期刊文献+
共找到89篇文章
< 1 2 5 >
每页显示 20 50 100
青少年清晨型-夜晚型偏好与抑郁症状的关系:一个链式中介模型 被引量:19
1
作者 石绪亮 范方 +1 位作者 曾彦莹 朱亚 《中国临床心理学杂志》 CSSCI CSCD 北大核心 2019年第6期1242-1245,共4页
目的:探讨睡眠质量与情绪调节困难在青少年的清晨型-夜晚型偏好与抑郁症状间的链式中介作用。方法:采用复合清晨型问卷、匹兹堡睡眠质量指数量表、情绪调节困难量表和抑郁症状筛查量表对462名青少年进行追踪调查。结果:①相关分析显示,... 目的:探讨睡眠质量与情绪调节困难在青少年的清晨型-夜晚型偏好与抑郁症状间的链式中介作用。方法:采用复合清晨型问卷、匹兹堡睡眠质量指数量表、情绪调节困难量表和抑郁症状筛查量表对462名青少年进行追踪调查。结果:①相关分析显示,青少年的清晨型-夜晚型偏好、睡眠质量、情绪调节困难和抑郁症状之间相关显著。②路径分析表明,在控制住性别和T1阶段的抑郁症状后,T1阶段的清晨型-夜晚型偏好对T4阶段抑郁症状的直接预测效应不显著;T2阶段的睡眠质量在T1阶段的清晨型-夜晚型偏好和T4阶段的抑郁症状间起中介作用;T2阶段的睡眠质量和情绪调节困难在T1阶段的清晨型-夜晚型偏好和T4阶段的抑郁症状间起链式中介作用。结论:睡眠质量和情绪调节困难在青少年清晨型-夜晚型偏好与抑郁症状之间起链式中介作用。 展开更多
关键词 清晨型-夜晚型偏好 抑郁症状 睡眠质量 情绪调节困难
原文传递
Prospective study of light dark matter search with a newly proposed DarkSHINE experiment
2
作者 Jing Chen Ji-Yuan Chen +31 位作者 Jun-Feng Chen Xiang Chen Chang-Bo Fu Jun Guo Le He Zheng-Ting He Kim Siang Khaw Jia-Lin Li liang Li Shu Li Meng Lv Dan-Ning Liu Han-Qing Liu Kun Liu Qi-Bin Liu Yang Liu Ze-Jia Lu Cen Mo Si-Yuan Song Xiao-Long Wang Yu-Feng Wang Zhen Wang Zi-Rui Wang Wei-Hao Wu Dao Xiang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao xu-liang Zhu Chun-Xiang Zhu Yi-fan Zhu 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2023年第1期124-138,共15页
Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary ap... Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models. 展开更多
关键词 dark matter dark photon electron-on-target experiment
原文传递
The dying accretion and jet in a powerful radio galaxy of Hercules A 被引量:3
3
作者 Lin-Hui Wu Qing-Wen Wu +2 位作者 Jian-Chao Feng Ru-Sen Lu xu-liang fan 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2020年第8期193-200,共8页
Hercules A(Her A)is one of a rare class of dying and transition-type objects,which has a pair of giant,powerful radio lobes and a weak radio core.We reduce and analyze the radio data of Her A that were observed by the... Hercules A(Her A)is one of a rare class of dying and transition-type objects,which has a pair of giant,powerful radio lobes and a weak radio core.We reduce and analyze the radio data of Her A that were observed by the Expanded Very Large Array(EVLA)during 2010-2011 at C band.The intensity distribution is very smooth along the edge of the lobe front and the intensity also sharply decreases at the edge,which supports that magnetic fields may play an important role in radio lobes.The spectrum of the weak core is very steep and the core flux becomes weaker by about ten percent when compared to what was observed twenty years ago,which suggest that the central engine is still dying quickly.Her A deviates a lot from the relation between[O III]luminosity and low-frequency 178 MHz luminosity(LO III-L178 MHz)as defined by other FR I/II sources.However,when only radio core emission is considered,it roughly follows an LO III-L178 MHzcorrelation.This result supports that the black-hole accretion and large-scale jet in Her A did not evolve simultaneously,and indicates that although the large-scale jet is still powerful,the accretion and inner jet have changed into an inactive state.Based on the estimated Bondi accretion rate,we model the spectrum of Her A with a radiatively inefficient accretion flow and jet model. 展开更多
