The selective catalytic hydrogenation of naphthalene to high-value tetralin was systematically investigated.A series of Al2O3 catalysts containing different active metals(Co,Mo,Ni,W)were prepared by incipient wetness ...The selective catalytic hydrogenation of naphthalene to high-value tetralin was systematically investigated.A series of Al2O3 catalysts containing different active metals(Co,Mo,Ni,W)were prepared by incipient wetness impregnation.The effects of different active metals forms(oxidation,reduction,sulfuration)and reaction conditions on naphthalene hydrogenation were investigated and the catalysts were characterized by XRD,XPS,BET,NH3-TPD and SEM.Especially,Ni-Mo/Al2O3 was first used in this reactive system.The results show that the oxidative4%Ni O-20%MoO3/Al2O3 is the best catalyst for the preparation of tetralin.The conversion of naphthalene and the selectivity of tetralin can reach 95.62%and 99.75%respectively at 200℃,8 h and 6 MPa.Compared with reduced and sulfureted 4%Ni O-20%MoO3/Al2O3 catalysts,oxidative 4%Ni O-20%MoO3/Al2O3 has a well dispersed and uniform monolayer of the active metals,larger pore volume and size,and larger total acidity.NiO-MoO3/Al2O3 has a synergistic effect between NiO activity and MoO3 selectivity.展开更多
background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whet...background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients.展开更多
Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;howev...Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.展开更多
In order to comprehensively understand the mechanical behavior of biological entities and aerospace applications subjected to hypergravity environments,we delve into the impact of hypergravity on the equivalent compli...In order to comprehensively understand the mechanical behavior of biological entities and aerospace applications subjected to hypergravity environments,we delve into the impact of hypergravity on the equivalent compliance of cubic lattice structures.Capitalizing on the periodic spatial distribution,we employ a unit cell methodology to deduce the homogenized stress-strain relationship for the lattice structures,subsequently obtaining the associated equivalent compliance.The equivalent compliance can be conveniently reduced to instances without hypergravity influence.Furthermore,numerical simulations are executed to validate the derivations and to illustrate that hypergravity indeed affects the mechanical properties of lattice structures.We introduce a non-dimensional hypergravity factor,which quantifies the impact of hypergravity magnitude relative to the Young’s modulus of the base material.Our findings reveal that the hypergravity factor influences perpendicular compliance quadratically and parallel compliance linearly.Simultaneously,the perpendicular shear compliance remains unaffected,whereas the parallel shear compliance experiences an inverse effect.Additionally,the lattice structure transforms into a gradient material oriented in the hypergravity direction,consequently generating a scale effect.展开更多
The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin injuries.Skin lesion healing can be achieved with nanomedicines and other drug application techniques.This study ...The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin injuries.Skin lesion healing can be achieved with nanomedicines and other drug application techniques.This study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca2+)and hydrogen peroxide(H2O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous form.Tests demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in vitro.The effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(S.aureus)-infected wound models based thereon.The results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both aspects.Notably,the infected rats’skin defects healed in 12 days.The benefits are linked to the functional role of Ca^(2+)coalesces with H2O_(2)as known antibacterial and healing-promoted agents.Therefore,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.展开更多
Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and mom...Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still limited.Here,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent photoluminescence.Together with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum origin.Remarkably,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics.展开更多
Objective： We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma. Methods： Fluorescence in situ hybridisation （FISH） and immunohistochemistry （IHC） techn...Objective： We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma. Methods： Fluorescence in situ hybridisation （FISH） and immunohistochemistry （IHC） techniques were used to detect HER2 gene status and p53 protein in 59 cases of gastric cancer. Results： FISH detection of HER2 gene amplification rate was 16.9% （10/59）, HER2 gene amplification in 49 cases without copy number gain and gene amplification were a total of 49.2% （29/59）. HER2 protein expression was 42.4% （25/59）, HER2 gene amplification rates in patients with ＋＋＋, ＋＋ HER2 protein expression were 3/3 and 5/8, while in patients with ＋ HER2 protein expression, it was 2/14, there was significant difference （P 0.05）. p21 protein expression rate was 49.2% （29/59）, HER2 gene amplification rates and p21 protein expression had significant difference in tumor invasion depth, lymph node metastasis （P 0.05）; had no statistical significance in histological type, age, gender differences （P 0.05）. Conclusion： HER2 gene amplification rate and gene copy number had positively correlation with p21 protein expression, HER2 gene status and expression of p21 protein combined detection can provide a reference value in gastric cancer metastasis, patient’s condition development and prognosis, it also can guide clinical development of individual treatment.展开更多
