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Effects of Perioperative Pain Intervention on Postoperative Rehabilitation of Patients with Partial Resection of Lung Cancer 被引量:3
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作者 yahong huang Cuijuan huang +1 位作者 Zhiqiong Ba Xiumei Chen 《Open Journal of Therapy and Rehabilitation》 2021年第3期99-109,共11页
<span style="font-family:Verdana;"><strong>Objective</strong><strong>:</strong> </span><span style="font-family:Verdana;">To explore the effect of perioper... <span style="font-family:Verdana;"><strong>Objective</strong><strong>:</strong> </span><span style="font-family:Verdana;">To explore the effect of perioperative pain intervention on postoperative rehabilitation of patients who underwent thoracoscopic partial resection of lung cancer.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> From January 2021 to May 2021, 100 patients with primary lung cancer who underwent thoracoscopic partial lung resection in Cardiopulmonary Department II of</span><span style="font-family:Verdana;"> Cancer Center in our hospital were selected. They were divided into observation group and control group by random number table</span><span style="font-family:Verdana;">. Routine nursing after surgery was used in both groups, the observation group was given perioperative pain intervention nursing on the basis of routine nursing, and the postoperative pain (6</span><span style="font-family:""> </span><span style="font-family:Verdana;">h, 12</span><span style="font-family:""> </span><span style="font-family:Verdana;">h, 24</span><span style="font-family:""> </span><span style="font-family:Verdana;">h, 48</span><span style="font-family:""> </span><span style="font-family:Verdana;">h after operation), the rate of out-of-bed activity within 24</span><span style="font-family:""> </span><span style="font-family:Verdana;">h after operation,</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">lien chest tube time, the incidence of postoperative complications, the influence of pain on daily life, the satisfaction of patients with pain control methods and pain education and the satisfaction of discharged patients were observed and recorded. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">There was no significant difference in general data (age, sex, educational level, course of disease, TNM stage of lung cancer, max 展开更多
关键词 Pain Intervention Lung Cancer REHABILITATION SATISFACTION
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靶向hTERT、hTR新型RNAi表达框架的构建及应用效果观察
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作者 李亚红 赵丹丹 +3 位作者 黄丹 刘蕾 朱文琦 彭剑雄 《中国普通外科杂志》 CAS CSCD 北大核心 2016年第12期1738-1744,共7页
目的:构建靶向hTERT、hTR的新型RNAi表达框架,探讨单独及联合干扰hTERT、hTR基因对肿瘤细胞端粒酶活性、细胞凋亡及周期的影响,以期找到肿瘤基因治疗的新策略。方法:融合PCR构建靶向hTERT、hTR的RNAi表达框架。各表达框架经鉴定后分别... 目的:构建靶向hTERT、hTR的新型RNAi表达框架,探讨单独及联合干扰hTERT、hTR基因对肿瘤细胞端粒酶活性、细胞凋亡及周期的影响,以期找到肿瘤基因治疗的新策略。方法:融合PCR构建靶向hTERT、hTR的RNAi表达框架。各表达框架经鉴定后分别或联合转染A549细胞,TRAP-银染法及TRAP-q PCR法检测端粒酶活性,流式细胞仪检测细胞凋亡及周期。结果:靶向hTERT、hTR的新型RNAi表达框架构建成功。与空白对照组或阴性对照组比较,无论转染靶向hTERT或靶向hTR的RNAi表达框架后,A549细胞的端粒酶活性均明显降低,细胞凋亡率均明显增加,细胞G1阻滞明显增加,而联合转染靶向hTERT与靶向hTR的RNAi表达框架后,A549细胞的上述改变较各自单独转染更为明显(均P<0.05)。结论:靶向hTERT、hTR的新型RNAi表达框架能够有效抑制A549细胞的端粒酶活性,诱导细胞凋亡,改变细胞周期。以人工mi RNA表达框架为基础的新型RNAi技术有望成为肿瘤基因治疗的新工具。 展开更多
关键词 末端转移酶端粒 RNA干扰 表达框架
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