The intrinsic oncogenic mechanisms and properties of the tumor microenvironment(TME)have been extensively investigated.Primary features of the TME include metabolic reprogramming,hypoxia,chronic inflammation,and tumor...The intrinsic oncogenic mechanisms and properties of the tumor microenvironment(TME)have been extensively investigated.Primary features of the TME include metabolic reprogramming,hypoxia,chronic inflammation,and tumor immunosuppression.Previous studies suggest that senescence-associated secretory phenotypes that mediate intercellular information exchange play a role in the dynamic evolution of the TME.Specifically,hypoxic adaptation,metabolic dysregulation,and phenotypic shifts in immune cells regulated by cellular senescence synergistically contribute to the development of an immunosuppressive microenvironment and chronic inflammation,thereby promoting the progression of tumor events.This review provides a comprehensive summary of the processes by which cellular senescence regulates the dynamic evolution of the tumor-adapted TME,with focus on the complex mechanisms underlying the relationship between senescence and changes in the biological functions of tumor cells.The available findings suggest that components of the TME collectively contribute to the progression of tumor events.The potential applications and challenges of targeted cellular senescence-based and combination therapies in clinical settings are further discussed within the context of advancing cellular senescence-related research.展开更多
The Oligocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China Sea.For effective appraisal, exploration and exploitation of such a deep-water hydrocarbon sandstone, samples ...The Oligocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China Sea.For effective appraisal, exploration and exploitation of such a deep-water hydrocarbon sandstone, samples of five wells from depths of 850 m to 3 000 m were studied. A series of comprehensive petrographic and geochemical analyses were performed to unravel the diagenetic features and their impact on the reservoir quality.Petrographically, the sandstones are dominated by feldspathic litharenites and lithic arenites with fine to medium grain sizes and moderate to good sorting. The reservoir quality varies greatly with a range of porosity from 0.2% to 36.1% and permeability from 0.016 ×10~(–3) μm~2 to 4 301 ×10~(–3) μm~2, which is attributed to complex diagenetic evolution related to sedimentary facies;these include compaction, cementation of calcite, dolomite, siderite and framboidal pyrite in eogenetic stage;further compaction, feldspar dissolution, precipitation of ferrocalcite and ankerite, quartz cements, formation of kaolinite and its illitization, precipitation of albite and nodular pyrite, as well as hydrocarbon charge in mesogenetic stage. The dissolution of feldspar and illitization of kaolinite provide internal sources for the precipitation of quartz cement, while carbonate cements are derived from external sources related to interbedded mudstones and deep fluid. Compaction is the predominant factor in reducing the total porosity, followed by carbonate cementation that leads to strong heterogeneity. Feldspar dissolution and concomitant quartz and clay cementation barely changes the porosity but significantly reduces the permeability.The high-quality reservoirs can be concluded as medium-grained sandstones lying in the central parts of thick underwater distributary channel sandbodies(>2 m) with a high content of detrital quartz but low cement.展开更多
Based on the systematic summary of current research on oil bank, the definition of oil bank in the process of fire flooding and its quantitative indices were proposed; and a new one-dimensional positive dry-fire flood...Based on the systematic summary of current research on oil bank, the definition of oil bank in the process of fire flooding and its quantitative indices were proposed; and a new one-dimensional positive dry-fire flooding model considering temperature gradient was established based on the steady flow theory of gas and liquid phases. Single factor analysis and orthogonal experiments were adopted to verify the reliability and reveal the formation mechanisms and the controlling factors of the oil bank. Then the optimal conditions for the oil bank to form were discussed. The study results show the formation of the oil bank is controlled by 3 factors:(1) Oil bank would come into being within a certain temperature interval and above a critical value of temperature gradient(absolute value), with temperature too high or too low and temperature gradient absolute value lower than the critical value, the oil bank couldn't form.(2) For fire flooding process in heavy oil reservoirs, the viscosity of oil influences the width of oil bank and the speed at which oil bank forms; the lower the oil viscosity is, the wider the oil bank is and the faster the oil bank forms.(3) Oil saturation could affect the developing temperature and speed of oil bank. The favorable temperature at which oil bank develops gets lower and the accumulating speed of oil gets faster when the oil saturation is higher. By orthogonal experiments with the model, the optimal combinations of reservoir conditions for forming oil bank during fire flooding in heavy oil reservoirs can be worked out.展开更多
Photoacoustic spectroscopy of C60 thin film is presented.The optical band edge of solid C60 and the optical absorption coefficient at absorption edge are determined.A weak absorption shoulder at 1.70eV is observed.Whi...Photoacoustic spectroscopy of C60 thin film is presented.The optical band edge of solid C60 and the optical absorption coefficient at absorption edge are determined.A weak absorption shoulder at 1.70eV is observed.While the thickness of C60 thin film is less than 1μm,photoacoustic saturation at band edge is avoided.展开更多
基金Grants from the Liaoning Nature Science Foundation of China,Grant/Award Number:2022JH2/101300042National Natural Science Foundation of China,Grant/Award Numbers:81672877,82173194。
文摘The intrinsic oncogenic mechanisms and properties of the tumor microenvironment(TME)have been extensively investigated.Primary features of the TME include metabolic reprogramming,hypoxia,chronic inflammation,and tumor immunosuppression.Previous studies suggest that senescence-associated secretory phenotypes that mediate intercellular information exchange play a role in the dynamic evolution of the TME.Specifically,hypoxic adaptation,metabolic dysregulation,and phenotypic shifts in immune cells regulated by cellular senescence synergistically contribute to the development of an immunosuppressive microenvironment and chronic inflammation,thereby promoting the progression of tumor events.This review provides a comprehensive summary of the processes by which cellular senescence regulates the dynamic evolution of the tumor-adapted TME,with focus on the complex mechanisms underlying the relationship between senescence and changes in the biological functions of tumor cells.The available findings suggest that components of the TME collectively contribute to the progression of tumor events.The potential applications and challenges of targeted cellular senescence-based and combination therapies in clinical settings are further discussed within the context of advancing cellular senescence-related research.
