目的:观察西格列汀联合胰岛素泵强化降糖治疗初发2型糖尿病(T2DM)患者的效果。方法:回顾性分析60例新诊断T2DM患者临床资料,其中单纯胰岛素泵降糖治疗组30例(A组),西格列汀联合胰岛素泵降糖组30例(B组),两组治疗时间均为2周。比较两组...目的:观察西格列汀联合胰岛素泵强化降糖治疗初发2型糖尿病(T2DM)患者的效果。方法:回顾性分析60例新诊断T2DM患者临床资料,其中单纯胰岛素泵降糖治疗组30例(A组),西格列汀联合胰岛素泵降糖组30例(B组),两组治疗时间均为2周。比较两组患者治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、空腹C肽、餐后2 h C肽、糖化血红蛋白(Hb A1C)、体质量指数(BMI)以及血糖达标时间及最终胰岛素用量、低糖血症发生率。结果:治疗两周后,两组的FPG、2 h PG均较治疗前降低(P<0.05),空腹C肽及餐后2 h C肽均较治疗前升高(P<0.05);治疗后B组2 h PG较A组降低(P<0.05),2 h C肽较A组升高(P<0.05),Hb A1c及BMI比较差异无统计学意义(P>0.05)。治疗后B组血糖达标时间短于A组,最终胰岛素用量少于A组,低血糖发生率低于A组,差异均有统计学意义(P<0.05)。结论:西格列汀联合胰岛素泵治疗初发2型糖尿病患者,能够更好地控制餐后血糖、提升胰岛功能,同时可缩短治疗时间,降低胰岛素使用量,减少低血糖的发生。展开更多
In this paper, the NCEP-NCAR daily reanalysis data are used to investigate the characteristics of the atmospheric heat source/sink （AHSS） over South Asia （SA） and southern Indian Ocean （SIO）. The thermal differe...In this paper, the NCEP-NCAR daily reanalysis data are used to investigate the characteristics of the atmospheric heat source/sink （AHSS） over South Asia （SA） and southern Indian Ocean （SIO）. The thermal differences between these two regions and their influence on the outbreak of the Indian summer monsoon （ISM） are explored. Composite analysis and correlation analysis are applied. The results indicate that the intraseasonal variability of AHSS is signi- ficant in SA but insignificant in the SIO. Large inland areas in the Northern Hemisphere still behave as a heat sink in March, similar to the situation in winter. Significant differences are found in the distribution of AHSS between the ocean and land, with distinct land-ocean thermal contrast in April, and the pattern presents in the transitional period right before the ISM onset. In May, strong heat centers appear over the areas from the Indochina Peninsula to the Bay of Bengal and south of the Tibetan Plateau （TP）, which is a typical pattern of AHSS distribution during the monsoon season. The timing of SA-SIO thermal difference turning positive is about 15 pentads in advance of the onset of the ISM. Then, after the thermal differences have turned positive, a pre-monsoon meridional circulation cell develops due to the near-surface heat center and the negative thermal contrast center, after which the meridional circulation of the ISM gradually establishes. In years of early （late） conversion of the SASIO thermal difference turning from neg- ative to positive, the AHSS at all levels over the TP and SIO converts later （earlier） than normal and the establish- ment of the ascending and descending branches of the ISM＇s meridional circulation is later （earlier） too. Meanwhile, the establishment of the South Asian high over the TP is later （earlier） than normal and the conversion of the Mas- carene high from winter to summer mode occurs anomalously late （early）. As a result, the onset of the ISM is later （earlier） than norma展开更多
文摘目的:观察西格列汀联合胰岛素泵强化降糖治疗初发2型糖尿病(T2DM)患者的效果。方法:回顾性分析60例新诊断T2DM患者临床资料,其中单纯胰岛素泵降糖治疗组30例(A组),西格列汀联合胰岛素泵降糖组30例(B组),两组治疗时间均为2周。比较两组患者治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、空腹C肽、餐后2 h C肽、糖化血红蛋白(Hb A1C)、体质量指数(BMI)以及血糖达标时间及最终胰岛素用量、低糖血症发生率。结果:治疗两周后,两组的FPG、2 h PG均较治疗前降低(P<0.05),空腹C肽及餐后2 h C肽均较治疗前升高(P<0.05);治疗后B组2 h PG较A组降低(P<0.05),2 h C肽较A组升高(P<0.05),Hb A1c及BMI比较差异无统计学意义(P>0.05)。治疗后B组血糖达标时间短于A组,最终胰岛素用量少于A组,低血糖发生率低于A组,差异均有统计学意义(P<0.05)。结论:西格列汀联合胰岛素泵治疗初发2型糖尿病患者,能够更好地控制餐后血糖、提升胰岛功能,同时可缩短治疗时间,降低胰岛素使用量,减少低血糖的发生。
基金Supported by the National Natural Science Foundation of China(91537214,41275079,41405069,41305077,and 41505078)China Meteorological Administration Special Public Welfare Research Fund(GYHY201506001)+1 种基金Scientific Research Fund of Sichuan Education Department(16ZA0203)Chengdu University of Information Technology Scientific Research Fund(J201516,J201518,and KYTZ201517)
文摘In this paper, the NCEP-NCAR daily reanalysis data are used to investigate the characteristics of the atmospheric heat source/sink （AHSS） over South Asia （SA） and southern Indian Ocean （SIO）. The thermal differences between these two regions and their influence on the outbreak of the Indian summer monsoon （ISM） are explored. Composite analysis and correlation analysis are applied. The results indicate that the intraseasonal variability of AHSS is signi- ficant in SA but insignificant in the SIO. Large inland areas in the Northern Hemisphere still behave as a heat sink in March, similar to the situation in winter. Significant differences are found in the distribution of AHSS between the ocean and land, with distinct land-ocean thermal contrast in April, and the pattern presents in the transitional period right before the ISM onset. In May, strong heat centers appear over the areas from the Indochina Peninsula to the Bay of Bengal and south of the Tibetan Plateau （TP）, which is a typical pattern of AHSS distribution during the monsoon season. The timing of SA-SIO thermal difference turning positive is about 15 pentads in advance of the onset of the ISM. Then, after the thermal differences have turned positive, a pre-monsoon meridional circulation cell develops due to the near-surface heat center and the negative thermal contrast center, after which the meridional circulation of the ISM gradually establishes. In years of early （late） conversion of the SASIO thermal difference turning from neg- ative to positive, the AHSS at all levels over the TP and SIO converts later （earlier） than normal and the establish- ment of the ascending and descending branches of the ISM＇s meridional circulation is later （earlier） too. Meanwhile, the establishment of the South Asian high over the TP is later （earlier） than normal and the conversion of the Mas- carene high from winter to summer mode occurs anomalously late （early）. As a result, the onset of the ISM is later （earlier） than norma
