Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progres...Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida （JLD） granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance （IGT） and its effect on the prevention of DM.Methods：Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily （JLD group,n =34） or no drug intervention （control group,n =31） for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c （HbA1c）,body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment （HOMA-IR） of all the patients were observed and compared before and after the treatment.Results：Sixty-one participants completed the trial （32 in JLD group and 29 in the control group）.There were statistically significant decreases in HbA1c （P 〈 0.001）,2-h plasma glucose （P 〈 0.001）,and HOMA-IR （P =0.029） in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two （6.9%） patients returned to normal blood glucose,and five （17.2%） patients turned into DM in control group,while in the JLD group,14 （43.8%） returned to normal blood glucose and 2 （6.2%） turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups （P =0.001）.Conclusions：JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.展开更多
HabRat richness influences and even determines biological diversity. Plant habitat suitability assessment can provide technical guidance and information support for ecological restoration. Thirteen factors in three ca...HabRat richness influences and even determines biological diversity. Plant habitat suitability assessment can provide technical guidance and information support for ecological restoration. Thirteen factors in three categories of terrain, meteorology and soil were chosen to build a habitat suitability assessment index framework in the Upper Reaches of the Min River, based on the local natural environment and the actual influencing factors of vegetative growth. Combined with the Analytic Hierarchy Process （AHP） and entropy method, which were used to calculate weights of indexes, habitat suitability was studied by using a multi-objective linear weighting model and geographic information systems （GIS） spatial analysis techniques. The assessment results are as follows： Altitude, soil stability, aspect and slope have more important effects on plant habitat suitability in the Upper Reaches of the Min River, and their weights are o.311, 0.260, o.198 and o.125, respectively. Suitable and sub-suitable habitats cover 4431.8o km2 and 6171.12 km2, respectively; most of which are distributed along both sides of rivers and have higher suitability. Unsuitable habitats cover the largest area （6679.76 km2）, accounting for 29.83% of the whole area; and the worst unsuitable habitats are 5107.23 km2 （22.81%）; they account for more than half of the study area. These results indicate that the plant habitat in the Upper Reaches of the Min River is poor and ecological restoration is both urgent and difficult. Therefore, based on the principle of taking measures suitable to the habitat in ecological restoration projects, ecological and engineering measures should be combined to have better effects, while increasing the strength of ecological protection.展开更多
目的了解引起手足口病(hand,foot and mouth disease,HFMD)的主要6种人类肠道病毒(enteroviru,EV)在我国婴幼儿人群中的流行情况,分析相同血清型EV重复感染以及不同血清型EV的感染特点,为HFMD多价疫苗的研发提供依据.方法采用前瞻性队...目的了解引起手足口病(hand,foot and mouth disease,HFMD)的主要6种人类肠道病毒(enteroviru,EV)在我国婴幼儿人群中的流行情况,分析相同血清型EV重复感染以及不同血清型EV的感染特点,为HFMD多价疫苗的研发提供依据.方法采用前瞻性队列研究的方法,对江苏省某地EV-A71疫苗Ⅲ期临床试验的181名6~35月龄婴幼儿在2012-2014年进行为期2年的随访.随访期间对受试者采集4次血清,采用微量细胞病变法检测血清中的肠道病毒A组71型(EV-A71)、柯萨奇病毒A组6型(CV-A6)、柯萨奇病毒A组10型(CV-A10)、柯萨奇病毒A组16型(CV-A16)、柯萨奇病毒B组3型(CV-B3)和柯萨奇病毒B组5型(CV-B5)中和抗体效价.对随访期间的HFMD发病病例采集咽拭子和肛拭子,采用实时定量PCR法和巢式PCR法鉴别EV.结果在随访结束时,CV-A10的血清累积阳性率和中和抗体GMT最高(82.2%,120.4).随访期间共有81人发生125次相同血清型EV的重复感染(中和抗体阳性者的中和抗体4倍及以上增高),其中CV-A10的重复感染率最高(27.8%,50/180).虽然相同血清型EV可重复感染,但未见同种病原感染后的再次发病;68.5%(124/181)的受试者至少感染了两种EV,2.2%(4/181)的受试者感染了5种EV.共发现25例HFMD发病病例(7例EV-A71,14例CV-A16,CV-A6、CV-A10、CV-B3和CV-B5各1例),患者均为轻症,未见重症病例.结论该地区婴幼儿人群中EV流行强度高,EV具有一定的相同血清型及不同血清型的重复感染率,值得进一步研究.展开更多
