目的:探究玻璃体切除(PPV)术联合或不联合抗VEGF药物治疗增殖性糖尿病性视网膜病变(PDR)的远期疗效。方法:计算机检索PUBMED、EMBASE、Cochrane Central Register of Controlled Trials(CENTRAL)、Web of Science等多个数据库,查找自建...目的:探究玻璃体切除(PPV)术联合或不联合抗VEGF药物治疗增殖性糖尿病性视网膜病变(PDR)的远期疗效。方法:计算机检索PUBMED、EMBASE、Cochrane Central Register of Controlled Trials(CENTRAL)、Web of Science等多个数据库,查找自建库至2020-07-02关于比较PPV术前是否行抗VEGF药物治疗PDR预后效果的临床随机对照试验(RCT),根据文献纳入与排除标准筛选文献,并进行数据提取和质量评价,主要评价指标包括术后视网膜脱离发生率、黄斑中心凹厚度和最佳矫正视力(BCVA)。结果:最终纳入11项(880眼)RCT研究。Meta分析结果显示,术前行抗VEGF治疗的PDR患者PPV术后视网膜脱离发生率明显低于未注射抗VEGF药物患者(RR=0.39,95%CI 0.22~0.71,P=0.002);亚裔和非亚裔患者中,单纯PPV与联合抗VEGF治疗患者PPV术后视网膜脱离发生率均具有显著差异(亚裔:RR=0.20,95%CI 0.05~0.87,P=0.03;非亚裔:RR=0.46,95%CI 0.24~0.89,P=0.02)。术前抗VEGF治疗的PDR患者PPV术后3、6mo黄斑中心凹厚度均低于PPV术前未行抗VEGF治疗的患者(MD=-78.49,95%CI-94.81~-62.17,P<0.00001;MD=-39.62,95%CI-48.44~-30.80,P<0.00001)。术前抗VEGF治疗的PDR患者PPV术后6mo BCVA优于未行抗VEGF治疗的患者(MD=-0.16,95%CI-0.21~-0.10,P<0.00001)。结论:PPV术前行抗VEGF治疗可有效降低PDR患者术后视网膜脱离发生率,缓解术后黄斑水肿,降低黄斑中心凹厚度,并改善视力预后。展开更多
Using(448.1±2.9)×10^(6)ψ(3686)for the weak baryonic decayψ(3686)→Λc+∑-+c.c..The analysis procedure is optimized using a blinded method.No significant signal is observed,and the upper limit on the branch...Using(448.1±2.9)×10^(6)ψ(3686)for the weak baryonic decayψ(3686)→Λc+∑-+c.c..The analysis procedure is optimized using a blinded method.No significant signal is observed,and the upper limit on the branching fraction(B)ofψ(3686)→Λc+∑-+c.c.is set as 1.4×10^(-5)at the 90%confidence level.展开更多
We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected ...We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the BESIII detector.The Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ c.c.We find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass energies.The upper limits of σ^(Born).B are found to be at the level of O(1)pb at each energy.Larger data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.展开更多
Using data taken at 29 center-of-mass energies between 4.16 and 4.70 GeV with the BESⅢdetector at the Beijing Electron Positron Collider corresponding to a total integrated luminosity of approximately 18.8 fb^(-1),th...Using data taken at 29 center-of-mass energies between 4.16 and 4.70 GeV with the BESⅢdetector at the Beijing Electron Positron Collider corresponding to a total integrated luminosity of approximately 18.8 fb^(-1),the process e^(+)e^(-)→pppñπ+c.c.is observed for the first time with a statistical significance of 11.5σ.The average Born cross sections in the energy ranges of(4.160,4.380)GeV,(4.400,4.600)GeV and(4.610,4.700)GeV are measured to be(21.5±5.7±1.2)fb,(46.3±10.6±2.5)fb and(59.0±9.4±3.2)fb,respectively,where the first uncertainties are statistical and the second are systematic.The line shapes of the pñ and ppπ^(-)invariant mass spectra are consistent with phase space distributions,indicating that no hexaquark or di-baryon state is observed.展开更多
Using electron-positron annihilation data samples corresponding to an integrated luminosity of 4.5 fb-1,collected by the BESⅢdetector in the energy region between 4599.53 MeV and 4698.82 MeV,we report the first obser...Using electron-positron annihilation data samples corresponding to an integrated luminosity of 4.5 fb-1,collected by the BESⅢdetector in the energy region between 4599.53 MeV and 4698.82 MeV,we report the first observations of the Cabibbo-suppressed decaysΛ_(c)^(+)→nπ^(+)π^(0),Λ_(c)^(+)→nπ^(+)π^(-)π^(+),and the Cabibbo-favored decayΛ_(c)^(+)→nK^(-)π^(+)π^(+)with statistical significances of 7.9σ,7.8σ,and>10σ,respectively.The branching fractions of these decays are measured to be B(Λ_(c)^(+)→nπ^(+)π^(0))=(0.64±0.09±0.02)%,B(Λ_(c)^(+)→nπ^(+)π^(-)π^(+))=(0.45±0.07±0.03)%,and B(Λ_(c)^(+)→nK^(-)π^(+)π^(+))=(1.90±0.08±0.09)%,where the first uncertainties are statistical and the second are systematic.We find that the branching fraction of the decayΛ_(c)^(+)→nπ^(+)π^(0)is about one order of magnitude higher than that ofΛ_(c)^(+)→nπ^(+).展开更多
