Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases...Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China.展开更多
For the estimation of MIMO frequency selective channel, to mitigate the curse of dimensionality, a novel particle filtering scheme combined with time delay domain processing is proposed. In order to extract the time d...For the estimation of MIMO frequency selective channel, to mitigate the curse of dimensionality, a novel particle filtering scheme combined with time delay domain processing is proposed. In order to extract the time delay domain channel impulse response from the observed signal, the least-squares （LS） and minimum mean squared error （MMSE） criteria are discussed and the comparable performance of LS with MMSE for sample- spaced channel is revealed. Incorporated the dynamical channel model, gradient particle filtering is further introduced to improve the estimation performance. The robustness of the channel estimator for underestimated Doppler frequency and the effectiveness of the new estimation scheme are illustrated through simulation at last.展开更多
For the issue of deterioration in detection performance caused by dynamically changing environment in ultra-wideband（UWB） multiple input multiple output（MIMO） radar, this paper proposes a novel adaptive waveform d...For the issue of deterioration in detection performance caused by dynamically changing environment in ultra-wideband（UWB） multiple input multiple output（MIMO） radar, this paper proposes a novel adaptive waveform design which is aimed to improve the ability of discriminating target and clutter from the radar scene. Firstly, a sequence of Morlet wavelet pulses with frequency hopping and pulse position modulation by Welch-Costas array is designed. Then a waveform optimization solution is proposed which is achieved by applying the minimization mutual-information（MI） strategy. After that, with subsequent iterations of the algorithm, simulation results demonstrate that the optimal waveform design method brings an improvement in the target detection ability in the presence of noise and clutter.展开更多
文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China.
文摘For the estimation of MIMO frequency selective channel, to mitigate the curse of dimensionality, a novel particle filtering scheme combined with time delay domain processing is proposed. In order to extract the time delay domain channel impulse response from the observed signal, the least-squares （LS） and minimum mean squared error （MMSE） criteria are discussed and the comparable performance of LS with MMSE for sample- spaced channel is revealed. Incorporated the dynamical channel model, gradient particle filtering is further introduced to improve the estimation performance. The robustness of the channel estimator for underestimated Doppler frequency and the effectiveness of the new estimation scheme are illustrated through simulation at last.
基金supported by the National Natural Science Foundation of China(6107114561271331)
文摘For the issue of deterioration in detection performance caused by dynamically changing environment in ultra-wideband（UWB） multiple input multiple output（MIMO） radar, this paper proposes a novel adaptive waveform design which is aimed to improve the ability of discriminating target and clutter from the radar scene. Firstly, a sequence of Morlet wavelet pulses with frequency hopping and pulse position modulation by Welch-Costas array is designed. Then a waveform optimization solution is proposed which is achieved by applying the minimization mutual-information（MI） strategy. After that, with subsequent iterations of the algorithm, simulation results demonstrate that the optimal waveform design method brings an improvement in the target detection ability in the presence of noise and clutter.
