Degenerative lumbar scoliosis is common in older patients. Decreased bone density and the degeneration of intervertebral discs are considered to be correlated with degenerative lumbar scoliosis. A means of quantifying...Degenerative lumbar scoliosis is common in older patients. Decreased bone density and the degeneration of intervertebral discs are considered to be correlated with degenerative lumbar scoliosis. A means of quantifying the retative signal intensity for degenerative disc disease has not been previously discussed. The purpose of this study was to compare bone mineral density and intervertebral disc degeneration between degenerative lumbar scoliosis and lumbar spinal stenosis patients in a nine-year retrospective study. Methods From January 2001 to August 2010, 96 patients with degenerative lumbar scoliosis were retrospectively enrolled and 96 patients with lumbar spinal stenosis were selected as controls. Cobb angle, height of the apical disc and the contiguous disc superiorly and inferiorly on convex and concave sides, the height of the convex and concave side of the apical and the contiguous vertebral body superiorly and inferiorly were measured in the scoliosis group. The height of L2/L3, L3/L4, L4/L5 discs and the height of L2/L4 vertebral body was measured in the control group. The grade of intervertebral disc degeneration was evaluated using T2Wl sagittal images in both groups. The bone density of lumbar vertebrae was measured with dual-energy X-ray. Results In scoliosis group, the intervertebral disc height on the convex side was greater than the height on the concave side （P 〈0.001）. The vertebral body height on the convex side was greater than the height on the concave side （P=0.016） There was a significant difference between the scoliosis group and the control group （P=0.003）, and between T-value and the rate of osteoporosis between the two groups （both P 〈0.001）. Results were verified using multiple linear regression analysis. Conclusions Degenerative lumbar scoliosis is accompanied by height asymmetry between the intervertebral disc and vertebral body regarding the convex and concave surfaces. There is a positive correlation between the angle of scoliosis and the disc index, the degre展开更多
AIM: To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio(NLR) can predict poor survival in patients with hepatocellular carcinoma(HCC).METHODS: We retrospectively reviewed 526 patients with ...AIM: To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio(NLR) can predict poor survival in patients with hepatocellular carcinoma(HCC).METHODS: We retrospectively reviewed 526 patients with HCC who underwent surgery between 2004 and 2011.RESULTS: Preoperative NLR ≥ 2.81 was an independent predictor of poor disease-free survival(DFS, P < 0.001) and overall survival(OS, P = 0.044). Compared with patients who showed a preoperative NLR < 2.81 and postoperative increase, patients who showed preoperative NLR ≥ 2.81 and postoperative decrease had worse survival(DFS, P < 0.001; OS, P < 0.001). Among patients with preoperative NLR ≥ 2.81, survival was significantly higher among those showing a postoperative decrease in NLR than among those showing an increase(DFS, P < 0.001; OS, P < 0.001). When elevated, alpha-fetoprotein(AFP) provided no prognostic information, and so preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS whenever AFP levels are low or high.CONCLUSION: Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information.展开更多
To overcome nonlinear and 6-DOF(degrees of freedom)under-actuated problems for the attitude and position of quadrotor UAVs,an adaptive backstepping sliding mode method for flight attitude of quadrotor UAVs is proposed...To overcome nonlinear and 6-DOF(degrees of freedom)under-actuated problems for the attitude and position of quadrotor UAVs,an adaptive backstepping sliding mode method for flight attitude of quadrotor UAVs is proposed,in which an adaptive law is designed to online estimate the parameter variations and the upper bound of external disturbances and the assessments is utilized to compensate the backstepping sliding mode control.In addition,the tracking error of the design method is shown to asymptotically converge to zero by using Lyapunov theory.Finally,based on the numerical simulation of quadrotor UAVs using the setting parameters,the results show that the proposed control approach can stabilize the attitude and has hover flight capabilities under the parameter perturbations and external disturbances.展开更多
