Background： D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer （GC）, while the necessity of No.14v lymph node （14v） dissection for distal GC is still cont...Background： D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer （GC）, while the necessity of No.14v lymph node （14v） dissection for distal GC is still controversial. Methods： A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were enrolled in this study, of whom, 243 patients also had the 14v dissected. Other 677 patients without 14v dissection were used for comparison. Results： Forty-five （18.5%） patients had 14v metastasis. There was no significant difference in 3-year overall survival （OS） rate between patients with and without 14v dissection. Following stratified analysis, in TNM stages I, II, IIIa and IV, 14v dissection did not affect 3-year OS; in contrast, patients with 14v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc. In multivariate analysis, 14v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio （HR）, 1.568; 95% confidence interval （CI）： 1.186-2.072; P=0.002]. GC patients with 14v dissection had a significant lower locoregional, especially lymph node, recurrence rate than those without 14v dissection （11.7 % vs. 21.1%, P=0.035）. Conclusions： Adding 14v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM IIIb/IIIc.展开更多
OBJECTIVE:To investigate the effect of acupotomy on knee osteoarthritis(KOA),compared to electro-acupuncture(EA).METHODS:Sixty KOA patients were randomly divided into 2 groups:ultrasound-guided acupotomy group and EA ...OBJECTIVE:To investigate the effect of acupotomy on knee osteoarthritis(KOA),compared to electro-acupuncture(EA).METHODS:Sixty KOA patients were randomly divided into 2 groups:ultrasound-guided acupotomy group and EA group;each had 3 weeks' therapy.After the treatment,by contrast before and after therapy,by comparing curative effects among groups,we looked into disease improvement degree through activities of daily living score(ADL),hospital for special surgery index(HSS),visual analogue scales score(VAS) and knee joint's infrared thermal imaging detection.RESULTS:Graded by ADL,the excellent rate in acupotomy group was much higher than EA group;both acupotomy group and EA group had obviouschanges in HSS index before and after the therapy(P < 0.01).And there was remarkable difference in HSS index variation between the groups(P < 0.01).Acupotomy group and EA group showed big difference in pain index before and after treatment(P <0.01).Apparent difference also existed in the comparison among groups(P < 0.01).Both acupotomy group and EA group had apparent changes in infrared thermal imaging detection before and after the treatment(P < 0.01).CONCLUSION:Acupotomy and EA both have significant effects in KOA treatment;the former is better than the latter in relieving pain and improving knee functions.展开更多
Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.Methods: In total, 1,0...Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.Methods: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. The patients were categorized into two groups based on the LVI status: a positive group(PG;presence of LVI) and a negative group(NG;absence of LVI). The clinicopathological factors corrected with LVI and prognostic variables were analyzed. Additionally, a pathological lymphovascular-node(lvN) classification system was proposed to evaluate the superiority of its prognostic prediction of GC patients compared with that of the eighth edition of the N staging system.Results: Two hundred twenty-four patients(22.2%) had LVI. The depth of invasion and lymph node metastasis were independently associated with the presence of LVI. GC patients with LVI demonstrated a significantly lower overall survival(OS) rate than those without LVI(42.8% vs. 68.9%, respectively;P<0.001). In multivariate analysis,LVI was identified as an independent prognostic factor for GC patients(hazard ratio: 1.370;95% confidence interval: 1.094-1.717;P=0.006). Using strata analysis, significant prognostic differences between the groups were only observed in patients at stage I-IIIa or N0-2. The lvN classification was found to be more appropriate to predict the OS of GC patients after curative surgery than the pN staging system. The-2 log-likelihood of lvN classification(4,746.922) was smaller than the value of pN(4,765.196), and the difference was statistically significant(χ^2=18.434, P<0.001).Conclusions: The presence of LVI influences the OS of GC patients at stage Ⅰ-Ⅲ a or N0-2. LVI should be incorporated into the pN staging system to enhance the accuracy of the prognostic prediction of GC patients.展开更多
Objective： Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preo...Objective： Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level（PDL） on overall survival（OS） of gastric cancer（GC） patients undergoing curative surgery by applying propensity score analysis.Methods： A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute ＆Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL： the elevated group（EG） and the normal group（NG）. To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results： In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm（67.5% vs. 55.8%, P=0.006）, elder mean age（64.0±10.8 years vs. 60.5±11.6 years, P〈0.001） and advanced tumor（T）, node（N）, and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL（27.0% vs. 42.6%, P〈0.001）, however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio： 1.13, 95% confidence interval（95% CI）： 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG（P=0.809, log-rank）.Conclusions： The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself.展开更多
A hydroponic experiment was conducted to investigate the effects of arsenic （As） stress on growth, nutrition and As uptake, and speciation in shoots and roots of winter wheat （Triticum aestivum L.）. Winter wheat h...A hydroponic experiment was conducted to investigate the effects of arsenic （As） stress on growth, nutrition and As uptake, and speciation in shoots and roots of winter wheat （Triticum aestivum L.）. Winter wheat has high tolerance to As. Most As is accumulated in the roots, and an As concentration of 4,421 mg/kg was observed at a solution concentration of 20 mg/L As. Arsenic concentrations in roots were approximately 40-100 times greater than those in shoots. Arsenic in winter wheat roots and shoots occurred as both As^3＋ and As^5＋ species, although As^3＋ was the main species in winter wheat tissues. Arsenic significantly decreased the biomass of winter wheat shoots and roots and affected absorption and transport of micro- and macro-elements in winter wheat tissue. Arsenic treatment significantly increased the concentrations of total Magnesium （Mg） and calcium （Ca） in shoots and enhanced the transport of Mg and Ca from roots to shoots but decreased potassium （K）, nitrogen （N）, and phosphorus （P） concentrations in both shoots and roots, particularly the concentration of P. Concentrations of iron, copper, and zinc in winter wheat shoots were negatively related to As rates, with correlation coefficients （R^2） of 0.93, 0.94, and 0.97, respectively.展开更多
