Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone...Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated.Compared with the binary Mg-2Sr alloys,the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance.Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation.The in vivo corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr.The in vitro cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy.Furthermore,these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.展开更多
Quantum information processing based on Rydberg atoms emerged as a promising direction two decades ago.Recent experimental and theoretical progresses have shined exciting light on this avenue.In this concise review,we...Quantum information processing based on Rydberg atoms emerged as a promising direction two decades ago.Recent experimental and theoretical progresses have shined exciting light on this avenue.In this concise review,we will briefly introduce the basics of Rydberg atoms and their recent applications in associated areas of neutral atom quantum computation and simulation.We shall also include related discussions on quantum optics with Rydberg atomic ensembles,which are increasingly used to explore quantum computation and quantum simulation with photons.展开更多
Magnesium alloys have shown prospective applications as a new biodegradable metal within bone. To garantee the longterm biocompatibility, a Mg-Zn-Ca alloy,composing of essential elements for human, was prepared and it...Magnesium alloys have shown prospective applications as a new biodegradable metal within bone. To garantee the longterm biocompatibility, a Mg-Zn-Ca alloy,composing of essential elements for human, was prepared and its feasibility for orthopedic applications was investigated. The in vitro and in vivo corrosion of Mg-Zn-Ca alloy as well as the biocompatibility were studied. The in vitro corrosion tests in five kinds of physiological solutions showed that the corrosion rates and corrosion morphologies of the alloy were strongly influenced by the solution used. The addition of serum in Hank’s and MEM significantly slowed down the corrosion rate and improved the corrosion uniformity of the alloy. The corrosion rate decreased with increasing serum concentration.The alloy showed the slowest corrosion rate as well as homogeneous corrosion morphology in MEM＋10%FBS. Both the indirect and direct cell experiments indicated good cytocompatibility of the extruded Mg-Zn-Ca alloy. In vivo, we observed a gradual degradation process from the surface of extruded Mg-Zn-Ca alloy and only 40% in volume of implant was left after 4 weeks implantation in medullary cavities of mice. The micro-CT and histological analyses revealed its good biocompatibility with peri-implant new bone formation and increasing cortical bone thickness with increasing implantation period. This study showed that the extruded MgZn-Ca alloy provided sufficient biocompatibility for orthopedic application, though the in vivo corrosion rate should be further reduced for clinical use.展开更多
ABSTRACT Embedding submicrocavities is an effective approach to improve the light out-coupling efficiency(LOCE)for planar perovskite light-emitting diodes(PeLEDs).In this work,we employ phenethylammonium iodide(PEAI)t...ABSTRACT Embedding submicrocavities is an effective approach to improve the light out-coupling efficiency(LOCE)for planar perovskite light-emitting diodes(PeLEDs).In this work,we employ phenethylammonium iodide(PEAI)to trigger the Ostwald ripening for the downward recrystallization of perovskite,resulting in spontaneous formation of buried submicrocavities as light output coupler.The simulation suggests the buried submicrocavities can improve the LOCE from 26.8 to 36.2%for near-infrared light.Therefore,PeLED yields peak external quantum efficiency(EQE)increasing from 17.3%at current density of 114 mA cm^(−2)to 25.5%at current density of 109 mA cm^(−2)and a radiance increasing from 109 to 487 W sr^(−1)m^(−2)with low rolling-off.The turn-on voltage decreased from 1.25 to 1.15 V at 0.1 W sr^(−1)m^(−2).Besides,downward recrystallization process slightly reduces the trap density from 8.90×10^(15)to 7.27×10^(15)cm^(−3).This work provides a self-assembly method to integrate buried output coupler for boosting the performance of PeLEDs.展开更多
In the present study, microstructure and texture of drawn copper wires with a large number of transverse grain boundaries have been characterized and their mechanical properties have been analyzed. The results show th...In the present study, microstructure and texture of drawn copper wires with a large number of transverse grain boundaries have been characterized and their mechanical properties have been analyzed. The results show that the texture evolution is accelerated by transverse grain boundary and the saturation value 60% of volume fraction of 〈111〉 fiber texture component is reached rapidly with increasing strain. For the microstructure of drawn wires with a large number of transverse grain boundaries, the critical strain, where lamellar boundaries form, is less than that for wires with equiaxed grains or columnar grains （all grain boundaries parallel to axis direction）. Since transverse grain boundary accelerates grain subdivision and dislocation density increases rapidly in drawn wires with a large number of transverse grain boundaries, there are a higher flow stress and a higher work hardening rate.展开更多
