COVID-19 (COVID-19) or COVID-19 is pneumonia caused by the novel coronavirus infection in patients in 2019. COVID-19 pneumonia epidemic is widespread, wide, and deep. To effectively combat the further spread of COVID-...COVID-19 (COVID-19) or COVID-19 is pneumonia caused by the novel coronavirus infection in patients in 2019. COVID-19 pneumonia epidemic is widespread, wide, and deep. To effectively combat the further spread of COVID-19: the overall protocol of the hospital: “three lines of defense” of community prevention and control, fever clinic and face-to-face treatment;grasp the good three-time limits: “2 hours, 12 hours and 24 hours”;do a good job of three key points: key areas and places and groups;carry out four early prevention and control measures: early detection, early reporting, early isolation and early treatment;management of confirmed, suspected, fever, close contact “four types of personnel”;implement l responsibility system;doing all receivable, should be treated, should be checked, should be separated by “four should be”;do investigation, control, supervision, education, and care “five in place”. Through the above methods, the People’s Hospital of Pingchang County has effectively controlled COVID-19.展开更多
Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug res...Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug resistance to antibiotics, and Hp drug resistance is the main cause of Hp eradication failure. It is severe for the multidrug resistance of Hp. Objective: To investigate the changing trend of Helicobacter pylori (Hp) resistance to metronidazole, clarithromycin and amoxicillin in children and adults in Chengdu. Methods: The Hp strain determined the minimum antibacterial concentration (MIC) from 585 patients with upper gastrointestinal symptoms, metronidazole, clarithromycin and amoxicillin was measured by the E-test. Clinically isolated Hp strains were obtained by microaerobic condition culture as the diagnostic standard. Results: The Hp resistance to metronidazole and clarithromycin in children in Chengdu were: 17.65% (27/153) and 18.06 (78/432) in adults. The Hp resistance to metronidazole and amoxicillin in children in Chengdu were: 11.76% (18/153) and 13.19 (57/432) in adults. The Hp resistance to metronidazole, clarithromycin and amoxicillin in children in Chengdu were: 3.92% (6/153) and 10.41 (45/432) in adults. There were 76.92% of the strains which were resistant to metronidazole, 24.11% to clarithromycin, and 18.46% to amoxicillin. The drug resistance rate of Hp has increased year by year from 2017 to 2021 year, especially the drug resistance rate of Hp to clarithromycin and metronidazole has generally increased. Conclusions: The drug resistance rate of Hp has increased year by year from 2017 to 2021 year.展开更多
Aggregation-induced thermally activated delayed fluorescence(TADF)phenomena have attracted extensive attention recently.In this paper,several theoretical models including monomer,dimer,and complex are used for the exp...Aggregation-induced thermally activated delayed fluorescence(TADF)phenomena have attracted extensive attention recently.In this paper,several theoretical models including monomer,dimer,and complex are used for the explanation of the luminescent properties of(R)-5-(9H-carbazol-9-yl)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)isoindoline-1,3-dione((R)-ImNCz),which was recently reported[Chemical Engineering Journal 418129167(2021)].The polarizable continuum model(PCM)and the combined quantum mechanics and molecular mechanics(QM/MM)method are adopted in simulation of the property of the molecule in the gas phase,solvated in acetonitrile and in aggregation states.It is found that large spin–orbit coupling(SOC)constants and a smaller energy gap between the first singlet excited state and the first triplet excited state(△E_(st))in prism-like single crystals(SC_(p)-form)are responsible for the TADF of(R)-lmNCz,while no TADF is found in block-like single crystals(SC_(b)-form)with a larger △E_(st).The multiple ultralong phosphorescence(UOP)peaks in the spectrum are of complex origins,and they are related not only to ImNCz but also to a minor amount of impurities(ImNBd)in the crystal prepared in the laboratory.The dimer has similar phosphorescence emission wavelengths to the(R)-lmNCz-SC_(p) monomers.The complex composed of(R)-lmNCz and(R)-lmNBd contributes to the phosphorescent emission peak at about 600 nm,and the phosphorescent emission peak at about 650 nm is generated by(R)-lmNBd.This indicates that the impurity could also contribute to emission in molecular crystals.The present calculations clarify the relationship between the molecular aggregation and the light-emitting properties of the TADF emitters and will therefore be helpful for the design of potentially more useful TADF emitters.展开更多
文摘COVID-19 (COVID-19) or COVID-19 is pneumonia caused by the novel coronavirus infection in patients in 2019. COVID-19 pneumonia epidemic is widespread, wide, and deep. To effectively combat the further spread of COVID-19: the overall protocol of the hospital: “three lines of defense” of community prevention and control, fever clinic and face-to-face treatment;grasp the good three-time limits: “2 hours, 12 hours and 24 hours”;do a good job of three key points: key areas and places and groups;carry out four early prevention and control measures: early detection, early reporting, early isolation and early treatment;management of confirmed, suspected, fever, close contact “four types of personnel”;implement l responsibility system;doing all receivable, should be treated, should be checked, should be separated by “four should be”;do investigation, control, supervision, education, and care “five in place”. Through the above methods, the People’s Hospital of Pingchang County has effectively controlled COVID-19.