Exposure to ethanol during human embryonic period has severe teratogenic effects on the cardiovascular system.In our study,we demonstrated that ethanol of gradient concentra-tions can interfere with the establishment ...Exposure to ethanol during human embryonic period has severe teratogenic effects on the cardiovascular system.In our study,we demonstrated that ethanol of gradient concentra-tions can interfere with the establishment of circulatory system in embryonic zebrafish.The ef-fective concentration to cause 50%malformations(EC_(50))was 182.5 mmol/L.The ethanol pulse exposure experiment displayed that dome stage during embryogenesis is the sensitive time window to ethanol.It is found that 400 mmol/L ethanol pulse exposure can induce circulatory defects in 43%treated embryos.We ruled out the possibility that ethanol can interfere with the process of hematopoiesis in zebrafish.By employing in situ hybridization with endothelial bio-marker(Flk-1),we revealed that ethanol disrupts the establishment of trunk axial vasculature,but has no effect on cranial vessels.Combined with the results of semi-thin histological sections,the in situ hybridization experiments with arterial and venous biomarkers(ephrinB2,ephB4)sug-gested that ethanol mainly interrupts the development of dorsal aorta while has little effect on axial vein.Further study indicated the negative influence of ethanol on the development of hy-pochord in zebrafish.The consequent lack of vasculogenic factors including Radar and Ang-1 partly explains the defects in formation and integrity of dorsal aorta.These results provide im-portant clues to the study of adverse effects of ethanol on the cardiovascular development in human fetus.展开更多
Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation.Ki-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer...Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation.Ki-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer and neuroendocrine tumors.However,its prognostic significance in pancreatic ductal adenocarcinoma(PDAC)remains uncertain.Methods:Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled,and relevant prognostic factors were examined.Grade of malignancy(GOM),a novel index based on histopathological differentiation and Ki-67,is proposed,and its clinical significance was evaluated.Results:The optimal threshold for Ki-67 was determined to be 30%.Patients with a Ki-67 expression level>30%rather than≤30%had significantly shorter 5-year overall survival(OS)and recurrence-free survival(RFS).In multivariate analysis,both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and RFS.The GOM was used to independently stratify OS and RFS into 3 tiers,regardless of TNM stage and other established prognostic factors.The tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers,and surpassed the predictive performance of TNM stage for OS and RFS.Conclusions:Ki-67 is a valuable prognostic indicator for PDAC.Inclusion of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.展开更多
In this study, an isotropic hardening constitutive model is presented to study the behavior of frozen soil under impact loading. In plasticity, a modified Drucker–Prager yield function is adopted. Based on the experi...In this study, an isotropic hardening constitutive model is presented to study the behavior of frozen soil under impact loading. In plasticity, a modified Drucker–Prager yield function is adopted. Based on the experimental investigations at different strain rates and different temperatures by means of split Hopkinson pressure bar, the Drucker–Prager criterion has been modified with consideration in the effect of strain rate, and the model parameters have been determined. Compared the constitutive model with the experimental results, the predicted tendencies of the model corresponded well to the test curves.展开更多
Photocatalysis-assisted removal of uranium has been proven as an effective method for the elimination of radioactive pollution from wastewater.In this work,carbon nitride materials were synthesized in potassium hydrox...Photocatalysis-assisted removal of uranium has been proven as an effective method for the elimination of radioactive pollution from wastewater.In this work,carbon nitride materials were synthesized in potassium hydroxide(KOH)molten salt and applied to photocatalytic uranyl extraction.Obtained materials were confirmed to possess the triazine-s-heptazine structure by NMR,XPS and UV-Vis characterization,and exhibited a wider visible light absorption than graphitic carbon nitride(g-C_(3)N_(4)).The photocatalytic activity of the carbon nitride materials was tailored by varying the precursor mass fractions.The carbon nitride obtained at 80%melamine as precursor(K-CN-80)exhibited the highest photocatalytic extraction ability and its photocatalytic reaction rate is 6.6 times faster than that of g-C_(3)N_(4).The influence of sacrificial agents was studied and the results showed that triethanolamine inhibited U(Ⅵ)photoreduction,but methanol can accelerate U(Ⅵ)photoreduction by consuming photogenerated holes.This unary KOH molten salt synthesis method has exceptional potential applications in the preparation of carbon nitrides,and the obtained products showed potential in extracting U(Ⅵ)from aqueous solutions for use in nuclear fuel industry and for U(Ⅵ)environmental pollution cleanup.展开更多
Due to the well condition and the un-expected imbalance movement of the pumping unit in use, the energy consumes a lot. The existing balancing equipment cannot adjust and monitor the pumping units in real time. Theref...Due to the well condition and the un-expected imbalance movement of the pumping unit in use, the energy consumes a lot. The existing balancing equipment cannot adjust and monitor the pumping units in real time. Therefore this paper introduces the new adaptive balancing equipment—fan-shaped adaptive balancing intelligent device, projects a design of such control system based on PLC, and determines the principle of the control system, the execution software and the design flow. Site commissioning effect on Daqing Oilfield shows this fan-shaped adaptive balancing intelligent device can effectively adjust and monitor the pumping unit in real time, the balance even adjusts from 0.787 to 0.901, and integrated energy saving rate is 14.2%. It is approved that this control device is professionally designed, with strong compatibility, and high reliability.展开更多
