Background Roux-en-Y gastric bypass （GBP） is the main surgical procedure used in type 2 diabetes. The objective of this study was to evaluate the different types of GBP in treatment of type 2 diabetes. Methods Patie...Background Roux-en-Y gastric bypass （GBP） is the main surgical procedure used in type 2 diabetes. The objective of this study was to evaluate the different types of GBP in treatment of type 2 diabetes. Methods Patients with type 2 diabetes were randomly divided into two groups： those who underwent gastrojejunal loop anastomosis bypass and those who underwent gastrojejunal Roux-en-Y bypass. Blood glucose alterations, operation time, and operation complications were observed. Results Gastrojejunal loop anastomosis bypass and gastrojejunal Roux-en-Y bypass were both effective in the treatment of selected patients with type 2 diabetes. Compared with gastrojejunal Roux-en-Y bypass, gastrojejunal loop anastomosis bypass had the advantages of easier implementation, shorter operation time, and fewer operation complications. Conclusions Gastrojejunal loop anastomosis is effective in treatment of type 2 diabetes. It is safe, easy to implement, and worthy of clinical popularization.展开更多
Although multiple drugs are accessible for recovering liver function in patients,none are considered efficient.Liver transplantation is the mainstay therapy for end-stage liver fibrosis.However,the worldwide shortage ...Although multiple drugs are accessible for recovering liver function in patients,none are considered efficient.Liver transplantation is the mainstay therapy for end-stage liver fibrosis.However,the worldwide shortage of healthy liver donors,organ rejection,complex surgery,and high costs are prompting researchers to develop novel approaches to deal with the overwhelming liver fibrosis cases.Mesenchymal stem cell(MSC)therapy is an emerging alternative method for treating patients with liver fibrosis.However,many aspects of this therapy remain unclear,such as the efficiency compared to conventional treatment,the ideal MSC sources,and the most effective way to use it.Because bone marrow(BM)is the largest source for MSCs,this paper used a systematic review approach to study the therapeutic efficiency of MSCs against liver fibrosis and related factors.We systematically searched multiple published articles to identify studies involving liver fibrosis and BM-MSC-based therapy.Analyzing the selected studies showed that compared with conventional treatment BM-MSC therapy may be more efficient for liver fibrosis in some cases.In contrast,the cotreatment presented a more efficient way.Nevertheless,BM-MSCs are lacking as a therapy for liver fibrosis;thus,this paper also reviews factors that affect BM-MSC efficiency,such as the implementation routes and strategies employed to enhance the potential in alleviating liver fibrosis.Ultimately,our review summarizes the recent advances in the BM-MSC therapy for liver fibrosis.It is grounded in recent developments underlying the efficiency of BM-MSCs as therapy,focusing on the preclinical in vivo experiments,and comparing to other treatments or sources and the strategies used to enhance its potential while mentioning the research gaps.展开更多
Objective:To evaluate the efficacy and safety of Pai-Neng-Da Capsule(panaxadiol saponins component,PNDC)in combination with the cyclosporine and androgen for patients with chronic aplastic anemia(CAA).Methods:A total ...Objective:To evaluate the efficacy and safety of Pai-Neng-Da Capsule(panaxadiol saponins component,PNDC)in combination with the cyclosporine and androgen for patients with chronic aplastic anemia(CAA).Methods:A total of 79 CAA patients was randomly divided into 2 groups by a random number table,including PCA group[43 cases,orally PNDC 320 mg/d plus cyclosporine 5 mg/(kg·d)plus andriol 80 mg/d]and CA group[36 cases,orally cyclosporine 5 mg/(kg·d)plus andriol 160 mg/d].All patients were treated and followed-up for 6 treatment courses over 24 weeks.The complete blood counts,score of Chinese medical(CM)symptoms were assessed and urine routine,electrocardiogram,hepatic and renal function were observed for safety evaluation.Female masculinization rating scale was established according to the actual clinical manifestations to evaluate the accurate degree of masculinization in female CAA patients treated by andriol.Results:The effective rates were 88.1%(37/42)in the PCA group and 77.8%(28/36)in the CA group based on the standard for the therapeutic efficacy evaluation of hematopathy.There was no significant difference in the white blood cell(WBC)counts,platelet counts and hemoglobin concentration of peripheral blood between two groups after 6 months treatment.The masculinization score of female patient in the PCA group was significantly lower than the CA group(P<0.05).The mild abdominal distention was observed in 1 case in the PCA group.In CA group,the abnormalities in the hepatic function developed in 2 cases and the renal disfunction was found in 1 case.Conclusion:The PNDC possesses certain curative effects in the treatment of CAA without obvious side-effects and can partially replace andriol thereby to reduce the degree of masculinization[Registried at Chinese Clinical Trial Registry(ChicTR1900028153)].展开更多
The performance of dual perforated floating plates in a rectangular tank is investigated based on the model tests under different external excitations for different filling rates.It is found that dual perforated float...The performance of dual perforated floating plates in a rectangular tank is investigated based on the model tests under different external excitations for different filling rates.It is found that dual perforated floating plates in the tank can remarkably mitigate violent resonant sloshing responses compared with the clean tank,especially when the external excitation frequency is in the vicinity of the first-order resonant frequency.Next,the parametric studies based on different filling rates and external excitation amplitudes are performed for the first-order resonant frequencies.The presence of dual perforated floating plates seldom shifts the sloshing natural frequencies.Further,dual perforated floating plates change the sloshing modes from the standing-wave mode in the clean tank to the Utube mode,which can arise from the sloshing reduction to some extent.展开更多