关键词 black hole physics galaxies:jets radiation mechanisms:non-thermal galaxies:magnetic fields radio continuum:galaxies
下载PDF
What determines the observational differences of blazars? 被引量:1
4
作者 xu-liang fan Jin-Ming Bai Ji-Rong Mao 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2016年第11期61-70,共10页
We examine the scenario that the Doppler factor determines the observational differences of blazars. Significantly negative correlations are found between the observational synchrotron peak frequency and the Doppler f... We examine the scenario that the Doppler factor determines the observational differences of blazars. Significantly negative correlations are found between the observational synchrotron peak frequency and the Doppler factor. After correcting the Doppler boosting, the intrinsic peak frequency has a tight linear relation with the Doppler factor. It is interesting that this relation is consistent with the scenario that the black hole mass governs both the bulk Lorentz factor and the synchrotron peak frequency. In addition, the distinction between the kinetic jet powers of BL Lac objects and fiat spectrum radio quasars disappears after the boosting factor δ2 is considered. The negative correlation between the peak frequency and the observational isotropic luminosity, known as the blazar sequence, also disappears after the Doppler boosting is corrected. We also find that the correlation between the Compton dominance and the Doppler factor exists for all types of blazars. Therefore, this correlation is unsuitable for examining the external Compton emission dominance. 展开更多
关键词 galaxies: jets - BL Lacertae objects: general - quasars: general - radiation mechanisms:non-thermal
下载PDF
Optical multi-color monitoring of OJ 287 from 2006 to 2012 被引量:1
5
作者 Qian Guo Ding-Rong Xiong +2 位作者 Jin-Ming Bai xu-liang fan Wei-Min Yi 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2017年第8期57-68,共12页
We present our optical multi-color monitoring of the BL Lac object OJ 287 from January 2006to December 2012 in the V,R and I bands.A relatively active state in OJ 287 has been found over all monitored epochs,among whi... We present our optical multi-color monitoring of the BL Lac object OJ 287 from January 2006to December 2012 in the V,R and I bands.A relatively active state in OJ 287 has been found over all monitored epochs,among which the variations of average magnitude in V/R/I bands were measured with ?V=1.956 mag,?R=2.067 mag and ?I=2.115 mag,respectively.No reliable intraday variability is detected,but possible variability is detected on 16 nights.Their relative variation amplitudes fall into the range between 