Microplasma based on glow discharge could act as a non-contact gaseous electrode and has attracted much attention in both fundamental research and application. Herein, with microplasma as the anode,the electrodepositi...Microplasma based on glow discharge could act as a non-contact gaseous electrode and has attracted much attention in both fundamental research and application. Herein, with microplasma as the anode,the electrodeposition process of a series of metal and metal alloys in molten salt has been systemically studied. Four metal cations with different valence states, silver(Ag~+), nickel(Ni^(2+)), copper(Cu^(2+)), and iron(Fe^(3+)), could all be reduced on the solid cathode with high current efficiency and the corresponding metal products were of high purity. The electrodeposition of aluminum-lanthanum(Al-Ln) alloy on the aluminum cathode was also successfully carried out with microplasma as the anode, and the same alloy was obtained by using the conventional anode electrode. These results indicated that microplasma anode based on non-contact direct-current(DC) glow discharge is a promising electrode to be applied in molten salt electrolysis.展开更多
To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-...To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3].展开更多
Electrochemical CO2 reduction(ECR)represents a promising strategy for utilizing CO2,an industrial waste,as an abundant and cheap carbon source for organic synthesis as well as storing intermittent renewable electricit...Electrochemical CO2 reduction(ECR)represents a promising strategy for utilizing CO2,an industrial waste,as an abundant and cheap carbon source for organic synthesis as well as storing intermittent renewable electricity from renewable sources.Efficient electrocatalysts allowing CO2 to be reduced selectively and actively are crucial since the ECR is a complex and sluggish process producing a variety of products.Metal-organic frameworks(MOFs)and covalentorganic frameworks(COFs)have emerged as versatile materials applicable in many fields due to their unique properties including high surface areas and tunable pore channels.Besides,the emerging reticular chemistry makes tuning their features on the atomic/molecular levels possible,thereby lending credence to the prospect of their utilizations.Herein,an overview of recent progress in employing framework material-based catalysts,including MOFs,COFs and their derivatives,for ECR is provided.The pertinent challenges,future trends,and opportunities associated with those systems are also discussed.展开更多
Single-crystalline Ag_(2)Se complex nanostructures have been synthesized via a solvothermal route in which selenophene(C4H4Se)as a selenylation source reacts with AgNO3 at a temperature of 240°C.An orthorhombic p...Single-crystalline Ag_(2)Se complex nanostructures have been synthesized via a solvothermal route in which selenophene(C4H4Se)as a selenylation source reacts with AgNO3 at a temperature of 240°C.An orthorhombic phaseβ-Ag_(2)Se nanostructure was identified by X-ray diffraction(XRD),Raman spectroscopy,field emission scanning electron microscopy(FE-SEM),high resolution transmission electron microscopy(HRTEM),and photoluminescence(PL)spectroscopy.The wettability of the as-synthesizedβ-Ag_(2)Se nanostructure was studied by measurement of the water contact angle(CA).Static water CA values of over 150°were obtained,which can be attributed to theβ-Ag_(2)Se complex nanostructure having a combination of micro-and nanostructures.The superhydrophobic Ag_(2)Se nanostructure may find applications in self-cleaning.Additionally,the photocatalytic activity of the as-synthesizedβ-Ag_(2)Se nanostructure was evaluated by photodegradation of rhodamine B(RhB)dye under ultraviolet(UV)light irradiation.展开更多
The objective of this study was to address the challenges associated with complex TRPO waste,by utiliz-ing a natural aluminosilicate material to produce glass-ceramic waste forms.When the simulated waste content was b...The objective of this study was to address the challenges associated with complex TRPO waste,by utiliz-ing a natural aluminosilicate material to produce glass-ceramic waste forms.When the simulated waste content was below 30 wt.%,glassy waste forms were successfully obtained.Ce and Fe played crucial roles in the formation of Si-O-Ce bonds and[FeO_(4)]-tetrahedra in the glass network,which effectively immo-bilized other waste elements.However,when the waste content exceeded 30 wt.%,the waste was incor-porated into feldspar,iron-manganese crystals,fluorite ceramic,and glass.This combination of ceramic and glass matrices synergistically immobilized the waste,resulting in excellent mechanical performance and chemical durability.The leaching rates of LR_(Ce)and LR_(Nd)were remarkably low around-10^(−6)to 10^(−7)g m^(−2)d^(−1),after 42 d.Furthermore,the study also investigated the role of multi-valence elements,such as Ce,Fe,and Mn,in the formation of iron-containing aluminosilicate glass-ceramics.The findings offer a novel approach to effectively immobilize complex nuclear waste.展开更多
Increasing porosity is one of the most direct ways to improve the thermal insulation and dielectric properties of materials.Until now,many wet methods for preparing Si_(3)N_(4) ceramic foams usually face the problems ...Increasing porosity is one of the most direct ways to improve the thermal insulation and dielectric properties of materials.Until now,many wet methods for preparing Si_(3)N_(4) ceramic foams usually face the problems of complex rheology,long period,and expensive cost,and the reported pore sizes of Si_(3)N_(4) ceramic foams are typically micron-grade,resulting in a lack of competitiveness in thermal insulation and wave-transparent applications.In this paper,the Si_(3)N_(4)@SiO_(2) ceramic foams were prepared using an efficient dry-method,which combined three processes of low temperature chemical vapor deposition(LTCVD),template,and isostatic pressing.The method has the advantages of simple operation and short preparation period,and can realize near-net size molding and mass production.In addition,the evolution mechanisms of honeycomb microstructure and composition of Si_(3)N_(4)@SiO_(2) ceramic foam during sintering were studied by chemical reaction thermodynamics.The as-prepared Si_(3)N_(4)@SiO_(2) ceramic foam possesses low density(0.377 g·cm^(-3)),high compressive strength(7.5 MPa),low thermal conductivity(0.0808 W·m^(-1)·K^(-1)),and excellent dielectric properties(ε<1.32,tanδ<0.009)in the frequency range of 8-18 GHz,and its maximum working temperature in air can reach up to 1100℃.It will be recommended to be applied in the interlayer of Si_(3)N_(4) ceramic radome to improve its thermal insulation and electromagnetic wave transparency performances.展开更多
