In order to improve rolled strip quality, precise plate shape control theory should be established. Roll flat- tening theory is an important part of the plate shape theory. To improve the accuracy of roll flattening c...In order to improve rolled strip quality, precise plate shape control theory should be established. Roll flat- tening theory is an important part of the plate shape theory. To improve the accuracy of roll flattening calculation based on semi infinite body model, especially near the two roll barrel edges, a new and more accurate roll flattening model is proposed. Based on boundary integral equation method, an analytical model for solving a finite length semi infinite body is established. The lateral surface displacement field of the finite length semi-infinite body is simulated by finite element method （FEM） and lateral surface displacement decay functions are established. Based on the boundary integral equation method, the numerical solution of the finite length semi-infinite body under the distribu ted force is obtained and an accurate roll flattening model is established. Different from the traditional semi-infinite body model, the matrix form of the new roll flattening model is established through the mathematical derivation. The result from the new model is more consistent with that by FEM especially near the edges.展开更多
目的:研究溃疡性结肠炎专利复方的用药规律和作用机制。方法:从专利数据库中筛选治疗溃疡性结肠炎的中医专利复方,录入数据库,进行频数、聚类和关联分析,再通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Ph...目的:研究溃疡性结肠炎专利复方的用药规律和作用机制。方法:从专利数据库中筛选治疗溃疡性结肠炎的中医专利复方,录入数据库,进行频数、聚类和关联分析,再通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)筛选排名前十的高频药的活性成分,然后通过DrugBank数据库找到这些成分对应的作用靶点,并通过基因免疫功能和基因通路富集分析找到这些靶点对应的免疫功能和信号通路。结果:总共发现治疗溃疡性结肠炎的专利复方224个,涉及中药387味;排名前十的高频药依次是黄连、甘草、白术、白芍、黄芪、白及、党参、白头翁、地榆、木香,主要使用的是补益药和清热药;发现中药配伍10对、关联规则16条;在排名前十的高频药中筛选出83个活性成分及其146个作用靶点,这些靶点作用于B细胞增殖、T细胞因子分泌等27个免疫功能,以及TNF信号通路、IL-17信号通路等47条信号通路。结论:专利数据库中治疗溃疡性结肠炎的中药复方用药规律符合临床实际,其作用机制和溃疡性结肠炎的病理机制较符合。展开更多
基金Item Sponsored by National Natural Science Foundation of China(51075353)
文摘In order to improve rolled strip quality, precise plate shape control theory should be established. Roll flat- tening theory is an important part of the plate shape theory. To improve the accuracy of roll flattening calculation based on semi infinite body model, especially near the two roll barrel edges, a new and more accurate roll flattening model is proposed. Based on boundary integral equation method, an analytical model for solving a finite length semi infinite body is established. The lateral surface displacement field of the finite length semi-infinite body is simulated by finite element method （FEM） and lateral surface displacement decay functions are established. Based on the boundary integral equation method, the numerical solution of the finite length semi-infinite body under the distribu ted force is obtained and an accurate roll flattening model is established. Different from the traditional semi-infinite body model, the matrix form of the new roll flattening model is established through the mathematical derivation. The result from the new model is more consistent with that by FEM especially near the edges.
文摘目的:研究溃疡性结肠炎专利复方的用药规律和作用机制。方法:从专利数据库中筛选治疗溃疡性结肠炎的中医专利复方,录入数据库,进行频数、聚类和关联分析,再通过中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)筛选排名前十的高频药的活性成分,然后通过DrugBank数据库找到这些成分对应的作用靶点,并通过基因免疫功能和基因通路富集分析找到这些靶点对应的免疫功能和信号通路。结果:总共发现治疗溃疡性结肠炎的专利复方224个,涉及中药387味;排名前十的高频药依次是黄连、甘草、白术、白芍、黄芪、白及、党参、白头翁、地榆、木香,主要使用的是补益药和清热药;发现中药配伍10对、关联规则16条;在排名前十的高频药中筛选出83个活性成分及其146个作用靶点,这些靶点作用于B细胞增殖、T细胞因子分泌等27个免疫功能,以及TNF信号通路、IL-17信号通路等47条信号通路。结论:专利数据库中治疗溃疡性结肠炎的中药复方用药规律符合临床实际,其作用机制和溃疡性结肠炎的病理机制较符合。