In complex networks,identifying influential spreader is of great significance for improving the reliability of networks and ensuring the safe and effective operation of networks.Nowadays,it is widely used in power net...In complex networks,identifying influential spreader is of great significance for improving the reliability of networks and ensuring the safe and effective operation of networks.Nowadays,it is widely used in power networks,aviation networks,computer networks,and social networks,and so on.Traditional centrality methods mainly include degree centrality,closeness centrality,betweenness centrality,eigenvector centrality,k-shell,etc.However,single centrality method is onesided and inaccurate,and sometimes many nodes have the same centrality value,namely the same ranking result,which makes it difficult to distinguish between nodes.According to several classical methods of identifying influential nodes,in this paper we propose a novel method that is more full-scaled and universally applicable.Taken into account in this method are several aspects of node’s properties,including local topological characteristics,central location of nodes,propagation characteristics,and properties of neighbor nodes.In view of the idea of the multi-attribute decision-making,we regard the basic centrality method as node’s attribute and use the entropy weight method to weigh different attributes,and obtain node’s combined centrality.Then,the combined centrality is applied to the gravity law to comprehensively identify influential nodes in networks.Finally,the classical susceptible-infected-recovered(SIR)model is used to simulate the epidemic spreading in six real-society networks.Our proposed method not only considers the four topological properties of nodes,but also emphasizes the influence of neighbor nodes from the aspect of gravity.It is proved that the new method can effectively overcome the disadvantages of single centrality method and increase the accuracy of identifying influential nodes,which is of great significance for monitoring and controlling the complex networks.展开更多
The plant protein phosphatase 2Cs(PP2Cs)play an essential role in response to stress and abscisic acid(ABA)signaling pathway.However,to date,no systemic characterization of the PP2Cs has yet bee n con ducted in potato...The plant protein phosphatase 2Cs(PP2Cs)play an essential role in response to stress and abscisic acid(ABA)signaling pathway.However,to date,no systemic characterization of the PP2Cs has yet bee n con ducted in potato(Solan um tuberosum L.).In the study,a comprehensive research was performed on genome-wide identification and expression analysis of StPP2C genes in potato.A total of 78 potato StPP2C genes were identified based on specific structure of PP2C domain,which were distributed across 11 out of 12 potato chromosomes and divided into 12(A-L)phylogenetic branches.The result from gene duplication an alysis showed that 14 StPP2Cs were in volved in gene tan dem duplication and 8 genes formed fragment duplicati on eve nts,which indicated that both tandem and fragment duplicati on contributed to the expa nsion of the gene family in evolution.Exon-intron structural analysis showed that they had a wide range of exon numbers.Analysis of protei n con servative motif dem on strated that StPP2Cs contained more similar motif structures in the same phyloge netic branches.The c/s-elements in StPP2C gene promoter regions were mainly responded to light,phytohormone and abiotic stress.Most of them exhibited tissue-specific expressi on patter ns,and some members could differe ntially express un der abiotic stress.The evidenee suggested that StPP2C genes may contribute to different functions in several physiological stress and environmental stress conditi ons.This study could provide new in sights to further in vestigate StPP2C functional characteristics responding to various stresses in potato.展开更多
The objectives of this study are to conduct a comprehensive literature search and bibliometric analysis to identify the breadth and volume of pharmacological and clinical studies on pine pollen(Pinus pollen)and to ide...The objectives of this study are to conduct a comprehensive literature search and bibliometric analysis to identify the breadth and volume of pharmacological and clinical studies on pine pollen(Pinus pollen)and to identify the potential effects and the use of pine pollen.Three Chinese electronic databases and two English electronic databases were searched for pharmacological and clinical studies on pine pollen.Data were extracted and analyzed and included publication year,authors,study type,pharmacological research topics or clinical diseases/conditions,usage and type of preparation,authors’conclusions,and adverse effects.Of 239 publications identified,180 were pharmacological studies,37 were clinical trials,and 22 were reviews.Numbers of publications increased particularly from 2004 onward.The top 10 most frequent topics in pharmacological studies were immune regulation,antisenility,antioxidation,liver protection,inhibiting