1% and 8%,with the majority between 2% and 4%.No time lags have been detected,but strong correlations exist among light curves in the three wavebands.The bluer-when-brighter trend is dominant over intraday timescales,which supports the shock-in-jet model.When combining with additional V/R band data obtained from SMARTS and the Steward Observatory,we also find a bluer-when-brighter trend over a long-term timescale.Some possible periods of 513,176,36,30,26,17 and 14 d are found in all time-series data sets from 2006 to 2017.Possible explanations about these periods are given. 展开更多
关键词 BL Lacertae objects individual(OJ 287)—galaxies active—galaxies PHOTOMETRY
下载PDF
Migration of a Hem-o-Lok clip to the renal pelvis after laparoscopic partial nephrectomy:A case report
6
作者 Ji Sun Li-Wei Zhao +2 位作者 xu-liang Wang Jia-Guo Huang Yi fan 《World Journal of Clinical Cases》 SCIE 2022年第10期3188-3193,共6页
BACKGROUND Hem-o-Lok clip(HOLC)has been widely used in laparoscopic surgery due to its ease of application and secure clamping,though the rare complications associated with this technique should not be ignored.The rar... BACKGROUND Hem-o-Lok clip(HOLC)has been widely used in laparoscopic surgery due to its ease of application and secure clamping,though the rare complications associated with this technique should not be ignored.The rare complications of laparoscopic partial nephrectomy consist of the clip migrating into the renal pelvis and acting as a nidus for stone formation.CASE SUMMARY The case described here involved a 63-year-old woman who was found with stones in the right kidney and upper ureter during a recent reexamination following laparoscopic partial nephrectomy.We performed percutaneous nephrolithotomy for her,but during the operation,it was found that the center of the stone within the kidney was a HOLC,which was removed with forceps.For this reason,we speculate that the HOLC,which was employed to halt tumor wound bleeding,spontaneously drifted into the renal pelvis and formed kidney stones,with the clip being initially misdiagnosed as a kidney stone.CONCLUSION By reviewing related case reports,we conclude that in order to prevent complications related to HOLC,loose clips should be actively searched for and retrieved from the wound during urinary tract surgery,while the deployment of clips in close proximity of anastomotic stoma of collecting systems should be avoided. 展开更多
关键词 Partial nephrectomy Foreign body stones Hem-o-Lok(surgical instrument) Case report
下载PDF
Microstructure and properties of co-continuous(β-TCP+MgO)/Zn-Mg composite fabricated by suction exsorption for biomedical applications
7
作者 Xiang WANG Qi-dong NIE +3 位作者 xu-liang MA Jin-long fan Ting-liang YAN Xin-lin LI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2017年第9期1996-2006,共11页
