Outstanding mechanical properties of graphene nanoplatelets(GNPs)make them ideal reinforcement for mass production of composites.In this research,the composites were fabricated by stir-casting method.GNPs were added i...Outstanding mechanical properties of graphene nanoplatelets(GNPs)make them ideal reinforcement for mass production of composites.In this research,the composites were fabricated by stir-casting method.GNPs were added in 1.5 and 3.0 wt.%into Mg–3wt.%Al–1wt.%Zn(AZ31)magnesium alloy.As cast ingots were preheated for one hour and extruded at 350℃ with extrusion ratio of 5.2:1.As extruded AZ31-GNPs composites were micro-structurally characterized with X-ray diffraction,optical microscopy and scanning electron microscopy.Vickers microhardness of synthesized materials was investigated both in parallel and perpendicular to extrusion directions.Room temperature mechanical testing revealed that with increasing GNP’s content,tensile fracture strain was remarkably increased without significant compromise in tensile strength.Furthermore,as extruded AZ31-3GNPs composites were subjected to tensile testing at temperatures ranging from 75℃ to 300℃ with initial strain rate of 2×10^(−3)s^(−1) to evaluate high temperature formability of composite.It was found that like CNTs,GNPs also have the potential to sustain tensile strength at high temperatures.展开更多
OBJECTIVE:To optimise point application therapy for the treatment of asthma.METHODS:A total of 456 patients with asthma were randomly divided into treatment groups 1,2,and 3,with 152 patients each.The Dazhui(GV14),Fei...OBJECTIVE:To optimise point application therapy for the treatment of asthma.METHODS:A total of 456 patients with asthma were randomly divided into treatment groups 1,2,and 3,with 152 patients each.The Dazhui(GV14),Feishu(BL13),Xinshu(BL15),Geshu(BL17),Pishu(BL20),Shenshu(BL23),and Guanyuan(CV4)acupoints were selected for treatment groups 1 and 2,with 2 and 4 h of application,respectively.The Feishu(BL13),Xinshu(BL15),and Geshu(BL17)acupoints were selected in group 3,with 2 h of application.All patients underwent application of the“prevention of disease”plaster during the dog days of summer(approximately July and August each year)between 2015 and 2019.RESULTS:The analysis showed that the numbers of asthma attacks and total serum immunoglobulin E(IgE)levels of the three groups after treatment were significantly lower than those before treatment.In addition,the reductions in treatment groups 1 and 2 were more significant than those in group 3.The total treatment efficacy rates and post-treatment quality of life scores of the patients in treatment groups 1 and 2 were significantly higher than those in group 3.CONCLUSIONS:Point application therapy can effectively improve the clinical symptoms of patients with asthma,reduce the number of attacks,improve the quality of life,and decrease the total serum IgE level.The choice of acupuncture points,but not the length of the application time,influenced the therapeutic effect of point application therapy in asthma.展开更多
A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8,...A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8, 8a -hexahydro-1-naphthalenecarboxylic acid] by the combination of 1D and 2D NMR techniques (HSQC, HMBC) and X-ray analysis.展开更多
In recent years,with the rapid development of medical research,cancer diagnosis and treatment technology have significantly improved young cancer patient’s survival rate.Anticancer therapy such as chemotherapy,radiot...In recent years,with the rapid development of medical research,cancer diagnosis and treatment technology have significantly improved young cancer patient’s survival rate.Anticancer therapy such as chemotherapy,radiotherapy,or hematopoietic stem cell transplantation can lead to premature ovarian insufficiency.The endocrine and reproductive function of the ovary is critical to women’s physical and mental health.Ovarian tissue cryopreservation and transplantation can protect not only female fertility but also preserve ovarian endocrine function.This paper interprets the guidelines for ovarian tissue cryopreservation and transplantation issued by the Chinese Society of Gynecological Endocrinology affiliated to the International Society of Gynecological Endocrinology.The purpose of this guideline’s interpretation is to promote more medical workers to understand the technology of ovarian tissue cryopreservation and transplantation,which can provide patients with more choices of fertility protection methods and improve their quality of life.展开更多
