During the past 30 years （1987-2016）, a great progress has been made in researches of soft-sediment deformation structures （SSDS）, seismites and pataeoearthquakes in China. However, the research thought of this ac...During the past 30 years （1987-2016）, a great progress has been made in researches of soft-sediment deformation structures （SSDS）, seismites and pataeoearthquakes in China. However, the research thought of this academic fietd is not open enough. It is atmost with one viewpoint or one voice, i.e., atmost art the papers pubtished in journals of China considered the layers with SSDS as seismites. On the other hand, the authors are very glad to learn that the professors and students of China University of Petroleum （East China） have proposed different academic viewpoints on the origin of SSDS in Lingshan Istand, Qingdao, Shandong Province, China. It is a very active academic atmosphere. The authors＇ ideas are as follows： （1） The SSDS are sedimentary structures with multi-origin. The term ＂SSDS＂ is a good sedimentary and geological term and shoutd be utilized continuat[y. （2） The term ＂seismites＂ is a term which is definitety assigned to the layers with SSDS induced by earthquakes. It is one type of the tayers with SSDS. It is not equal to SSDS. （3） Some geotogists suggested obsoleting the term ＂seismites＂. These suggestions are rational However, since the term ＂seismites＂ has been utilized for a long time in China and worldwide, to obsolete this term should be discussed and agreement should be acquired from numerous geologists in China and worldwide. It may be suitable that let the geological practice decide whether to obsolete it or not. （4） Hopefully, further progress will be made in the researches of SSDS.展开更多
BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of h...BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs.展开更多
Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus Western medicine in treating patients with diabetic peripheral neuropathy(DPN).Methods:A total of 70 patients with DPN were divided into an...Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus Western medicine in treating patients with diabetic peripheral neuropathy(DPN).Methods:A total of 70 patients with DPN were divided into an observation group and a control group by sealed envelope method combined with the random number table method,with 35 cases in each group.The control group was treated with routine medicine,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control group.After 2 courses of treatment,the scores of Toronto clinical scoring system(TCSS)and vibration perception threshold(VPT)in both groups were observed,and the clinical efficacy was compared.Results:During treatment,3 cases dropped out in the control group and 4 cases in the observation group.After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The scores of TCSS and VPT in both groups decreased after treatment,and the intra-group comparison showed statistical significance(both P<0.05).The scores of TCSS and VPT in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion:Heat-sensitive moxibustion plus Western medicine can improve the symptoms in patients with DPN,and has a better curative effect than the Western medicine alone.展开更多
The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led t...The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an eff ective and rapid detection method.With an increasing number of COVID-19 infections,medical pressure is severe.Therefore,more e fficient and accurate diagnosis methods were keen urgently established.In this review,we summarized several methods that can rapidly and sensitively identify COVID-19;some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries,some diagnostic technologies refer to SARS(Severe Acute Respiratory Syndrome)or/and MERS(Middle East Respiratory Syndrome)detection,which may provide potential diagnosis ideas.展开更多
Bloch surface waves（BSWs） are excited in one-dimensional photonic crystals（Ph Cs） terminated by a graphene monolayer under the Kretschmann configuration. The field distribution and reflectance spectra are numerica...Bloch surface waves（BSWs） are excited in one-dimensional photonic crystals（Ph Cs） terminated by a graphene monolayer under the Kretschmann configuration. The field distribution and reflectance spectra are numerically calculated by the transverse magnetic method under transfer-matrix polarization, while the sensitivity is analyzed and compared with those of the surface plasmon resonance sensing method. It is found that the intensity of magnetic field is considerably enhanced in the region of the terminated layer of the multilayer stacks, and that BSW resonance appears only in the interface of the graphene and solution. Influences of the graphene layers and the thickness of a unit cell in Ph Cs on the reflectance are studied as well. In particular, by analyzing the performance of BSW sensors with the graphene monolayer,the wavelength sensitivity of the proposed sensor is 1040 nm/RIU whereas the angular sensitivity is 25.1°/RIU. In addition,the maximum of figure of merit can reach as high as 3000 RIU^-1. Thus, by integrating graphene in a simple Kretschmann structure, one can obtain an enhancement of the light–graphene interaction, which is prospective for creating label-free,low-cost and high-sensitivity optical biosensors.展开更多
