目的探讨碎裂QRS波群与陈旧性心肌梗死患者心率变异性分析(heart rate variability,HRV)及室性心律失常发生情况的关系。方法2018年8月至2019年10月首次就诊于河北北方学院附属第一医院心脏功能检查科的陈旧性心肌梗死患者200例,依据患...目的探讨碎裂QRS波群与陈旧性心肌梗死患者心率变异性分析(heart rate variability,HRV)及室性心律失常发生情况的关系。方法2018年8月至2019年10月首次就诊于河北北方学院附属第一医院心脏功能检查科的陈旧性心肌梗死患者200例,依据患者首次就诊于我院的病例库资料及常规十二导联心电图诊断分为陈旧性心肌梗死碎裂QRS波群组99例与陈旧性心肌梗死无碎裂QRS波群组101例,之后回顾性分析患者出院后1年内复查的24 h动态心电图,采用χ^(2)检验比较两组室性心律失常的发生情况,秩和检验比较两组心率变异性的差异,采用多元Logistic回归分析心率变异性不同指标的对陈旧性心肌梗死碎裂QRS波群的评估价值,绘制受试者工作特性曲线(receiver operating characteristic,ROC),通过曲线下面积(area under the curve,AUC)分析心率变异性不同指标的对陈旧性心肌梗死碎裂QRS波群的诊断准确性。结果依据室性期前收缩Lown分级,Lown分级室性期前收缩Ⅰ级、室性期前收缩Ⅲ-Ⅴ级患者室性心律失常发生率陈旧性心肌梗死碎裂QRS组均高于陈旧性心肌梗死无碎裂QRS组[室性期前收缩Ⅰ级:54.5%(54/99)与39.6%(40/101)(χ^(2)=4.484,P<0.05;室性期前收缩Ⅲ-Ⅴ级:34.3%(34/99)与9.9%(10/101)(χ^(2)=17.406,P<0.05)]。室性期前收缩0级陈旧性心肌梗死碎裂QRS组发生率为8.1%(8/99),低于陈旧性心肌梗死无碎裂QRS组48.5%(49/101)(χ^(2)=37.995,P<0.05)。室性心律失常陈旧性心肌梗死碎裂QRS波群组发生率为91.9%(91/99)高于陈旧性心肌梗死无碎裂QRS波群组51.5%(52/101)(χ^(2)=57.146,P<0.05)。室性期前收缩Ⅱ级陈旧性心肌梗死碎裂QRS组室性心律失常阳性发生例数与陈旧性心肌梗死无碎裂QRS组之间比较差异无统计学意义(P>0.05)。陈旧性心肌梗死碎裂QRS波群组较陈旧性心肌梗死无碎裂QRS波群组HRV时域指标全部窦性心搏间期的标准差(standard diviation of NN intervals,展开更多
AIM： To analyze cytokines as biomarkers for evaluation of severity of glaucoma. METHODS： This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as...AIM： To analyze cytokines as biomarkers for evaluation of severity of glaucoma. METHODS： This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups： acute angle closure glaucoma （AACG）, chronic angle closure glaucoma （CACG）, primary open angle glaucoma （POAG） and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system： y-interferon （IFNg）, interleukin （IL-10, IL-2, IL-4, IL-5, interferon-y-inducible protein （IP）-10, monocyte chemoattractant protein （MCP）-I, tumor necrosis factor （TNF） -Q, and vascular endothelial growth factor （VEGF）. We also recorded the intraocular pressure （lOP） of patients in each group and Pearson correlated analysis was performed to analysis the correlation between each type of cytokine with IOR RESULTS： Vitreous levels of IL-2, iL-5, MCP-1, TNF-a and IP-10 were significantly higher （P〈0.05） in AACG group. Patients with AACG, CACG and POAG have higher lOP than senile cataract, but we didn＇t find any significant correlation between lOP with any type of the cytokines. CONCLUSION： Inflammation and immune reaction have a strong link with the pathology of glaucoma especially AACG, Some cytokines may act as biomarkers to evaluate the severity of glaucoma, Anti-inflammatory treatments and controlling of lOP are necessary for the therapy of glaucoma.展开更多