Slope stability assessment is a geotechnical problem characterized by many sources of uncertainty. In clas- sical reliability analysis, only the randomness of uncertainties is taken into account but the fuzziness of t...Slope stability assessment is a geotechnical problem characterized by many sources of uncertainty. In clas- sical reliability analysis, only the randomness of uncertainties is taken into account but the fuzziness of them is ignored. In this paper, a fuzzy probability approach and a fuzzy JC method are presented for the reliability analysis. The two methods have been applied to stability analysis of a certain slope of permanent ship lock in the Three-Gorges Project. The results obtained from these two methods are basically the same. However, compared with the fuzzy probability means, the fuzzy JC method can reflect the real situation better because it uses a fuzzy-based analysis applied to not only limit state equation but also mechanical parameters.展开更多
Rotating structural components are omnipresent in engineering structures and natural world. This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cyl...Rotating structural components are omnipresent in engineering structures and natural world. This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cylinders rotating with respect to the axis of symmetry based on the nonlinear elasticity and linear incremental theories. The formulations indicate that the biasing deformation, instantaneous elastic moduli, and incremental equations of motion strongly depend on the rotating speed. The characteristic equation for the natural frequency is derived using the state-space method and approximate laminate technique.The numerical examples included in this work demonstrate that the centrifugal and Coriolis forces might have significant effects on the vibrational characteristics of the cylinder. Results of this work will benefit the design and control of novel engineering systems with rotating soft cylinders or shafts.展开更多
The development of logistics finance business for agricultural products is the best way to realize the common interests of logistics enterprises,small and medium-sized agricultural product enterprises and financial in...The development of logistics finance business for agricultural products is the best way to realize the common interests of logistics enterprises,small and medium-sized agricultural product enterprises and financial institutions,which will contribute to the development of China's new socialist rural economy and the construction of " two-oriented society". As the agricultural products have some special attributes,it's easy to create the risk in carrying out the logistics finance business. The paper constructs a risk evaluation indicator system for logistics finance of agricultural product,and uses the Fuzzy-AHP model to evaluate. The results show that the comprehensive risk level is normal risk,which shows that third-party logistics enterprises can carry out the logistics financial business of agricultural products,but the risks from logistics enterprises and agricultural collateral need to be prevented.展开更多
The unpredictable rupture of saccular aneurysms especially of the intracerebral aneurysm is a knotty problem that always results in high mortality. Traditional diagnosis of medical images, which gives the aneurysm siz...The unpredictable rupture of saccular aneurysms especially of the intracerebral aneurysm is a knotty problem that always results in high mortality. Traditional diagnosis of medical images, which gives the aneurysm size and compares with a speculated critical size from clinical statistics, was demonstrated inadequate to forecasting rupture. Here, we propose a new detecting strategy that uses a dielectric elastomer （DE） capacitance sensor to monitor the growth of saccular aneurysms and deliver both the wall stress and geometric parameters, Based on the elastic growth theory together with the finite deformation analyses, the correlation between the real-time output capacitance of the DE sensor and the wall stress and/or geometry of an aneurysm is derived. Compared to clinic statistics and biomechanics simulations, the wall stress and geometric size may be used as combined indicators to assess the rupture risk of a saccular aneurysm, Numerical results show that an output relative capacitance of 30 indicates a high risk of rupture, Finally, the sensitivity and resolution of the DE sensor are proved adequately high for monitoring the growth state and evaluating the rupture risk of a saccular aneurysm.展开更多
1 Introduction Yanchang Formation in Upper Triassic,Ordos basin contains the most abundant hydrocarbon resources in North China(Wang et al.,2014).The sandstones are the most important oil-bearing reservoirs in Yanchang