Objective: The aim of this retrospective study was to evaluate diagnostic accuracy of serum thyroglobulin antibody (TgAb) in thyroglobulin (Tg)-negative and TgAb-positive (Tg<sup>-</sup>TgAb<sup>+<...Objective: The aim of this retrospective study was to evaluate diagnostic accuracy of serum thyroglobulin antibody (TgAb) in thyroglobulin (Tg)-negative and TgAb-positive (Tg<sup>-</sup>TgAb<sup>+</sup>) patients with differentiated thyroid carcinoma (DTC). Method: We studied 341 patients with histologically confirmed DTC who had undergone remnant ablation and showed Tg<sup>-</sup>TgAb<sup>+</sup> assessed by electrochemiluminescence immunoassay (ECLIA). The cases were divided into two groups, including recurrence group 119 cases and no evidence of disease (NED) group 222 cases. Receiver operating characteristic (ROC) curve analysis was carried out. The symmetric measures of the two diagnostic methods (the golden standard and the diagnostic standard as serum TgAb level alone) were analyzed using McNemar test and measure of agreement Kappa. Results: Serum TgAb level (1381.292 ± 1017.221) IU/ml of patients with recurrent group was significantly higher than that (125.559 ± 314.047) IU/ml of NED group (P = 0.000 0.001). The area under the ROC curve was 0.962 and its asymptotic 95% confidence interval (CI) was (0.942, 0.982) that was high statistical significance. The cut-off value of TgAb was determined and interpreted at 246.695 IU/ml with sensitivity (92.40%) and specificity (92.30%). McNemar test showed that the diagnostic results of the two methods were not significant difference (P = 0.230 > 0.05). Measure of agreement Kappa was 0.841, P = 0.000 0.001 that showed the agreement of the two diagnostic methods was significant. Conclusion: Serum TgAb is a useful tumor marker for recurrence in Tg-negative and TgAb-positive DTC patients who underwent thyroidectomy and remnant ablation. The cut-off value of TgAb is 246.695 IU/ml, that is to say, serum TgAb level upon 246.695 IU/ml may be associated with the persistence or recurrence of DTC.展开更多
Together with the development of the focused assessment with sonography for trauma protocol for ultrasound in trauma patients,point-of-care ultrasound is widely used in the field of emergency and critical care medicin...Together with the development of the focused assessment with sonography for trauma protocol for ultrasound in trauma patients,point-of-care ultrasound is widely used in the field of emergency and critical care medicine.Researchers have established several classic operating protocols for different diseases,such as acute respiratory failure,shock,and cardiac arrest,in the emergency department and intensive care unit.With further development in the portability and popularity of ultrasonic equipment,it is expected to be used as a new type of technology for physical examination,including inspection,palpation,percussion,auscultation,and insonation,which will improve the clinical medicine practice in the future.展开更多
Background:Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates,which increases the medical burden.This necessitates identification of patients at risk of severe disease.Early ...Background:Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates,which increases the medical burden.This necessitates identification of patients at risk of severe disease.Early assessment plays a crucial role in identifying patients at risk of severe disease.This study is to assess the effectiveness of SUPER score as a predictor of severe COVID-19 cases.Methods:We consecutively enrolled COVID-19 patients admitted to a comprehensive medical center in Wuhan,China,and recorded clinical characteristics and laboratory indexes.The SUPER score was calculated using pa-rameters including oxygen saturation,urine volume,pulse,emotional state,and respiratory rate.In addition,the area under the receiver operating characteristic curve(AUC),specificity,and sensitivity of the SUPER score for the diagnosis of severe COVID-19 were calculated and compared with the National Early Warning Score 2(NEWS2).Results:The SUPER score at admission,with a threshold of 4,exhibited good predictive performance for early identification of severe COVID-19 cases,yielding an AUC of 0.985(95%confidence interval[CI]0.897-1.000),sensitivity of 1.00(95%CI 0.715-1.000),and specificity of 0.92(95%CI 0.775-0.982),similar to NEWS2(AUC 0.984;95%CI 0.895-1.000,sensitivity 0.91;95%CI 0.587-0.998,specificity 0.97;95%CI 0.858-0.999).Com-pared with patients with a SUPER score<4,patients in the high-risk group exhibited lower lymphocyte counts,interleukin-2,interleukin-4 and higher fibrinogen,C-reactive protein,aspartate aminotransferase,and lactate dehydrogenase levels.Conclusions:In conclusion,the SUPER score demonstrated equivalent accuracy to the NEWS2 score in predicting severe COVID-19.Its application in prognostic assessment therefore offers an effective early warning system for critical management and facilitating efficient allocation of health resources.展开更多
Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the ...Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future.展开更多
In this study a Cu_(43)Zr_(48)Al_(9)bulk metallic glass prepared by the copper mold casting method is considered.In recent years,Cu-Zr-Al systems like this have enjoyed widespread attention due to their high strength,...In this study a Cu_(43)Zr_(48)Al_(9)bulk metallic glass prepared by the copper mold casting method is considered.In recent years,Cu-Zr-Al systems like this have enjoyed widespread attention due to their high strength,high hardness,high corrosion resistance and low cost.Here samples of this substance are studied using DSC(Differential scanning calorimetry)to determine the effect of different test conditions(heating rate,sample mass,sample specific surface area and sample crystal phase)on the characteristic thermodynamic temperature of the bulk metallic glass.Experimental results show that almost all of the five characteristic thermodynamic temperatures(T_(g),T_(x),T_(p),T_(m),T_(l))of this substance have higher values when the heating rate is increased.The influence of the variation of sample mass,sample specific surface area and sample crystal phase on the amorphous alloy characteristic temperature is very weak.lower the heating rate,the more developed the crystalline phase in the amorphous alloy will be.展开更多
基金supported by the National Key R&D Program of China(2018YFC1106600)A Foundation for the Author of National Excellent Doctoral Dissertation of PR China(201463)+2 种基金Young Elite Scientists Sponsorship Program By CAST(2017QNRC001)Beijing Natural Science Foundation(2192027)the National Natural Science Foundation of China(81572109).
文摘Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated.Compared with the binary Mg-2Sr alloys,the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance.Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation.The in vivo corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr.The in vitro cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy.Furthermore,these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.
基金Project supported by the National Key R&D Program of China(Grant Nos.2018YFA0306504 and 2018YFA0306503)the Key-Area Research and Development Program of Guang Dong Province,China(Grant No.2019B030330001)+1 种基金the National Natural Science Foundation of China(Grant Nos.91636213,11654001,91736311,91836302,and U1930201)support from Beijing Academy of Quantum Information Sciences(BAQIS)Research Program(Grant No.Y18G24)。
文摘Quantum information processing based on Rydberg atoms emerged as a promising direction two decades ago.Recent experimental and theoretical progresses have shined exciting light on this avenue.In this concise review,we will briefly introduce the basics of Rydberg atoms and their recent applications in associated areas of neutral atom quantum computation and simulation.We shall also include related discussions on quantum optics with Rydberg atomic ensembles,which are increasingly used to explore quantum computation and quantum simulation with photons.
基金supported by the National Natural Science Foundation of China(51401007,11472032,11120101001 and 11421202)a foundation for the author of the National Excellent Doctoral Dissertation of China(201463)+1 种基金Young Elite Scientists Sponsorship Program By CAST(2017QNRC001)the National Key Research and Development Plan(2016YFC1102203 and 2016YFC1101100)
文摘Magnesium alloys have shown prospective applications as a new biodegradable metal within bone. To garantee the longterm biocompatibility, a Mg-Zn-Ca alloy,composing of essential elements for human, was prepared and its feasibility for orthopedic applications was investigated. The in vitro and in vivo corrosion of Mg-Zn-Ca alloy as well as the biocompatibility were studied. The in vitro corrosion tests in five kinds of physiological solutions showed that the corrosion rates and corrosion morphologies of the alloy were strongly influenced by the solution used. The addition of serum in Hank’s and MEM significantly slowed down the corrosion rate and improved the corrosion uniformity of the alloy. The corrosion rate decreased with increasing serum concentration.The alloy showed the slowest corrosion rate as well as homogeneous corrosion morphology in MEM＋10%FBS. Both the indirect and direct cell experiments indicated good cytocompatibility of the extruded Mg-Zn-Ca alloy. In vivo, we observed a gradual degradation process from the surface of extruded Mg-Zn-Ca alloy and only 40% in volume of implant was left after 4 weeks implantation in medullary cavities of mice. The micro-CT and histological analyses revealed its good biocompatibility with peri-implant new bone formation and increasing cortical bone thickness with increasing implantation period. This study showed that the extruded MgZn-Ca alloy provided sufficient biocompatibility for orthopedic application, though the in vivo corrosion rate should be further reduced for clinical use.