prostate hyperplasia,inhibiting tumor cell proliferation,lowering blood glucose,lowering blood lipids,antifatigue,and improving intestinal function.The top 10 most frequent clinical diseases treated or where pine pollen was used as an adjuvant were bedsores,diaper dermatitis,hyperlipidemia,oral mucositis,eczema,hyperplasia of prostate,hypertension,prostatitis,type 2 diabetes mellitus,and radiodermatitis.Eight trials reported no adverse events associated with pine pollen,one reported mild gastrointestinal reactions,but symptoms disappeared without special management.There have been an increasing number of publications on pine pollen during the past 20 years.Pharmacological studies have shown many potential benefits,and clinical studies have indicated some positive effects when it is either used as a single herb or as an adjuvant to treat disease.Its use as a topical agent,especially for skin diseases,was notable.展开更多
In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by usi...In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by using FLUENT software,and the numerical simulation analysis of tunnel drilling ventilation and dust removal parameters was carried out.The results show that it is difficult to control the dust pollution of the face by conventional ventilation,and the drilling dust is distributed in the range of 10 m from the face;after the introduction of the long pressure and short suction ventilation scheme,when the ratio of compressed air volume to exhaust air volume is 0.72,the height of the pressure fan is 2.5 m,the distance between the pressure fan and the palm face is 20 m,and the exhaust fan is 12 m away from the palm,the dust concentration control efficiency of the working face is increased by about 60%.Therefore,in the similar long-distance single head tunnel construction,it is appropriate to adopt the dust removal method of long-distance short suction and exhaust fan to ensure the working environment.展开更多
Heavy water-moderated molten salt reactors(HWMSRs)are novel molten salt reactors that adopt heavy water rather than graphite as the moderator while employing liquid fuel.Owing to the high moderating ratio of the heavy...Heavy water-moderated molten salt reactors(HWMSRs)are novel molten salt reactors that adopt heavy water rather than graphite as the moderator while employing liquid fuel.Owing to the high moderating ratio of the heavy water moderator and the utilization of liquid fuel,HWMSRs can achieve a high neutron economy.In this study,a large-scale small modular HWMSR with a thermal power of 500 MWth was proposed and studied.The criticality of the core was evaluated using an in-house critical search calculation code(CSCC),which was developed based on Standardized Computer Analyses for Licensing Evaluation,version 6.1.The preliminary fuel cycle performances(initial conversion ratio(CR),initialfissile fuel loading mass,and temperature coefficient)were investigated by varying the lattice pitch(P)and the molten salt volume fraction(VF).The results demonstrate that the temperature coefficient can be negative over the range of investigated Ps and VFs for both 233U-Th and LEU-Th fuels.A core with a P of 20 cm and a VF of 20%is recommended for 233U-Th and LEU-Th fuels to achieve a high performance of initial CR and fuel loading.Regarding TRU-Th fuel,a core with a smaller P(~5 cm)and larger VF(~24%)is recommended to obtain a negative temperature coefficient.展开更多
AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with he...AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined.RESULTS Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.展开更多
We present geomorphological evidence for multiple glacial fluctuations during the Quaternary in the Taniantaweng Mountain, which is situated at the transition zone of the southeastern Qinghai-Tibet Plateau and the Yun...We present geomorphological evidence for multiple glacial fluctuations during the Quaternary in the Taniantaweng Mountain, which is situated at the transition zone of the southeastern Qinghai-Tibet Plateau and the Yunnan-Guizhou Plateau. To reconstruct the history of glacial evolution during the Quaternary Glaciation, we present a ~13000 km^2 geomorphologic map(1:440,000) for the Quaternary glaciations, as well as three electron spin resonance(ESR) ages and three optically stimulated luminescence(OSL) ages from the landforms. By integrating these with ages from previous studies, four major glacial advances are identified during marine oxygen isotope stages(MIS) 6, 3, 2 and 1. This glacial chronology is in reasonable agreement with existing glacial chronologies from other parts of the Hengduan Mountains and surrounding mountains. Glaciers had extended to the Yuqu River during the glacial maximum advance(MIS 6), but became successively more restricted from MIS 3 to MIS 1. The glacial distribution show that precipitation brought by the south Asian monsoon might play a primary role in driving glacial advances during the last glacial period in the southeastern Qinghai-Tibet Plateau.展开更多