1 Introduction Some Cyprinidae fossils have been reported about 420km east of the fossil site in the same period of Wulan Husentu1 layer,and have been used as an important fossil evidence for a deep understanding of the
Objective To explore the clinical pathological features and immunophenotypes of cervical intraepithelial neoplasia(CIN).Methods The protein expression of p16, p53, Bcl-2, and c-erb B-2 in 59 cases of CIN, 20 cases of ...Objective To explore the clinical pathological features and immunophenotypes of cervical intraepithelial neoplasia(CIN).Methods The protein expression of p16, p53, Bcl-2, and c-erb B-2 in 59 cases of CIN, 20 cases of cervical squamous cell carcinoma, and 20 cases of normal cervical tissues were tested using immunohistochemistry staining.Results The expression rates of p16, p53, Bcl-2, and c-erb B-2 in CIN tissues were 76.3%(45/59), 28.85(17/59), 61.0%(36/59), and 40.0%(23/59), respectively. The expression rates of p16, p53, Bcl-2, and c-erb B-2 in cervical squamous cell carcinoma tissues were 60.0%(12/20), 60.0%(12/20), 75.0%(15/20), and 65.0%(13/20), respectively. The expression rates of p16, p53, Bcl-2, and c-erb B-2 in normal cervical tissues were 0.0%(0/20), 0.0%(0/20), 35.0%(7/20), 0.0%(0/20), respectively. In comparison to normal tissues, the differential expressions of p16, p53, and Bcl-2 in squamous cell carcinoma and CIN were statistically significant(P <0.001), whereas the difference between the squamous cell carcinoma and CIN was not significant(P >0.05). In comparison to normal tissues, the differential expressions of c-erb B-2 and p53 in squamous cell carcinoma and CIN were statistically significant(P >0.05). The differential expressions of Bcl-2, c-erb B-2, and p53 in CIN 3 were statistically significant in comparison to CIN 1 and CIN 2(P <0.05). Conclusion Overexpression of Bcl-2 occurs early in the development of cervical cancer, whereas p16 and c-erb B-2 overexpression are markers for cell malignancy. The expression of p53 is correlated with the development of cervical cancer.展开更多
The periodic-phase-diagram similarity method is proposed to identify the frequency of weak harmonic signals.The key technology is to find a set of optimal coefficients for Duffing system,which leads to the periodic mo...The periodic-phase-diagram similarity method is proposed to identify the frequency of weak harmonic signals.The key technology is to find a set of optimal coefficients for Duffing system,which leads to the periodic motion under the influence of weak signal and strong noise.Introducing the phase diagram similarity,the influences of strong noise on the similarity of periodic phase diagram are discussed.The principle of highest similarity of periodic phase diagram with the same frequency is detected by discussing the persistence of similarity of periodic motion phase diagram under the strong noise and the periodic-phase-diagram similarity method is constructed.The weak signals of early fault and strong noise are input into Duffing system to obtain the identified system.The stochastic subharmonic Melnikov method is extended to obtain the conditions of the optimal coefficients for the identified system.Based on the results,the constructed frequency conversion harmonic weak signals are considered to form a datum periodic system.With the change of frequency in the datum periodic system,the phase diagram similarity of the two constructed systems can be calculated.Based on the periodic-phase-diagram similarity method,the frequency of weak harmonic signals can be identified by the principle of highest similarity of periodic phase diagram with the same frequency.The results of numerical simulation and the early fault diagnosis results of actual bearings verify the feasibility of the periodic-phase-diagram similarity method.The accuracy of the detection effect is 97%,and the minimum signal-to-noise ratio is−80.71 dB.展开更多
Preliminary research was conducted about how to incorporate sorption/desorption of organic pollutants with suspended solids and sediments into single-chemical and one-dimensional water quality model of Jinghang Canal....Preliminary research was conducted about how to incorporate sorption/desorption of organic pollutants with suspended solids and sediments into single-chemical and one-dimensional water quality model of Jinghang Canal. Sedimentation-resuspension coefficient k 3 was deduced; characteristics of organic pollutants, concentrations and components of suspended solids/sediments and hydrological and hydraulic conditions were integrated into k 3 and further into river water quality model; impact of sorption/desorption of organic pollutants with suspended solids and sediments on prediction function of the model was discussed. Results demonstrated that this impact is pronounced for organic pollutants with relatively large K oc and K ow, especially when they are also conservative and f oc of river suspended solids/sediments is high, and that incorporation of sorption/ desorption of organic pollutants into river water quality model can improve its prediction accuracy.展开更多
