This article introduces the clinical experience of Professor Jian-qiao FANG in treatment of postherpetic neuralgia(PHN)with acupuncture and moxibustion.Jian-qiao FANG believes that PHN is characterized by“stagnation...This article introduces the clinical experience of Professor Jian-qiao FANG in treatment of postherpetic neuralgia(PHN)with acupuncture and moxibustion.Jian-qiao FANG believes that PHN is characterized by“stagnation”and“deficiency”in pathogenesis and it is treated by“resolving stasis”and“replenishing for deficiency”.Electroacupuncture is predominated in treatment and the combined regimen of various techniques of acupuncture and moxibustion is adopted in therapeutic strategy.According to the pain characteristics of patients,the acupuncture and moxibustion prescription is drafted for resolving stasis and masses,replenishing for deficiency and regulating the mind.The acupoints include Ashi points,Jiaji(EX-B2),Hegu(LI4),Waiguan(TE5),Zusanli(ST36),Sanyinjiao(SP6),Shenting(GV24),Baihui(GV20)and Sishencong(EX-HN1).In treatment with electroacupuncture,the stimulation parameters are selected flexibly according to different pain characteristics.The frequency of 2/100 Hz is the first option,100 Hz is used for the acute seizure and 2 Hz is for mild pain.After electric stimulation,the treatment with roller type of dermal needle and moxibustion can be applied to ensure clinical efficacy.展开更多
Objective:To observe the law of changes in mechanical paw-withdrawal threshold(MPWT) and thermal paw-withdrawal latency(TPWL) on the modeled side of rats with pain transition(hyperalgesic priming[HP]),and the expressi...Objective:To observe the law of changes in mechanical paw-withdrawal threshold(MPWT) and thermal paw-withdrawal latency(TPWL) on the modeled side of rats with pain transition(hyperalgesic priming[HP]),and the expression of prostaglandin E receptor 1(EP1) and transient receptor potential vanilloid type 1(TRPV1) in the dorsal root ganglion(DRG) of the affected side of rats.To observe the effects of electroacupuncture(EA) on the TPWL on the modeled side of rats with pain transition and regulation of EP1 and TRPV1 expression in DRG.Methods:Part 1:Eighteen SD rats were randomly divided into control,sham HP,and HP groups,with 6rats in each group.The modeling comprised two injections.The rats in the HP group were subcutaneously injected with 1% carrageenan(100 μL) into the left hind paw in the first injection(those in the control and sham HP groups were injected with saline).The second injection was administered 8 days later by injecting prostaglandin E2(PGE2)(100 ng/25 μL) into the dorsum of the paw(the rats in the control group were administered with saline and those in the sham HP group PGE2),thereby developing a pain transition model.TPWL and MPWT were measured before rat modeling,4 h,and 1,2,3,and 7 days after the first injection,and 1,4,24,and 48 h after the second injection(8 days after the first injection).The expression rates of EP1-and TRPV1-positive cells in the affected DRG were measured by immunofluorescence(IF).Part 2:Eighteen SD rats were randomly divided into sham HP(6 rats),and HP groups(12rats),then the rats in HP group were randomly divided into HP(6 rats) and HP+EP1 antagonist(6 rats)groups for the detection of TPWL.Rats in the EP1 antagonist group were injected with EP1 antagonist5 min before PGE2 injection.The expression rate of TRPV1-positive cells in the affected DRG 48 h after PGE2 injection was detected using the IF method.Part 3:Twenty-four SD rats were randomly divided into sham HP(6 rats),and HP groups(18 rats),then the rats in HP group were randomly divided into HP(6 rats),sham EA(6 rats)展开更多