The biomedical co-continuous(β-TCP+MgO)/Zn-Mg composite was fabricated by infiltrating Zn-Mg alloy into porousβ-TCP+MgO using suction exsorption technique.The microstructure,mechanical properties and corrosion behav... The biomedical co-continuous(β-TCP+MgO)/Zn-Mg composite was fabricated by infiltrating Zn-Mg alloy into porousβ-TCP+MgO using suction exsorption technique.The microstructure,mechanical properties and corrosion behaviors of the composite were evaluated by means of scanning electron microscopy(SEM),X-ray diffraction(XRD),mechanical testing,electrochemical and immersion test.It was found that the molten Zn-Mg alloy had infiltrated not only into the pores but also into the struts of the porousβ-TCP+MgO scaffold to form a compact composite.The Zn-Mg alloy contacted to theβ-TCP+MgO scaffold closely,and no reaction layer can be found between the alloy and the scaffold.The compressive strength of the composite was as high as244MPa,which was about1000times higher than that of the original porousβ-TCP+MgO scaffold and2/3of the strength of the Zn-Mg bulk alloy.The electrochemical and immersion tests in simulated body fluid(SBF)solution indicated that the corrosion resistance of the composite was better than that of the Zn-Mg bulk alloy.The corrosion products on the composite surface were mainly Zn(OH)2.Appropriate mechanical and corrosion properties indicated that the(β-TCP+MgO)/Zn?Mg composite fabricated by suction exsorption would be a very promising candidate for bone substitute. 展开更多
关键词 (β-TCP+MgO)/Zn-Mg composite microstructure mechanical properties corrosion behavior suction exsorption
下载PDF
The connection between radio and γ-ray emission in Fermi/LAT blazars
8
作者 xu-liang fan Jin-Ming Bai +2 位作者 Hong-Tao Liu liang Chen Neng-Hui Liao 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第11期1475-1485,共11页
We collect the second Large Area Telescope AGN catalog (2LAC) and Monitor of Jets in AGN with VLBA Equipment (MOJAVE) quasi-simultaneous data to investigate the radio-γ connection of blazars. The cross sample con... We collect the second Large Area Telescope AGN catalog (2LAC) and Monitor of Jets in AGN with VLBA Equipment (MOJAVE) quasi-simultaneous data to investigate the radio-γ connection of blazars. The cross sample contains 166 sources. The statistical analysis based on this sample confirms positive correlations between these two bands, but the correlations become weaker as the γ-ray energy increases. The statistical results between various parameters show negative correla- tions of γ-ray photon spectral index with γ-ray loudness for both Flat Spectrum Radio Quasars (FSRQs) and BL Lacertae objects, positive correlations of γ-ray variability index with the γ-ray loudness for FSRQs, a negative correlation of the γ-ray variabil- ity index with the γ-ray photon spectral index for FSRQs, and negative correlations of γ-ray photon spectral index with γ-ray luminosity for FSRQs. These results suggest that the γ-ray variability may be due to changes inside the γ-ray emission region like the injected power, rather than changes in the photon density of the external radiation fields, and the variability amplitude tends to be larger as the γ-rays are closer to the high energy peak of the spectral energy distribution (SED). No correlation of variabil- ity index found for BL Lacertae objects implies that variability behavior may differ below and above the peak energy. 展开更多