The separation of radionuclides is critical for the sustainable development of nuclear energy. It is urgent to design and prepare functionalized materials for efficient radionuclides separation. Porous materials are c...The separation of radionuclides is critical for the sustainable development of nuclear energy. It is urgent to design and prepare functionalized materials for efficient radionuclides separation. Porous materials are considered excellent candidates for the separation of radionuclides under complex conditions due to their high specific surface areas, tunable pore structures and controllable functionalities. In this review, we summarized the design, preparation and functionalization of porous materials and their application for separation of radionuclides in the past five years, discussed the separation performance and analyzed the structure-activity relationship between various radionuclides and porous materials, and systematically clarified their characterization and mechanism of different type porous materials. We also introduced the detection, irradiation and chemical toxicity of different reflective radionuclides.展开更多
Potassium ion-based dual-graphite batteries(KDGBs)emerge as promising devices for large-scale applications due to their high voltage,low cost,environmental friendliness.However,conventional KPF6/carbonate-based electr...Potassium ion-based dual-graphite batteries(KDGBs)emerge as promising devices for large-scale applications due to their high voltage,low cost,environmental friendliness.However,conventional KPF6/carbonate-based electrolytes suffer from severe oxidation decomposition,low concentration,flammability,which limit the capacity and cyclability of KDGBs.Herein,a nonflammable potassium bis(fluorosulfonyl)imide/triethyl phosphate(KFSI/TEP)electrolyte was designed for KDGBs.When the salt-to-solvent molar ratio increases to 1:1.3,graphite cathode operated at the cut-off potential of 5.2 V exhibits much enhanced capacity,excellent rate capability(26.4 mAh∙g^(−1) at 1.0 A∙g^(−1)),superior cyclability with 98%capacity retention after 350 cycles.Inorganic compounds-rich electrode/electrolyte interphase layers derived from the preferential decomposition of FSI−anions ensure good compatibility of the 1:1.3 KFSI/TEP electrolyte with K metal and graphite anodes.Based on this electrolyte,asassembled KDGBs show high operation voltage of 4.3 V and good cycling performance.This work provides feasibility for developing long-life and safe-operation DGBs.展开更多
Photocatalytic removal of uranium has attracted much attention in nuclear wastewater treatment and it is highly needed to develop functional photocatalyst with excellent removal performance.In this work,seven kinds of...Photocatalytic removal of uranium has attracted much attention in nuclear wastewater treatment and it is highly needed to develop functional photocatalyst with excellent removal performance.In this work,seven kinds of carbon dots/carbon nitride(CDs/CN)composites were synthesized and Ser CDs/CN with the best photo-assisted uranium removal performance was screened out.It was found that the introduction of CDs could bring in higher photocurrent density,lower interfacial charge transfer impedance and narrower band gap,resulting in a much-improved removal performance.SerCDs/CN had shown a removal capacity as high as 1690 mg/g and the reaction could be operated under air atmosphere which is promising in real application.展开更多
Well-ordered TiO 2 nanotube arrays (TNAs) were fabricated by electrochemical anodization in a mixed organic electrolyte consisting of ethylene glycol and glycerol. The morphology, structure, crystalline phase, and pho...Well-ordered TiO 2 nanotube arrays (TNAs) were fabricated by electrochemical anodization in a mixed organic electrolyte consisting of ethylene glycol and glycerol. The morphology, structure, crystalline phase, and photocatalytic properties of TNAs were characterized by using TEM, SEM, XRD and photodegradation of methylene blue. It was found that the morphology and structure of TNAs could be significantly influenced by the anodization time and applied voltage. The obtained tube length was found to be proportional to anodization time, and the calculated growth rate of nanotubes was 0.6 m/h. The microstructure analysis demonstrated that the diameter and thickness of the nanotubes increased with the increase of anodization voltage. The growth mechanism of TNAs was also proposed according to the observed relationship between current density and time during anodization. As expected, the obtained TNAs showed a higher photocatalytic activity than the commercial TiO 2 P25 nanoparticles.展开更多
文摘Background： D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer （GC）, while the necessity of No.14v lymph node （14v） dissection for distal GC is still controversial. Methods： A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were enrolled in this study, of whom, 243 patients also had the 14v dissected. Other 677 patients without 14v dissection were used for comparison. Results： Forty-five （18.5%） patients had 14v metastasis. There was no significant difference in 3-year overall survival （OS） rate between patients with and without 14v dissection. Following stratified analysis, in TNM stages I, II, IIIa and IV, 14v dissection did not affect 3-year OS; in contrast, patients with 14v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc. In multivariate analysis, 14v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio （HR）, 1.568; 95% confidence interval （CI）： 1.186-2.072; P=0.002]. GC patients with 14v dissection had a significant lower locoregional, especially lymph node, recurrence rate than those without 14v dissection （11.7 % vs. 21.1%, P=0.035）. Conclusions： Adding 14v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM IIIb/IIIc.