基金supported by Startup Funds from the Central Organization Department and the South China University of Technology(SCUT),as well as funds from the national natural science foundation of China(Grant No:U2001217)the Guangdong Science and Technology Program(2020B121201003,2019ZT08L075,2019QN01L118,2021A1515012545)the Fundamental Research Fund for the Central Universities,SCUT(2020ZYGXZR095).
文摘ABSTRACT Embedding submicrocavities is an effective approach to improve the light out-coupling efficiency(LOCE)for planar perovskite light-emitting diodes(PeLEDs).In this work,we employ phenethylammonium iodide(PEAI)to trigger the Ostwald ripening for the downward recrystallization of perovskite,resulting in spontaneous formation of buried submicrocavities as light output coupler.The simulation suggests the buried submicrocavities can improve the LOCE from 26.8 to 36.2%for near-infrared light.Therefore,PeLED yields peak external quantum efficiency(EQE)increasing from 17.3%at current density of 114 mA cm^(−2)to 25.5%at current density of 109 mA cm^(−2)and a radiance increasing from 109 to 487 W sr^(−1)m^(−2)with low rolling-off.The turn-on voltage decreased from 1.25 to 1.15 V at 0.1 W sr^(−1)m^(−2).Besides,downward recrystallization process slightly reduces the trap density from 8.90×10^(15)to 7.27×10^(15)cm^(−3).This work provides a self-assembly method to integrate buried output coupler for boosting the performance of PeLEDs.
基金the financial support of the National Natural Science Foundation of China(Nos.51171135and 50890171)the Key Science and Technology Program of Shaanxi Province,China(No.2012K07-08)
文摘In the present study, microstructure and texture of drawn copper wires with a large number of transverse grain boundaries have been characterized and their mechanical properties have been analyzed. The results show that the texture evolution is accelerated by transverse grain boundary and the saturation value 60% of volume fraction of 〈111〉 fiber texture component is reached rapidly with increasing strain. For the microstructure of drawn wires with a large number of transverse grain boundaries, the critical strain, where lamellar boundaries form, is less than that for wires with equiaxed grains or columnar grains （all grain boundaries parallel to axis direction）. Since transverse grain boundary accelerates grain subdivision and dislocation density increases rapidly in drawn wires with a large number of transverse grain boundaries, there are a higher flow stress and a higher work hardening rate.
文摘Objective: The aim of this retrospective study was to evaluate diagnostic accuracy of serum thyroglobulin antibody (TgAb) in thyroglobulin (Tg)-negative and TgAb-positive (Tg<sup>-</sup>TgAb<sup>+</sup>) patients with differentiated thyroid carcinoma (DTC). Method: We studied 341 patients with histologically confirmed DTC who had undergone remnant ablation and showed Tg<sup>-</sup>TgAb<sup>+</sup> assessed by electrochemiluminescence immunoassay (ECLIA). The cases were divided into two groups, including recurrence group 119 cases and no evidence of disease (NED) group 222 cases. Receiver operating characteristic (ROC) curve analysis was carried out. The symmetric measures of the two diagnostic methods (the golden standard and the diagnostic standard as serum TgAb level alone) were analyzed using McNemar test and measure of agreement Kappa. Results: Serum TgAb level (1381.292 ± 1017.221) IU/ml of patients with recurrent group was significantly higher than that (125.559 ± 314.047) IU/ml of NED group (P = 0.000 0.001). The area under the ROC curve was 0.962 and its asymptotic 95% confidence interval (CI) was (0.942, 0.982) that was high statistical significance. The cut-off value of TgAb was determined and interpreted at 246.695 IU/ml with sensitivity (92.40%) and specificity (92.30%). McNemar test showed that the diagnostic results of the two methods were not significant difference (P = 0.230 > 0.05). Measure of agreement Kappa was 0.841, P = 0.000 0.001 that showed the agreement of the two diagnostic methods was significant. Conclusion: Serum TgAb is a useful tumor marker for recurrence in Tg-negative and TgAb-positive DTC patients who underwent thyroidectomy and remnant ablation. The cut-off value of TgAb is 246.695 IU/ml, that is to say, serum TgAb level upon 246.695 IU/ml may be associated with the persistence or recurrence of DTC.
