Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected pa...Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.展开更多
A novel tie point matching algorithm of aerial images with the assistance of airborne LiDAR point clouds and POS data is proposed Firstly,the conjugate point searching strategy used in traditional correlation coeffici...A novel tie point matching algorithm of aerial images with the assistance of airborne LiDAR point clouds and POS data is proposed Firstly,the conjugate point searching strategy used in traditional correlation coefficient matching is improved and a fast algorithm is presented.Secondly,an automatic camera boresight misalignment calibration method based on virtual ground control points is proposed,and then the searching range of image matching is adaptively determined and applied to the image matching of the entire surveying area.Test results verified that the fast correlation coefficient matching algorithm proposed in this paper can reduce approximately 25% of the matching time without the loss of matching accuracy.The camera boresight misalignment calibration method can effectively increase the accuracy of exterior orientation elements of images calculated from POS data,and thus can significantly improve the predicted position of conjugate point for tie point matching.Our proposed image matching algorithm can achieve superior matching accuracy with multi-scale,multi-view,and cross-flight aerial images.展开更多
文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.
基金The National Natural Science Foundation of China under Grants(41171292,41322010)The National Basic Research Program of China(973 Program)(2012CB719904).
文摘A novel tie point matching algorithm of aerial images with the assistance of airborne LiDAR point clouds and POS data is proposed Firstly,the conjugate point searching strategy used in traditional correlation coefficient matching is improved and a fast algorithm is presented.Secondly,an automatic camera boresight misalignment calibration method based on virtual ground control points is proposed,and then the searching range of image matching is adaptively determined and applied to the image matching of the entire surveying area.Test results verified that the fast correlation coefficient matching algorithm proposed in this paper can reduce approximately 25% of the matching time without the loss of matching accuracy.The camera boresight misalignment calibration method can effectively increase the accuracy of exterior orientation elements of images calculated from POS data,and thus can significantly improve the predicted position of conjugate point for tie point matching.Our proposed image matching algorithm can achieve superior matching accuracy with multi-scale,multi-view,and cross-flight aerial images.