BACKGROUND Circular RNAs(circRNAs)are a newly discovered class of endogenous noncoding RNAs that may have roles in cancer genesis and development.In the recent literature,dysregulated circRNAs have been extensively in...BACKGROUND Circular RNAs(circRNAs)are a newly discovered class of endogenous noncoding RNAs that may have roles in cancer genesis and development.In the recent literature,dysregulated circRNAs have been extensively investigated in hepatocellular carcinoma(HCC).Whether or not circRNAs are of clinical value for the management of HCC has not been characterized.AIM To meta-analyze the diagnostic and prognostic value of abnormally expressed circRNAs in HCC.METHODS Eligible studies were sourced from PubMed,EMBASE,and CNKI online databases.Data on patients’clinical characteristics,including diagnostic efficacy and overall survival,were extracted.The diagnostic and prognostic parameters were respectively synthesized using the bivariate meta-analysis model and multivariate Cox hazard regression analysis based on Stata 12.0.The trim and fill method was adopted to assess the possible effects from publication bias.RESULTS A total of 21 eligible studies were included.The pooled sensitivity,specificity,and area under the curve of abnormally expressed circRNAs in distinguishing HCC from non-cancer controls were 0.78(95%CI:0.69–0.85),0.80(95%CI:0.74–0.86),and 0.86,respectively.Survival analyses showed that the downregulated circRNA expression signature correlated perfectly with HCC survival[hazard ratio(HR)=0.42,95%CI:0.19–0.91,P=0.028;I2=92.7%,P=0.000],whereas the HCC cases with high circRNA levels had significantly poorer prognoses than those of patients with low circRNA levels(HR=2.22,95%CI:1.50–3.30,P=0.000;I2=91%,P=0.000).Moreover,abnormally expressed circRNAs were intimately associated with tumor size,differentiation grade,microvascular invasion,metastasis,TNM stage,and serum alpha fetal protein level in patients with HCC.Stratified analysis based on sample type,control source,and expression status also yielded robust results.CONCLUSION Abnormally expressed circRNA signatures show immense potential as novel non-invasive biomarker(s)for HCC diagnosis and prognosis.展开更多
Constructing two-dimensional(2D)structures for transition-metal oxides(TMOs)can optimize their electronic structures and enable high specific surface areas,thereby offering routes to enhancing the performance of TMOs ...Constructing two-dimensional(2D)structures for transition-metal oxides(TMOs)can optimize their electronic structures and enable high specific surface areas,thereby offering routes to enhancing the performance of TMOs in energy storage and conversion.However,most 2D TMOs,e.g.,Fe_(2)O^(3),remain so far synthetically challenging due to their intrinsic non-layered structures.Herein,inspired by the mechanism of biomineralization,we report the synthesis of CuO/Fe_(2)O^(3)hybrid ultrathin nanosheets by using polyvinylpyrrolidone-decorated CuO nanosheets as growth modifiers to modulate the hydrolysis process of Fe^(2+).The formulated“absorption-and-crystallization”two-step formation processes of such 2D hybrid structures accorded well with the biomineralization scheme in nature.Combining the in-situ transmission electron microscopy(TEM)study,theoretical calculation,and control experiments,we validated that the large density of 2D/2D interfaces enabled by this bio-inspired synthesis process can overcome the self-stacking phenomenon during lithium-ion battery cycling,leading to their high operation stability.This work emphasizes the bio-inspired synthesis of 2D TMOs as a promising pathway toward material design and performance optimization.展开更多
文摘Background：Diabetes mellitus （DM） remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida （JLD） granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance （IGT） and its effect on the prevention of DM.Methods：Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily （JLD group,n =34） or no drug intervention （control group,n =31） for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c （HbA1c）,body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment （HOMA-IR） of all the patients were observed and compared before and after the treatment.Results：Sixty-one participants completed the trial （32 in JLD group and 29 in the control group）.There were statistically significant decreases in HbA1c （P 〈 0.001）,2-h plasma glucose （P 〈 0.001）,and HOMA-IR （P =0.029） in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two （6.9%） patients returned to normal blood glucose,and five （17.2%） patients turned into DM in control group,while in the JLD group,14 （43.8%） returned to normal blood glucose and 2 （6.2%） turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups （P =0.001）.Conclusions：JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.