文摘目的探讨碎裂QRS波群与陈旧性心肌梗死患者心率变异性分析(heart rate variability,HRV)及室性心律失常发生情况的关系。方法2018年8月至2019年10月首次就诊于河北北方学院附属第一医院心脏功能检查科的陈旧性心肌梗死患者200例,依据患者首次就诊于我院的病例库资料及常规十二导联心电图诊断分为陈旧性心肌梗死碎裂QRS波群组99例与陈旧性心肌梗死无碎裂QRS波群组101例,之后回顾性分析患者出院后1年内复查的24 h动态心电图,采用χ^(2)检验比较两组室性心律失常的发生情况,秩和检验比较两组心率变异性的差异,采用多元Logistic回归分析心率变异性不同指标的对陈旧性心肌梗死碎裂QRS波群的评估价值,绘制受试者工作特性曲线(receiver operating characteristic,ROC),通过曲线下面积(area under the curve,AUC)分析心率变异性不同指标的对陈旧性心肌梗死碎裂QRS波群的诊断准确性。结果依据室性期前收缩Lown分级,Lown分级室性期前收缩Ⅰ级、室性期前收缩Ⅲ-Ⅴ级患者室性心律失常发生率陈旧性心肌梗死碎裂QRS组均高于陈旧性心肌梗死无碎裂QRS组[室性期前收缩Ⅰ级:54.5%(54/99)与39.6%(40/101)(χ^(2)=4.484,P<0.05;室性期前收缩Ⅲ-Ⅴ级:34.3%(34/99)与9.9%(10/101)(χ^(2)=17.406,P<0.05)]。室性期前收缩0级陈旧性心肌梗死碎裂QRS组发生率为8.1%(8/99),低于陈旧性心肌梗死无碎裂QRS组48.5%(49/101)(χ^(2)=37.995,P<0.05)。室性心律失常陈旧性心肌梗死碎裂QRS波群组发生率为91.9%(91/99)高于陈旧性心肌梗死无碎裂QRS波群组51.5%(52/101)(χ^(2)=57.146,P<0.05)。室性期前收缩Ⅱ级陈旧性心肌梗死碎裂QRS组室性心律失常阳性发生例数与陈旧性心肌梗死无碎裂QRS组之间比较差异无统计学意义(P>0.05)。陈旧性心肌梗死碎裂QRS波群组较陈旧性心肌梗死无碎裂QRS波群组HRV时域指标全部窦性心搏间期的标准差(standard diviation of NN intervals,
基金Supported by the National Natural Science Fundation of China(No.81371040)Shanghai Pujiang Program(No.15PJD028)Scientific Research Project of Shanghai Municipal Health Bureau(No.20124149)
文摘AIM： To analyze cytokines as biomarkers for evaluation of severity of glaucoma. METHODS： This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups： acute angle closure glaucoma （AACG）, chronic angle closure glaucoma （CACG）, primary open angle glaucoma （POAG） and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system： y-interferon （IFNg）, interleukin （IL-10, IL-2, IL-4, IL-5, interferon-y-inducible protein （IP）-10, monocyte chemoattractant protein （MCP）-I, tumor necrosis factor （TNF） -Q, and vascular endothelial growth factor （VEGF）. We also recorded the intraocular pressure （lOP） of patients in each group and Pearson correlated analysis was performed to analysis the correlation between each type of cytokine with IOR RESULTS： Vitreous levels of IL-2, iL-5, MCP-1, TNF-a and IP-10 were significantly higher （P〈0.05） in AACG group. Patients with AACG, CACG and POAG have higher lOP than senile cataract, but we didn＇t find any significant correlation between lOP with any type of the cytokines. CONCLUSION： Inflammation and immune reaction have a strong link with the pathology of glaucoma especially AACG, Some cytokines may act as biomarkers to evaluate the severity of glaucoma, Anti-inflammatory treatments and controlling of lOP are necessary for the therapy of glaucoma.