目的:系统评价眼用0.01%、0.025%和0.05%阿托品对于近视儿童等效球镜度及眼轴长度的影响。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普网、中国生物医学文献数据库中从建库至2022-05期间...目的:系统评价眼用0.01%、0.025%和0.05%阿托品对于近视儿童等效球镜度及眼轴长度的影响。方法:检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普网、中国生物医学文献数据库中从建库至2022-05期间发表的关于0.01%、0.025%和0.05%阿托品进行近视控制的研究。使用Cochrane手册对纳入文献进行偏倚风险评价及质量评价,并使用Revman 5.4软件进行Meta分析,利用STATA12.0软件检测发表偏倚。结果:共计纳入6篇文献1 239眼,其中5项为随机对照试验,1项为病例对照研究。Meta分析显示,0.025%阿托品对SE及AL的抑制效果好于0.01%阿托品(SE:WMD=-0.15,95%CI:-0.23~-0.06,P<0.001;AL:WMD=0.07,95%CI:0.03~0.10,P<0.001)。0.05%阿托品对SE及AL抑制效果好于0.01%阿托品(SE:WMD=-0.35,95%CI:-0.44~-0.26,P<0.001;AL:WMD=0.16,95%CI:0.12~0.20,P<0.001)。0.05%阿托品对SE及AL增加的抑制效果好于0.025%阿托品(SE:WMD=-0.20,95%CI:-0.28~-0.11,P<0.001;AL:WMD=0.09,95%CI:0.06~0.12,P<0.001)。结论:0.05%阿托品对SE及AL的控制效果优于0.025%及0.01%阿托品,但长期使用的副作用仍有待进一步观察。展开更多
目的了解老年骨质疏松患者髋部骨折术后骨转换生化标志物的变化规律,并比较骨代谢标志物在股骨颈骨折和股骨粗隆间骨折的异同。方法收集在北京积水潭医院老年髋部骨折病房住院的髋部骨折患者138例,其中女性106例,男性32例;股骨粗隆间骨...目的了解老年骨质疏松患者髋部骨折术后骨转换生化标志物的变化规律,并比较骨代谢标志物在股骨颈骨折和股骨粗隆间骨折的异同。方法收集在北京积水潭医院老年髋部骨折病房住院的髋部骨折患者138例,其中女性106例,男性32例;股骨粗隆间骨折68例,股骨颈骨折70例;明确骨折日期、手术日期,检测术前、术后血清碱性磷酸酶ALP(alkaline phosphatase,ALP)、1型前胶原氨基末端前肽(Npropeptide of type 1 collagen,P1NP)、1型胶原羧基末端肽交联(C-terminal crosslinking telopeptides of type 1 collagen,CTX)、25羟维生素D(25 hydroxy vitamine D,25OHD)水平以及骨密度(bone mineral density,BMD)。结果 (1)髋部骨折以女性居多;(2)骨折后1周内术前男性、女性之间,以及两种髋部骨折之间的骨代谢标志物均未见明显差异,骨折术后40~50 d骨代谢标志物均有明显上升;(3)股骨颈骨折人工股骨头置换术组和股骨粗隆间骨折髓内钉内固定组,术后40~50 d女性患者的P1NP上升约3倍,男性患者P1NP上升达到4倍左右;CTX及ALP上升幅度均在1.5倍左右;(4)在股骨颈骨折空心钉内固定组,P1NP上升约1.5倍,CTX变化不明显;(5)女性股骨颈骨折人工股骨头置换组中部分患者术后CTX呈下降趋势,与基线血磷水平呈负相关。结论老年髋部骨折后骨代谢标志物的变化有一定规律,骨折类型不同会影响骨代谢标志物变化总体变化趋势,研究标志物变化规律有助于评估骨折术后骨愈合的进程。展开更多
基金Supported by the Academic Experience Inheritance of the Seventh Batch of National Senior TCM Experts:2021-272The seventh batch of national academic experience inheritance work construction project of veteran traditional Chinese medicine experts:2022-76Zhejiang TCM Science and Technology Program:2023ZR030。
文摘This article introduces the clinical experience of Professor Jian-qiao FANG in treatment of postherpetic neuralgia(PHN)with acupuncture and moxibustion.Jian-qiao FANG believes that PHN is characterized by“stagnation”and“deficiency”in pathogenesis and it is treated by“resolving stasis”and“replenishing for deficiency”.Electroacupuncture is predominated in treatment and the combined regimen of various techniques of acupuncture and moxibustion is adopted in therapeutic strategy.According to the pain characteristics of patients,the acupuncture and moxibustion prescription is drafted for resolving stasis and masses,replenishing for deficiency and regulating the mind.The acupoints include Ashi points,Jiaji(EX-B2),Hegu(LI4),Waiguan(TE5),Zusanli(ST36),Sanyinjiao(SP6),Shenting(GV24),Baihui(GV20)and Sishencong(EX-HN1).In treatment with electroacupuncture,the stimulation parameters are selected flexibly according to different pain characteristics.The frequency of 2/100 Hz is the first option,100 Hz is used for the acute seizure and 2 Hz is for mild pain.After electric stimulation,the treatment with roller type of dermal needle and moxibustion can be applied to ensure clinical efficacy.