基金Supported by Beijing Medical Research Development Fund:the Clinical Study on Ultrasound-guided Needle-knife Treatment of Knee Osteoarthritis(No.SF-2009-46)
文摘OBJECTIVE:To investigate the effect of acupotomy on knee osteoarthritis(KOA),compared to electro-acupuncture(EA).METHODS:Sixty KOA patients were randomly divided into 2 groups:ultrasound-guided acupotomy group and EA group;each had 3 weeks' therapy.After the treatment,by contrast before and after therapy,by comparing curative effects among groups,we looked into disease improvement degree through activities of daily living score(ADL),hospital for special surgery index(HSS),visual analogue scales score(VAS) and knee joint's infrared thermal imaging detection.RESULTS:Graded by ADL,the excellent rate in acupotomy group was much higher than EA group;both acupotomy group and EA group had obviouschanges in HSS index before and after the therapy(P < 0.01).And there was remarkable difference in HSS index variation between the groups(P < 0.01).Acupotomy group and EA group showed big difference in pain index before and after treatment(P <0.01).Apparent difference also existed in the comparison among groups(P < 0.01).Both acupotomy group and EA group had apparent changes in infrared thermal imaging detection before and after the treatment(P < 0.01).CONCLUSION:Acupotomy and EA both have significant effects in KOA treatment;the former is better than the latter in relieving pain and improving knee functions.
基金supported in part by grants from the Program of National Natural Science Foundation of China (No. 81572372)National Key Research and Development Program of Major Chronic Non-infectious Disease Prevention and Control Research (No. 2016YFC1303202)+2 种基金National Key Research and Development Program “Precision Medicine Research” Program (No. 2017 YFC0908300)Application Foundation and Advanced Technology Program of Tianjin Municipal Science and Technology Commission (No. 15JCYBJC24800)Scientific Research Project of Tianjin Municipal Education Commission (No. 2018KJ015)
文摘Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.Methods: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. The patients were categorized into two groups based on the LVI status: a positive group(PG;presence of LVI) and a negative group(NG;absence of LVI). The clinicopathological factors corrected with LVI and prognostic variables were analyzed. Additionally, a pathological lymphovascular-node(lvN) classification system was proposed to evaluate the superiority of its prognostic prediction of GC patients compared with that of the eighth edition of the N staging system.Results: Two hundred twenty-four patients(22.2%) had LVI. The depth of invasion and lymph node metastasis were independently associated with the presence of LVI. GC patients with LVI demonstrated a significantly lower overall survival(OS) rate than those without LVI(42.8% vs. 68.9%, respectively;P<0.001). In multivariate analysis,LVI was identified as an independent prognostic factor for GC patients(hazard ratio: 1.370;95% confidence interval: 1.094-1.717;P=0.006). Using strata analysis, significant prognostic differences between the groups were only observed in patients at stage I-IIIa or N0-2. The lvN classification was found to be more appropriate to predict the OS of GC patients after curative surgery than the pN staging system. The-2 log-likelihood of lvN classification(4,746.922) was smaller than the value of pN(4,765.196), and the difference was statistically significant(χ^2=18.434, P<0.001).Conclusions: The presence of LVI influences the OS of GC patients at stage Ⅰ-Ⅲ a or N0-2. LVI should be incorporated into the pN staging system to enhance the accuracy of the prognostic prediction of GC patients.
文摘Objective： Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level（PDL） on overall survival（OS） of gastric cancer（GC） patients undergoing curative surgery by applying propensity score analysis.Methods： A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute ＆Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL： the elevated group（EG） and the normal group（NG）. To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results： In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm（67.5% vs. 55.8%, P=0.006）, elder mean age（64.0±10.8 years vs. 60.5±11.6 years, P〈0.001） and advanced tumor（T）, node（N）, and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL（27.0% vs. 42.6%, P〈0.001）, however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio： 1.13, 95% confidence interval（95% CI）： 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG（P=0.809, log-rank）.Conclusions： The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself.
文摘A hydroponic experiment was conducted to investigate the effects of arsenic （As） stress on growth, nutrition and As uptake, and speciation in shoots and roots of winter wheat （Triticum aestivum L.）. Winter wheat has high tolerance to As. Most As is accumulated in the roots, and an As concentration of 4,421 mg/kg was observed at a solution concentration of 20 mg/L As. Arsenic concentrations in roots were approximately 40-100 times greater than those in shoots. Arsenic in winter wheat roots and shoots occurred as both As^3＋ and As^5＋ species, although As^3＋ was the main species in winter wheat tissues. Arsenic significantly decreased the biomass of winter wheat shoots and roots and affected absorption and transport of micro- and macro-elements in winter wheat tissue. Arsenic treatment significantly increased the concentrations of total Magnesium （Mg） and calcium （Ca） in shoots and enhanced the transport of Mg and Ca from roots to shoots but decreased potassium （K）, nitrogen （N）, and phosphorus （P） concentrations in both shoots and roots, particularly the concentration of P. Concentrations of iron, copper, and zinc in winter wheat shoots were negatively related to As rates, with correlation coefficients （R^2） of 0.93, 0.94, and 0.97, respectively.
基金This work was supported by the Nat ional Natural ScienceFoundation of China(Grant No.30328009)National Special Fundfor“211 Project”of China to Fudan University.