The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals o...The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals of DAMPE is to observe Ge V-Te V high energy γ-rays with accurate energy,angular and time resolution,to indirectly search for dark matter particles and for the study of high energy astrophysics. Due to the comparatively higher fluxes of charged cosmic rays with respect to γ-rays,it is challenging to identify γ-rays with sufficiently high efficiency,minimizing the amount of charged cosmic ray contamination. In this work we present a method to identify γ-rays in DAMPE data based on Monte Carlo simulations,using the powerful electromagnetic/hadronic shower discrimination provided by the calorimeter and the veto detection of charged particles provided by the plastic scintillation detector. Monte Carlo simulations show that after this selection the number of electrons and protons that contaminate the selected γ-ray events at～10 Ge V amounts to less than 1% of the selected sample.Finally,we use flight data to verify the effectiveness of the method by highlighting known γ-ray sources in the sky and by reconstructing preliminary light curves of the Geminga pulsar.展开更多
In this paper, thermoelastic problem of onedimensional copper rod under thermal shock is simulated using molecular dynamics method by adopting embedded atom method potential. The rod is on axis x, the left outermost s...In this paper, thermoelastic problem of onedimensional copper rod under thermal shock is simulated using molecular dynamics method by adopting embedded atom method potential. The rod is on axis x, the left outermost surface of which is traction free and the right outermost surface is fixed. Free boundary condition is imposed on the outermost surfaces in direction y and z. The left and right ends of the rod are subjected to hot and cold baths, respectively. Temperature, displacement and stress distributions are obtained along the rod at different moments, which are shown to be limited in the mobile region, indicating that the heat propagation speed is limited rather than infinite. This is consistent with the prediction given by generalized thermoelastic theory. From simulation results we find that the speed of heat conduction is the same as the speed of thermal stress wave. In the present paper, the simulations are conducted using the large-scale atomic/molecular massively parallel simulator and completed visualization software.展开更多
基金supported by the National Key Research and Development Program of China(No.2021YFA1500703 to Ganglong Cui)Distinguished Professorship of Chang Jiang Scholars of Ministry of Education of China(Ganglong Cui)+1 种基金the Fundamental Research Funds for the Central Universitiesthe National Natural Science Foundation of China(No.22233001 to Ganglong Cui,No.22003043 to Xiang-Yang Liu)。
文摘Degenerative lumbar scoliosis is common in older patients. Decreased bone density and the degeneration of intervertebral discs are considered to be correlated with degenerative lumbar scoliosis. A means of quantifying the retative signal intensity for degenerative disc disease has not been previously discussed. The purpose of this study was to compare bone mineral density and intervertebral disc degeneration between degenerative lumbar scoliosis and lumbar spinal stenosis patients in a nine-year retrospective study. Methods From January 2001 to August 2010, 96 patients with degenerative lumbar scoliosis were retrospectively enrolled and 96 patients with lumbar spinal stenosis were selected as controls. Cobb angle, height of the apical disc and the contiguous disc superiorly and inferiorly on convex and concave sides, the height of the convex and concave side of the apical and the contiguous vertebral body superiorly and inferiorly were measured in the scoliosis group. The height of L2/L3, L3/L4, L4/L5 discs and the height of L2/L4 vertebral body was measured in the control group. The grade of intervertebral disc degeneration was evaluated using T2Wl sagittal images in both groups. The bone density of lumbar vertebrae was measured with dual-energy X-ray. Results In scoliosis group, the intervertebral disc height on the convex side was greater than the height on the concave side （P 〈0.001）. The vertebral body height on the convex side was greater than the height on the concave side （P=0.016） There was a significant difference between the scoliosis group and the control group （P=0.003）, and between T-value and the rate of osteoporosis between the two groups （both P 〈0.001）. Results were verified using multiple linear regression analysis. Conclusions Degenerative lumbar scoliosis is accompanied by height asymmetry between the intervertebral disc and vertebral body regarding the convex and concave surfaces. There is a positive correlation between the angle of scoliosis and the disc index, the degre