AIM: To investigation the anti-coxsackievirus B3 (CVB3m)effect of the ethyl acetate extract of Tian-hua-fen on HeLacells infected with CVB3m.METHODS: HeLa cells were infected with CVB3m and thecytopathic effects (CPE)...AIM: To investigation the anti-coxsackievirus B3 (CVB3m)effect of the ethyl acetate extract of Tian-hua-fen on HeLacells infected with CVB3m.METHODS: HeLa cells were infected with CVB3m and thecytopathic effects (CPE) were observed through light microscope and crystal violet staining on 96-well plate and A600 was detected using spectrophotometer. The protective effect of the extract to HeLa cells and the mechanism of the effect were also evaluated through the change of CPE and value of A600.RESULTS: The extract had some toxicity to HeLa cells at a higher concentration while had a marked inhibitory effect on cell pathological changes at a lower concentration.Consistent results were got through these two methods.We also investigated the mechanism of its anti-CVB3m effectand the results indicated that the extract represented an inhibitory effect through all the processes of CVB3m attachment, entry, biosynthesis and assemble in cells.CONCLUSION: The results demonstrate that the ethyl acetate extract of Tian-hua-fen has a significantprotectiveeffect on HeLa cells infected with CVB3m in a dose-dependent manner and this effect exists through the process of CVB3mattachment, entry, biosynthesis and assemble in cells,suggesting that the ethyl acetate extract of Tian-hua-fen can be developed as an anti-virus agent.展开更多
In this paper,we explored to develop a new concept of computer-and internet-based learning and training method in medicine,especially in obstetrics and gynecology,which is named as Virtual Academy of Women'Health(...In this paper,we explored to develop a new concept of computer-and internet-based learning and training method in medicine,especially in obstetrics and gynecology,which is named as Virtual Academy of Women'Health(VA).Especially in the times of infectious disease pandemics worldwide,learning at home rather than in big lectures hall,might be necessary and practical as never before.The VA is based on worldwide knowledge in medicine—free accessible on the internet-in terms of homepages,video and audio platforms,scientific papers,medical books,and different guidelines.A collection of different video-clips in various fields of women's health can assist the student or doctor in understanding the symptoms,diagnostics,and treatment of various diseases.There are two major targets of it-one is online education,and one is testing the knowledge by simulation of clinical cases.展开更多
In Anyue dialect,the meaning of the word“che”is very rich.It can be used as a verb to express the meaning of“argument,”“discussion,”“tearing,”“receiving,”“cutting,”“picking,”“opening,”“buying,”and“p...In Anyue dialect,the meaning of the word“che”is very rich.It can be used as a verb to express the meaning of“argument,”“discussion,”“tearing,”“receiving,”“cutting,”“picking,”“opening,”“buying,”and“pulling.”It can also be used as an adjective to express the meaning of“immoral,”“unreliable,”and“naughty.”This article describes the semantics and usage of“che”in Anyue dialect as well as the usage of special phrases with“che”in other areas of southwest Mandarin.Finally,this article analyzes the semantic evolution of“che”and constructs a semantic evolution diagram.展开更多
OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to a...OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to analyze the solubility of chlorogeninc acid polymorphs;solid chlorogeninc acid in different forms were orally administered to the rats,and a HPLC method was established to determinate plasma lever of metabolite-acyclovir and the bioavailability was analyzed.RESULTS The indirect pharmacokinetic parameters of Chlorogeninc acid,as the metabolites of the form Ⅰ,Ⅱ,Ⅲ,were as follows:cmaxwas 0.37,0.34 and 0.44mg·L-1,respectively;AUC0→twas 0.71,0.76 and 0.79mg·L-1·h,respectively.CONCLUSION The solubility of form Ⅲ was larger than the other forms′.The solubility of Chlorogeninc acid polymorphs:form Ⅰ,form Ⅱ,form Ⅲ were merely the same,there was no statistically significant difference in pharmacokinetic parameters among these three forms.展开更多
A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evide...A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evidences and confirmed by X-ray analysis, the stereochemistry of the compound was also defined by X-ray analysis.展开更多
基金the National Natural Science Foundation of China(Projects 51531002,51474043,51571043)Fundamental Research Funds for the Central Universities(Grant 106112015CDJZR135515)Chongqing Municipal Government(CSTC2013JCYJC60001,CEC project,Two River Scholar Project andThe Chief Scientist Studio Project).