文摘Exposure to ethanol during human embryonic period has severe teratogenic effects on the cardiovascular system.In our study,we demonstrated that ethanol of gradient concentra-tions can interfere with the establishment of circulatory system in embryonic zebrafish.The ef-fective concentration to cause 50%malformations(EC_(50))was 182.5 mmol/L.The ethanol pulse exposure experiment displayed that dome stage during embryogenesis is the sensitive time window to ethanol.It is found that 400 mmol/L ethanol pulse exposure can induce circulatory defects in 43%treated embryos.We ruled out the possibility that ethanol can interfere with the process of hematopoiesis in zebrafish.By employing in situ hybridization with endothelial bio-marker(Flk-1),we revealed that ethanol disrupts the establishment of trunk axial vasculature,but has no effect on cranial vessels.Combined with the results of semi-thin histological sections,the in situ hybridization experiments with arterial and venous biomarkers(ephrinB2,ephB4)sug-gested that ethanol mainly interrupts the development of dorsal aorta while has little effect on axial vein.Further study indicated the negative influence of ethanol on the development of hy-pochord in zebrafish.The consequent lack of vasculogenic factors including Radar and Ang-1 partly explains the defects in formation and integrity of dorsal aorta.These results provide im-portant clues to the study of adverse effects of ethanol on the cardiovascular development in human fetus.
文摘Objective:Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation.Ki-67,an indicator of cellular proliferation,has been used for tumor grading and classification in breast cancer and neuroendocrine tumors.However,its prognostic significance in pancreatic ductal adenocarcinoma(PDAC)remains uncertain.Methods:Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled,and relevant prognostic factors were examined.Grade of malignancy(GOM),a novel index based on histopathological differentiation and Ki-67,is proposed,and its clinical significance was evaluated.Results:The optimal threshold for Ki-67 was determined to be 30%.Patients with a Ki-67 expression level>30%rather than≤30%had significantly shorter 5-year overall survival(OS)and recurrence-free survival(RFS).In multivariate analysis,both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and RFS.The GOM was used to independently stratify OS and RFS into 3 tiers,regardless of TNM stage and other established prognostic factors.The tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers,and surpassed the predictive performance of TNM stage for OS and RFS.Conclusions:Ki-67 is a valuable prognostic indicator for PDAC.Inclusion of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.
基金supported by the National Natural Science Foundation of China (11172251)the Open Fund of State Key Laboratory of Frozen Soil Engineering (SKLFSE201001)the Open Research Project of State Key Laboratory of Explosion Science and Technology in Beijing Institute of Technology (KFJJ1310M)
文摘In this study, an isotropic hardening constitutive model is presented to study the behavior of frozen soil under impact loading. In plasticity, a modified Drucker–Prager yield function is adopted. Based on the experimental investigations at different strain rates and different temperatures by means of split Hopkinson pressure bar, the Drucker–Prager criterion has been modified with consideration in the effect of strain rate, and the model parameters have been determined. Compared the constitutive model with the experimental results, the predicted tendencies of the model corresponded well to the test curves.
基金financially supported by the National Natural Science Foundation of China(Nos.22376059 and 21976104)the Young Elite Scientists Sponsorship Program of China Association for Science and Technology(No.2021QNRC001)the Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation of Korea(No.NRF-2022H1D3A2A02051548).
文摘Photocatalysis-assisted removal of uranium has been proven as an effective method for the elimination of radioactive pollution from wastewater.In this work,carbon nitride materials were synthesized in potassium hydroxide(KOH)molten salt and applied to photocatalytic uranyl extraction.Obtained materials were confirmed to possess the triazine-s-heptazine structure by NMR,XPS and UV-Vis characterization,and exhibited a wider visible light absorption than graphitic carbon nitride(g-C_(3)N_(4)).The photocatalytic activity of the carbon nitride materials was tailored by varying the precursor mass fractions.The carbon nitride obtained at 80%melamine as precursor(K-CN-80)exhibited the highest photocatalytic extraction ability and its photocatalytic reaction rate is 6.6 times faster than that of g-C_(3)N_(4).The influence of sacrificial agents was studied and the results showed that triethanolamine inhibited U(Ⅵ)photoreduction,but methanol can accelerate U(Ⅵ)photoreduction by consuming photogenerated holes.This unary KOH molten salt synthesis method has exceptional potential applications in the preparation of carbon nitrides,and the obtained products showed potential in extracting U(Ⅵ)from aqueous solutions for use in nuclear fuel industry and for U(Ⅵ)environmental pollution cleanup.
文摘Due to the well condition and the un-expected imbalance movement of the pumping unit in use, the energy consumes a lot. The existing balancing equipment cannot adjust and monitor the pumping units in real time. Therefore this paper introduces the new adaptive balancing equipment—fan-shaped adaptive balancing intelligent device, projects a design of such control system based on PLC, and determines the principle of the control system, the execution software and the design flow. Site commissioning effect on Daqing Oilfield shows this fan-shaped adaptive balancing intelligent device can effectively adjust and monitor the pumping unit in real time, the balance even adjusts from 0.787 to 0.901, and integrated energy saving rate is 14.2%. It is approved that this control device is professionally designed, with strong compatibility, and high reliability.