Objective： The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods： Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistoc...Objective： The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods： Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistochemistry, and follow-up methods were studied. Results： Histopathology of gastric adenoma characteristics： nuclear anaplasia, showing increase of nuclear volume and irregular, and the emergence of one or more nucleoli, mitotic ≤ 2/10 high power field （HPF）. Structural changes in the gland： adenoma of the duct much more consistent, sometimes the size of the gland and irregular contour, might be associated with intestinal metaplasia. Increased significantly when the nuclear volume, mitotic 〉 2/10 HPF, irregular gland distortion, branched structures, suggesting the development of adenomas. Immunophenotype： tumor-associated carbohydrate antigens had a higher expression; adenomatous polyposis coli gene （APC） and carcinoembryonic antigen （CEA） expression of closely related with the formation of adenoma. Mucin muc-2 high expression was negatively correlated with muc-1 low expression, the combination of both can help to determine the development and changes in gastric adenoma. Survivin, Bcl-2, p21 and p53 protein expression rare cases, four were combined with the malignant transformation of gastric adenoma was important discriminant. Ki-67 positive cells 20%-40%, and could be used as degree of cell proliferation, a reference indicator of prognosis. Thirty-six to 49 months of follow-up results showed that cured 44.8% （30/67）, there adenomatous hyperplasia 35.8% （24167）, with the development of dysplasia showed 14.4% （11/67）, the development of intramucosal carci- noma were 3.0% （2/67）. Conclusion： Gastric adenomas occur significantly increased nuclear volume, mitotic 〉 2/10 HPF, ir- regular gland distortion, branch-like structure; immunohistochemical staining showed positive expression of muc-2 decreased, muc-1 positive expression; cell proliferation index Ki -67 �展开更多
Objective: The aim of the study was to investigate the human epidermal growth factor receptor 2(HER2) gene amplification and protein expression and interpretation points in the stomach mixed carcinomas. Methods: Immun...Objective: The aim of the study was to investigate the human epidermal growth factor receptor 2(HER2) gene amplification and protein expression and interpretation points in the stomach mixed carcinomas. Methods: Immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH) technique were used to detect HER2 gene amplification and expression of HER2 protein in 442 cases of gastric mixed carcinoma. Results: The expression rate of HER2 protein was 41.2%(182/442): the HER2 protein expression IHC 3+ extensive type in 18 cases, partial type in 21 cases, focal type in 8 cases, accounting for 10.6%(47/442); the HER2 protein expression IHC 2+ extensive type in 23 cases, partial type in 28 cases, focal type in 11 cases, accounting for 14.0%(62/442); the HER2 protein expression IHC 1+ extensive type in 27 cases, partial type in 31 cases, focal type in 15 cases, accounting for 16.5%(73/442). HER2 gene amplification rate of 442 cases was 16.1%(71/442). In 182 cases of HER2 protein positive expression, the HER2 gene cluster amplification rate was 14.8%(27/182), large granular amplification rate 11.0%(20/182), punctate amplification rate 6.0%(11/182) and high polysomy 7.1%(13/182). In 71 cases of HER2 gene amplification, there was 42 cases of HER2 protein expression IHC 3+, 22 cases of HER2 protein expression IHC 2+, and 7 cases of IHC 1+. Conclusion: HER2 detection of gastric mixed carcinoma has great heterogeneity, HER2 protein positive expression is divided into extensive type, partial type and focal type, and HER2 gene positive amplification is divided into cluster amplification, large granular amplification, punctate amplification and high polysomy. These typing of HER2 protein expression and HER2 gene amplification provide reference index to quantify for targeted therapeutic effect of anticancer drugs.展开更多
基金supported by the Joint Funds of National Key R&D Program of China(2018YFB0604603)the National Natural Science Foundation of China(21536009,21776229)+2 种基金Science and Technology Plan Projects of Shaanxi Province(2017ZDCXL-GY-10-03,2018ZDXMGY-167)The Young Science and Technology Star Project of Shaanxi Province(2017KJXX-62)Science and Technology Program of Yulin(2018-2-22)。
文摘The selective catalytic hydrogenation of naphthalene to high-value tetralin was systematically investigated.A series of Al2O3 catalysts containing different active metals(Co,Mo,Ni,W)were prepared by incipient wetness impregnation.The effects of different active metals forms(oxidation,reduction,sulfuration)and reaction conditions on naphthalene hydrogenation were investigated and the catalysts were characterized by XRD,XPS,BET,NH3-TPD and SEM.Especially,Ni-Mo/Al2O3 was first used in this reactive system.The results show that the oxidative4%Ni O-20%MoO3/Al2O3 is the best catalyst for the preparation of tetralin.The conversion of naphthalene and the selectivity of tetralin can reach 95.62%and 99.75%respectively at 200℃,8 h and 6 MPa.Compared with reduced and sulfureted 4%Ni O-20%MoO3/Al2O3 catalysts,oxidative 4%Ni O-20%MoO3/Al2O3 has a well dispersed and uniform monolayer of the active metals,larger pore volume and size,and larger total acidity.NiO-MoO3/Al2O3 has a synergistic effect between NiO activity and MoO3 selectivity.