文摘Outstanding mechanical properties of graphene nanoplatelets(GNPs)make them ideal reinforcement for mass production of composites.In this research,the composites were fabricated by stir-casting method.GNPs were added in 1.5 and 3.0 wt.%into Mg–3wt.%Al–1wt.%Zn(AZ31)magnesium alloy.As cast ingots were preheated for one hour and extruded at 350℃ with extrusion ratio of 5.2:1.As extruded AZ31-GNPs composites were micro-structurally characterized with X-ray diffraction,optical microscopy and scanning electron microscopy.Vickers microhardness of synthesized materials was investigated both in parallel and perpendicular to extrusion directions.Room temperature mechanical testing revealed that with increasing GNP’s content,tensile fracture strain was remarkably increased without significant compromise in tensile strength.Furthermore,as extruded AZ31-3GNPs composites were subjected to tensile testing at temperatures ranging from 75℃ to 300℃ with initial strain rate of 2×10^(−3)s^(−1) to evaluate high temperature formability of composite.It was found that like CNTs,GNPs also have the potential to sustain tensile strength at high temperatures.
基金Supported by Major Science and Technology Special Project of Zhejiang Province:Research and Application of Key Techniques of Point Application Therapy for Treating Winter Diseases and Summer Diseases to Prevent and Treat Respiratory Allergic Diseases(No.2014C03046-2)the Young Scientists of National Natural Science Foundation of China:Study on the Mechanism of Point Application Therapy Regulating Autophagy of Airway Epithelial Cells in the Treatment of Asthma Based on AMPK/mTOR Signal Pathway,(No.82004454)Zhejiang Traditional Chinese Medicine Administration:based on the Theory of"Lung Intestine Axis",a Comparative Study on the Therapeutic Effect of Different Point Application Therapy on Patients with AnaphyLactic Asthma in Remission Stage(No.2021ZQ035)。
文摘OBJECTIVE:To optimise point application therapy for the treatment of asthma.METHODS:A total of 456 patients with asthma were randomly divided into treatment groups 1,2,and 3,with 152 patients each.The Dazhui(GV14),Feishu(BL13),Xinshu(BL15),Geshu(BL17),Pishu(BL20),Shenshu(BL23),and Guanyuan(CV4)acupoints were selected for treatment groups 1 and 2,with 2 and 4 h of application,respectively.The Feishu(BL13),Xinshu(BL15),and Geshu(BL17)acupoints were selected in group 3,with 2 h of application.All patients underwent application of the“prevention of disease”plaster during the dog days of summer(approximately July and August each year)between 2015 and 2019.RESULTS:The analysis showed that the numbers of asthma attacks and total serum immunoglobulin E(IgE)levels of the three groups after treatment were significantly lower than those before treatment.In addition,the reductions in treatment groups 1 and 2 were more significant than those in group 3.The total treatment efficacy rates and post-treatment quality of life scores of the patients in treatment groups 1 and 2 were significantly higher than those in group 3.CONCLUSIONS:Point application therapy can effectively improve the clinical symptoms of patients with asthma,reduce the number of attacks,improve the quality of life,and decrease the total serum IgE level.The choice of acupuncture points,but not the length of the application time,influenced the therapeutic effect of point application therapy in asthma.
文摘A new compound, named heteraltaic acid was isolated from the flowers of Heteropappus altaicus (willd) Novopokr.. The compound was elucidated as (5R, 6S, 8aS) –5- [2-(3-furyl ) ethyl-5, 6, 8a-trimethyl-4a, 5, 6, 7, 8, 8a -hexahydro-1-naphthalenecarboxylic acid] by the combination of 1D and 2D NMR techniques (HSQC, HMBC) and X-ray analysis.
基金supported by Capital's Funds for Health Improvement and Research of China(Grant No.2020-2-2112)Beijing Municipal Administration of Hospitals’Ascent Plan of China(Grant No.DFL20181401)the Beijing Natural Science Foundation of China(Grant No.7202047),References。
文摘In recent years,with the rapid development of medical research,cancer diagnosis and treatment technology have significantly improved young cancer patient’s survival rate.Anticancer therapy such as chemotherapy,radiotherapy,or hematopoietic stem cell transplantation can lead to premature ovarian insufficiency.The endocrine and reproductive function of the ovary is critical to women’s physical and mental health.Ovarian tissue cryopreservation and transplantation can protect not only female fertility but also preserve ovarian endocrine function.This paper interprets the guidelines for ovarian tissue cryopreservation and transplantation issued by the Chinese Society of Gynecological Endocrinology affiliated to the International Society of Gynecological Endocrinology.The purpose of this guideline’s interpretation is to promote more medical workers to understand the technology of ovarian tissue cryopreservation and transplantation,which can provide patients with more choices of fertility protection methods and improve their quality of life.