文摘目的:探究玻璃体切除(PPV)术联合或不联合抗VEGF药物治疗增殖性糖尿病性视网膜病变(PDR)的远期疗效。方法:计算机检索PUBMED、EMBASE、Cochrane Central Register of Controlled Trials(CENTRAL)、Web of Science等多个数据库,查找自建库至2020-07-02关于比较PPV术前是否行抗VEGF药物治疗PDR预后效果的临床随机对照试验(RCT),根据文献纳入与排除标准筛选文献,并进行数据提取和质量评价,主要评价指标包括术后视网膜脱离发生率、黄斑中心凹厚度和最佳矫正视力(BCVA)。结果:最终纳入11项(880眼)RCT研究。Meta分析结果显示,术前行抗VEGF治疗的PDR患者PPV术后视网膜脱离发生率明显低于未注射抗VEGF药物患者(RR=0.39,95%CI 0.22~0.71,P=0.002);亚裔和非亚裔患者中,单纯PPV与联合抗VEGF治疗患者PPV术后视网膜脱离发生率均具有显著差异(亚裔:RR=0.20,95%CI 0.05~0.87,P=0.03;非亚裔:RR=0.46,95%CI 0.24~0.89,P=0.02)。术前抗VEGF治疗的PDR患者PPV术后3、6mo黄斑中心凹厚度均低于PPV术前未行抗VEGF治疗的患者(MD=-78.49,95%CI-94.81~-62.17,P<0.00001;MD=-39.62,95%CI-48.44~-30.80,P<0.00001)。术前抗VEGF治疗的PDR患者PPV术后6mo BCVA优于未行抗VEGF治疗的患者(MD=-0.16,95%CI-0.21~-0.10,P<0.00001)。结论:PPV术前行抗VEGF治疗可有效降低PDR患者术后视网膜脱离发生率,缓解术后黄斑水肿,降低黄斑中心凹厚度,并改善视力预后。
基金supported in part by National Key Research and Development Program of China(2020YFA0406400,2020YFA0406300)National Natural Science Foundation of China(NSFC,11975118,11635010,11735014,11835012,11935015,11935016,11935018,11961141012,12022510,12025502,12035009,12035013,12192260,12192261,12192262,12192263,12192264,12192265,12061131003)+18 种基金the Natural Science Foundation of Hunan Province of China(2019JJ30019)the Science and Technology Innovation Program of Hunan Province(2020RC3054)the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(U1832207)CAS Key Research Program of Frontier Sciences(QYZDJ-SSW-SLH040)100 Talents Program of CASThe Institute of Nuclear and Particle Physics(INPAC)and Shanghai Key Laboratory for Particle Physics and Cosmology,ERC(758462)European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement(894790)German Research Foundation DFG(443159800)Collaborative Research Center CRC 1044,GRK 2149Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development of Turkey(DPT2006K-120470)National Science and Technology fundNational Science Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources and Institutional Development,Research and Innovation(B16F640076)STFC(United Kingdom)Suranaree University of Technology(SUT),Thailand Science Research and Innovation(TSRI),and National Science Research and Innovation Fund(NSRF,160355)The Royal Society,UK(DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(DE-FG02-05ER41374)。
文摘Using(448.1±2.9)×10^(6)ψ(3686)for the weak baryonic decayψ(3686)→Λc+∑-+c.c..The analysis procedure is optimized using a blinded method.No significant signal is observed,and the upper limit on the branching fraction(B)ofψ(3686)→Λc+∑-+c.c.is set as 1.4×10^(-5)at the 90%confidence level.
基金Supported in part by National Key R&D Program of China(Grant Nos.2020YFA0406400,2020YFA0406300)National Natural Science Foundation of China(NSFC)(Grant Nos.11635010,11735014,11805086,11835012,11935015,11935016,11935018,11961141012,12022510,12025502,12035009,12035013,12192260,12192261,12192262,12192263,12192264,12192265)+18 种基金the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(Grant No.U1832207)the CAS Center for Excellence in Particle Physics(CCEPP)100 Talents Program of CASFundamental Research Funds for the Central Universities,Lanzhou University,University of Chinese Academy of SciencesThe Institute of Nuclear and Particle Physics(INPAC)and Shanghai Key Laboratory for Particle Physics and CosmologyERC(Grant No.758462)European Union's Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement(Grant No.894790)German Research Foundation DFG(Grant No.443159800),Collaborative Research Center CRC 1044,GRK 2149Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development of Turkey(Grant No.DPT2006K-120470)National Science and Technology fundNational Science Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources&Institutional Development,Research and Innovation(Grant No.B16F640076)Olle Engkvist Foundation(Grant No.200-0605)STFC(United Kingdom)Suranaree University of Technology(SUT),Thailand Science Research and Innovation(TSRI),and National Science Research and Innovation Fund(NSRF)(Grant No.160355)The Royal Society,UK(Grant Nos.DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(Grant No.DE-FG02-05ER41374)。
文摘We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the BESIII detector.The Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ c.c.We find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass energies.The upper limits of σ^(Born).B are found to be at the level of O(1)pb at each energy.Larger data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.