基金financially supported by the National Natural Science Foundation of China (Nos.21976104, 21906051)Young Elite Scientists Sponsorship Program (No.2021QNRC001) of China Association for Science and Technology。
文摘Microplasma based on glow discharge could act as a non-contact gaseous electrode and has attracted much attention in both fundamental research and application. Herein, with microplasma as the anode,the electrodeposition process of a series of metal and metal alloys in molten salt has been systemically studied. Four metal cations with different valence states, silver(Ag~+), nickel(Ni^(2+)), copper(Cu^(2+)), and iron(Fe^(3+)), could all be reduced on the solid cathode with high current efficiency and the corresponding metal products were of high purity. The electrodeposition of aluminum-lanthanum(Al-Ln) alloy on the aluminum cathode was also successfully carried out with microplasma as the anode, and the same alloy was obtained by using the conventional anode electrode. These results indicated that microplasma anode based on non-contact direct-current(DC) glow discharge is a promising electrode to be applied in molten salt electrolysis.
基金supported by a senior investigator LWW’s fundings from the Innovation Group Project of Shanghai Municipal Health Commission(2019CXJQ03),National Natural Science Foundation of China(81874048),Shang-haiMunicipal Commission of Health and Family Planning(2018ZHYL0223),Fostering Fund of Renji Hospital affili-ated to Shanghai Jiao Tong University School of Medicine(PYIV-17-001),Shanghai Municipal Commission of Health and Family Planning Grant(2018ZHYL0223),Clinical Research Plan of SHDC(No.SHDC2020CR1035B),Shang-hai Key Clinical Speciality(Oncology),Shanghai leading talents project,Innovative research teamof high-level local universities in Shanghai.Also supported by XFZ’s grant from Clinical plus Excellence Project(2020ZYA003)from Shanghai Nucleic Acid Chemistry and Nanomedicine Key Laboratory.
文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3].
基金financially supported by the National Natural Science Foundation of China(21671096 and 11775105)Shenzhen Peacock Plan(KQTD2016022620054656)。
文摘Electrochemical CO2 reduction(ECR)represents a promising strategy for utilizing CO2,an industrial waste,as an abundant and cheap carbon source for organic synthesis as well as storing intermittent renewable electricity from renewable sources.Efficient electrocatalysts allowing CO2 to be reduced selectively and actively are crucial since the ECR is a complex and sluggish process producing a variety of products.Metal-organic frameworks(MOFs)and covalentorganic frameworks(COFs)have emerged as versatile materials applicable in many fields due to their unique properties including high surface areas and tunable pore channels.Besides,the emerging reticular chemistry makes tuning their features on the atomic/molecular levels possible,thereby lending credence to the prospect of their utilizations.Herein,an overview of recent progress in employing framework material-based catalysts,including MOFs,COFs and their derivatives,for ECR is provided.The pertinent challenges,future trends,and opportunities associated with those systems are also discussed.
基金support from the National Natural Science Foundation of China(Nos.20921001 and 20535020)the Innovation Method Fund of China(No.20081885189)the National High Technology Research and Development Program of China(No.2009AA03Z321).
文摘Single-crystalline Ag_(2)Se complex nanostructures have been synthesized via a solvothermal route in which selenophene(C4H4Se)as a selenylation source reacts with AgNO3 at a temperature of 240°C.An orthorhombic phaseβ-Ag_(2)Se nanostructure was identified by X-ray diffraction(XRD),Raman spectroscopy,field emission scanning electron microscopy(FE-SEM),high resolution transmission electron microscopy(HRTEM),and photoluminescence(PL)spectroscopy.The wettability of the as-synthesizedβ-Ag_(2)Se nanostructure was studied by measurement of the water contact angle(CA).Static water CA values of over 150°were obtained,which can be attributed to theβ-Ag_(2)Se complex nanostructure having a combination of micro-and nanostructures.The superhydrophobic Ag_(2)Se nanostructure may find applications in self-cleaning.Additionally,the photocatalytic activity of the as-synthesizedβ-Ag_(2)Se nanostructure was evaluated by photodegradation of rhodamine B(RhB)dye under ultraviolet(UV)light irradiation.
基金supported by the National Natural Science Foundation of China(Nos.21976146 and U2167221)the Project of State Key Laboratory of Environment-friendly Energy Materials,Southwest University of Science and Technology(No.23fksy10)+2 种基金the Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital(No.2021HYX028)the Sichuan Science and Technology Program(No.2023NSFSC0353)the Applied Basic Research Project of Science and Technology Department of Sichuan Province(No.2022NSFSC1197)。
文摘The objective of this study was to address the challenges associated with complex TRPO waste,by utiliz-ing a natural aluminosilicate material to produce glass-ceramic waste forms.When the simulated waste content was below 30 wt.%,glassy waste forms were successfully obtained.Ce and Fe played crucial roles in the formation of Si-O-Ce bonds and[FeO_(4)]-tetrahedra in the glass network,which effectively immo-bilized other waste elements.However,when the waste content exceeded 30 wt.%,the waste was incor-porated into feldspar,iron-manganese crystals,fluorite ceramic,and glass.This combination of ceramic and glass matrices synergistically immobilized the waste,resulting in excellent mechanical performance and chemical durability.The leaching rates of LR_(Ce)and LR_(Nd)were remarkably low around-10^(−6)to 10^(−7)g m^(−2)d^(−1),after 42 d.Furthermore,the study also investigated the role of multi-valence elements,such as Ce,Fe,and Mn,in the formation of iron-containing aluminosilicate glass-ceramics.The findings offer a novel approach to effectively immobilize complex nuclear waste.
基金supported by the Special Project of Science and Technology Cooperation and Exchange of Shanxi Province(No.202204041101014)the National Key Research and Development Program of China(No.2023YFB3811302)+1 种基金the Jinzhong University Research Funds for Doctor(No.JUD2023014)the Shanxi Provincial Key Research and Development Project(No.2022ZDYF027).