文摘During the past 30 years （1987-2016）, a great progress has been made in researches of soft-sediment deformation structures （SSDS）, seismites and pataeoearthquakes in China. However, the research thought of this academic fietd is not open enough. It is atmost with one viewpoint or one voice, i.e., atmost art the papers pubtished in journals of China considered the layers with SSDS as seismites. On the other hand, the authors are very glad to learn that the professors and students of China University of Petroleum （East China） have proposed different academic viewpoints on the origin of SSDS in Lingshan Istand, Qingdao, Shandong Province, China. It is a very active academic atmosphere. The authors＇ ideas are as follows： （1） The SSDS are sedimentary structures with multi-origin. The term ＂SSDS＂ is a good sedimentary and geological term and shoutd be utilized continuat[y. （2） The term ＂seismites＂ is a term which is definitety assigned to the layers with SSDS induced by earthquakes. It is one type of the tayers with SSDS. It is not equal to SSDS. （3） Some geotogists suggested obsoleting the term ＂seismites＂. These suggestions are rational However, since the term ＂seismites＂ has been utilized for a long time in China and worldwide, to obsolete this term should be discussed and agreement should be acquired from numerous geologists in China and worldwide. It may be suitable that let the geological practice decide whether to obsolete it or not. （4） Hopefully, further progress will be made in the researches of SSDS.
基金Supported by Chinese Ministry of Science and Technology Grants the Major Science and Technology Special Project Fund Scheme,No.2013ZX10005002Beijing the Special Clinical Application Research and Translational Grants,No.Z151100004015221
文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs.
文摘Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus Western medicine in treating patients with diabetic peripheral neuropathy(DPN).Methods:A total of 70 patients with DPN were divided into an observation group and a control group by sealed envelope method combined with the random number table method,with 35 cases in each group.The control group was treated with routine medicine,and the observation group was treated with heat-sensitive moxibustion on the basis of the treatment in the control group.After 2 courses of treatment,the scores of Toronto clinical scoring system(TCSS)and vibration perception threshold(VPT)in both groups were observed,and the clinical efficacy was compared.Results:During treatment,3 cases dropped out in the control group and 4 cases in the observation group.After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The scores of TCSS and VPT in both groups decreased after treatment,and the intra-group comparison showed statistical significance(both P<0.05).The scores of TCSS and VPT in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion:Heat-sensitive moxibustion plus Western medicine can improve the symptoms in patients with DPN,and has a better curative effect than the Western medicine alone.
基金The Shandong Natural Science Foundation(ZR2018ZC0233)the Taishan Scholar Program at Shandong Province。
文摘The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an eff ective and rapid detection method.With an increasing number of COVID-19 infections,medical pressure is severe.Therefore,more e fficient and accurate diagnosis methods were keen urgently established.In this review,we summarized several methods that can rapidly and sensitively identify COVID-19;some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries,some diagnostic technologies refer to SARS(Severe Acute Respiratory Syndrome)or/and MERS(Middle East Respiratory Syndrome)detection,which may provide potential diagnosis ideas.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61203211 and 41675154)the Six Major Talent Peak Expert of Jiangsu Province,China(Grant No.2015-XXRJ-014)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20141483)
文摘Bloch surface waves（BSWs） are excited in one-dimensional photonic crystals（Ph Cs） terminated by a graphene monolayer under the Kretschmann configuration. The field distribution and reflectance spectra are numerically calculated by the transverse magnetic method under transfer-matrix polarization, while the sensitivity is analyzed and compared with those of the surface plasmon resonance sensing method. It is found that the intensity of magnetic field is considerably enhanced in the region of the terminated layer of the multilayer stacks, and that BSW resonance appears only in the interface of the graphene and solution. Influences of the graphene layers and the thickness of a unit cell in Ph Cs on the reflectance are studied as well. In particular, by analyzing the performance of BSW sensors with the graphene monolayer,the wavelength sensitivity of the proposed sensor is 1040 nm/RIU whereas the angular sensitivity is 25.1°/RIU. In addition,the maximum of figure of merit can reach as high as 3000 RIU^-1. Thus, by integrating graphene in a simple Kretschmann structure, one can obtain an enhancement of the light–graphene interaction, which is prospective for creating label-free,low-cost and high-sensitivity optical biosensors.
