文摘Objective:To observe the effects of Danggui Shaoyao powder(DSP)on hepatic lipid metabolism and further explore its mechanism of action by peroxisome proliferator-activated receptor(PPARγ)-liver X receptor(LXRα)-adenosine triphosphate(ATP)-binding cassette transporter A1(ABCA1)pathway regulation.Methods: Eight C57BL/6J male mice were selected as the control group,and 24 ApoE^(−/−)male mice were randomly divided into the atherosclerosis model(AS)group,atorvastatin calcium(AC)group,and DSP group(n=8 each group).To establish an AS model,ApoE^(−/−)mice were fed a high-fat diet for 16 weeks.Pathologic changes in the aortic vasculature and liver were identified using Oil Red O staining.Triglyceride(TG),cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)levels were determined in the livers using a single-reagent GPO-PAP method.Fluorescence quantitative polymerase chain reaction and western blot were used to observe and evaluate the mRNA and protein expression of the PPARγ-LXRα-ABCA1 intermediates in the liver.Results: After 16 weeks of a high-fat diet,ApoE^(−/−)mice showed more Oil Red O staining in the aorta and liver compared to the CONT group.Compared to the AS group,the DSP and AC treatment reduced aortic plaque and hepatic lipid deposition to varying degrees.Furthermore,DSP significantly reduced the hepatic lipid area in ApoE^(−/−)mice(P<.001)and decreased the levels of TG,TC,and LDL-C in liver(P<.001,P=.027,P<.001,respectively).DSP also significantly increased the levels of PPARγ,LXRα,ABCA1,and ABCG1 mRNA expression,as well as the PPARγ,LXRα,ABCA1,and ABCG1 protein expression in liver.Conclusion: DSP improved hepatic lipid metabolism via PPARγ-LXRα-ABCA1 pathway modulation for AS treatment.
基金supported by the National Natural Science Foundation of China,Nos.82204083(to ML)and 12372303(to BW)the Natural Science Foundation of Chongqing,No.cstc2021jcy-jmsxmX0171(to ML).
文摘Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases.Although various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of neuroscience.To identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 years.First,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were identified.The hotspots in this field were also systematically identified.Subsequently,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively discussed.Towards that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.
基金supported by the National Natural Science Foundation of China(Grant Nos.51972261 and 51302206)。
文摘In recent years,the rapid development of portable/wearable electronics has created an urgent need for the development of flexible energy storage devices.Flexible lithium-ion batteries(FLIBs)have emerged as the most attractive and versatile flexible electronic storage devices available.Carbon nanotubes(CNTs)are hollow-structured tubular nanomaterials with high electrical conductivity,large specific surface area,and excellent mechanical properties.Graphene(G)is to some extent comparable to CNTs,because both have unlimited value in flexible electrodes.Herein,a systematic summary of the application of CNT and G in FLIBs electrodes is presented,including different functional applications and services at different temperatures.Furthermore,the effects of electrode structures,including powder,wire-shaped,and film-shaped structures,on electrochemical properties is highlighted.The assembly structures of the FLIBs consisting of CNT and G-based flexible electrodes to realize different functions,including bendability,stretchability,foldability,self-healing,and self-detecting,are systematically reviewed.The current challenges and development prospects of flexible CNT and G-based flexible electrodes and corresponding FLIBs are discussed.
