AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wu...AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wuhan,China.METHODS In this cross-sectional study,a total of 358 consecutive patients with GERD were enrolled in Wuhan,China,of which 176 subjects had complaints of chest pain.Those with chest pain underwent coronary angiography and were divided into a CCP group(52 cases)and NCCP group(124 cases).Validated GERD questionnaires were completed,and the 36-item Short-Form Health Survey and Hospital Anxiety/Depression Scale were used for evaluation of Qo L and psychological symptoms,respectively.RESULTS There were similar ratios and levels of depression and anxiety in GERD with NCCP and CCP.However,the QoL was obviously lower in GERD with CCP than NCCP(48.34±17.68 vs 60.21±20.27,P<0.01).In the GERD-NCCP group,rather than the GERD-CCP group,the physical and mental QoL were much poorer in subjects with depression and/or anxiety than those without anxiety or depression.Anxiety and depression had strong negative correlations with both physical and mental health in GERD-NCCP(all P<0.01),but only a weak relationship with mental components of QoL in GERD-CCP.CONCLUSION High levels of anxiety and depression may be more related to the poorer QoL in GERD patients with NCCP than those with CCP.This highlights the importance of evaluation and management of psychological impact for improving QoL in GERD-NCCP patients.展开更多
Background:Although congenital hypothyroidism(CH)has been widely studied in Western countries,CH incidence at different administrative levels in China during the past decade remains unknown.This study aimed to update ...Background:Although congenital hypothyroidism(CH)has been widely studied in Western countries,CH incidence at different administrative levels in China during the past decade remains unknown.This study aimed to update the incidence and revealed the spatial pattern of CH incidence in the mainland of China,which could be helpful in the planning and implementation of preventative measures.Methods:The data used in our study were derived from 245 newborns screening centers that cover 30 provinces of the Chinese Newborn Screening Information System.Spatial auto-correlation was analyzed by Global Moran I and Getis-Ord Gi statistics at the provincial level.Kriging interpolation methods were applied to estimate a further detailed spatial distribution of CH incidence at city level throughout the mainland of China,and Kulldorff space scanning statistical methods were used to identify the spatial clusters of CH cases at the city level.Results:A total of 91,921,334 neonates were screened from 2013 to 2018 and 42,861 cases of primary CH were identified,yielding an incidence of 4.66 per 10,000 newborns screened(95%confidence interval[CI]:4.62–4.71).Neonates in central(risk ratio[RR]=0.84,95%CI:0.82–0.85)and western districts(RR=0.71,95%CI:0.69–0.73)had lower probability of CH cases compared with the eastern region.The CH incidence indicated a moderate positive global spatial autocorrelation(Global Moran I value=0.394,P<0.05),and the CH cases were significantly clustered in spatial distribution.A most likely city-cluster(log-likelihood ratio[LLR]=588.82,RR=2.36,P<0.01)and 25 secondary city-clusters of high incidence were scanned.The incidence of each province and each city in the mainland of China was estimated by kriging interpolation,revealing the most affected province and city to be Zhejiang Province and Hangzhou city,respectively.Conclusion:This study offers an insight into the space clustering of CH incidence at provincial and city scales.Future work on environmental factors need to focus on the effects of CH occurren展开更多
目的以宏基因组学为技术手段,了解温州口岸在进口南非盐湿牛皮上检疫发现的无色扇头蜱体内微生物群落结构特征,及抗生素抗性基因(ARGs)、毒力因子携带情况。方法将截获的蜱随机分成5份,经HiPure Bacterial DNA Kits提取DNA后,采用高通...目的以宏基因组学为技术手段,了解温州口岸在进口南非盐湿牛皮上检疫发现的无色扇头蜱体内微生物群落结构特征,及抗生素抗性基因(ARGs)、毒力因子携带情况。方法将截获的蜱随机分成5份,经HiPure Bacterial DNA Kits提取DNA后,采用高通量测序的方法,分析其微生物群落结构、致病菌、抗生素抗性基因及毒力因子。结果5份样本微生物组成相似。在门水平上,均以厚壁菌门、变形菌门为主要菌门。其中厚壁菌门丰度最高,占全部门的66.00%以上。在属水平上,均以链球菌属(>55.30%)、芽孢杆菌属(>11.20%)为优势菌属。在全部蜱样本中均检测到变形链球菌、蜡样芽孢杆菌、肠沙门菌、肺炎链球菌等常见条件致病菌,占注释总水平的71.00%以上。抗性基因分析发现蜱样本含有Acr,bacA,mdtK,arnA,mdtH等16种抗性基因,其中Acr丰度最高(30.19%),其次是bacA(20.75%)。这些抗性基因分别介导对大环内酯类、氨基糖苷类、β-内酰胺酶、甘氨酰环素、吖啶黄素等多种抗菌药物的耐药。细菌毒力因子数据库(VFDB)注释分析发现蜱样本共有3923个毒力基因,主要与黏附(22.66%)、分泌系统(13.97%)、侵袭(13.56%)等毒力因子相关。结论无色扇头蜱体内病原体种类较多,检出肠沙门菌等危害较大的致病菌,同时携带大量抗生素抗性基因及毒力因子,因此相关部门及一线从业人员应注意防控跨境蜱传疾病传入,防止对我国公共卫生造成影响。展开更多
基金the Key Clinical Construction Projects of Gastroenterology of the National Health and Family Planning Commission of China
文摘AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wuhan,China.METHODS In this cross-sectional study,a total of 358 consecutive patients with GERD were enrolled in Wuhan,China,of which 176 subjects had complaints of chest pain.Those with chest pain underwent coronary angiography and were divided into a CCP group(52 cases)and NCCP group(124 cases).Validated GERD questionnaires were completed,and the 36-item Short-Form Health Survey and Hospital Anxiety/Depression Scale were used for evaluation of Qo L and psychological symptoms,respectively.RESULTS There were similar ratios and levels of depression and anxiety in GERD with NCCP and CCP.However,the QoL was obviously lower in GERD with CCP than NCCP(48.34±17.68 vs 60.21±20.27,P<0.01).In the GERD-NCCP group,rather than the GERD-CCP group,the physical and mental QoL were much poorer in subjects with depression and/or anxiety than those without anxiety or depression.Anxiety and depression had strong negative correlations with both physical and mental health in GERD-NCCP(all P<0.01),but only a weak relationship with mental components of QoL in GERD-CCP.CONCLUSION High levels of anxiety and depression may be more related to the poorer QoL in GERD patients with NCCP than those with CCP.This highlights the importance of evaluation and management of psychological impact for improving QoL in GERD-NCCP patients.