Objective: Bone morphogenetic proteins (BMPs) are known to play an important role in bone and cartilage development. Recent research has shown that BMPs may induce tumorigenesis and promote tumor to spread, but the mo...Objective: Bone morphogenetic proteins (BMPs) are known to play an important role in bone and cartilage development. Recent research has shown that BMPs may induce tumorigenesis and promote tumor to spread, but the molecular mechanisms have not been elucidated. The aim of the present study was to investigate the regulatory function of BMP-2 in the migration of COS-7 cells and the underlying mechanisms. Methods: Human BMP-2 genetic fragment was amplified and introduced into the pEGFP-C1 vector. After being confirmed by XhoI and BamHI digestion analyses and DNA sequencing, the recombinant pEGFP-C1-BMP-2 plasmid was transfected into COS-7 cells. The influence of BMP-2 on cell migration and cofilin activity was detected by cell scratch assay and Western blotting. Results: The recombinant pEGFP-C1-BMP-2 was effectively expressed in COS-7 cells. An increased phosphorylation of both LIMK1 and cofilin and an enhancement of cell migration were observed in cells with overexpression of BMP-2. Conclusions: A recombinant pEGFP-C1-BMP-2 vector was successfully constructed and overexpression of BMP-2 regulated the activities of the downstream molecules of the Rho GTPase signaling pathway, which might contribute to the enhancement of cell migration.展开更多
The fundamental question of super-low-ash coal preparation is how to furthest depress high ash component pollution. A jigging process was used to remove high ash refuse and middling, then a high precision heavy medium...The fundamental question of super-low-ash coal preparation is how to furthest depress high ash component pollution. A jigging process was used to remove high ash refuse and middling, then a high precision heavy medium cyclone was used to further separate near gravity light material. A two-stage heavy medium cylindrical cyclone with the same separation density was used to increase the precision of separation. The feed was de-slimed and fine-grind coal was added with media to improve the stability of the suspension. The pump frequency conversion timing and an air spring were used to steady the cyclone inlet pressure. Based on a series of study and pilot tests, a 1.00 Mt/a (output) commercial separation system with Ep value under 0.015 was built up. Super low ash (Ad≤2.00%) Taixi Anthracite has been put into commercial production.展开更多
文摘Background Roux-en-Y gastric bypass （GBP） is the main surgical procedure used in type 2 diabetes. The objective of this study was to evaluate the different types of GBP in treatment of type 2 diabetes. Methods Patients with type 2 diabetes were randomly divided into two groups： those who underwent gastrojejunal loop anastomosis bypass and those who underwent gastrojejunal Roux-en-Y bypass. Blood glucose alterations, operation time, and operation complications were observed. Results Gastrojejunal loop anastomosis bypass and gastrojejunal Roux-en-Y bypass were both effective in the treatment of selected patients with type 2 diabetes. Compared with gastrojejunal Roux-en-Y bypass, gastrojejunal loop anastomosis bypass had the advantages of easier implementation, shorter operation time, and fewer operation complications. Conclusions Gastrojejunal loop anastomosis is effective in treatment of type 2 diabetes. It is safe, easy to implement, and worthy of clinical popularization.
基金Supported by Key Research and Development Program of Hebei Province,No.19277779DThe Program of Introduce International Intelligence of Hebei Province。
文摘Although multiple drugs are accessible for recovering liver function in patients,none are considered efficient.Liver transplantation is the mainstay therapy for end-stage liver fibrosis.However,the worldwide shortage of healthy liver donors,organ rejection,complex surgery,and high costs are prompting researchers to develop novel approaches to deal with the overwhelming liver fibrosis cases.Mesenchymal stem cell(MSC)therapy is an emerging alternative method for treating patients with liver fibrosis.However,many aspects of this therapy remain unclear,such as the efficiency compared to conventional treatment,the ideal MSC sources,and the most effective way to use it.Because bone marrow(BM)is the largest source for MSCs,this paper used a systematic review approach to study the therapeutic efficiency of MSCs against liver fibrosis and related factors.We systematically searched multiple published articles to identify studies involving liver fibrosis and BM-MSC-based therapy.Analyzing the selected studies showed that compared with conventional treatment BM-MSC therapy may be more efficient for liver fibrosis in some cases.In contrast,the cotreatment presented a more efficient way.Nevertheless,BM-MSCs are lacking as a therapy for liver fibrosis;thus,this paper also reviews factors that affect BM-MSC efficiency,such as the implementation routes and strategies employed to enhance the potential in alleviating liver fibrosis.Ultimately,our review summarizes the recent advances in the BM-MSC therapy for liver fibrosis.It is grounded in recent developments underlying the efficiency of BM-MSCs as therapy,focusing on the preclinical in vivo experiments,and comparing to other treatments or sources and the strategies used to enhance its potential while mentioning the research gaps.