基金Supported in part by National Key R&D Program of China under Contracts Nos.Supported in part by National Key R&D Program of China(2020YFA0406300,2020YFA0406400)National Natural Science Foundation of China(NSFC)(11975118,11625523,11635010,11735014,11822506,11835012,11935015,11935016,11935018,11961141012,12022510,12025502,12035009,12035013,12061131003,12075252,12192260,12192261,12192262,12192263,12192264,12192265)+19 种基金the Natural Science Foundation of Hunan Province of China(2019JJ30019)the Science and Technology Innovation Program of Hunan Province(2020RC3054)the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(U1732263,U1832207)CAS Key Research Program of Frontier Sciences(QYZDJ-SSW-SLH040)100 Talents Program of CASINPAC and Shanghai Key Laboratory for Particle Physics and CosmologyERC(758462)European Union Horizon 2020 research and innovation programme under Contract No.Marie Sklodowska-Curie grant agreement(894790)German Research Foundation DFG(43159800)Collaborative Research Center CRC 1044,FOR 2359,GRK 2149Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development of Turkey(DPT2006K-120470)National Science and Technology fundOlle Engkvist Foundation(200-0605)STFC(United Kingdom)The Knut and Alice Wallenberg Foundation(Sweden)(2016.0157)The Royal Society,UK(DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(DE-FG02-05ER41374,DE-SC-0012069)。
文摘Using data taken at 29 center-of-mass energies between 4.16 and 4.70 GeV with the BESⅢdetector at the Beijing Electron Positron Collider corresponding to a total integrated luminosity of approximately 18.8 fb^(-1),the process e^(+)e^(-)→pppñπ+c.c.is observed for the first time with a statistical significance of 11.5σ.The average Born cross sections in the energy ranges of(4.160,4.380)GeV,(4.400,4.600)GeV and(4.610,4.700)GeV are measured to be(21.5±5.7±1.2)fb,(46.3±10.6±2.5)fb and(59.0±9.4±3.2)fb,respectively,where the first uncertainties are statistical and the second are systematic.The line shapes of the pñ and ppπ^(-)invariant mass spectra are consistent with phase space distributions,indicating that no hexaquark or di-baryon state is observed.
基金Supported in part by National Key R&D Program of China(2020YFA0406400,2020YFA0406300)National Natural Science Foundation of China(NSFC)(11635010,11735014,11805086,11835012,11935015,11935016,11935018,11975011,11961141012,12022510,12025502,12035009,12035013,12192260,12192261,12192262,12192263,12192264,12192265)+20 种基金the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(U1832207)the CAS Center for Excellence in Particle Physics(CCEPP)100 Talents Program of CASFundamental Research Funds for the Central Universities,Lanzhou University,University of Chinese Academy of SciencesThe Institute of Nuclear and Particle Physics(INPAC)Shanghai Key Laboratory for Particle Physics and CosmologyERC(758462)German Research Foundation DFG(443159800)Collaborative Research Center CRC 1044,GRK 2149Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development of Turkey(DPT2006K-120470)National Science and Technology fundNational Science Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources&Institutional Development,Research and Innovation(B16F640076STFC)(United Kingdom)Suranaree University of Technology(SUT)Thailand Science Research and Innovation(TSRI)National Science Research and Innovation Fund(NSRF)(160355)The Royal Society,UK(DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(DEFG02-05ER41374)。
文摘Using electron-positron annihilation data samples corresponding to an integrated luminosity of 4.5 fb-1,collected by the BESⅢdetector in the energy region between 4599.53 MeV and 4698.82 MeV,we report the first observations of the Cabibbo-suppressed decaysΛ_(c)^(+)→nπ^(+)π^(0),Λ_(c)^(+)→nπ^(+)π^(-)π^(+),and the Cabibbo-favored decayΛ_(c)^(+)→nK^(-)π^(+)π^(+)with statistical significances of 7.9σ,7.8σ,and>10σ,respectively.The branching fractions of these decays are measured to be B(Λ_(c)^(+)→nπ^(+)π^(0))=(0.64±0.09±0.02)%,B(Λ_(c)^(+)→nπ^(+)π^(-)π^(+))=(0.45±0.07±0.03)%,and B(Λ_(c)^(+)→nK^(-)π^(+)π^(+))=(1.90±0.08±0.09)%,where the first uncertainties are statistical and the second are systematic.We find that the branching fraction of the decayΛ_(c)^(+)→nπ^(+)π^(0)is about one order of magnitude higher than that ofΛ_(c)^(+)→nπ^(+).