基金The study was funded by Boehringer Ingelheim(China)Investment.The study was also funded by Clinical Research with Features for Application in the Capital(no.Z161100000516079)and the National Key Research and Development Plan(no.2017YFC1308204)。
文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients.
基金supported by the National Natural Science Foundation of China(12032007,31971242)the Natural Science Foundation of Chongqing(cstc2020jcyj-msxmX0330)+3 种基金the Project of Science and Technology of Chongqing Yuzhong District(20170119,20170113)the Project of Tutorial System of Medical Undergraduate in Lab Teaching&Management Center in Chongqing Medical University(LTMCMTS202003)the National Project of University Students Innovation and Entrepreneurship Training Program(201910631002)the Project of‘Ying Yao Program’for College Student in School of Basic Medical Sciences in ChongqingMedical University(JCYY202003).
文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.
基金supported by the National Natural Science Foundation of China(Grant Nos.11925206,51988101,and 12272340)Zhejiang Provincial Natural Science Foundation of China(Grant No.LD21A020002).
文摘In order to comprehensively understand the mechanical behavior of biological entities and aerospace applications subjected to hypergravity environments,we delve into the impact of hypergravity on the equivalent compliance of cubic lattice structures.Capitalizing on the periodic spatial distribution,we employ a unit cell methodology to deduce the homogenized stress-strain relationship for the lattice structures,subsequently obtaining the associated equivalent compliance.The equivalent compliance can be conveniently reduced to instances without hypergravity influence.Furthermore,numerical simulations are executed to validate the derivations and to illustrate that hypergravity indeed affects the mechanical properties of lattice structures.We introduce a non-dimensional hypergravity factor,which quantifies the impact of hypergravity magnitude relative to the Young’s modulus of the base material.Our findings reveal that the hypergravity factor influences perpendicular compliance quadratically and parallel compliance linearly.Simultaneously,the perpendicular shear compliance remains unaffected,whereas the parallel shear compliance experiences an inverse effect.Additionally,the lattice structure transforms into a gradient material oriented in the hypergravity direction,consequently generating a scale effect.
基金supported by grants from the Natural Science Foundation of Chongqing(cstc2020jcyj-msxmX0330,cstc2021jsyjyzysbA0057)the National Natural Science Foundation of China(31971242,12032007)+1 种基金the Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001)the Project of Tutorial System of Medical Undergraduate in Lab Teaching&Management Center in Chongqing Medical University(LTMCMTS202107).
文摘The most common socioeconomic healthcare issues in clinical are burns,surgical incisions and other skin injuries.Skin lesion healing can be achieved with nanomedicines and other drug application techniques.This study developed a nano-spray based on cross-linked amorphous calcium peroxide(CaO_(2))nanoparticles of polyacrylic acid(PAA)for treating skin wounds(PAA-CaO_(2)nanoparticles).CaO_(2)serves as a‘drug’precursor,steadily and continuously releasing calcium ions(Ca2+)and hydrogen peroxide(H2O_(2))under mildly acidic conditions,while PAA-CaO_(2)nanoparticles exhibited good spray behavior in aqueous form.Tests demonstrated that PAA-CaO_(2)nanoparticles exhibited low cytotoxicity and allowed L929 cells proliferation and migration in vitro.The effectiveness of PAA-CaO_(2)nanoparticles in promoting wound healing and inhibiting bacterial growth in vivo was assessed in SD rats using full-thickness skin defect and Staphylococcus aureus(S.aureus)-infected wound models based thereon.The results revealed that PAA-CaO_(2)nanoparticles demonstrated significant advantages in both aspects.Notably,the infected rats’skin defects healed in 12 days.The benefits are linked to the functional role of Ca^(2+)coalesces with H2O_(2)as known antibacterial and healing-promoted agents.Therefore,we developed nanoscale PAA-CaO_(2)sprays to prevent bacterial development and heal skin lesions.