文摘Increasing porosity is one of the most direct ways to improve the thermal insulation and dielectric properties of materials.Until now,many wet methods for preparing Si_(3)N_(4) ceramic foams usually face the problems of complex rheology,long period,and expensive cost,and the reported pore sizes of Si_(3)N_(4) ceramic foams are typically micron-grade,resulting in a lack of competitiveness in thermal insulation and wave-transparent applications.In this paper,the Si_(3)N_(4)@SiO_(2) ceramic foams were prepared using an efficient dry-method,which combined three processes of low temperature chemical vapor deposition(LTCVD),template,and isostatic pressing.The method has the advantages of simple operation and short preparation period,and can realize near-net size molding and mass production.In addition,the evolution mechanisms of honeycomb microstructure and composition of Si_(3)N_(4)@SiO_(2) ceramic foam during sintering were studied by chemical reaction thermodynamics.The as-prepared Si_(3)N_(4)@SiO_(2) ceramic foam possesses low density(0.377 g·cm^(-3)),high compressive strength(7.5 MPa),low thermal conductivity(0.0808 W·m^(-1)·K^(-1)),and excellent dielectric properties(ε<1.32,tanδ<0.009)in the frequency range of 8-18 GHz,and its maximum working temperature in air can reach up to 1100℃.It will be recommended to be applied in the interlayer of Si_(3)N_(4) ceramic radome to improve its thermal insulation and electromagnetic wave transparency performances.
基金supported by the National Natural Science Foundation of China (22341602, U2067215, 22006036, U2167218, U2341289, 22327807, 22176077)the Beijing Outstanding Young Scientist Program, and the Fundamental Research Funds for the Central Universities (lzujbky-2023-stlt01)。
文摘The separation of radionuclides is critical for the sustainable development of nuclear energy. It is urgent to design and prepare functionalized materials for efficient radionuclides separation. Porous materials are considered excellent candidates for the separation of radionuclides under complex conditions due to their high specific surface areas, tunable pore structures and controllable functionalities. In this review, we summarized the design, preparation and functionalization of porous materials and their application for separation of radionuclides in the past five years, discussed the separation performance and analyzed the structure-activity relationship between various radionuclides and porous materials, and systematically clarified their characterization and mechanism of different type porous materials. We also introduced the detection, irradiation and chemical toxicity of different reflective radionuclides.
基金the National Natural Science Foundation of China(Nos.52002081,51972294,and 51872271).
文摘Potassium ion-based dual-graphite batteries(KDGBs)emerge as promising devices for large-scale applications due to their high voltage,low cost,environmental friendliness.However,conventional KPF6/carbonate-based electrolytes suffer from severe oxidation decomposition,low concentration,flammability,which limit the capacity and cyclability of KDGBs.Herein,a nonflammable potassium bis(fluorosulfonyl)imide/triethyl phosphate(KFSI/TEP)electrolyte was designed for KDGBs.When the salt-to-solvent molar ratio increases to 1:1.3,graphite cathode operated at the cut-off potential of 5.2 V exhibits much enhanced capacity,excellent rate capability(26.4 mAh∙g^(−1) at 1.0 A∙g^(−1)),superior cyclability with 98%capacity retention after 350 cycles.Inorganic compounds-rich electrode/electrolyte interphase layers derived from the preferential decomposition of FSI−anions ensure good compatibility of the 1:1.3 KFSI/TEP electrolyte with K metal and graphite anodes.Based on this electrolyte,asassembled KDGBs show high operation voltage of 4.3 V and good cycling performance.This work provides feasibility for developing long-life and safe-operation DGBs.
基金the National Natural Science Foundation of China(Nos.21976104,21906051)the Fundamental Research Funds for the Central Universities(No.2019MS046)LingChuang Research Project of China National Nuclear Corporation is also gratefully acknowledged。
文摘Photocatalytic removal of uranium has attracted much attention in nuclear wastewater treatment and it is highly needed to develop functional photocatalyst with excellent removal performance.In this work,seven kinds of carbon dots/carbon nitride(CDs/CN)composites were synthesized and Ser CDs/CN with the best photo-assisted uranium removal performance was screened out.It was found that the introduction of CDs could bring in higher photocurrent density,lower interfacial charge transfer impedance and narrower band gap,resulting in a much-improved removal performance.SerCDs/CN had shown a removal capacity as high as 1690 mg/g and the reaction could be operated under air atmosphere which is promising in real application.
基金financially supported by the National Natural Science Foundation of China (51072189, 21003111, 21003112)Natural Science Foundation of Zhejiang Province (Y4090507)Scientific Research Foundation of Education Department of Zhejiang Province(Y201018867)
文摘Well-ordered TiO 2 nanotube arrays (TNAs) were fabricated by electrochemical anodization in a mixed organic electrolyte consisting of ethylene glycol and glycerol. The morphology, structure, crystalline phase, and photocatalytic properties of TNAs were characterized by using TEM, SEM, XRD and photodegradation of methylene blue. It was found that the morphology and structure of TNAs could be significantly influenced by the anodization time and applied voltage. The obtained tube length was found to be proportional to anodization time, and the calculated growth rate of nanotubes was 0.6 m/h. The microstructure analysis demonstrated that the diameter and thickness of the nanotubes increased with the increase of anodization voltage. The growth mechanism of TNAs was also proposed according to the observed relationship between current density and time during anodization. As expected, the obtained TNAs showed a higher photocatalytic activity than the commercial TiO 2 P25 nanoparticles.
