Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these co...Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these conditions.Methods This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or SC.Patients underwent comprehensive ocular examinations and imaging（OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography）.Findings were examined and compared between eyes with SC and Tb-SLC.Results Nine patients with active Tb-SLC（14 eyes） and 8 with active SC（12 eyes） were included.The following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group： vitreal hyper-reflective spots [5 Tb-SLC eyes（36%）,no SC eyes：P = 0.02],intraretinal edema [11 Tb-SLC eyes（79%）,3 SC eyes（25%）：P = 0.01],sub-retinal pigment epithelium（RPE） drusenoid deposits [11 Tb-SLC eyes（79%）,2 SC eyes（17%）：P 〈 0.01],and choroidal granulomas [8 Tb-SLC eyes（57%）,2 SC eyes（17%）：P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes（36%）,9 SC eyes（75%）：P = 0.045] than in the Tb-SLC group.The incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like hyper-reflection.Conclusion Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate Tb-SLC.Additionally,a hyporeflective,wedge-shaped band may indicate SC.Therefore,OCT is likely helpful in differentiating between Tb-SLC and SC.展开更多
基金supported by the National Natural Science Foundation of China[No.81400422 and 81271034]2015 Outstanding Young Scholar of Beijing[2015000021223ZK22]+1 种基金Key Discipline Leading Plan in Beijing Institute of Ophthalmology[201503]Capital’s Funds for Health Improvement and Research[2018-2-1081]
文摘Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these conditions.Methods This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or SC.Patients underwent comprehensive ocular examinations and imaging（OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography）.Findings were examined and compared between eyes with SC and Tb-SLC.Results Nine patients with active Tb-SLC（14 eyes） and 8 with active SC（12 eyes） were included.The following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group： vitreal hyper-reflective spots [5 Tb-SLC eyes（36%）,no SC eyes：P = 0.02],intraretinal edema [11 Tb-SLC eyes（79%）,3 SC eyes（25%）：P = 0.01],sub-retinal pigment epithelium（RPE） drusenoid deposits [11 Tb-SLC eyes（79%）,2 SC eyes（17%）：P 〈 0.01],and choroidal granulomas [8 Tb-SLC eyes（57%）,2 SC eyes（17%）：P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes（36%）,9 SC eyes（75%）：P = 0.045] than in the Tb-SLC group.The incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like hyper-reflection.Conclusion Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate Tb-SLC.Additionally,a hyporeflective,wedge-shaped band may indicate SC.Therefore,OCT is likely helpful in differentiating between Tb-SLC and SC.
