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Effect of operational and geometric parameters on the hydrodynamics of a Wurster coater:A CFD-DEM study
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作者 yinqiang song Tuo Zhou +2 位作者 Ruiqi Bai Man Zhang Hairui Yang 《Particuology》 SCIE EI CAS CSCD 2024年第2期62-76,共15页
A coupled CFD-DEM method was used to study the hydrodynamics of a Wurster coater.Firstly,the CFD part of the model was validated by the accurate prediction of the pressure drops over a pseudo-2D fluidized bed under va... A coupled CFD-DEM method was used to study the hydrodynamics of a Wurster coater.Firstly,the CFD part of the model was validated by the accurate prediction of the pressure drops over a pseudo-2D fluidized bed under various gas velocities.The effect of gas velocity,gap height,tube length and batch volume of the particles on the cycle time and the residence time of the particles was thoroughly investigated.The central jet gas velocity ui was found to speed up the particle cycle but undermine the coating efficiency.The gas velocity at the horizontal transport zone u2 was able to promote the horizontal transport of the particles but should not be too high,otherwise,it would obstruct the normal falling back of the particles in the downward zone.Big gap heights would decrease the coating efficiency but tube length had little impact on that.The increment of batch volume would commonly abase the cycle time and the working efficiency under a given u1.The de-fluidization problem arose when the batch volume increased to 550 mL.However,this problem could be swept out by the optimization of u1 and u2.In a mixture of different sizes,the coarse particles enjoyed higher coating efficiency and could travel closer to the nozzles.This may shield the fine particles from getting enough coating liquids,and thus coarse particles and fine particles were not recommended to get coated in the same batch. 展开更多
关键词 Numerical simulation CFD-DEM Wurster coater HYDRODYNAMICS Cycle time Residence time
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温阳利湿化瘀方对乙肝相关慢加急性肝衰竭患者早期血清内毒素和炎症因子的影响 被引量:5
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作者 张修举 郭瑞 +2 位作者 张引强 陈艳 宋烨闻 《中国中医急症》 2022年第1期38-41,共4页
目的探讨温阳利湿化瘀方对乙肝相关慢加急性肝衰竭(HBV-ACLF)患者早期血清内毒素(ET)和炎症因子的影响。方法将146例HBV-ACLF早期患者按照随机数字表法分为观察组与对照组各73例。对照组患者参照指南予以西医常规治疗,观察组在对照组治... 目的探讨温阳利湿化瘀方对乙肝相关慢加急性肝衰竭(HBV-ACLF)患者早期血清内毒素(ET)和炎症因子的影响。方法将146例HBV-ACLF早期患者按照随机数字表法分为观察组与对照组各73例。对照组患者参照指南予以西医常规治疗,观察组在对照组治疗基础上采用温阳利湿化瘀方治疗。比较两组治疗前后的中性粒细胞/淋巴细胞比值(NLR)、血清白细胞介素-6(IL-6)和ET水平,观察两组肝功能指标、中医证候评分、MELD评分和凝血功能的差异性,比较两组中医证候疗效。结果观察组治疗后NLR、IL-6、ET水平显著低于对照组(P<0.05)。观察组治疗后肝功能指标和凝血功能指标较对照组显著改善(P<0.05)。观察组治疗后1周、2周、3周的中医证候评分和MELD评分显著低于对照组(P<0.05)。观察组中医证候总有效率为86.30%,明显高于对照组的65.75%(P<0.05)。结论在西医治疗基础上联合温阳利湿化瘀方治疗HBV-ACLF患者可显著改善其肝功能和凝血功能指标,疗效良好,有助于患者病情严重程度和中医证候评分,可能与降低血清内毒素和炎症因子水平有关。 展开更多
关键词 乙肝相关慢加急性肝衰竭 温阳利湿化瘀方 内毒素 炎症因子
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