背景与目的:全直肠系膜切除术(TME)是治疗直肠癌的标准术式,与开放TME比较,腹腔镜辅助TME(LaTME)不仅降低了手术创伤,且疗效相当。但对于肥胖、骨盆狭窄、男性低位直肠癌患者,LaTME的盆腔操作仍十分困难,且环周切缘(CRM)阳性的风险增加...背景与目的:全直肠系膜切除术(TME)是治疗直肠癌的标准术式,与开放TME比较,腹腔镜辅助TME(LaTME)不仅降低了手术创伤,且疗效相当。但对于肥胖、骨盆狭窄、男性低位直肠癌患者,LaTME的盆腔操作仍十分困难,且环周切缘(CRM)阳性的风险增加。腹腔镜辅助经肛TME(TaTME)的出现为低位直肠癌切除术提供了一种创新的微创选择,给外科医生提供新的解决方案。本研究比较分析腹腔镜辅助TaTME与LaTME治疗低位直肠癌的临床疗效。方法:回顾性分析广东省中医院胃肠外科2018年7月—2019年1月收治的30例低位直肠癌患者(肿瘤下缘距肛门距离≤5 cm)的临床资料。其中12例行腹腔镜辅助TaTME(TaTME组),18例行LaTME(LaTME组)。比较两组患者的相关临床指标。结果:两组患者在年龄、性别、BMI、ASA分级、肿瘤学分期、肿瘤下缘距肛门距离、肿瘤直径等一般资料均无明显差异(均P>0.05)。两组患者无中转开腹手术,无近期死亡病例。TaTME组较LaTME组手术时间明显缩短(168.5 min vs.239.33 min,P=0.007)、出血量明显减少(66.50 mL vs.160.00 mL,P=0.002)。两组在预防性造口、保肛率、CRM阳性率、淋巴结清扫总数方面差异无统计学意义(均P>0.05)。TaTME组术后住院时间明显短于LaTME组(6.33 d vs.10.83 d,P<0.001)、住院费用明显低于LaTME组(58963元vs.81341元,P<0.001),TaTME组的术后排气时间及恢复全流饮食时间均短于LaTME组,但差异无统计学意义(均P>0.05)。两组术后并发症发生率差异无统计学意义(P>0.05)。结论:腹腔镜辅助TaTME治疗低位直肠癌与LaTME的短期疗效相当,且在某些方面具有一定优势;是安全可行的,值得临床进一步研究和应用。展开更多
According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiol...According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020.展开更多
Light scattering by small particles has a long and interesting history in physics.Nonetheless,it continues to surprise with new insights and applications.This includes new discoveries,such as novel plasmonic effects,a...Light scattering by small particles has a long and interesting history in physics.Nonetheless,it continues to surprise with new insights and applications.This includes new discoveries,such as novel plasmonic effects,as well as exciting theoretical and experimental developments such as optical trapping,anomalous light scattering,optical tweezers,nanospasers,and novel aspects and realizations of Fano resonances.These have led to important new applications,including several ones in the biomedical area and in sensing techniques at the single-molecule level.There are additionally many potential future applications in optical devices and solar energy technologies.Here we review the fundamental aspects of light scattering by small spherical particles,emphasizing the phenomenological treatments and new developments in this field.展开更多
SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power bala...SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here.展开更多
No natural gas pool of industrial importance could be formed at the low-evolution stage of organic matter. In the 1980s, on the basis of the development in exploration practice, the hypotheses of bio-thermo-catalytic ...No natural gas pool of industrial importance could be formed at the low-evolution stage of organic matter. In the 1980s, on the basis of the development in exploration practice, the hypotheses of bio-thermo-catalytic transitional zone gases and early thermogenic gases were proposed. The lower-limit Ro values for the formation and accumulation of natural gases of industrial importance have been expanded to 0.3%―0.4%. In the light of the two-stage model established on the basis of carbon isotope fractionation in coal-type natural gases, the upper-limit Ro values have been set at 0.8%―1.0%. In terms of the geological practice in the low-mature gas zones and China's main coal-type gas fields, it is feasible and proper to set the upper-limit Ro value of low-mature gases at 0.8%. Supper-large gas fields such as the Urengoy gas field in western Siberian Basin should belong to low-mature gas fields, of which the natural gas reserves account for more than 20% of the global proven reserves, providing strong evidence for the significance of such a type of resources. The proven natural gas reserves in the Turpan-Hami Basin of China have almost reached 1000 × 108 m3. The main source rocks in this area are the Jurassic Xishanyao Formation, which occurs as a suite of coal series strata. The corresponding thermal evolution indices (Ro ) are mainly within the range of about 0.4%―0.8%, the δ 13C1 values of methane vary between-44‰ and-39‰ (correspondingly Ro =0.6%―0.8%), and those of ethane are within the range of-29‰―-26‰, indicating that natural gases in the Turpan-Hami Basin should be designated to coal-type low-mature gases. The light hydrocarbon evolution indices of natural gases also fall within the area of low evolution while the precursor type of light hydrocarbons also shows the characteristics of the coal-type. The geological background, carbon isotopic composition and light hydrocarbon index all provide strong evidence suggesting that the proven natural gases in the Turpan-Hami Basin are low-mature g展开更多