基金supported by the National Natural Science Foundation of China (NSFC)(Grant No.41071115)the National Science and Technology Support Program of the Ministry of Science and Technology "Twelfth Five-Year" of China (Grant No.2011BAK12B04)
文摘HabRat richness influences and even determines biological diversity. Plant habitat suitability assessment can provide technical guidance and information support for ecological restoration. Thirteen factors in three categories of terrain, meteorology and soil were chosen to build a habitat suitability assessment index framework in the Upper Reaches of the Min River, based on the local natural environment and the actual influencing factors of vegetative growth. Combined with the Analytic Hierarchy Process （AHP） and entropy method, which were used to calculate weights of indexes, habitat suitability was studied by using a multi-objective linear weighting model and geographic information systems （GIS） spatial analysis techniques. The assessment results are as follows： Altitude, soil stability, aspect and slope have more important effects on plant habitat suitability in the Upper Reaches of the Min River, and their weights are o.311, 0.260, o.198 and o.125, respectively. Suitable and sub-suitable habitats cover 4431.8o km2 and 6171.12 km2, respectively; most of which are distributed along both sides of rivers and have higher suitability. Unsuitable habitats cover the largest area （6679.76 km2）, accounting for 29.83% of the whole area; and the worst unsuitable habitats are 5107.23 km2 （22.81%）; they account for more than half of the study area. These results indicate that the plant habitat in the Upper Reaches of the Min River is poor and ecological restoration is both urgent and difficult. Therefore, based on the principle of taking measures suitable to the habitat in ecological restoration projects, ecological and engineering measures should be combined to have better effects, while increasing the strength of ecological protection.
文摘目的了解引起手足口病(hand,foot and mouth disease,HFMD)的主要6种人类肠道病毒(enteroviru,EV)在我国婴幼儿人群中的流行情况,分析相同血清型EV重复感染以及不同血清型EV的感染特点,为HFMD多价疫苗的研发提供依据.方法采用前瞻性队列研究的方法,对江苏省某地EV-A71疫苗Ⅲ期临床试验的181名6~35月龄婴幼儿在2012-2014年进行为期2年的随访.随访期间对受试者采集4次血清,采用微量细胞病变法检测血清中的肠道病毒A组71型(EV-A71)、柯萨奇病毒A组6型(CV-A6)、柯萨奇病毒A组10型(CV-A10)、柯萨奇病毒A组16型(CV-A16)、柯萨奇病毒B组3型(CV-B3)和柯萨奇病毒B组5型(CV-B5)中和抗体效价.对随访期间的HFMD发病病例采集咽拭子和肛拭子,采用实时定量PCR法和巢式PCR法鉴别EV.结果在随访结束时,CV-A10的血清累积阳性率和中和抗体GMT最高(82.2%,120.4).随访期间共有81人发生125次相同血清型EV的重复感染(中和抗体阳性者的中和抗体4倍及以上增高),其中CV-A10的重复感染率最高(27.8%,50/180).虽然相同血清型EV可重复感染,但未见同种病原感染后的再次发病;68.5%(124/181)的受试者至少感染了两种EV,2.2%(4/181)的受试者感染了5种EV.共发现25例HFMD发病病例(7例EV-A71,14例CV-A16,CV-A6、CV-A10、CV-B3和CV-B5各1例),患者均为轻症,未见重症病例.结论该地区婴幼儿人群中EV流行强度高,EV具有一定的相同血清型及不同血清型的重复感染率,值得进一步研究.