基金supported by the Key R&D Program of Shandong Province(2021ZLGX02)the Education and Teaching Reform Research Project of Shandong University(2020Y118)+7 种基金the Clinical Research Center of Shandong University(no.2020SDUCRCC018,2020SDUCRCA006,and 2020 SDUCRCB003)the National Natural Science Foundation of China(81801942)supported by the National Key R&D Program of China(2020YFC1512700,2020YFC1512705,2020YFC1512703,and 2020YFC0846600)National S&T Fundamental Resources Investigation Project(2018FY100600,and 2018FY100602)Taishan Pandeng Scholar Program of Shandong Province(tspd20181220)Taishan Young Scholar Program of Shandong Province(tsqn20161065,tsqn201812129)Undergraduate Education Development Fund,Cheeloo College of Medicine,Shandong University(qlyxjy-201824)Youth Top-Talent Project of National Ten Thousand Talents Plan,and the Qilu Young Scholar Program.
文摘Together with the development of the focused assessment with sonography for trauma protocol for ultrasound in trauma patients,point-of-care ultrasound is widely used in the field of emergency and critical care medicine.Researchers have established several classic operating protocols for different diseases,such as acute respiratory failure,shock,and cardiac arrest,in the emergency department and intensive care unit.With further development in the portability and popularity of ultrasonic equipment,it is expected to be used as a new type of technology for physical examination,including inspection,palpation,percussion,auscultation,and insonation,which will improve the clinical medicine practice in the future.
文摘Background:Some COVID-19 patients deteriorate to severe cases with relatively higher case-fatality rates,which increases the medical burden.This necessitates identification of patients at risk of severe disease.Early assessment plays a crucial role in identifying patients at risk of severe disease.This study is to assess the effectiveness of SUPER score as a predictor of severe COVID-19 cases.Methods:We consecutively enrolled COVID-19 patients admitted to a comprehensive medical center in Wuhan,China,and recorded clinical characteristics and laboratory indexes.The SUPER score was calculated using pa-rameters including oxygen saturation,urine volume,pulse,emotional state,and respiratory rate.In addition,the area under the receiver operating characteristic curve(AUC),specificity,and sensitivity of the SUPER score for the diagnosis of severe COVID-19 were calculated and compared with the National Early Warning Score 2(NEWS2).Results:The SUPER score at admission,with a threshold of 4,exhibited good predictive performance for early identification of severe COVID-19 cases,yielding an AUC of 0.985(95%confidence interval[CI]0.897-1.000),sensitivity of 1.00(95%CI 0.715-1.000),and specificity of 0.92(95%CI 0.775-0.982),similar to NEWS2(AUC 0.984;95%CI 0.895-1.000,sensitivity 0.91;95%CI 0.587-0.998,specificity 0.97;95%CI 0.858-0.999).Com-pared with patients with a SUPER score<4,patients in the high-risk group exhibited lower lymphocyte counts,interleukin-2,interleukin-4 and higher fibrinogen,C-reactive protein,aspartate aminotransferase,and lactate dehydrogenase levels.Conclusions:In conclusion,the SUPER score demonstrated equivalent accuracy to the NEWS2 score in predicting severe COVID-19.Its application in prognostic assessment therefore offers an effective early warning system for critical management and facilitating efficient allocation of health resources.
文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future.
基金This work was supported financially by the President Fund of Xi’an Technological University(No.0852-302021407).
文摘In this study a Cu_(43)Zr_(48)Al_(9)bulk metallic glass prepared by the copper mold casting method is considered.In recent years,Cu-Zr-Al systems like this have enjoyed widespread attention due to their high strength,high hardness,high corrosion resistance and low cost.Here samples of this substance are studied using DSC(Differential scanning calorimetry)to determine the effect of different test conditions(heating rate,sample mass,sample specific surface area and sample crystal phase)on the characteristic thermodynamic temperature of the bulk metallic glass.Experimental results show that almost all of the five characteristic thermodynamic temperatures(T_(g),T_(x),T_(p),T_(m),T_(l))of this substance have higher values when the heating rate is increased.The influence of the variation of sample mass,sample specific surface area and sample crystal phase on the amorphous alloy characteristic temperature is very weak.lower the heating rate,the more developed the crystalline phase in the amorphous alloy will be.
