针对配电网中突出存在的电压暂降与电压不平衡的电压质量问题,以光伏发电系统（photovoltaicgeneration system,PVGS）最大程度提高并网点（point of common coupling,PCC）供电质量为目标,提出配电网不同工况与PVGS不同出力下,有功功...针对配电网中突出存在的电压暂降与电压不平衡的电压质量问题,以光伏发电系统（photovoltaicgeneration system,PVGS）最大程度提高并网点（point of common coupling,PCC）供电质量为目标,提出配电网不同工况与PVGS不同出力下,有功功率、无功功率优化分配的补偿方案,重点讨论PVGS容量、有功出力、系统容量、线路阻抗、最大电流限制因素对并网点电压的影响,对比分析采用不同电压质量补偿方案,PVGS对配电网电压的改善效果。最后通过仿真和实验,采用正负序dq同步旋转坐标下的有功无功解耦独立控制算法验证所提方法的有效性。展开更多
Atomically precise gold(Au)nanoclusters(NCs)as visible light photosensitizers supported on the substrate for photoredox catalysis have attracted considerable attentions.However,eficient control of their photocatalytic...Atomically precise gold(Au)nanoclusters(NCs)as visible light photosensitizers supported on the substrate for photoredox catalysis have attracted considerable attentions.However,eficient control of their photocatalytic activity and long-term stability is still challenging.Herein,we report a coordination-assisted self-assembly strategy in combination with electrostatic interaction to sandwich Au2:(Capt)18(abbreviated as AU25,Capt=captopril)NCs between an inner core and an outer shell made of UiO-66,denoted as UiO-66@Au25@UiO-66.Notably,the sandwich-like nanocomposite displays significantly enhanced catalytic activity along with an excellent stability when used in the selective photocatalytic aerobic oxidation of sulfide to sulfoxide.As comparison,AU25 NCs simply located at the outer surface or insider matrix of UiO-66(short as Au2/UiO-66 and AU2s@UiO-66)show poor stability and low conversion,respectively.This structure regulated difference in the catalytic performances of three nanocomposites is assigned to the varied distribution of active sites(Au NCs)in metal-organic frameworks(MOFs).This work offers the opportunity for application of nanoclusters in catalysis,energy conversion and even biology.展开更多
Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the...Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the clini-cal significance of PGK1 expression and function in cancer progression is unclear.Here,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism regulation.Methods:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas datasets.Using specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer types.Results:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,respectively.In breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor prognosis.Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal cancers.PGK1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach cancer.Conclusions:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer.PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers.展开更多
Inflammatory bowel disease （IBD） is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer （CAC） models induced using both dextran sulf...Inflammatory bowel disease （IBD） is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer （CAC） models induced using both dextran sulfate sodium （DSS） and the azoxymethane/DSS protocol were established in wild-type （WT） and CTRP4 transgenic （CTRP4-tg） C57BL6/J mice. Body weight, stool consistency and the presence of blood in the stool were analyzed; tumor quantity, size and histological characteristics were analyzed during the development of CAC. The CTRP4-tg mice exhibited significantly reduced colitis and developed far fewer macroscopic tumors; these tumors were smaller in size, and a majority of the colon tumors in these mice were restricted to the superficial mucosa. Tumors of lower grades were observed in the CTRP4-tg mice. Interleukin-6 was markedly downregulated in the CTRP4-tg mice during CAC tumorigenesis. The phosphorylation of ERK, signal transducer and activator of transcription 3 and Akt in the colon and the proliferation of intestinal epithelial cells were decreased in the CTRP4-tg mice. The injection of recombinant CTRP4 protein significantly reduced the colitis symptoms of the WT mice. CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis, and our research may provide a novel method for the treatment of IBD and CAC.展开更多
文摘针对配电网中突出存在的电压暂降与电压不平衡的电压质量问题,以光伏发电系统（photovoltaicgeneration system,PVGS）最大程度提高并网点（point of common coupling,PCC）供电质量为目标,提出配电网不同工况与PVGS不同出力下,有功功率、无功功率优化分配的补偿方案,重点讨论PVGS容量、有功出力、系统容量、线路阻抗、最大电流限制因素对并网点电压的影响,对比分析采用不同电压质量补偿方案,PVGS对配电网电压的改善效果。最后通过仿真和实验,采用正负序dq同步旋转坐标下的有功无功解耦独立控制算法验证所提方法的有效性。
基金the National Key Basic Research Program of China(No.2016YFA0200700,Z.Y.T)the National Natural Science Foundation of China(Nos.21890381 and 21721002,Z.Y.T)+1 种基金Frontier Science Key Project of Chinese Academy of Sciences(No.QYZDJ-SSW-SLH038,Z.Y.T)K.C.Wong Education Foundation(Z.Y.T).