关键词 BL Lacertae objects general -- galaxies: jets -- quasars general -- radio continuum galaxies -- gamma rays observations
下载PDF
Constraining evolution of magnetic field strength in the dissipation region of two BL Lac objects
9
作者 xu-liang fan Da-Hai Yan +1 位作者 Qing-Wen Wu xu Chen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第12期351-356,共6页
With the assumption that the optical variability timescale is dominated by the cooling time of the synchrotron process for BL Lac objects,we estimate time dependent magnetic field strength of the emission region for t... With the assumption that the optical variability timescale is dominated by the cooling time of the synchrotron process for BL Lac objects,we estimate time dependent magnetic field strength of the emission region for two BL Lac objects.The average magnetic field strengths are consistent with those estimated from core shift measurement and spectral energy distribution modelling.Variation of magnetic field strength in the dissipation region is discovered.Variability of flux and magnetic field strength shows no clear correlation,which indicates the variation of magnetic field is not the dominant reason of the variability origin.The evolution of magnetic field strength can provide another approach to constrain the energy dissipation mechanism in jets. 展开更多
关键词 BL Lacertae objects:general BL Lacertae objects:individual(S50716+714 BL Lacertae) galaxies:magnetic fields
下载PDF
R-band host galaxy contamination of TeV γ-ray blazar Mrk 501: effects of aperture size and seeing
10
作者 Hai-Cheng Feng Hong-Tao Liu +3 位作者 Ying-He Zhao Jin-Ming Bai fang Wang xu-liang fan 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2018年第2期93-104,共12页
We simulated the R-band contribution of the host galaxy of TeV γ-ray BL Lac object Mrk 501 in different aperture sizes and seeing conditions. An intensive set of observations was acquired with the 1.02m optical teles... We simulated the R-band contribution of the host galaxy of TeV γ-ray BL Lac object Mrk 501 in different aperture sizes and seeing conditions. An intensive set of observations was acquired with the 1.02m optical telescope, managed by Yunnan Observatories, from 2010 May 15 to 18. Based on the host subtraction data usually used in the literature, the subtraction of host galaxy contamination results in significant seeing-brightness correlations. These correlations would lead to illusive large amplitude variations at short timescales, which will mask the intrinsic