基金Supported by Project of National Nature Science Foundation of China,No.39970691 and Project from Education Comment of Shanghai,China,No.2000B04
文摘AIM: To investigation the anti-coxsackievirus B3 (CVB3m)effect of the ethyl acetate extract of Tian-hua-fen on HeLacells infected with CVB3m.METHODS: HeLa cells were infected with CVB3m and thecytopathic effects (CPE) were observed through light microscope and crystal violet staining on 96-well plate and A600 was detected using spectrophotometer. The protective effect of the extract to HeLa cells and the mechanism of the effect were also evaluated through the change of CPE and value of A600.RESULTS: The extract had some toxicity to HeLa cells at a higher concentration while had a marked inhibitory effect on cell pathological changes at a lower concentration.Consistent results were got through these two methods.We also investigated the mechanism of its anti-CVB3m effectand the results indicated that the extract represented an inhibitory effect through all the processes of CVB3m attachment, entry, biosynthesis and assemble in cells.CONCLUSION: The results demonstrate that the ethyl acetate extract of Tian-hua-fen has a significantprotectiveeffect on HeLa cells infected with CVB3m in a dose-dependent manner and this effect exists through the process of CVB3mattachment, entry, biosynthesis and assemble in cells,suggesting that the ethyl acetate extract of Tian-hua-fen can be developed as an anti-virus agent.
基金This paper was supported by Beijing Municipal Administration of HospitaFs Ascent Plan of China (No.DFL20181401).
文摘In this paper,we explored to develop a new concept of computer-and internet-based learning and training method in medicine,especially in obstetrics and gynecology,which is named as Virtual Academy of Women'Health(VA).Especially in the times of infectious disease pandemics worldwide,learning at home rather than in big lectures hall,might be necessary and practical as never before.The VA is based on worldwide knowledge in medicine—free accessible on the internet-in terms of homepages,video and audio platforms,scientific papers,medical books,and different guidelines.A collection of different video-clips in various fields of women's health can assist the student or doctor in understanding the symptoms,diagnostics,and treatment of various diseases.There are two major targets of it-one is online education,and one is testing the knowledge by simulation of clinical cases.
文摘In Anyue dialect,the meaning of the word“che”is very rich.It can be used as a verb to express the meaning of“argument,”“discussion,”“tearing,”“receiving,”“cutting,”“picking,”“opening,”“buying,”and“pulling.”It can also be used as an adjective to express the meaning of“immoral,”“unreliable,”and“naughty.”This article describes the semantics and usage of“che”in Anyue dialect as well as the usage of special phrases with“che”in other areas of southwest Mandarin.Finally,this article analyzes the semantic evolution of“che”and constructs a semantic evolution diagram.
基金The project supported by the Ministry of Science and Technology of China(2007FY130100)the 12th Five-Year Plan project(2012ZX09301002-001-013)
文摘OBJECTIVE To enhance the quality and efficiency of chlorogeninc acid by investigating the differences among the chlorogeninc acid polymorphs in bioavailability and solubility.METHODS Determinative method was used to analyze the solubility of chlorogeninc acid polymorphs;solid chlorogeninc acid in different forms were orally administered to the rats,and a HPLC method was established to determinate plasma lever of metabolite-acyclovir and the bioavailability was analyzed.RESULTS The indirect pharmacokinetic parameters of Chlorogeninc acid,as the metabolites of the form Ⅰ,Ⅱ,Ⅲ,were as follows:cmaxwas 0.37,0.34 and 0.44mg·L-1,respectively;AUC0→twas 0.71,0.76 and 0.79mg·L-1·h,respectively.CONCLUSION The solubility of form Ⅲ was larger than the other forms′.The solubility of Chlorogeninc acid polymorphs:form Ⅰ,form Ⅱ,form Ⅲ were merely the same,there was no statistically significant difference in pharmacokinetic parameters among these three forms.
文摘A novel cycloartane, named sphaerophysone A, 9, 19-cycloart-7b, 24b, 25-triol-1-en-3- one, was isolated from the ethanol extract of Sphaerophysa salsula DC. The structure was elucidated on the basis of spectral evidences and confirmed by X-ray analysis, the stereochemistry of the compound was also defined by X-ray analysis.