文摘背景与目的:全直肠系膜切除术(TME)是治疗直肠癌的标准术式,与开放TME比较,腹腔镜辅助TME(LaTME)不仅降低了手术创伤,且疗效相当。但对于肥胖、骨盆狭窄、男性低位直肠癌患者,LaTME的盆腔操作仍十分困难,且环周切缘(CRM)阳性的风险增加。腹腔镜辅助经肛TME(TaTME)的出现为低位直肠癌切除术提供了一种创新的微创选择,给外科医生提供新的解决方案。本研究比较分析腹腔镜辅助TaTME与LaTME治疗低位直肠癌的临床疗效。方法:回顾性分析广东省中医院胃肠外科2018年7月—2019年1月收治的30例低位直肠癌患者(肿瘤下缘距肛门距离≤5 cm)的临床资料。其中12例行腹腔镜辅助TaTME(TaTME组),18例行LaTME(LaTME组)。比较两组患者的相关临床指标。结果:两组患者在年龄、性别、BMI、ASA分级、肿瘤学分期、肿瘤下缘距肛门距离、肿瘤直径等一般资料均无明显差异(均P>0.05)。两组患者无中转开腹手术,无近期死亡病例。TaTME组较LaTME组手术时间明显缩短(168.5 min vs.239.33 min,P=0.007)、出血量明显减少(66.50 mL vs.160.00 mL,P=0.002)。两组在预防性造口、保肛率、CRM阳性率、淋巴结清扫总数方面差异无统计学意义(均P>0.05)。TaTME组术后住院时间明显短于LaTME组(6.33 d vs.10.83 d,P<0.001)、住院费用明显低于LaTME组(58963元vs.81341元,P<0.001),TaTME组的术后排气时间及恢复全流饮食时间均短于LaTME组,但差异无统计学意义(均P>0.05)。两组术后并发症发生率差异无统计学意义(P>0.05)。结论:腹腔镜辅助TaTME治疗低位直肠癌与LaTME的短期疗效相当,且在某些方面具有一定优势;是安全可行的,值得临床进一步研究和应用。
基金supported by grants from the National Natural Science Fund for Distinguished Young Scholars(No.31825011 to L.Y.)the Chongqing Special Research Project for Novel Coronavirus Pneumonia Prevention and Control(No.cstc2020jscx-2 to L.Y.,No.cstc2020jscx-fyzx0074 to Y.C.,cstc2020jscx-fyzx0135 to Y.C.).
文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020.
基金Work at ORNL was supported by the United States Department of Energy,Basic Energy Sciences,Materials Sciences and Engineering Division.
文摘Light scattering by small particles has a long and interesting history in physics.Nonetheless,it continues to surprise with new insights and applications.This includes new discoveries,such as novel plasmonic effects,as well as exciting theoretical and experimental developments such as optical trapping,anomalous light scattering,optical tweezers,nanospasers,and novel aspects and realizations of Fano resonances.These have led to important new applications,including several ones in the biomedical area and in sensing techniques at the single-molecule level.There are additionally many potential future applications in optical devices and solar energy technologies.Here we review the fundamental aspects of light scattering by small spherical particles,emphasizing the phenomenological treatments and new developments in this field.
文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here.
基金the Leading Scientific Research Project "The Rules of Accumulation of Low-mature Gases and Biogenic Gases and Techniques for Resource Assessment" undertaken by PetroChina Company Limited
文摘No natural gas pool of industrial importance could be formed at the low-evolution stage of organic matter. In the 1980s, on the basis of the development in exploration practice, the hypotheses of bio-thermo-catalytic transitional zone gases and early thermogenic gases were proposed. The lower-limit Ro values for the formation and accumulation of natural gases of industrial importance have been expanded to 0.3%―0.4%. In the light of the two-stage model established on the basis of carbon isotope fractionation in coal-type natural gases, the upper-limit Ro values have been set at 0.8%―1.0%. In terms of the geological practice in the low-mature gas zones and China's main coal-type gas fields, it is feasible and proper to set the upper-limit Ro value of low-mature gases at 0.8%. Supper-large gas fields such as the Urengoy gas field in western Siberian Basin should belong to low-mature gas fields, of which the natural gas reserves account for more than 20% of the global proven reserves, providing strong evidence for the significance of such a type of resources. The proven natural gas reserves in the Turpan-Hami Basin of China have almost reached 1000 × 108 m3. The main source rocks in this area are the Jurassic Xishanyao Formation, which occurs as a suite of coal series strata. The corresponding thermal evolution indices (Ro ) are mainly within the range of about 0.4%―0.8%, the δ 13C1 values of methane vary between-44‰ and-39‰ (correspondingly Ro =0.6%―0.8%), and those of ethane are within the range of-29‰―-26‰, indicating that natural gases in the Turpan-Hami Basin should be designated to coal-type low-mature gases. The light hydrocarbon evolution indices of natural gases also fall within the area of low evolution while the precursor type of light hydrocarbons also shows the characteristics of the coal-type. The geological background, carbon isotopic composition and light hydrocarbon index all provide strong evidence suggesting that the proven natural gases in the Turpan-Hami Basin are low-mature g