基金The National Natural Science Foundation of China under contract No. 42262020the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region under contract No. NJZY22445。
文摘The Oligocene Zhuhai sandstones are significant reservoirs for hydrocarbons in the Baiyun Sag, South China Sea.For effective appraisal, exploration and exploitation of such a deep-water hydrocarbon sandstone, samples of five wells from depths of 850 m to 3 000 m were studied. A series of comprehensive petrographic and geochemical analyses were performed to unravel the diagenetic features and their impact on the reservoir quality.Petrographically, the sandstones are dominated by feldspathic litharenites and lithic arenites with fine to medium grain sizes and moderate to good sorting. The reservoir quality varies greatly with a range of porosity from 0.2% to 36.1% and permeability from 0.016 ×10~(–3) μm~2 to 4 301 ×10~(–3) μm~2, which is attributed to complex diagenetic evolution related to sedimentary facies;these include compaction, cementation of calcite, dolomite, siderite and framboidal pyrite in eogenetic stage;further compaction, feldspar dissolution, precipitation of ferrocalcite and ankerite, quartz cements, formation of kaolinite and its illitization, precipitation of albite and nodular pyrite, as well as hydrocarbon charge in mesogenetic stage. The dissolution of feldspar and illitization of kaolinite provide internal sources for the precipitation of quartz cement, while carbonate cements are derived from external sources related to interbedded mudstones and deep fluid. Compaction is the predominant factor in reducing the total porosity, followed by carbonate cementation that leads to strong heterogeneity. Feldspar dissolution and concomitant quartz and clay cementation barely changes the porosity but significantly reduces the permeability.The high-quality reservoirs can be concluded as medium-grained sandstones lying in the central parts of thick underwater distributary channel sandbodies(>2 m) with a high content of detrital quartz but low cement.
基金Supported by the China National Science and Technology Major Project(2016ZX05012-004)the PetroChina Science and Technology Project(2016B-1402)
文摘Based on the systematic summary of current research on oil bank, the definition of oil bank in the process of fire flooding and its quantitative indices were proposed; and a new one-dimensional positive dry-fire flooding model considering temperature gradient was established based on the steady flow theory of gas and liquid phases. Single factor analysis and orthogonal experiments were adopted to verify the reliability and reveal the formation mechanisms and the controlling factors of the oil bank. Then the optimal conditions for the oil bank to form were discussed. The study results show the formation of the oil bank is controlled by 3 factors:(1) Oil bank would come into being within a certain temperature interval and above a critical value of temperature gradient(absolute value), with temperature too high or too low and temperature gradient absolute value lower than the critical value, the oil bank couldn't form.(2) For fire flooding process in heavy oil reservoirs, the viscosity of oil influences the width of oil bank and the speed at which oil bank forms; the lower the oil viscosity is, the wider the oil bank is and the faster the oil bank forms.(3) Oil saturation could affect the developing temperature and speed of oil bank. The favorable temperature at which oil bank develops gets lower and the accumulating speed of oil gets faster when the oil saturation is higher. By orthogonal experiments with the model, the optimal combinations of reservoir conditions for forming oil bank during fire flooding in heavy oil reservoirs can be worked out.
基金the National Natural Science Foundation of China,and MAC of Nanjing University.
文摘Photoacoustic spectroscopy of C60 thin film is presented.The optical band edge of solid C60 and the optical absorption coefficient at absorption edge are determined.A weak absorption shoulder at 1.70eV is observed.While the thickness of C60 thin film is less than 1μm,photoacoustic saturation at band edge is avoided.
