INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, ...INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, Class Ⅰ and Ⅲ antiarrhythmic drugs have been shown to be associated with the development of proarrhythmias and an increase in the likelihood of causing higher mortality by inducing torsade de pointes ventricular tachycardia and other serious adverse reactions. Consequently, the development of safe and effective antiarrhythmic regimens remains a primary focus of contemporary cardiovascular research.展开更多
结合陕西省两个婴幼儿配方乳粉加工厂婴配粉生产工艺,对生产原辅料、车间环境、加工设备及工厂周边土壤进行采样,检测克罗诺杆菌的污染状况,并对菌株进行脉冲场凝胶电泳(Pulse field gel electrophoresis,PFGE)分型溯源,定位克罗诺杆菌...结合陕西省两个婴幼儿配方乳粉加工厂婴配粉生产工艺,对生产原辅料、车间环境、加工设备及工厂周边土壤进行采样,检测克罗诺杆菌的污染状况,并对菌株进行脉冲场凝胶电泳(Pulse field gel electrophoresis,PFGE)分型溯源,定位克罗诺杆菌在生产过程的污染点。结果表明,采集的1246份样品中检出14份(1.12%)克罗诺杆菌阳性样品,分离得到克罗诺杆菌33株。33株分离株被分为14种基因型别,相似度为85.9%~100.0%。结合PFGE分型结果和乳粉生产工序,明确了乳粉糖、工作人员鞋底、工厂周边土壤、后包车间、净化系统进风口和车间阴沟等均可能是克罗诺杆菌污染的关键点。研究结果可为婴幼儿配方粉生产过程中克罗诺杆菌污染源的甄别和控制提供依据。展开更多
文摘INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, Class Ⅰ and Ⅲ antiarrhythmic drugs have been shown to be associated with the development of proarrhythmias and an increase in the likelihood of causing higher mortality by inducing torsade de pointes ventricular tachycardia and other serious adverse reactions. Consequently, the development of safe and effective antiarrhythmic regimens remains a primary focus of contemporary cardiovascular research.
文摘目的观察过氧化氢(H_(2)O_(2))对兔离体左室复极相关电生理指标及心律失常的影响。方法制备经冠状动脉灌注兔左室楔形组织块标本。实验分为对照组(灌注正常台式液)和实验组(灌注正常台式液+1.0 mmol/L H_(2)O_(2))。两组依次给予基础周长(BCL)为2 000、1 000、500 ms的刺激,持续时间依次为7、1、0.5 min,观察QT间期、T波峰值至终点的时程(Tp-e间期)、Tp-e/QT、ΔQT、ΔTp-e、ΔTp-e/QT、ΔQT%、ΔTp-e%、ΔTp-e/QT%的变化,及是否发生早后除极、晚后除极及室性心律失常。结果对照组和实验组QT间期、Tp-e间期均随刺激周长的增加而延长,且实验组呈现慢频率依赖性(P<0.01)。在2 000 ms BCL刺激下,对照组Tp-e/QT随时间无明显变化,但实验组Tp-e/QT随H_(2)O_(2)作用时间延长呈先增大后减小的变化趋势,其值始终大于对照组(3 min P<0.05,4~9 min P<0.01),而且与对照组相比实验组发生了不同程度的室性心律失常(P<0.001)。结论 H_(2)O_(2)对复极相关电生理指标的影响表现为慢频率依赖性;慢频率条件下,跨壁复极异质性的电生理指标呈先增大后减小的时间依赖性变化,同时也增加复极相关室性心律失常发生风险。
文摘结合陕西省两个婴幼儿配方乳粉加工厂婴配粉生产工艺,对生产原辅料、车间环境、加工设备及工厂周边土壤进行采样,检测克罗诺杆菌的污染状况,并对菌株进行脉冲场凝胶电泳(Pulse field gel electrophoresis,PFGE)分型溯源,定位克罗诺杆菌在生产过程的污染点。结果表明,采集的1246份样品中检出14份(1.12%)克罗诺杆菌阳性样品,分离得到克罗诺杆菌33株。33株分离株被分为14种基因型别,相似度为85.9%~100.0%。结合PFGE分型结果和乳粉生产工序,明确了乳粉糖、工作人员鞋底、工厂周边土壤、后包车间、净化系统进风口和车间阴沟等均可能是克罗诺杆菌污染的关键点。研究结果可为婴幼儿配方粉生产过程中克罗诺杆菌污染源的甄别和控制提供依据。
