Here we report 1.3μm electrical injection lasers based on InAs/GaAs quantum dots(QDs)grown on a GaAs substrate,which can steadily work at 110-℃without visible degradation.The QD structure is designed by applying the...Here we report 1.3μm electrical injection lasers based on InAs/GaAs quantum dots(QDs)grown on a GaAs substrate,which can steadily work at 110-℃without visible degradation.The QD structure is designed by applying the Stranski-Krastanow growth mode in solid source molecular beam epitaxy.The density of InAs QDs in the active region is increased from 3.8×10^(10)cm^(-2)to 5.9×10^(10)cm^(-2).As regards laser performance,the maximum output power of devices with lowdensity QDs as the active region is 65 m W at room temperature,and that of devices with the high-density QDs is 103 mW.Meanwhile the output power of high-density devices is 131 mW under an injection current of 4 A at 110-℃.展开更多
目的:探索临床实际情境下新护士规范化培训技能考核的客观评价方法。方法:采取技能直接观察考核法(Direct Observation of Procedural Skills,DOPS),在临床实际情境下对新护士从技能操作中所展现的行为与能力共10个指标进行考核。结果:...目的:探索临床实际情境下新护士规范化培训技能考核的客观评价方法。方法:采取技能直接观察考核法(Direct Observation of Procedural Skills,DOPS),在临床实际情境下对新护士从技能操作中所展现的行为与能力共10个指标进行考核。结果:除"操作前的解释和知情同意"超出预期目标外,其余9项指标均为接近或达到预期目标;其中"操作中相关制度、法律、行业标准的执行""患者体验""操作后处置"是新护士临床技能中最薄弱的项目,未达到预期目标的人员比例>17%;传统考核法与DOPS考核法在平均成绩上无统计学差异(P>0.05),但DOPS考核法对技能中行为与能力的评价较传统考核法更敏感。结论:DOPS考核法是临床实际情境下客观多维度评价新护士临床技能中行为与能力的方法。展开更多
运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100...运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100倍的基因共8个,下调50~100倍的基因共14个,同时按基因转录水平将这些基因进行了分类。运用KEGG(Kyoto Encyclopedia of Genes and Genomes)通路分析技术分析相关基因通路,结果显示松乳菇多糖主要抑制人喉癌Hep-2细胞中的MAPK信号转导通路和PI3K-AKT信号转导通路。在松乳菇多糖的刺激作用下,人喉癌Hep-2细胞的凋亡是多种基因共同作用的综合结果。用筛选出的基因进一步研究肿瘤凋亡的分子机制,对寻找潜在的抗肿瘤作用靶点具有重要生物学意义。展开更多
基金the Science and Technology Program of Guangzhou(Grant No.202103030001)the KeyArea Research and Development Program of Guangdong Province(Grant No.2018B030329001)+8 种基金the National Natural Science Foundation of China(Grant Nos.62035017,61505196,and 62204238)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(Grant No.YJKYYQ20170032)the Major Program of the National Natural Science Foundation of China(Grant Nos.61790580 and 61790581)the Chinese Academy of Sciences and Changchun City Science and Technology Innovation Cooperation Project(Grant No.21SH06)Jincheng Key Research and Development Project(Grant No.20210209)the Key R&D Program of Shanxi Province(Grant No.202102030201004)the R&D Program of Guangdong Province(Grant Nos.2018B030329001 and2020B0303020001)Shenzhen Technology Research Project(Grant No.JSGG20201102145200001)the National Key Technologies R&D Program of China(Grant No.2018YFA0306100)。
文摘Here we report 1.3μm electrical injection lasers based on InAs/GaAs quantum dots(QDs)grown on a GaAs substrate,which can steadily work at 110-℃without visible degradation.The QD structure is designed by applying the Stranski-Krastanow growth mode in solid source molecular beam epitaxy.The density of InAs QDs in the active region is increased from 3.8×10^(10)cm^(-2)to 5.9×10^(10)cm^(-2).As regards laser performance,the maximum output power of devices with lowdensity QDs as the active region is 65 m W at room temperature,and that of devices with the high-density QDs is 103 mW.Meanwhile the output power of high-density devices is 131 mW under an injection current of 4 A at 110-℃.
文摘目的:探索临床实际情境下新护士规范化培训技能考核的客观评价方法。方法:采取技能直接观察考核法(Direct Observation of Procedural Skills,DOPS),在临床实际情境下对新护士从技能操作中所展现的行为与能力共10个指标进行考核。结果:除"操作前的解释和知情同意"超出预期目标外,其余9项指标均为接近或达到预期目标;其中"操作中相关制度、法律、行业标准的执行""患者体验""操作后处置"是新护士临床技能中最薄弱的项目,未达到预期目标的人员比例>17%;传统考核法与DOPS考核法在平均成绩上无统计学差异(P>0.05),但DOPS考核法对技能中行为与能力的评价较传统考核法更敏感。结论:DOPS考核法是临床实际情境下客观多维度评价新护士临床技能中行为与能力的方法。
文摘运用基因芯片技术分析松乳菇多糖对人喉癌Hep-2细胞肿瘤相关基因表达的影响及分子机制。结果表明,经松乳菇多糖600μg/m L处理48 h后,在人喉癌Hep-2细胞中发现相关肿瘤差异基因共68个,其中人喉癌Hep-2细胞肿瘤相关基因下调倍数大于100倍的基因共8个,下调50~100倍的基因共14个,同时按基因转录水平将这些基因进行了分类。运用KEGG(Kyoto Encyclopedia of Genes and Genomes)通路分析技术分析相关基因通路,结果显示松乳菇多糖主要抑制人喉癌Hep-2细胞中的MAPK信号转导通路和PI3K-AKT信号转导通路。在松乳菇多糖的刺激作用下,人喉癌Hep-2细胞的凋亡是多种基因共同作用的综合结果。用筛选出的基因进一步研究肿瘤凋亡的分子机制,对寻找潜在的抗肿瘤作用靶点具有重要生物学意义。
