目的:基于网状meta分析对不同中药汤剂治疗成人重症肺炎的疗效进行评价。方法:计算机检索中国知网(CNKI)、维普(VIP)、万方(Wangfang)、Cochrane Library、Embase、PubMed、Web of science数据库。搜集数据库建库至2023年7月31日有关中...目的:基于网状meta分析对不同中药汤剂治疗成人重症肺炎的疗效进行评价。方法:计算机检索中国知网(CNKI)、维普(VIP)、万方(Wangfang)、Cochrane Library、Embase、PubMed、Web of science数据库。搜集数据库建库至2023年7月31日有关中药汤剂治疗成人重症肺炎的随机对照试验(randomized controlled trial,RCT)。采用Cochrane偏倚风险评价工具评估纳入文献的质量,应用Stata17.0软件基于频率学框架进行网状Meta分析。结果:最终纳入40项RCTs,涉及13种中药,3773例患者。网状Meta分析结果显示,麻杏石甘汤合千金苇茎汤加减+西医常规在改善临床疗效方面可能是最有效的干预措施,清肺通腑汤加减+西医常规在在改善CRP方面可能是最有效的,清金化痰汤+西医常规在改善IL‑6、TNF‑α方面可能是最有效的,麻杏石甘汤加减加减+西医常规在改善PCT方面可能是最有效的,宣白承气汤加减+西医常规在改善APACHEⅡ、CPIS方面可能是最有效的。结论:中药汤剂联合西医常规治疗成人重症肺炎的疗效优于西医常规治疗且不良反应少。但受限于纳入文献质量及数目,上述结论仍需进一步验证。展开更多
The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-s...The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.展开更多
Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidem...Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.展开更多
Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing significantly.However,the specific Bartonella species carried by Marmota himalayana(M.himalayana),...Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing significantly.However,the specific Bartonella species carried by Marmota himalayana(M.himalayana),a large rodent species,and the potential risk it poses to human populations remain unknown.What is added by this report?Bartonella washoensis(B.washoensis),associated with human endocarditis,was initially identified in M.himalayana,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.The discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of B.washoensis.What are the implications for public health practice?Individuals residing within the M.himalayana plague focus are at an elevated risk for B.washoensis infection.Consequently,there is a pressing need for public health warnings and efficient clinical case identification in this population.展开更多
基金supported by the Strategic Priority Program on Space Science,the Chinese Academy of Sciences。
文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.
基金Supported by the National Key Research and Development Program of China(2022YFC2602203).
文摘Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics.
基金Supported by the National Key Research and Development Program of China(2022YFC2602203).
文摘Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing significantly.However,the specific Bartonella species carried by Marmota himalayana(M.himalayana),a large rodent species,and the potential risk it poses to human populations remain unknown.What is added by this report?Bartonella washoensis(B.washoensis),associated with human endocarditis,was initially identified in M.himalayana,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.The discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of B.washoensis.What are the implications for public health practice?Individuals residing within the M.himalayana plague focus are at an elevated risk for B.washoensis infection.Consequently,there is a pressing need for public health warnings and efficient clinical case identification in this population.
