OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, c...OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients.展开更多
Besides the Indonesian throughflow(ITF), the South China Sea throughflow(SCSTF) also contributes to the water transport from the Pacific to the Indian Ocean. However, this South China Sea(SCS) branch at the Karimata S...Besides the Indonesian throughflow(ITF), the South China Sea throughflow(SCSTF) also contributes to the water transport from the Pacific to the Indian Ocean. However, this South China Sea(SCS) branch at the Karimata Strait is poorly observed until 2007, even though its importance has been suggested by numerical studies for decades. In this paper, we review the nearly 10-year field measurement in the Karimata Strait by the execution of the projects of "SCS-Indonesian Seas Transport/Exchange(SITE) and Impacts on Seasonal Fish Migration" and "The Transport, Internal Waves and Mixing in the Indonesian Throughflow regions(TIMIT) and Impacts on Marine Ecosystem", which extend the observations from the western Indonesian seas to the east to include the main channels of the ITF, is introduced. Some major achievements from these projects are summarized.展开更多
为深入了解白酒窖泥领域的研究现状和热点,本文基于Web of Science核心合集数据库和中国知网(CNKI)学术期刊数据库,从年度发文量、发文作者和机构、高引文章和关键词等角度出发,采用文献计量法对1980—2021年该领域522篇中文文献和112...为深入了解白酒窖泥领域的研究现状和热点,本文基于Web of Science核心合集数据库和中国知网(CNKI)学术期刊数据库,从年度发文量、发文作者和机构、高引文章和关键词等角度出发,采用文献计量法对1980—2021年该领域522篇中文文献和112篇英文文献进行知识图谱分析,详细阐述白酒窖泥的研究进展,并结合研究热点分析本领域未来的发展态势。窖泥研究对白酒产业高质量发展和品质提升具有重要作用,近10年来有关窖泥的文献数量总体呈现波动上升态势,目前尚未达到成熟阶段,未来仍有广阔空间。中国学者是窖泥研究领域的主力军,张文学、唐玉明、周荣清、吴重德、徐岩等作为主要贡献者,所发表文献的影响力和学术价值都很高。窖泥研究主要机构有四川大学、四川轻化工大学、江南大学等,研究热点多集中在微生物群落、人工窖泥、有机酸、丁酸菌、功能菌等方面。通过本文综合分析,可以为我国科研人员了解窖泥相关的研究动态和研究方向、开展科研合作与学术交流提供信息帮助。展开更多
基金Supported by National Key Technology R&D Programs in the 11th Five-Year Plan of China:Study on Comprehensive Evaluation Method of Integral Effect of Traditional Chinese Medicine Treatment for Heart Failure(No.2006BAI08B02-01)Ministry of Education of People's Republic of China"Program for Innovative Research Team in University"–Research on TCM for the Prevention and Treatment of Cardiovascular Diseases(No.IRT_16R54)Tianjin Science and Technology Program:Tianjin TCM Clinical Medicine Research Center(No.15ZXLCSY00020)
文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients.
基金The National Key Research and Development Program of China under contract No.2016YFC1402604the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)under contract No.2015ASKJ01+4 种基金the SOA Program on Global Change and Air-Sea Interactions under contract Nos GASI-IPOVAI-03,GASI-IPOVAI-02 and GASI-IPOVAI-01-02the National Natural Science Foundation of China under contract Nos 40476025,41506036 and 41876027the NSFC-Shandong Joint Fund for Marine Science Research Centers under contract No.U1606405the Office of Naval Research of United States under contract No.N00014-08-01-0618the China-Indonesia Maritime Cooperation Fund
文摘Besides the Indonesian throughflow(ITF), the South China Sea throughflow(SCSTF) also contributes to the water transport from the Pacific to the Indian Ocean. However, this South China Sea(SCS) branch at the Karimata Strait is poorly observed until 2007, even though its importance has been suggested by numerical studies for decades. In this paper, we review the nearly 10-year field measurement in the Karimata Strait by the execution of the projects of "SCS-Indonesian Seas Transport/Exchange(SITE) and Impacts on Seasonal Fish Migration" and "The Transport, Internal Waves and Mixing in the Indonesian Throughflow regions(TIMIT) and Impacts on Marine Ecosystem", which extend the observations from the western Indonesian seas to the east to include the main channels of the ITF, is introduced. Some major achievements from these projects are summarized.
文摘为深入了解白酒窖泥领域的研究现状和热点,本文基于Web of Science核心合集数据库和中国知网(CNKI)学术期刊数据库,从年度发文量、发文作者和机构、高引文章和关键词等角度出发,采用文献计量法对1980—2021年该领域522篇中文文献和112篇英文文献进行知识图谱分析,详细阐述白酒窖泥的研究进展,并结合研究热点分析本领域未来的发展态势。窖泥研究对白酒产业高质量发展和品质提升具有重要作用,近10年来有关窖泥的文献数量总体呈现波动上升态势,目前尚未达到成熟阶段,未来仍有广阔空间。中国学者是窖泥研究领域的主力军,张文学、唐玉明、周荣清、吴重德、徐岩等作为主要贡献者,所发表文献的影响力和学术价值都很高。窖泥研究主要机构有四川大学、四川轻化工大学、江南大学等,研究热点多集中在微生物群落、人工窖泥、有机酸、丁酸菌、功能菌等方面。通过本文综合分析,可以为我国科研人员了解窖泥相关的研究动态和研究方向、开展科研合作与学术交流提供信息帮助。