基金Supported by Research Foundation of Chinese Medicine Program of Zhejiang Province(No.2015ZA211)National Major Project for the Innovative New Drugs of"the 13th Five-Year Plan"(No.2016ZX09101071)。
文摘Objective:To evaluate the efficacy and safety of Pai-Neng-Da Capsule(panaxadiol saponins component,PNDC)in combination with the cyclosporine and androgen for patients with chronic aplastic anemia(CAA).Methods:A total of 79 CAA patients was randomly divided into 2 groups by a random number table,including PCA group[43 cases,orally PNDC 320 mg/d plus cyclosporine 5 mg/(kg·d)plus andriol 80 mg/d]and CA group[36 cases,orally cyclosporine 5 mg/(kg·d)plus andriol 160 mg/d].All patients were treated and followed-up for 6 treatment courses over 24 weeks.The complete blood counts,score of Chinese medical(CM)symptoms were assessed and urine routine,electrocardiogram,hepatic and renal function were observed for safety evaluation.Female masculinization rating scale was established according to the actual clinical manifestations to evaluate the accurate degree of masculinization in female CAA patients treated by andriol.Results:The effective rates were 88.1%(37/42)in the PCA group and 77.8%(28/36)in the CA group based on the standard for the therapeutic efficacy evaluation of hematopathy.There was no significant difference in the white blood cell(WBC)counts,platelet counts and hemoglobin concentration of peripheral blood between two groups after 6 months treatment.The masculinization score of female patient in the PCA group was significantly lower than the CA group(P<0.05).The mild abdominal distention was observed in 1 case in the PCA group.In CA group,the abnormalities in the hepatic function developed in 2 cases and the renal disfunction was found in 1 case.Conclusion:The PNDC possesses certain curative effects in the treatment of CAA without obvious side-effects and can partially replace andriol thereby to reduce the degree of masculinization[Registried at Chinese Clinical Trial Registry(ChicTR1900028153)].
基金This study is financially supported by Hainan Provincial Natural Science Foundation of China(Grant No.519MS026)Scientific Research Foundation of Hainan University(Grant No.KYQD(ZR)1878).
文摘The performance of dual perforated floating plates in a rectangular tank is investigated based on the model tests under different external excitations for different filling rates.It is found that dual perforated floating plates in the tank can remarkably mitigate violent resonant sloshing responses compared with the clean tank,especially when the external excitation frequency is in the vicinity of the first-order resonant frequency.Next,the parametric studies based on different filling rates and external excitation amplitudes are performed for the first-order resonant frequencies.The presence of dual perforated floating plates seldom shifts the sloshing natural frequencies.Further,dual perforated floating plates change the sloshing modes from the standing-wave mode in the clean tank to the Utube mode,which can arise from the sloshing reduction to some extent.
基金Project supported by the National Natural Science Foundation of China(No.81000535)the Zhejiang Provincial Natural Science Foundation of China(No.Y2100508)
文摘Objective: Bone morphogenetic proteins (BMPs) are known to play an important role in bone and cartilage development. Recent research has shown that BMPs may induce tumorigenesis and promote tumor to spread, but the molecular mechanisms have not been elucidated. The aim of the present study was to investigate the regulatory function of BMP-2 in the migration of COS-7 cells and the underlying mechanisms. Methods: Human BMP-2 genetic fragment was amplified and introduced into the pEGFP-C1 vector. After being confirmed by XhoI and BamHI digestion analyses and DNA sequencing, the recombinant pEGFP-C1-BMP-2 plasmid was transfected into COS-7 cells. The influence of BMP-2 on cell migration and cofilin activity was detected by cell scratch assay and Western blotting. Results: The recombinant pEGFP-C1-BMP-2 was effectively expressed in COS-7 cells. An increased phosphorylation of both LIMK1 and cofilin and an enhancement of cell migration were observed in cells with overexpression of BMP-2. Conclusions: A recombinant pEGFP-C1-BMP-2 vector was successfully constructed and overexpression of BMP-2 regulated the activities of the downstream molecules of the Rho GTPase signaling pathway, which might contribute to the enhancement of cell migration.
基金Project 2004300z019 supported by the Ningxia Municipal Torch Science and Technology
文摘The fundamental question of super-low-ash coal preparation is how to furthest depress high ash component pollution. A jigging process was used to remove high ash refuse and middling, then a high precision heavy medium cyclone was used to further separate near gravity light material. A two-stage heavy medium cylindrical cyclone with the same separation density was used to increase the precision of separation. The feed was de-slimed and fine-grind coal was added with media to improve the stability of the suspension. The pump frequency conversion timing and an air spring were used to steady the cyclone inlet pressure. Based on a series of study and pilot tests, a 1.00 Mt/a (output) commercial separation system with Ep value under 0.015 was built up. Super low ash (Ad≤2.00%) Taixi Anthracite has been put into commercial production.