文摘Atomically precise gold(Au)nanoclusters(NCs)as visible light photosensitizers supported on the substrate for photoredox catalysis have attracted considerable attentions.However,eficient control of their photocatalytic activity and long-term stability is still challenging.Herein,we report a coordination-assisted self-assembly strategy in combination with electrostatic interaction to sandwich Au2:(Capt)18(abbreviated as AU25,Capt=captopril)NCs between an inner core and an outer shell made of UiO-66,denoted as UiO-66@Au25@UiO-66.Notably,the sandwich-like nanocomposite displays significantly enhanced catalytic activity along with an excellent stability when used in the selective photocatalytic aerobic oxidation of sulfide to sulfoxide.As comparison,AU25 NCs simply located at the outer surface or insider matrix of UiO-66(short as Au2/UiO-66 and AU2s@UiO-66)show poor stability and low conversion,respectively.This structure regulated difference in the catalytic performances of three nanocomposites is assigned to the varied distribution of active sites(Au NCs)in metal-organic frameworks(MOFs).This work offers the opportunity for application of nanoclusters in catalysis,energy conversion and even biology.
基金This study was funded by The National Key R&D Program of China(2017YFC1308702,2017YFC1311000,2018YFC1312100)the Beijing Municipal Science&Technology Commission(Z181100006218032,Z181100001918002)+1 种基金the CAMS Initiative for Innovative Medicine(2017-I2M-1-005,2017-I2M-2-003,2019-I2M-2-002)Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2017PT32001,2017PT32017).
文摘Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the clini-cal significance of PGK1 expression and function in cancer progression is unclear.Here,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism regulation.Methods:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas datasets.Using specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer types.Results:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,respectively.In breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor prognosis.Positively correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal cancers.PGK1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach cancer.Conclusions:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of cancer.PGK1 and PDHK1 phosphorylation may be potential prognostic biomarkers.
文摘Inflammatory bowel disease （IBD） is an important factor in the induction of colon cancer, but its mechanism is unclear. Colitis and colitis-associated colorectal cancer （CAC） models induced using both dextran sulfate sodium （DSS） and the azoxymethane/DSS protocol were established in wild-type （WT） and CTRP4 transgenic （CTRP4-tg） C57BL6/J mice. Body weight, stool consistency and the presence of blood in the stool were analyzed; tumor quantity, size and histological characteristics were analyzed during the development of CAC. The CTRP4-tg mice exhibited significantly reduced colitis and developed far fewer macroscopic tumors; these tumors were smaller in size, and a majority of the colon tumors in these mice were restricted to the superficial mucosa. Tumors of lower grades were observed in the CTRP4-tg mice. Interleukin-6 was markedly downregulated in the CTRP4-tg mice during CAC tumorigenesis. The phosphorylation of ERK, signal transducer and activator of transcription 3 and Akt in the colon and the proliferation of intestinal epithelial cells were decreased in the CTRP4-tg mice. The injection of recombinant CTRP4 protein significantly reduced the colitis symptoms of the WT mice. CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis, and our research may provide a novel method for the treatment of IBD and CAC.
文摘目的了解中小学生焦虑干扰生活程度现状及其心理社会影响因素,为明确中小学健康教育工作方向和重点提供依据。方法 2016年1-6月采取随机整群抽样方法,抽取河南省3 573名小学生和2 748名初中生完成儿童焦虑干扰生活量表(Child Anxiety Life Interference Scale, CALIS)、青少年心理韧性量表(Resilience Scale of Chinese Adolescents, RSCA)、领悟社会支持量表(Perceived Social Support Scale, PSSS)、自尊问卷(Self-esteem Scale, SES)、一般自我效能感量表(General Self-efficacy Scale, GSES)。结果焦虑干扰生活程度在不同性别、学段、焦虑程度、父亲受教育水平、母亲受教育水平的中小学生中差异均有统计学意义(t/F值分别为2.07,-2.29,119.93,13.38,9.65,P值均<0.05);焦虑干扰生活程度与心理弹性、社会支持、自我效能感等心理社会因素均呈负相关(r值分别为-0.25,-0.09,-0.12,P值均<0.01),与自尊呈正相关(r=0.23,P<0.01);线性回归分析结果显示,心理弹性(β=-0.21)负向预测焦虑干扰生活程度,自尊(β=0.13)、社会支持(β=0.06)均正向预测焦虑干扰生活程度。结论中小学生生活受焦虑干扰程度较严重,心理弹性是影响中小学生焦虑干扰生活程度的主要心理社会因素。