基金Supported by National Natural Science Foundation of China,No.81260331the Key Laboratory for High-Incidence Tumor Prevention and Treatment,Ministry of Education,No.GKE2015-ZZ05
文摘AIM: To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio(NLR) can predict poor survival in patients with hepatocellular carcinoma(HCC).METHODS: We retrospectively reviewed 526 patients with HCC who underwent surgery between 2004 and 2011.RESULTS: Preoperative NLR ≥ 2.81 was an independent predictor of poor disease-free survival(DFS, P < 0.001) and overall survival(OS, P = 0.044). Compared with patients who showed a preoperative NLR < 2.81 and postoperative increase, patients who showed preoperative NLR ≥ 2.81 and postoperative decrease had worse survival(DFS, P < 0.001; OS, P < 0.001). Among patients with preoperative NLR ≥ 2.81, survival was significantly higher among those showing a postoperative decrease in NLR than among those showing an increase(DFS, P < 0.001; OS, P < 0.001). When elevated, alpha-fetoprotein(AFP) provided no prognostic information, and so preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS whenever AFP levels are low or high.CONCLUSION: Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information.
基金Project(61203021)supported by the National Natural Science Foundation of ChinaProject(2011216011)supported by the Scientific and Technological Project of Liaoning Province,China+1 种基金Project(2013020024)supported by the Natural Science Foundation of Liaoning Province,ChinaProjects(LJQ2015061,LR2015034)supported by the Program for Liaoning Excellent Talents in University,China
文摘To overcome nonlinear and 6-DOF(degrees of freedom)under-actuated problems for the attitude and position of quadrotor UAVs,an adaptive backstepping sliding mode method for flight attitude of quadrotor UAVs is proposed,in which an adaptive law is designed to online estimate the parameter variations and the upper bound of external disturbances and the assessments is utilized to compensate the backstepping sliding mode control.In addition,the tracking error of the design method is shown to asymptotically converge to zero by using Lyapunov theory.Finally,based on the numerical simulation of quadrotor UAVs using the setting parameters,the results show that the proposed control approach can stabilize the attitude and has hover flight capabilities under the parameter perturbations and external disturbances.
基金Project support by the National Key Research and Development Program of China(Grant No.2018YFF0301000)the National Natural Science Foundation of China(Grant Nos.71673161 and 71790613)。
文摘In complex networks,identifying influential spreader is of great significance for improving the reliability of networks and ensuring the safe and effective operation of networks.Nowadays,it is widely used in power networks,aviation networks,computer networks,and social networks,and so on.Traditional centrality methods mainly include degree centrality,closeness centrality,betweenness centrality,eigenvector centrality,k-shell,etc.However,single centrality method is onesided and inaccurate,and sometimes many nodes have the same centrality value,namely the same ranking result,which makes it difficult to distinguish between nodes.According to several classical methods of identifying influential nodes,in this paper we propose a novel method that is more full-scaled and universally applicable.Taken into account in this method are several aspects of node’s properties,including local topological characteristics,central location of nodes,propagation characteristics,and properties of neighbor nodes.In view of the idea of the multi-attribute decision-making,we regard the basic centrality method as node’s attribute and use the entropy weight method to weigh different attributes,and obtain node’s combined centrality.Then,the combined centrality is applied to the gravity law to comprehensively identify influential nodes in networks.Finally,the classical susceptible-infected-recovered(SIR)model is used to simulate the epidemic spreading in six real-society networks.Our proposed method not only considers the four topological properties of nodes,but also emphasizes the influence of neighbor nodes from the aspect of gravity.It is proved that the new method can effectively overcome the disadvantages of single centrality method and increase the accuracy of identifying influential nodes,which is of great significance for monitoring and controlling the complex networks.