基金This work was supported by the National Natural Science Foundation of China(NSFC)(12274447,61888102,11834017,61734001,and 12074412)the National Key Research and Development Program(2021YFA1202900 and 2021YFA1400502)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB30000000)the Key-Area Research and Development Program of Guangdong Province(2020B0101340001).
文摘Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still limited.Here,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent photoluminescence.Together with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum origin.Remarkably,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics.
文摘Objective： We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma. Methods： Fluorescence in situ hybridisation （FISH） and immunohistochemistry （IHC） techniques were used to detect HER2 gene status and p53 protein in 59 cases of gastric cancer. Results： FISH detection of HER2 gene amplification rate was 16.9% （10/59）, HER2 gene amplification in 49 cases without copy number gain and gene amplification were a total of 49.2% （29/59）. HER2 protein expression was 42.4% （25/59）, HER2 gene amplification rates in patients with ＋＋＋, ＋＋ HER2 protein expression were 3/3 and 5/8, while in patients with ＋ HER2 protein expression, it was 2/14, there was significant difference （P 0.05）. p21 protein expression rate was 49.2% （29/59）, HER2 gene amplification rates and p21 protein expression had significant difference in tumor invasion depth, lymph node metastasis （P 0.05）; had no statistical significance in histological type, age, gender differences （P 0.05）. Conclusion： HER2 gene amplification rate and gene copy number had positively correlation with p21 protein expression, HER2 gene status and expression of p21 protein combined detection can provide a reference value in gastric cancer metastasis, patient’s condition development and prognosis, it also can guide clinical development of individual treatment.
文摘Slope stability assessment is a geotechnical problem characterized by many sources of uncertainty. In clas- sical reliability analysis, only the randomness of uncertainties is taken into account but the fuzziness of them is ignored. In this paper, a fuzzy probability approach and a fuzzy JC method are presented for the reliability analysis. The two methods have been applied to stability analysis of a certain slope of permanent ship lock in the Three-Gorges Project. The results obtained from these two methods are basically the same. However, compared with the fuzzy probability means, the fuzzy JC method can reflect the real situation better because it uses a fuzzy-based analysis applied to not only limit state equation but also mechanical parameters.
基金supported by the National Natural Science Foundation of China(Grant Nos.51988101,11925206,and 11772295)。
文摘Rotating structural components are omnipresent in engineering structures and natural world. This work investigates the effects of the centrifugal and Coriolis forces on the free vibrational characteristics of soft cylinders rotating with respect to the axis of symmetry based on the nonlinear elasticity and linear incremental theories. The formulations indicate that the biasing deformation, instantaneous elastic moduli, and incremental equations of motion strongly depend on the rotating speed. The characteristic equation for the natural frequency is derived using the state-space method and approximate laminate technique.The numerical examples included in this work demonstrate that the centrifugal and Coriolis forces might have significant effects on the vibrational characteristics of the cylinder. Results of this work will benefit the design and control of novel engineering systems with rotating soft cylinders or shafts.
文摘The development of logistics finance business for agricultural products is the best way to realize the common interests of logistics enterprises,small and medium-sized agricultural product enterprises and financial institutions,which will contribute to the development of China's new socialist rural economy and the construction of " two-oriented society". As the agricultural products have some special attributes,it's easy to create the risk in carrying out the logistics finance business. The paper constructs a risk evaluation indicator system for logistics finance of agricultural product,and uses the Fuzzy-AHP model to evaluate. The results show that the comprehensive risk level is normal risk,which shows that third-party logistics enterprises can carry out the logistics financial business of agricultural products,but the risks from logistics enterprises and agricultural collateral need to be prevented.
基金supported by the National Natural Science Foundation of China(11322216,11621062,and 11321202)the Zhejiang Provincial Natural Science Foundation(LR13A020001)
文摘The unpredictable rupture of saccular aneurysms especially of the intracerebral aneurysm is a knotty problem that always results in high mortality. Traditional diagnosis of medical images, which gives the aneurysm size and compares with a speculated critical size from clinical statistics, was demonstrated inadequate to forecasting rupture. Here, we propose a new detecting strategy that uses a dielectric elastomer （DE） capacitance sensor to monitor the growth of saccular aneurysms and deliver both the wall stress and geometric parameters, Based on the elastic growth theory together with the finite deformation analyses, the correlation between the real-time output capacitance of the DE sensor and the wall stress and/or geometry of an aneurysm is derived. Compared to clinic statistics and biomechanics simulations, the wall stress and geometric size may be used as combined indicators to assess the rupture risk of a saccular aneurysm, Numerical results show that an output relative capacitance of 30 indicates a high risk of rupture, Finally, the sensitivity and resolution of the DE sensor are proved adequately high for monitoring the growth state and evaluating the rupture risk of a saccular aneurysm.
