Synaptic dysfunction is a core component of the pathophysiology of schizophrenia.However,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood.The Stonin 2(ST...Synaptic dysfunction is a core component of the pathophysiology of schizophrenia.However,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood.The Stonin 2(STON2)gene encodes a major adaptor for clathrin-mediated endocytosis(CME)of synaptic vesicles.In this study,we showed that the C-C(307Pro-851Ala)haplotype of STON2 increases the susceptibility to schizophrenia and examined whether STON2 variations cause schizophrenia-like behaviors through the regulation of CME.We found that schizophrenia-related STON2 variations led to protein dephosphorylation,which affected its interaction with synaptotagmin 1(Syt1),a calcium sensor protein located in the presynaptic membrane that is critical for CME.STON2307Pro851Ala knockin mice exhibited deficits in synaptic transmission,short-term plasticity,and schizophrenia-like behaviors.Moreover,among seven antipsychotic drugs,patients with the C-C(307Pro-851Ala)haplotype responded better to haloperidol than did the T-A(307Ser-851Ser)carriers.The recovery of deficits in Syt1 sorting and synaptic transmission by acute administration of haloperidol effectively improved schizophrenia-like behaviors in STON2307Pro851Ala knockin mice.Our findings demonstrated the effect of schizophreniarelated STON2 variations on synaptic dysfunction through the regulation of CME,which might be attractive therapeutic targets for treating schizophrenia-like phenotypes.展开更多
利用CST studio suite程序对边耦合直线加速结构的加速腔及耦合腔进行建模仿真,并进行优化。加速腔结构由11个参数决定,优化过程需平衡多个参数,包括本征模式、高频特性、最大表面电场、有效分路阻抗及渡越时间因子;耦合腔的优化基于维...利用CST studio suite程序对边耦合直线加速结构的加速腔及耦合腔进行建模仿真,并进行优化。加速腔结构由11个参数决定,优化过程需平衡多个参数,包括本征模式、高频特性、最大表面电场、有效分路阻抗及渡越时间因子;耦合腔的优化基于维持本征模式3 GHz。结果表明,在26~120 MeV整个加速过程中,加速腔的有效分路阻抗为22.5~59.8 MΩ·m^(-1),加速梯度为11~14.7 MV·m^(-1)。展开更多
由于正交相五氧化二铌(T-Nb_(2)O_(5))为ReO_(3)型层状结构,锂、钠离子可以在其(001)平面快速脱嵌,而在[001]方向的传输一般较难。本研究通过原位透射电子显微镜(Transmission Electron Microscope,TEM)方法研究钠在T-Nb_(2)O_(5)纳米片...由于正交相五氧化二铌(T-Nb_(2)O_(5))为ReO_(3)型层状结构,锂、钠离子可以在其(001)平面快速脱嵌,而在[001]方向的传输一般较难。本研究通过原位透射电子显微镜(Transmission Electron Microscope,TEM)方法研究钠在T-Nb_(2)O_(5)纳米片(001)面内及[001]方向的钠离子电化学嵌入行为,发现由于纳米片晶体存在大量的位错和畴界,钠离子可通过这些缺陷穿越(001)面扩散,并进而在深层的(001)面内快速扩散。同时,本研究还发现刚合成的T-Nb_(2)O_(5)纳米片在[001]方向上存在调制结构,存在交替分布的压应变和张应变区域,而钠离子的嵌入可以调节这些应变分布。展开更多
基金supported by the Key Realm R&D Program of Guangdong Province(2019B030335001)the National Natural Science Foundation of China(82330042,81825009,82071541,81971283,82271576,and 82101570)+2 种基金Changping Laboratory(2021B-01-01)the China Postdoctoral Science Foundation(2021M690421)the Non-profit Central Research Institute Chinese Academy of Medical Sciences(2023-PT320-08).
文摘Synaptic dysfunction is a core component of the pathophysiology of schizophrenia.However,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood.The Stonin 2(STON2)gene encodes a major adaptor for clathrin-mediated endocytosis(CME)of synaptic vesicles.In this study,we showed that the C-C(307Pro-851Ala)haplotype of STON2 increases the susceptibility to schizophrenia and examined whether STON2 variations cause schizophrenia-like behaviors through the regulation of CME.We found that schizophrenia-related STON2 variations led to protein dephosphorylation,which affected its interaction with synaptotagmin 1(Syt1),a calcium sensor protein located in the presynaptic membrane that is critical for CME.STON2307Pro851Ala knockin mice exhibited deficits in synaptic transmission,short-term plasticity,and schizophrenia-like behaviors.Moreover,among seven antipsychotic drugs,patients with the C-C(307Pro-851Ala)haplotype responded better to haloperidol than did the T-A(307Ser-851Ser)carriers.The recovery of deficits in Syt1 sorting and synaptic transmission by acute administration of haloperidol effectively improved schizophrenia-like behaviors in STON2307Pro851Ala knockin mice.Our findings demonstrated the effect of schizophreniarelated STON2 variations on synaptic dysfunction through the regulation of CME,which might be attractive therapeutic targets for treating schizophrenia-like phenotypes.
文摘由于正交相五氧化二铌(T-Nb_(2)O_(5))为ReO_(3)型层状结构,锂、钠离子可以在其(001)平面快速脱嵌,而在[001]方向的传输一般较难。本研究通过原位透射电子显微镜(Transmission Electron Microscope,TEM)方法研究钠在T-Nb_(2)O_(5)纳米片(001)面内及[001]方向的钠离子电化学嵌入行为,发现由于纳米片晶体存在大量的位错和畴界,钠离子可通过这些缺陷穿越(001)面扩散,并进而在深层的(001)面内快速扩散。同时,本研究还发现刚合成的T-Nb_(2)O_(5)纳米片在[001]方向上存在调制结构,存在交替分布的压应变和张应变区域,而钠离子的嵌入可以调节这些应变分布。
文摘以IPDI、PTMG-2000、DMPA为原料,通过预聚体法合成水性聚氨酯,以硫酸铝、硫酸镁、硫酸锌、二氧化钛对竹炭微粉进行改性,将改性后的竹炭微粉与水性聚氨酯进行物理混合,通过改变改性竹炭微粉的质量制备出一系列白度化后的竹炭微粉/水性聚氨酯复合涂料,将其制备成75 mm×25 mm规格的漆膜样品,对制备的样品进行红外光谱、吸水性、力学性能、白度以及甲醛吸附性表征,研究表明:当加入竹炭质量分数为0.3%时,复合涂料具有良好的综合性能,此时白度值为21.4,白度效果较为理想,吸水率为370%,经过240 h后的甲醛吸附量测试,样品吸附甲醛0.051 g.