基金This research was supported by the Nationml Natural Science Foundation of China(31660416 and 31560413)and the Potato In dustry Tech no logy System of Gansu Provi nee,China(GARS-03-P1).
文摘The plant protein phosphatase 2Cs(PP2Cs)play an essential role in response to stress and abscisic acid(ABA)signaling pathway.However,to date,no systemic characterization of the PP2Cs has yet bee n con ducted in potato(Solan um tuberosum L.).In the study,a comprehensive research was performed on genome-wide identification and expression analysis of StPP2C genes in potato.A total of 78 potato StPP2C genes were identified based on specific structure of PP2C domain,which were distributed across 11 out of 12 potato chromosomes and divided into 12(A-L)phylogenetic branches.The result from gene duplication an alysis showed that 14 StPP2Cs were in volved in gene tan dem duplication and 8 genes formed fragment duplicati on eve nts,which indicated that both tandem and fragment duplicati on contributed to the expa nsion of the gene family in evolution.Exon-intron structural analysis showed that they had a wide range of exon numbers.Analysis of protei n con servative motif dem on strated that StPP2Cs contained more similar motif structures in the same phyloge netic branches.The c/s-elements in StPP2C gene promoter regions were mainly responded to light,phytohormone and abiotic stress.Most of them exhibited tissue-specific expressi on patter ns,and some members could differe ntially express un der abiotic stress.The evidenee suggested that StPP2C genes may contribute to different functions in several physiological stress and environmental stress conditi ons.This study could provide new in sights to further in vestigate StPP2C functional characteristics responding to various stresses in potato.
基金supported by the fund from Beijing University of Chinese Medicine for the Project on Research and Development of Evidence-Based Medicine of Clinical Scientific Research Capacity and International Development in TCM(No.2016-ZXFZJJ-011,No.1000061020008)partially supported by the NCCIH grant(AT001293 with Sub Award No.020468C)funded by Overseas Expertise Project,Ministry of Education of China(MS20180009)。
文摘The objectives of this study are to conduct a comprehensive literature search and bibliometric analysis to identify the breadth and volume of pharmacological and clinical studies on pine pollen(Pinus pollen)and to identify the potential effects and the use of pine pollen.Three Chinese electronic databases and two English electronic databases were searched for pharmacological and clinical studies on pine pollen.Data were extracted and analyzed and included publication year,authors,study type,pharmacological research topics or clinical diseases/conditions,usage and type of preparation,authors’conclusions,and adverse effects.Of 239 publications identified,180 were pharmacological studies,37 were clinical trials,and 22 were reviews.Numbers of publications increased particularly from 2004 onward.The top 10 most frequent topics in pharmacological studies were immune regulation,antisenility,antioxidation,liver protection,inhibiting prostate hyperplasia,inhibiting tumor cell proliferation,lowering blood glucose,lowering blood lipids,antifatigue,and improving intestinal function.The top 10 most frequent clinical diseases treated or where pine pollen was used as an adjuvant were bedsores,diaper dermatitis,hyperlipidemia,oral mucositis,eczema,hyperplasia of prostate,hypertension,prostatitis,type 2 diabetes mellitus,and radiodermatitis.Eight trials reported no adverse events associated with pine pollen,one reported mild gastrointestinal reactions,but symptoms disappeared without special management.There have been an increasing number of publications on pine pollen during the past 20 years.Pharmacological studies have shown many potential benefits,and clinical studies have indicated some positive effects when it is either used as a single herb or as an adjuvant to treat disease.Its use as a topical agent,especially for skin diseases,was notable.