文摘BACKGROUND Circular RNAs(circRNAs)are a newly discovered class of endogenous noncoding RNAs that may have roles in cancer genesis and development.In the recent literature,dysregulated circRNAs have been extensively investigated in hepatocellular carcinoma(HCC).Whether or not circRNAs are of clinical value for the management of HCC has not been characterized.AIM To meta-analyze the diagnostic and prognostic value of abnormally expressed circRNAs in HCC.METHODS Eligible studies were sourced from PubMed,EMBASE,and CNKI online databases.Data on patients’clinical characteristics,including diagnostic efficacy and overall survival,were extracted.The diagnostic and prognostic parameters were respectively synthesized using the bivariate meta-analysis model and multivariate Cox hazard regression analysis based on Stata 12.0.The trim and fill method was adopted to assess the possible effects from publication bias.RESULTS A total of 21 eligible studies were included.The pooled sensitivity,specificity,and area under the curve of abnormally expressed circRNAs in distinguishing HCC from non-cancer controls were 0.78(95%CI:0.69–0.85),0.80(95%CI:0.74–0.86),and 0.86,respectively.Survival analyses showed that the downregulated circRNA expression signature correlated perfectly with HCC survival[hazard ratio(HR)=0.42,95%CI:0.19–0.91,P=0.028;I2=92.7%,P=0.000],whereas the HCC cases with high circRNA levels had significantly poorer prognoses than those of patients with low circRNA levels(HR=2.22,95%CI:1.50–3.30,P=0.000;I2=91%,P=0.000).Moreover,abnormally expressed circRNAs were intimately associated with tumor size,differentiation grade,microvascular invasion,metastasis,TNM stage,and serum alpha fetal protein level in patients with HCC.Stratified analysis based on sample type,control source,and expression status also yielded robust results.CONCLUSION Abnormally expressed circRNA signatures show immense potential as novel non-invasive biomarker(s)for HCC diagnosis and prognosis.
基金supported by the National Natural Science Foundation of China(Nos.U1932213,51732011,81788101,11227901,and 21805192)the National key Research and Development Program of China(No.2021YFA0715700)+7 种基金the National Basic Research Program of China(No.2021YFA0715700)the National Key Research and Development Program of China(No.2018YFE0202201)Science and Technology Major Project of Anhui Province(No.201903a05020003)the Fundamental Research Funds for the Central Universities(No.WK2060000031)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB22040502)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110735)China Postdoctoral Science Foundation(No.2020M671612)Jiangsu Postdoctoral Science Foundation(No.2020Z082)。
文摘Constructing two-dimensional(2D)structures for transition-metal oxides(TMOs)can optimize their electronic structures and enable high specific surface areas,thereby offering routes to enhancing the performance of TMOs in energy storage and conversion.However,most 2D TMOs,e.g.,Fe_(2)O^(3),remain so far synthetically challenging due to their intrinsic non-layered structures.Herein,inspired by the mechanism of biomineralization,we report the synthesis of CuO/Fe_(2)O^(3)hybrid ultrathin nanosheets by using polyvinylpyrrolidone-decorated CuO nanosheets as growth modifiers to modulate the hydrolysis process of Fe^(2+).The formulated“absorption-and-crystallization”two-step formation processes of such 2D hybrid structures accorded well with the biomineralization scheme in nature.Combining the in-situ transmission electron microscopy(TEM)study,theoretical calculation,and control experiments,we validated that the large density of 2D/2D interfaces enabled by this bio-inspired synthesis process can overcome the self-stacking phenomenon during lithium-ion battery cycling,leading to their high operation stability.This work emphasizes the bio-inspired synthesis of 2D TMOs as a promising pathway toward material design and performance optimization.