基金financially supported by the National Natural Science Foundation of China (grant No. 41272115)
文摘1 Introduction Yanchang Formation in Upper Triassic,Ordos basin contains the most abundant hydrocarbon resources in North China(Wang et al.,2014).The sandstones are the most important oil-bearing reservoirs in Yanchang
基金Supported by the National Natural Science Foundation of China (Grant No. 41272115,41290253)
文摘1 Introduction Some Cyprinidae fossils have been reported about 420km east of the fossil site in the same period of Wulan Husentu1 layer,and have been used as an important fossil evidence for a deep understanding of the
文摘Objective To explore the clinical pathological features and immunophenotypes of cervical intraepithelial neoplasia(CIN).Methods The protein expression of p16, p53, Bcl-2, and c-erb B-2 in 59 cases of CIN, 20 cases of cervical squamous cell carcinoma, and 20 cases of normal cervical tissues were tested using immunohistochemistry staining.Results The expression rates of p16, p53, Bcl-2, and c-erb B-2 in CIN tissues were 76.3%(45/59), 28.85(17/59), 61.0%(36/59), and 40.0%(23/59), respectively. The expression rates of p16, p53, Bcl-2, and c-erb B-2 in cervical squamous cell carcinoma tissues were 60.0%(12/20), 60.0%(12/20), 75.0%(15/20), and 65.0%(13/20), respectively. The expression rates of p16, p53, Bcl-2, and c-erb B-2 in normal cervical tissues were 0.0%(0/20), 0.0%(0/20), 35.0%(7/20), 0.0%(0/20), respectively. In comparison to normal tissues, the differential expressions of p16, p53, and Bcl-2 in squamous cell carcinoma and CIN were statistically significant(P <0.001), whereas the difference between the squamous cell carcinoma and CIN was not significant(P >0.05). In comparison to normal tissues, the differential expressions of c-erb B-2 and p53 in squamous cell carcinoma and CIN were statistically significant(P >0.05). The differential expressions of Bcl-2, c-erb B-2, and p53 in CIN 3 were statistically significant in comparison to CIN 1 and CIN 2(P <0.05). Conclusion Overexpression of Bcl-2 occurs early in the development of cervical cancer, whereas p16 and c-erb B-2 overexpression are markers for cell malignancy. The expression of p53 is correlated with the development of cervical cancer.
基金This study was supported by the National Natural Science Foundation of China(Nos.12072203,11872253,12032017)the Hundred Excellent Innovative Talents in Hebei Province(No.SLRC2019037)+3 种基金the“333 talent project”in Hebei Province(No.A202005007)the Natural Science Foundation in Hebei Province of China(Nos.A2019421005,A2019402043,E2019210278)the Hebei Provincial Department of Education Project(Nos.ZD2020328,QN2019149,QN2018237)the Graduate Student Innovation Ability Training Project of Hebei Education Department(CXZZSS2021080).
文摘The periodic-phase-diagram similarity method is proposed to identify the frequency of weak harmonic signals.The key technology is to find a set of optimal coefficients for Duffing system,which leads to the periodic motion under the influence of weak signal and strong noise.Introducing the phase diagram similarity,the influences of strong noise on the similarity of periodic phase diagram are discussed.The principle of highest similarity of periodic phase diagram with the same frequency is detected by discussing the persistence of similarity of periodic motion phase diagram under the strong noise and the periodic-phase-diagram similarity method is constructed.The weak signals of early fault and strong noise are input into Duffing system to obtain the identified system.The stochastic subharmonic Melnikov method is extended to obtain the conditions of the optimal coefficients for the identified system.Based on the results,the constructed frequency conversion harmonic weak signals are considered to form a datum periodic system.With the change of frequency in the datum periodic system,the phase diagram similarity of the two constructed systems can be calculated.Based on the periodic-phase-diagram similarity method,the frequency of weak harmonic signals can be identified by the principle of highest similarity of periodic phase diagram with the same frequency.The results of numerical simulation and the early fault diagnosis results of actual bearings verify the feasibility of the periodic-phase-diagram similarity method.The accuracy of the detection effect is 97%,and the minimum signal-to-noise ratio is−80.71 dB.