基金Project(51874016)supported by the National Natural Science Foundation of China。
文摘In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by using FLUENT software,and the numerical simulation analysis of tunnel drilling ventilation and dust removal parameters was carried out.The results show that it is difficult to control the dust pollution of the face by conventional ventilation,and the drilling dust is distributed in the range of 10 m from the face;after the introduction of the long pressure and short suction ventilation scheme,when the ratio of compressed air volume to exhaust air volume is 0.72,the height of the pressure fan is 2.5 m,the distance between the pressure fan and the palm face is 20 m,and the exhaust fan is 12 m away from the palm,the dust concentration control efficiency of the working face is increased by about 60%.Therefore,in the similar long-distance single head tunnel construction,it is appropriate to adopt the dust removal method of long-distance short suction and exhaust fan to ensure the working environment.
基金supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(No.XDA02010000)the National Natural Science Foundation of China(No.11905285)+1 种基金the National Natural Science Foundation of China(No.11790321)the Frontier Science Key Program of the Chinese Academy of Sciences(No.QYZDY-SSW-JSC016)。
文摘Heavy water-moderated molten salt reactors(HWMSRs)are novel molten salt reactors that adopt heavy water rather than graphite as the moderator while employing liquid fuel.Owing to the high moderating ratio of the heavy water moderator and the utilization of liquid fuel,HWMSRs can achieve a high neutron economy.In this study,a large-scale small modular HWMSR with a thermal power of 500 MWth was proposed and studied.The criticality of the core was evaluated using an in-house critical search calculation code(CSCC),which was developed based on Standardized Computer Analyses for Licensing Evaluation,version 6.1.The preliminary fuel cycle performances(initial conversion ratio(CR),initialfissile fuel loading mass,and temperature coefficient)were investigated by varying the lattice pitch(P)and the molten salt volume fraction(VF).The results demonstrate that the temperature coefficient can be negative over the range of investigated Ps and VFs for both 233U-Th and LEU-Th fuels.A core with a P of 20 cm and a VF of 20%is recommended for 233U-Th and LEU-Th fuels to achieve a high performance of initial CR and fuel loading.Regarding TRU-Th fuel,a core with a smaller P(~5 cm)and larger VF(~24%)is recommended to obtain a negative temperature coefficient.
基金Supported by National Natural Science Foundation of China,No.81260331Key Laboratory for High-Incidence Tumor Prevention and Treatment,Ministry of Education,No.GKE2015-ZZ05
文摘AIM to determine whether cyclooxygenase-2(COX-2) and prostaglandin E1 receptor(EP1) contribute to disease and whether they help predict prognosis.METHODS We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma(HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffinembedded tissues using polyclonal antibodies. Possible associations between immunohistochemical scores and survival were determined.RESULTS Factors associated with poor overall survival(OS) were alpha-fetoprotein > 400 ng/m L, tumor size ≥ 5 cm, and high EP1 receptor expression, but not high COX-2 expression. Disease-free survival was not significantly different between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues(Edmondson grade Ⅰ-Ⅱ) than in poorly differentiated tissues(Edmondson grade Ⅲ-Ⅳ)(P = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue(P = 0.001).CONCLUSION COX-2 expression appears to be linked to early HCC events(initiation), while EP1 receptor expression may participate in tumor progression and predict survival.