基金supported by a grant from the National Key Research and Development Program of China(No.2017YFC1001700).
文摘Background:Although congenital hypothyroidism(CH)has been widely studied in Western countries,CH incidence at different administrative levels in China during the past decade remains unknown.This study aimed to update the incidence and revealed the spatial pattern of CH incidence in the mainland of China,which could be helpful in the planning and implementation of preventative measures.Methods:The data used in our study were derived from 245 newborns screening centers that cover 30 provinces of the Chinese Newborn Screening Information System.Spatial auto-correlation was analyzed by Global Moran I and Getis-Ord Gi statistics at the provincial level.Kriging interpolation methods were applied to estimate a further detailed spatial distribution of CH incidence at city level throughout the mainland of China,and Kulldorff space scanning statistical methods were used to identify the spatial clusters of CH cases at the city level.Results:A total of 91,921,334 neonates were screened from 2013 to 2018 and 42,861 cases of primary CH were identified,yielding an incidence of 4.66 per 10,000 newborns screened(95%confidence interval[CI]:4.62–4.71).Neonates in central(risk ratio[RR]=0.84,95%CI:0.82–0.85)and western districts(RR=0.71,95%CI:0.69–0.73)had lower probability of CH cases compared with the eastern region.The CH incidence indicated a moderate positive global spatial autocorrelation(Global Moran I value=0.394,P<0.05),and the CH cases were significantly clustered in spatial distribution.A most likely city-cluster(log-likelihood ratio[LLR]=588.82,RR=2.36,P<0.01)and 25 secondary city-clusters of high incidence were scanned.The incidence of each province and each city in the mainland of China was estimated by kriging interpolation,revealing the most affected province and city to be Zhejiang Province and Hangzhou city,respectively.Conclusion:This study offers an insight into the space clustering of CH incidence at provincial and city scales.Future work on environmental factors need to focus on the effects of CH occurren
文摘目的以宏基因组学为技术手段,了解温州口岸在进口南非盐湿牛皮上检疫发现的无色扇头蜱体内微生物群落结构特征,及抗生素抗性基因(ARGs)、毒力因子携带情况。方法将截获的蜱随机分成5份,经HiPure Bacterial DNA Kits提取DNA后,采用高通量测序的方法,分析其微生物群落结构、致病菌、抗生素抗性基因及毒力因子。结果5份样本微生物组成相似。在门水平上,均以厚壁菌门、变形菌门为主要菌门。其中厚壁菌门丰度最高,占全部门的66.00%以上。在属水平上,均以链球菌属(>55.30%)、芽孢杆菌属(>11.20%)为优势菌属。在全部蜱样本中均检测到变形链球菌、蜡样芽孢杆菌、肠沙门菌、肺炎链球菌等常见条件致病菌,占注释总水平的71.00%以上。抗性基因分析发现蜱样本含有Acr,bacA,mdtK,arnA,mdtH等16种抗性基因,其中Acr丰度最高(30.19%),其次是bacA(20.75%)。这些抗性基因分别介导对大环内酯类、氨基糖苷类、β-内酰胺酶、甘氨酰环素、吖啶黄素等多种抗菌药物的耐药。细菌毒力因子数据库(VFDB)注释分析发现蜱样本共有3923个毒力基因,主要与黏附(22.66%)、分泌系统(13.97%)、侵袭(13.56%)等毒力因子相关。结论无色扇头蜱体内病原体种类较多,检出肠沙门菌等危害较大的致病菌,同时携带大量抗生素抗性基因及毒力因子,因此相关部门及一线从业人员应注意防控跨境蜱传疾病传入,防止对我国公共卫生造成影响。