文摘Preliminary research was conducted about how to incorporate sorption/desorption of organic pollutants with suspended solids and sediments into single-chemical and one-dimensional water quality model of Jinghang Canal. Sedimentation-resuspension coefficient k 3 was deduced; characteristics of organic pollutants, concentrations and components of suspended solids/sediments and hydrological and hydraulic conditions were integrated into k 3 and further into river water quality model; impact of sorption/desorption of organic pollutants with suspended solids and sediments on prediction function of the model was discussed. Results demonstrated that this impact is pronounced for organic pollutants with relatively large K oc and K ow, especially when they are also conservative and f oc of river suspended solids/sediments is high, and that incorporation of sorption/ desorption of organic pollutants into river water quality model can improve its prediction accuracy.
文摘Objective： The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods： Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistochemistry, and follow-up methods were studied. Results： Histopathology of gastric adenoma characteristics： nuclear anaplasia, showing increase of nuclear volume and irregular, and the emergence of one or more nucleoli, mitotic ≤ 2/10 high power field （HPF）. Structural changes in the gland： adenoma of the duct much more consistent, sometimes the size of the gland and irregular contour, might be associated with intestinal metaplasia. Increased significantly when the nuclear volume, mitotic 〉 2/10 HPF, irregular gland distortion, branched structures, suggesting the development of adenomas. Immunophenotype： tumor-associated carbohydrate antigens had a higher expression; adenomatous polyposis coli gene （APC） and carcinoembryonic antigen （CEA） expression of closely related with the formation of adenoma. Mucin muc-2 high expression was negatively correlated with muc-1 low expression, the combination of both can help to determine the development and changes in gastric adenoma. Survivin, Bcl-2, p21 and p53 protein expression rare cases, four were combined with the malignant transformation of gastric adenoma was important discriminant. Ki-67 positive cells 20%-40%, and could be used as degree of cell proliferation, a reference indicator of prognosis. Thirty-six to 49 months of follow-up results showed that cured 44.8% （30/67）, there adenomatous hyperplasia 35.8% （24167）, with the development of dysplasia showed 14.4% （11/67）, the development of intramucosal carci- noma were 3.0% （2/67）. Conclusion： Gastric adenomas occur significantly increased nuclear volume, mitotic 〉 2/10 HPF, ir- regular gland distortion, branch-like structure; immunohistochemical staining showed positive expression of muc-2 decreased, muc-1 positive expression; cell proliferation index Ki -67 �
基金Supported by a grant from the Henan Provincial Key Scientific and Technological Project(No.132102310008)
文摘Objective: The aim of the study was to investigate the human epidermal growth factor receptor 2(HER2) gene amplification and protein expression and interpretation points in the stomach mixed carcinomas. Methods: Immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH) technique were used to detect HER2 gene amplification and expression of HER2 protein in 442 cases of gastric mixed carcinoma. Results: The expression rate of HER2 protein was 41.2%(182/442): the HER2 protein expression IHC 3+ extensive type in 18 cases, partial type in 21 cases, focal type in 8 cases, accounting for 10.6%(47/442); the HER2 protein expression IHC 2+ extensive type in 23 cases, partial type in 28 cases, focal type in 11 cases, accounting for 14.0%(62/442); the HER2 protein expression IHC 1+ extensive type in 27 cases, partial type in 31 cases, focal type in 15 cases, accounting for 16.5%(73/442). HER2 gene amplification rate of 442 cases was 16.1%(71/442). In 182 cases of HER2 protein positive expression, the HER2 gene cluster amplification rate was 14.8%(27/182), large granular amplification rate 11.0%(20/182), punctate amplification rate 6.0%(11/182) and high polysomy 7.1%(13/182). In 71 cases of HER2 gene amplification, there was 42 cases of HER2 protein expression IHC 3+, 22 cases of HER2 protein expression IHC 2+, and 7 cases of IHC 1+. Conclusion: HER2 detection of gastric mixed carcinoma has great heterogeneity, HER2 protein positive expression is divided into extensive type, partial type and focal type, and HER2 gene positive amplification is divided into cluster amplification, large granular amplification, punctate amplification and high polysomy. These typing of HER2 protein expression and HER2 gene amplification provide reference index to quantify for targeted therapeutic effect of anticancer drugs.