基金financially supported by the National Natural Science Foundation of China(Nos.41671005,41230743 and 41501068)the Distinguished Professor Programme of the Liaoning Province
文摘We present geomorphological evidence for multiple glacial fluctuations during the Quaternary in the Taniantaweng Mountain, which is situated at the transition zone of the southeastern Qinghai-Tibet Plateau and the Yunnan-Guizhou Plateau. To reconstruct the history of glacial evolution during the Quaternary Glaciation, we present a ~13000 km^2 geomorphologic map(1:440,000) for the Quaternary glaciations, as well as three electron spin resonance(ESR) ages and three optically stimulated luminescence(OSL) ages from the landforms. By integrating these with ages from previous studies, four major glacial advances are identified during marine oxygen isotope stages(MIS) 6, 3, 2 and 1. This glacial chronology is in reasonable agreement with existing glacial chronologies from other parts of the Hengduan Mountains and surrounding mountains. Glaciers had extended to the Yuqu River during the glacial maximum advance(MIS 6), but became successively more restricted from MIS 3 to MIS 1. The glacial distribution show that precipitation brought by the south Asian monsoon might play a primary role in driving glacial advances during the last glacial period in the southeastern Qinghai-Tibet Plateau.
基金founded by the strategic priority science and technology projects in space science of the Chinese Academy of Sciences (Nos.XDA04040000 and XDA04040400)supported in part by the National Key Research and Development Program of China (2016YFA0400200)+7 种基金the National Basic Research Program of China (No.2013CB837000)the Strategic Priority Research Program of the Chinese Academy of Sciences “Multi-Waveband Gravitational Wave Universe” (No.XDB23040000)Youth Innovation Promotion Association of CASthe National Natural Science Foundation of China (Nos.11525313,11673075,11773086,11303107,11303105,11773085,U1738123,U1738136,U1738207 and U1738210)the Young Elite Scientists Sponsorship program by CAST (No.YESS20160196)the 100 Talents Program of Chinese Academy of Sciencessupport by the Swiss National Science Foundation (SNSF)Switzerland and the National Institute for Nuclear Physics (INFN),Italy
文摘The DArk Matter Particle Explorer（DAMPE）,also known as Wukong in China,which was launched on 2015 December 17,is a new high energy cosmic ray and γ-ray satellite-borne observatory.One of the main scientific goals of DAMPE is to observe Ge V-Te V high energy γ-rays with accurate energy,angular and time resolution,to indirectly search for dark matter particles and for the study of high energy astrophysics. Due to the comparatively higher fluxes of charged cosmic rays with respect to γ-rays,it is challenging to identify γ-rays with sufficiently high efficiency,minimizing the amount of charged cosmic ray contamination. In this work we present a method to identify γ-rays in DAMPE data based on Monte Carlo simulations,using the powerful electromagnetic/hadronic shower discrimination provided by the calorimeter and the veto detection of charged particles provided by the plastic scintillation detector. Monte Carlo simulations show that after this selection the number of electrons and protons that contaminate the selected γ-ray events at～10 Ge V amounts to less than 1% of the selected sample.Finally,we use flight data to verify the effectiveness of the method by highlighting known γ-ray sources in the sky and by reconstructing preliminary light curves of the Geminga pulsar.
基金supported by the National Natural Science Foundation of China (10872158)
文摘In this paper, thermoelastic problem of onedimensional copper rod under thermal shock is simulated using molecular dynamics method by adopting embedded atom method potential. The rod is on axis x, the left outermost surface of which is traction free and the right outermost surface is fixed. Free boundary condition is imposed on the outermost surfaces in direction y and z. The left and right ends of the rod are subjected to hot and cold baths, respectively. Temperature, displacement and stress distributions are obtained along the rod at different moments, which are shown to be limited in the mobile region, indicating that the heat propagation speed is limited rather than infinite. This is consistent with the prediction given by generalized thermoelastic theory. From simulation results we find that the speed of heat conduction is the same as the speed of thermal stress wave. In the present paper, the simulations are conducted using the large-scale atomic/molecular massively parallel simulator and completed visualization software.