基金Supported by National Natural Science Foundation of China:8217151552Zhejiang Chinese Medical University Postgraduate Scientific Research Fund:2022YKJ08。
文摘Objective:To observe the law of changes in mechanical paw-withdrawal threshold(MPWT) and thermal paw-withdrawal latency(TPWL) on the modeled side of rats with pain transition(hyperalgesic priming[HP]),and the expression of prostaglandin E receptor 1(EP1) and transient receptor potential vanilloid type 1(TRPV1) in the dorsal root ganglion(DRG) of the affected side of rats.To observe the effects of electroacupuncture(EA) on the TPWL on the modeled side of rats with pain transition and regulation of EP1 and TRPV1 expression in DRG.Methods:Part 1:Eighteen SD rats were randomly divided into control,sham HP,and HP groups,with 6rats in each group.The modeling comprised two injections.The rats in the HP group were subcutaneously injected with 1% carrageenan(100 μL) into the left hind paw in the first injection(those in the control and sham HP groups were injected with saline).The second injection was administered 8 days later by injecting prostaglandin E2(PGE2)(100 ng/25 μL) into the dorsum of the paw(the rats in the control group were administered with saline and those in the sham HP group PGE2),thereby developing a pain transition model.TPWL and MPWT were measured before rat modeling,4 h,and 1,2,3,and 7 days after the first injection,and 1,4,24,and 48 h after the second injection(8 days after the first injection).The expression rates of EP1-and TRPV1-positive cells in the affected DRG were measured by immunofluorescence(IF).Part 2:Eighteen SD rats were randomly divided into sham HP(6 rats),and HP groups(12rats),then the rats in HP group were randomly divided into HP(6 rats) and HP+EP1 antagonist(6 rats)groups for the detection of TPWL.Rats in the EP1 antagonist group were injected with EP1 antagonist5 min before PGE2 injection.The expression rate of TRPV1-positive cells in the affected DRG 48 h after PGE2 injection was detected using the IF method.Part 3:Twenty-four SD rats were randomly divided into sham HP(6 rats),and HP groups(18 rats),then the rats in HP group were randomly divided into HP(6 rats),sham EA(6 rats)
文摘目的了解老年骨质疏松患者髋部骨折术后骨转换生化标志物的变化规律,并比较骨代谢标志物在股骨颈骨折和股骨粗隆间骨折的异同。方法收集在北京积水潭医院老年髋部骨折病房住院的髋部骨折患者138例,其中女性106例,男性32例;股骨粗隆间骨折68例,股骨颈骨折70例;明确骨折日期、手术日期,检测术前、术后血清碱性磷酸酶ALP(alkaline phosphatase,ALP)、1型前胶原氨基末端前肽(Npropeptide of type 1 collagen,P1NP)、1型胶原羧基末端肽交联(C-terminal crosslinking telopeptides of type 1 collagen,CTX)、25羟维生素D(25 hydroxy vitamine D,25OHD)水平以及骨密度(bone mineral density,BMD)。结果 (1)髋部骨折以女性居多;(2)骨折后1周内术前男性、女性之间,以及两种髋部骨折之间的骨代谢标志物均未见明显差异,骨折术后40~50 d骨代谢标志物均有明显上升;(3)股骨颈骨折人工股骨头置换术组和股骨粗隆间骨折髓内钉内固定组,术后40~50 d女性患者的P1NP上升约3倍,男性患者P1NP上升达到4倍左右;CTX及ALP上升幅度均在1.5倍左右;(4)在股骨颈骨折空心钉内固定组,P1NP上升约1.5倍,CTX变化不明显;(5)女性股骨颈骨折人工股骨头置换组中部分患者术后CTX呈下降趋势,与基线血磷水平呈负相关。结论老年髋部骨折后骨代谢标志物的变化有一定规律,骨折类型不同会影响骨代谢标志物变化总体变化趋势,研究标志物变化规律有助于评估骨折术后骨愈合的进程。
