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ER和PR阴性乳腺癌雄激素受体与HER2表达相关性及其临床意义 被引量:22
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作者 吴晶晶 张妍 +4 位作者 林琳 陈雄 解方为 欧阳学农 陈曦 《中华肿瘤防治杂志》 CAS 北大核心 2016年第23期1544-1549,共6页
目的激素受体阴性(ER-/PR-)乳腺癌具有明显的肿瘤异质性,临床治疗手段相对有限。本研究探讨激素受体阴性乳腺癌组织中,雄激素受体(androgen receptor,AR)和HER2表达的相关性,及其与临床病理参数和预后的相关性。方法收集中国人民解放军... 目的激素受体阴性(ER-/PR-)乳腺癌具有明显的肿瘤异质性,临床治疗手段相对有限。本研究探讨激素受体阴性乳腺癌组织中,雄激素受体(androgen receptor,AR)和HER2表达的相关性,及其与临床病理参数和预后的相关性。方法收集中国人民解放军福州总医院经手术治疗并病理确诊的乳腺癌120例,中位年龄52岁。采用FISH法检测收集的激素受体阴性乳腺癌组织HER2/neu基因状态,分为HER2阳性(HER2过表达组)和HER2阴性(三阴组)两组,每组60例。并采用EliVisionTMplus免疫组化法检测AR、Ki-67、EGFR表达,分析HER2和AR表达与临床病理参数、3年无病生存期(disease free survival,DFS)的相关性。结果 AR在激素受体阴性乳腺癌组织阳性率为61.67%(74/120),HER2过表达组和三阴组分别为73.33%(44/60)和50.00%(30/60)。激素受体阴性乳腺癌组织中,AR表达与月经状态、肿瘤大小、组织学分级、EGFR表达及HER2状态相关,均P值<0.05;在HER2过表达组中,AR表达与月经状态、淋巴结受累、EGFR表达相关,均P值<0.05;三阴组中,AR表达与肿瘤大小和组织学分级相关,均P值<0.05。Kaplan-Meier法分析显示,HER2过表达组中AR表达与患者的3年DFS呈正相关,P<0.05;Cox回归法分析结果示,肿瘤大小、淋巴结受累、EGFR表达、AR表达均与患者的3年DFS有关,P<0.05。结论 AR可能成为筛选激素受体阴性乳腺癌高危人群和预测其预后的辅助指标之一,可作为激素受体阴性乳腺癌的新治疗靶点,为不同HER2状态乳腺癌治疗提供新思路。 展开更多
关键词 乳腺癌 ER PR AR HER2 无病生存期
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Hydrodynamic Analogy to Special Relativity
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作者 xue-nong chen 《World Journal of Mechanics》 2016年第10期406-418,共13页
By studying of a slender body moving in a fluid wave-medium, e.g., in air or in shallow water, it was found that the hydrodynamic momentum mass and the total energy of the fluid field can be expressed in forms of and ... By studying of a slender body moving in a fluid wave-medium, e.g., in air or in shallow water, it was found that the hydrodynamic momentum mass and the total energy of the fluid field can be expressed in forms of and E=mc<sup>2</sup>, where v is the body moving speed, c is the wave speed and is the hydrodynamic mass at the zero speed. Thus a hydrodynamic analogy to the relativistic particle motion in vacuum can be traced. The velocity dependence of mass and the mass-energy equivalence are universal for any wave medium, which should not be regarded as a consequence of relative Lorentz time-space, but one of the existence of wave in the medium. Its further inference leads to an even more significant physical picture. If the mass particle moves in an unbounded space at a supercritical speed, i.e. , waves are generated and radiated from it, like the Mach waves by the supersonic plane, and the particle itself experiences a resistance as reaction from the wave radiation. By an extension of this analogy, it can be interred from a hydrodynamic superconductive phenomenon that particles or waves can move possibly at a superluminal speed without experiencing any resistance through a tunnel (a bounded space) under certain conditions. Therefore the speed of light is not the limit of our physical world and superluminal phenomena are possible. 展开更多
关键词 Hydrodynamic Mass Water Waves Special Relativity Velocity Dependence of Mass Mass-Energy Equivalence
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