microvariability, thus giving rise to difficulty in detecting the intrinsic microvariability. Both aperture size and seeing condition influence the flux measurements, but the aperture size impacts the result more significantly. Based on the parameters of an elliptical galaxy provided in the literature, we simulated the host contributions of Mrk 501 in different aperture sizes and seeing conditions. Our simulation data of the host galaxy obviously weaken these significant seeing-brightness correlations for the host-subtracted brightness of Mrk 501, and can help us discover the intrinsic short timescale microvariability. The pure nuclear flux is -8.0 mJy in the R band, i.e., the AGN has a magnitude of R - 13.96 mag. 展开更多
关键词 galaxies: active - BL Lacertae objects: individual (Mrk 501) - techniques: photometric-- methods: data analysis
下载PDF
昼夜节律类型量表中文版在倒班护士中的信效度检验 被引量:18
11
作者 祁海颖 石绪亮 +2 位作者 李琳 杨蕾 范方 《中国临床心理学杂志》 CSSCI CSCD 北大核心 2019年第2期258-262,共5页
目的:对昼夜节律类型量表(Circadian Type Inventory, CTI)进行翻译,并检验其信度和效度。方法:对725名护士进行CTI中文版施测,采用Epworth嗜睡量表(ESS)、Chalder疲劳量表(CFS)及睡眠障碍问卷作为预测效度的效标。结果:探索性因子分析... 目的:对昼夜节律类型量表(Circadian Type Inventory, CTI)进行翻译,并检验其信度和效度。方法:对725名护士进行CTI中文版施测,采用Epworth嗜睡量表(ESS)、Chalder疲劳量表(CFS)及睡眠障碍问卷作为预测效度的效标。结果:探索性因子分析得到灵活性/刚性和困倦/活力两个因子,与英文版量表一致,累计解释量表总方差的48.99%;验证性因子分析表明模型拟合良好(χ~2/df=2.503,CFI=0.939,TLI=0.922,NFI=0.903,IFI=0.939,RMSEA=0.064)。纵向测量等值性检验表明该量表具有跨时间的测量不变性。预测效度检验说明该量表能预测之后的嗜睡、疲乏、失眠等症状。CTI量表总分及其分量表的内部一致性信度在0.60-0.80之间,两周重测信度在0.64-0.73之间。结论:中文版的昼夜节律类型量表在中国倒班护士群体中具有良好的信效度,适宜作为评估个体是否适应倒班工作的有效工具。 展开更多
关键词 昼夜节律类型量表 信度 效度 纵向测量等值性
原文传递
留守儿童心理弹性在不安全依恋与心理健康问题间的纵向中介作用:一项追踪研究 被引量:3
12
作者 石绪亮 李晓萌 +1 位作者 蒋丙翀 范方 《中国临床心理学杂志》 CSCD 北大核心 2023年第6期1375-1379,共5页
目的:探讨留守儿童心理弹性在不安全依恋与内外化问题行为间的纵向中介作用。方法:采用青少年依恋量表、心理弹性量表和长处与困难问卷对湖南省652名留守初中生进行为期三年的3次追踪调查。结果:(1)相关分析显示,留守儿童的不安全依恋(T... 目的:探讨留守儿童心理弹性在不安全依恋与内外化问题行为间的纵向中介作用。方法:采用青少年依恋量表、心理弹性量表和长处与困难问卷对湖南省652名留守初中生进行为期三年的3次追踪调查。结果:(1)相关分析显示,留守儿童的不安全依恋(T_(1))、心理弹性(T_(1)、T_(2))和内外化问题(T_(1)、T_(3))相关显著。(2)路径分析表明,在控制性别、T_(1)阶段的心理弹性和内外化问题后,T_(1)阶段的不安全依恋对内化问题的直接预测效应不显著,但对外化问题的直接预测效应显著;T_(2)阶段的心理弹性在T_(1)阶段的不安全依恋和T_(3)阶段的内外化问题间起中介作用。结论:不安全依恋通过心理弹性的中介作用间接影响留守儿童的内外化问题。 展开更多
关键词 不安全依恋 心理弹性 心理健康 追踪研究 留守儿童
原文传递
睡眠担忧量表在倒班护士群体中的信效度检验 被引量:1
13
作者 石绪亮 乔小飞 +1 位作者 姜亚琦 范方 《中国临床心理学杂志》 CSCD 北大核心 2023年第5期1180-1183,共4页
目的:对睡眠担忧量表(Anxiety and Preoccupation about Sleep Questionnaire, APSQ)进行翻译,并检验其信度和效度。方法:对650名倒班护士进行APSQ中文版施测。采用匹兹堡睡眠质量指数问卷、Epworth嗜睡量表、抑郁症状筛查量表、Chalde... 目的:对睡眠担忧量表(Anxiety and Preoccupation about Sleep Questionnaire, APSQ)进行翻译,并检验其信度和效度。方法:对650名倒班护士进行APSQ中文版施测。采用匹兹堡睡眠质量指数问卷、Epworth嗜睡量表、抑郁症状筛查量表、Chalder疲劳量表和压力感知量表检验效标关联效度。间隔4周后,随机选取65名护士进行APSQ重测,以检验其重测信度。结果:探索性因素分析和验证性因素分析的结果支持APSQ的单因子模型。APSQ的内部一致性系数、分半信度和重测信度分别为0.88、0.92和0.73。APSQ与睡眠问题、嗜睡、抑郁、疲乏感和压力感知存在显著的正相关(0.41~0.62)。结论:中文版睡眠担忧量表的信效度符合心理测量学标准,可应用于倒班护士睡眠障碍的相关研究。 展开更多
关键词 睡眠担忧 效度 信度 倒班护士
原文传递
森林火灾与森林质量——来自集体林权制度改革的证据 被引量:3
14
作者 徐拓远 梁文远 +1 位作者 李凡 刘金龙 《林业经济》 北大核心 2017年第9期81-87,共7页