文摘Background: The treatment of Hp infection has been the most popular topic of the most attention and research by gastrointestinal disease workers, and the biggest problem in the treatment of Hp infection is Hp drug resistance to antibiotics, and Hp drug resistance is the main cause of Hp eradication failure. It is severe for the multidrug resistance of Hp. Objective: To investigate the changing trend of Helicobacter pylori (Hp) resistance to metronidazole, clarithromycin and amoxicillin in children and adults in Chengdu. Methods: The Hp strain determined the minimum antibacterial concentration (MIC) from 585 patients with upper gastrointestinal symptoms, metronidazole, clarithromycin and amoxicillin was measured by the E-test. Clinically isolated Hp strains were obtained by microaerobic condition culture as the diagnostic standard. Results: The Hp resistance to metronidazole and clarithromycin in children in Chengdu were: 17.65% (27/153) and 18.06 (78/432) in adults. The Hp resistance to metronidazole and amoxicillin in children in Chengdu were: 11.76% (18/153) and 13.19 (57/432) in adults. The Hp resistance to metronidazole, clarithromycin and amoxicillin in children in Chengdu were: 3.92% (6/153) and 10.41 (45/432) in adults. There were 76.92% of the strains which were resistant to metronidazole, 24.11% to clarithromycin, and 18.46% to amoxicillin. The drug resistance rate of Hp has increased year by year from 2017 to 2021 year, especially the drug resistance rate of Hp to clarithromycin and metronidazole has generally increased. Conclusions: The drug resistance rate of Hp has increased year by year from 2017 to 2021 year.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11974216,11874242,21933002 and 11904210)Shandong Provincial Natural Science Foundation,China(Grant No.ZR2019MA056)+1 种基金the support of the Taishan Scholar Project of Shandong Provincethe project funded by China Postdoctoral Science Foundation(Grant No.2018M642689)。
文摘Aggregation-induced thermally activated delayed fluorescence(TADF)phenomena have attracted extensive attention recently.In this paper,several theoretical models including monomer,dimer,and complex are used for the explanation of the luminescent properties of(R)-5-(9H-carbazol-9-yl)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)isoindoline-1,3-dione((R)-ImNCz),which was recently reported[Chemical Engineering Journal 418129167(2021)].The polarizable continuum model(PCM)and the combined quantum mechanics and molecular mechanics(QM/MM)method are adopted in simulation of the property of the molecule in the gas phase,solvated in acetonitrile and in aggregation states.It is found that large spin–orbit coupling(SOC)constants and a smaller energy gap between the first singlet excited state and the first triplet excited state(△E_(st))in prism-like single crystals(SC_(p)-form)are responsible for the TADF of(R)-lmNCz,while no TADF is found in block-like single crystals(SC_(b)-form)with a larger △E_(st).The multiple ultralong phosphorescence(UOP)peaks in the spectrum are of complex origins,and they are related not only to ImNCz but also to a minor amount of impurities(ImNBd)in the crystal prepared in the laboratory.The dimer has similar phosphorescence emission wavelengths to the(R)-lmNCz-SC_(p) monomers.The complex composed of(R)-lmNCz and(R)-lmNBd contributes to the phosphorescent emission peak at about 600 nm,and the phosphorescent emission peak at about 650 nm is generated by(R)-lmNBd.This indicates that the impurity could also contribute to emission in molecular crystals.The present calculations clarify the relationship between the molecular aggregation and the light-emitting properties of the TADF emitters and will therefore be helpful for the design of potentially more useful TADF emitters.