文章基于2002~2009年中国省级面板数据,结合2003年开展的新一轮集体林权制度改革这一外生政策在省级层面逐步推进的准自然实验特征,运用双重差分模型估计了森林火灾控制水平对森林质量的作用效果,一定程度上克服了以往研究中忽视森林火... 文章基于2002~2009年中国省级面板数据,结合2003年开展的新一轮集体林权制度改革这一外生政策在省级层面逐步推进的准自然实验特征,运用双重差分模型估计了森林火灾控制水平对森林质量的作用效果,一定程度上克服了以往研究中忽视森林火灾控制水平与森林质量二者之间的内生性问题,对模型估计结果进行了稳健性检验。研究结果表明:第一,集体林权制度改革政策能够显著地提高森林质量,平均增长率约为8.970%,但该政策对南北森林质量的提高存在显著差异;第二,集体林权制度改革政策能够显著地降低森林火灾发生次数,全国森林火灾发生次数减幅高达41.8%,其中北方地区森林火灾发生次数减幅为30.7%,南方地区森林火灾发生次数减幅为44.0%;第三,森林火灾发生次数每降低1%,森林质量则相应地提高21.46%,北方地区森林火灾控制对森林质量的作用效果远高于南方地区。 展开更多
关键词 森林火灾 森林质量 集体林权制度改革 双重差分模型
下载PDF
基于磁开关的固态近方波Marx发生器初步模拟设计 被引量:1
15
作者 樊旭亮 孙旭 +1 位作者 潘亚峰 范红艳 《现代应用物理》 2018年第4期76-80,共5页
对基于磁开关Marx发生器的电路结构进行了改造,设计了一种能输出方波脉冲,且结构紧凑、原理简单的电路。对设计的这种输出功率达10GW的近方波Marx发生器进行了模拟研究。结果表明,所设计的脉冲发生器输出脉冲电压接近1MV,前沿约为20ns,... 对基于磁开关Marx发生器的电路结构进行了改造,设计了一种能输出方波脉冲,且结构紧凑、原理简单的电路。对设计的这种输出功率达10GW的近方波Marx发生器进行了模拟研究。结果表明,所设计的脉冲发生器输出脉冲电压接近1MV,前沿约为20ns,半高宽为70ns,发生器全系统无需气体开关。从波形来看,输出脉冲平顶波动小于10%,能够满足实际应用需求。 展开更多
关键词 磁开关 固态 MARX发生器 方波脉冲 可饱和脉冲变压器
下载PDF
三维打印制备不同大孔形态含锶介孔生物玻璃支架的体外细胞实验
16
作者 张旭 吴良浩 +4 位作者 李得见 敖荣广 陈帆成 俞斌 禹宝庆 《中国组织工程研究》 CAS 北大核心 2017年第18期2858-2863,共6页
背景:三维打印支架的大孔孔径形态对生物组织工程支架理化性能及生物性能有很大的影响。目的:利用三维打印技术制备不同大孔结构的含锶介孔生物玻璃支架,探讨其对MC3T3-E1细胞增殖和成骨分化的影响,寻找最佳的大孔形态。方法:利用三维... 背景:三维打印支架的大孔孔径形态对生物组织工程支架理化性能及生物性能有很大的影响。目的:利用三维打印技术制备不同大孔结构的含锶介孔生物玻璃支架,探讨其对MC3T3-E1细胞增殖和成骨分化的影响,寻找最佳的大孔形态。方法:利用三维打印技术制备含锶介孔生物玻璃/聚己内酯复合支架,其中纵横交错的各纤维状经纬线之间的夹角设置为45°,60°和90°,根据其角度命名为45°,60°,90°含锶介孔生物玻璃支架,检测MC3T3-E1细胞在复合支架上的增殖能力和碱性磷酸酶活性。结果与结论:(1)CCK-8方法检测结果表明,3组支架材料都能够支持细胞增殖,第1天和第4天45°含锶介孔生物玻璃支架上的细胞数量略高于60°和90°含锶介孔生物玻璃支架,但差异无显著性意义(P>0.05);第7天45°含锶介孔生物玻璃支架上的细胞数量显著高于60°和90°含锶介孔生物玻璃支架,差异有显著性意义(P<0.05);(2)在第14天,45°含锶介孔生物玻璃支架的细胞碱性磷酸酶活性显著高于60°和90°含锶介孔生物玻璃支架,差异有显著性意意义(P<0.05);在第21天,3组支架的碱性磷酸酶活性差异无显著性意义(P>0.05);(3)结果表明,45°含锶介孔生物玻璃支架相较于60°和90°含锶介孔生物玻璃支架,更能促进MC3T3-E1细胞的增殖和成骨分化。 展开更多
关键词 生物材料 材料相容性 三维打印 生物相容性 含锶介孔生物玻璃 聚己内酯 MC3T3-E1细胞 支架 大孔形态 CCK-8 碱性磷酸酶
下载PDF
西藏生态安全屏障保护与建设工程的宏观生态效应 被引量:26
17
作者 黄麟 曹巍 +2 位作者 徐新良 樊江文 王军邦 《自然资源学报》 CSSCI CSCD 北大核心 2018年第3期398-411,共14页
西藏高原是我国重要的生态屏障、江河源区与生物物种基因库,为了保障其生态功能的持续有效发挥,2008年开始实施西藏高原生态安全屏障保护与建设工程。论文基于工程规划目标,通过对比监测2000—2008年与2008—2015年西藏高原生态系统及... 西藏高原是我国重要的生态屏障、江河源区与生物物种基因库,为了保障其生态功能的持续有效发挥,2008年开始实施西藏高原生态安全屏障保护与建设工程。论文基于工程规划目标,通过对比监测2000—2008年与2008—2015年西藏高原生态系统及其关键服务的时空变化,科学地评估西藏高原生态工程的生态效应。结果表明:工程实施前、后8 a相比,1)西藏高原生态系统格局稳定少动,生态系统宏观状况趋向良性发展。森林面积持续增加,荒漠面积显著减少,水体与湿地面积从减少转变为增加。2)草地退化趋势明显减弱、草地恢复态势显著,退化草地占比下降了19.9%,恢复草地占比增加了33%。植被覆盖度增加趋势明显,平均提高了1.9%,特别是高寒草甸类。草地载畜压力明显减少,牧草供给能力提升,草畜矛盾有所缓解。3)生态系统水源涵养能力增加,碳汇总量略有提高,防风固沙服务能力稳步上升。然而,降雨量增加导致降雨侵蚀力增强,植被覆盖度增加但植被根系土壤层无法短时期内恢复,从而导致土壤保持服务能力有所下降。4)西藏高原的暖湿化气候有利于减缓荒漠化进程并促进生态系统恢复,而生态安全屏障保护与建设工程的实施对西藏高原生态系统服务能力的提升特别是工程区局部生态恢复具有一定的正面作用。 展开更多
关键词 西藏高原 生态工程 宏观结构 生态服务 生态效应
原文传递
经颅直流电刺激联合上肢机器人训练对脑卒中后偏瘫上肢运动功能影响的磁共振弥散张量成像研究 被引量:19
18
作者 杨婷 陈慧柚 +4 位作者 高政 许亮 范吉法 徐晨曦 王晓菊 《中华物理医学与康复杂志》 CAS CSCD 北大核心 2021年第9期781-786,共6页
目的观察经颅直流电刺激(tDCS)结合上肢康复机器人训练对脑卒中偏瘫上肢运动功能的影响,并通过磁共振弥散张量成像(DTI)分析其潜在的神经可塑性机制。方法将脑卒中偏瘫患者20例按随机数字表法分为治疗组和对照组,每组患者10例。2组患者... 目的观察经颅直流电刺激(tDCS)结合上肢康复机器人训练对脑卒中偏瘫上肢运动功能的影响,并通过磁共振弥散张量成像(DTI)分析其潜在的神经可塑性机制。方法将脑卒中偏瘫患者20例按随机数字表法分为治疗组和对照组,每组患者10例。2组患者均给予常规药物和康复治疗,治疗组在此基础上增加tDCS结合上肢康复机器人训练,即在上肢康复机器人训练的同时进行tDCS治疗,tDCS刺激电流在10 s内从0上升到1 mA,保持20 min后,在10 s从1 mA下降到0。DCS结合上肢康复机器人训练每日1次,每次20 min,连续治疗15 d。对照组则仅增加上肢康复机器人训练,tDCS治疗为假刺激。于治疗前和治疗15 d后(治疗后)采用Fugl-Meyer评定量表上肢部分(UE-FMA)和Wolf运动功能评价量表(WMFT)对2组患者的上肢运动功能进行评估。2组患者均于治疗前、后进行DTI检查。结果治疗后,2组患者的UE-FMA和WMFT评分较组内治疗前均显著改善,差异均有统计学意义(P<0.05),且治疗组治疗后的UE-FMA评分为(35.32±13.25)分,显著高于对照组治疗后的(21.80±13.93)分,差异有统计学意义(P<0.05)。治疗后,治疗组内囊后肢层面的FA值、rFA、FAasy和中央前回FA、CST长度与组内治疗前比较,差异均有统计学意义(P<0.05)。结论tDCS结合上肢康复机器人训练可显著改善偏瘫上肢运动功能,这可能是基于促进CST完整性和对称性改变的神经可塑性机制,因此临床上可以将tDCS可作为神经康复中重要的辅助治疗方法。 展开更多
关键词 脑卒中 上肢运动功能 经颅直流电刺激 上肢康复机器人训练 弥散张量成像
原文传递
反应性氧化物、脂联素在慢性乙型肝炎病毒感染合并非酒精性脂肪性肝病中的研究 被引量:19
19
作者 徐亮 钟燕 +9 位作者 苏淑婷 刘勇钢 吕菲南 周小莉 任金晴 李萍 石瑞芳 江勇 范建高 宓余强 《中华肝脏病杂志》 CAS CSCD 北大核心 2020年第3期247-253,共7页
目的探讨反应性氧化物(ROS)、脂联素(ADPN)在慢性乙型肝炎病毒感染合并非酒精性脂肪性肝病(NAFLD)肝脏炎症判断中的应用价值。方法收集2016年6月至2018年12月就诊且经肝组织病理学确诊的NAFLD(21例)、慢性乙型肝炎病毒感染(57例)、慢性... 目的探讨反应性氧化物(ROS)、脂联素(ADPN)在慢性乙型肝炎病毒感染合并非酒精性脂肪性肝病(NAFLD)肝脏炎症判断中的应用价值。方法收集2016年6月至2018年12月就诊且经肝组织病理学确诊的NAFLD(21例)、慢性乙型肝炎病毒感染(57例)、慢性乙型肝炎病毒感染合并NAFLD(81例)共159例患者资料,留取同期血清采用酶联免疫吸附法测定受试者血清ROS、ADPN水平,以肝组织病理检查为金标准,探讨其对慢性乙型肝炎病毒感染合并NAFLD患者发生非酒精性脂肪性肝炎的诊断价值。多组间比较采用单因素方差分析,组间两两比较采用LSD-t检验。对非正态分布的计量资料用M(P25,P75)表示,组间比较采用Mann-Whitney U或Kruskal-Wallis H检验。计数资料组间比较采用卡方检验。相关性分析采用Spearman相关分析。以肝组织病理分组为金标准,应用受试者工作特征曲线下面积评价回归公式的诊断效能。结果(1)慢性乙型肝炎病毒感染合并NAFLD患者中,无肝脂肪变组及轻度肝脂肪变组ROS水平显著低于中、重度肝脂肪变组,而无肝脂肪变组的ADPN水平显著高于肝脂肪变组,P值均<0.05;(2)相关性分析结果显示ROS与NAS积分、肝脂肪变程度、小叶内炎症均显著相关,P值均<0.05;ADPN与肝脂肪变程度呈显著负相关,P<0.05。(3)Logistic回归分析结果显示慢性乙型肝炎病毒感染合并非酒精性脂肪性肝炎的诊断公式:0.02×受控衰减指数+0.584×白细胞/10^9+0.587×ROS-10.982,受试者工作特征曲线下面积=0.896,灵敏度97.1%,特异度71.2%,阳性预测值64.2%,阴性预测值97.9%。结论ADPN、ROS对慢性乙型肝炎病毒感染合并NAFLD的肝脂肪变程度与炎症鉴别具有一定参考价值,慢性乙型肝炎病毒感染合并非酒精性脂肪性肝炎诊断公式则对非酒精性脂肪性肝炎的诊断及排除均具有较高的应用价值。 展开更多
关键词 氧化物 脂联素 肝炎病毒 乙型 脂肪肝 非酒精性 炎症
原文传递
CT平扫漩涡征与黑洞征在预测脑出血早期血肿扩大中的价值研究 被引量:19
20
作者 王业青 时代 +7 位作者 陆宽 金丹 王锐 徐亮 范国华 沈钧康 龚建平 钱铭辉 《中华神经医学杂志》 CAS CSCD 北大核心 2020年第1期29-35,共7页
目的比较CT平扫漩涡征、黑洞征及"漩涡征和黑洞征"在自发性脑出血患者早期血肿扩大中的预测价值。方法选择自2012年1月至2018年12月在苏州大学附属第二医院神经内科首诊并住院治疗的210例自发性脑出血患者进入研究,按照有无... 目的比较CT平扫漩涡征、黑洞征及"漩涡征和黑洞征"在自发性脑出血患者早期血肿扩大中的预测价值。方法选择自2012年1月至2018年12月在苏州大学附属第二医院神经内科首诊并住院治疗的210例自发性脑出血患者进入研究,按照有无出现早期血肿扩大将患者分为血肿扩大组及血肿未扩大组,按照按征象的有无再将患者分为征象阳性组与征象阴性组,分别比较不同组别患者的影像学及临床特征。运用受试者工作特征(ROC)曲线分析漩涡征、黑洞征及"漩涡征和黑洞征"预测早期血肿扩大的准确性,运用多因素Logistic回归分析明确早期血肿扩大的独立危险因素。结果(1)57例早期血肿扩大的患者中,出现漩涡征21例(36.8%),黑洞征17例(29.8%);153例血肿未扩大的患者中,出现漩涡征12例(7.8%),黑洞征22例(14.4%);影像学征象阳性患者比例差异有统计学意义(P<0.05)。与血肿未扩大组患者比较,血肿扩大组患者入院收缩压显著升高,破入脑室者比例显著增多,差异均有统计学意义(P<0.05)。(2)漩涡征阳性(33例)与漩涡征阴性(177例)患者临床及影像学各项指标差异均无统计学意义(P>0.05)。黑洞征阳性患者(39例)的初始血肿量较黑洞征阴性患者(171例)明显增加,差异有统计学意义(P<0.05)。"漩涡征和黑洞征"阳性患者初始血肿量较阴性患者明显增加,差异有统计学意义(P<0.05)。(3)漩涡征、黑洞征及"漩涡征和黑洞征"的ROC曲线下面积分别为0.645、0.577与0.570。(4)多因素Logistic回归分析结果显示,入院收缩压、漩涡征与黑洞征均为早期血肿扩大的独立危险因素(P<0.05)。结论相较于CT平扫黑洞征及"漩涡征和黑洞征",漩涡征在自发性脑出血患者早期血肿扩大中的预测价值更大。 展开更多
关键词 自发性脑出血 血肿扩大 漩涡征 黑洞征
原文传递
上一页 1 2 5 下一页 到第
使用帮助 返回顶部