Background Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown. The aim of our study was to investigate the relat...Background Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown. The aim of our study was to investigate the relationship between serum vaspin level and glucose metabolism or obesity in Chinese adults. Methods A total of 123 subjects, including 84 subjects with normal glucose tolerance （NGT） and 39 subjects with diabetes, were enrolled in this study. Anthropometric parameters, abdominal fat areas, plasma glucose concentration, serum insulin, lipids, and vaspin level were measured in each participant. Results Serum vaspin concentration was significantly higher in diabetic patients than that in NGT subjects （592 （438-695） pg/ml vs 380 （294-517） pg/ml, P=0.020） in women. In all participants, age, fasting plasma glucose concentration （FPG）, 2-hour post-load plasma glucose （PG2h）, hemoglobin Alc （HbAlc） and high-density lipoprotein cholesterol （HDL-c） significantly increased from the lower tertile to the higher tertile of vaspin. Univariate linear regression analyses revealed that vaspin level was only positively correlated with age （β=0.340, P=0.002） in NGT subjects. And vaspin was positively associated with FPG （β=0.365, P=0.023）, PG2h （β=0.526, P=0.001）, HbAlc （β=0.388, P=0.016）, and HDL-c （β=0.353, P=0.027）, while negatively with homeostasis model assessment of beta cell function （HOMA-β） （β=-0.361, P=-0.024） in diabetic patients. In stepwise multivariate regression analyses, age was independently associated with circulating vaspin in NGT subjects, whereas PG2h was an independent predictor of vaspin in diabetic patients. In addition, there was no significant difference of serum vaspin level between men and women. And no significant correlations between vaspin and body fat indexes were detected. Conclusions Serum vaspin level is higher in diabetic patients than that in NGT subjects in women. Age predicts serum vaspin level in NGT subjects, while PG展开更多
Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis....Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as well as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine （TCM） have been found to modulate the levels of autophagy in tumor cells, nerve cells, myocardial cells and endothelial cells. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can significantly reduce dependence and improve the quality of life of stroke survivors. In healthy cells, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cell death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as well as its roles in cerebral ischemia and the roles of TCM in modulating its activity.展开更多
INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in 1986.Early diagnosis of FFI might be important for early and sufficient counseling of pa...INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in 1986.Early diagnosis of FFI might be important for early and sufficient counseling of patients and their relatives, also concerning the risk of inheritance, and potentially also for treatment studies. However, the diagnosis of FFI might be difficult because of the heterogeneity of clinical features, low sensitivity of diagnostic tests, and absence of family history. The aim of the present study was to develop a clinical scheme and diagnostic criteria for FFI based on our research and expert consensus.展开更多
城市不同区域网约车供需缺口预测可为车辆调度策略提供支持,从而提高车辆运行效率和乘客服务水平.为实现网约车供需缺口短时预测,提出一种基于时空数据挖掘的深度学习预测模型(Spatio-Temporal Deep Learning Model, S-TDL).该模型由时...城市不同区域网约车供需缺口预测可为车辆调度策略提供支持,从而提高车辆运行效率和乘客服务水平.为实现网约车供需缺口短时预测,提出一种基于时空数据挖掘的深度学习预测模型(Spatio-Temporal Deep Learning Model, S-TDL).该模型由时空变量模型、空间属性变量模型和环境变量模型3个子模型融合而成,可捕捉时空关联性、区域差异性和环境变化对供需缺口的影响.同时,提出特征聚类—最大信息系数两阶段特征选择方法,筛选与供需缺口相关性强的特征变量,提高训练效率,减少过拟合.滴滴出行实例分析证明,特征选择后的STDL模型预测精度显著优于BP神经网络、长短期记忆网络和卷积神经网络.展开更多
文摘Background Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown. The aim of our study was to investigate the relationship between serum vaspin level and glucose metabolism or obesity in Chinese adults. Methods A total of 123 subjects, including 84 subjects with normal glucose tolerance （NGT） and 39 subjects with diabetes, were enrolled in this study. Anthropometric parameters, abdominal fat areas, plasma glucose concentration, serum insulin, lipids, and vaspin level were measured in each participant. Results Serum vaspin concentration was significantly higher in diabetic patients than that in NGT subjects （592 （438-695） pg/ml vs 380 （294-517） pg/ml, P=0.020） in women. In all participants, age, fasting plasma glucose concentration （FPG）, 2-hour post-load plasma glucose （PG2h）, hemoglobin Alc （HbAlc） and high-density lipoprotein cholesterol （HDL-c） significantly increased from the lower tertile to the higher tertile of vaspin. Univariate linear regression analyses revealed that vaspin level was only positively correlated with age （β=0.340, P=0.002） in NGT subjects. And vaspin was positively associated with FPG （β=0.365, P=0.023）, PG2h （β=0.526, P=0.001）, HbAlc （β=0.388, P=0.016）, and HDL-c （β=0.353, P=0.027）, while negatively with homeostasis model assessment of beta cell function （HOMA-β） （β=-0.361, P=-0.024） in diabetic patients. In stepwise multivariate regression analyses, age was independently associated with circulating vaspin in NGT subjects, whereas PG2h was an independent predictor of vaspin in diabetic patients. In addition, there was no significant difference of serum vaspin level between men and women. And no significant correlations between vaspin and body fat indexes were detected. Conclusions Serum vaspin level is higher in diabetic patients than that in NGT subjects in women. Age predicts serum vaspin level in NGT subjects, while PG
基金supported by the National Natural Science Foundation of China (No. 81102557)the Aid Project for Innovation Platform Open Fund of Hunan Province University (No. 14K068)+4 种基金the Key Project of Administration of Traditional Chinese Medicine of Hunan Province (No. 201301, No. 201508)General Project of Science and Technology Department of Hunan Province (No. 2014SK3001)the Ministry of Education Key Laboratory Open Fund Established by the Province and the Ministry (No. ZYNK201405)the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Provincethe Hunan Province Natural Science Innovation Group
文摘Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as well as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine （TCM） have been found to modulate the levels of autophagy in tumor cells, nerve cells, myocardial cells and endothelial cells. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can significantly reduce dependence and improve the quality of life of stroke survivors. In healthy cells, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cell death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as well as its roles in cerebral ischemia and the roles of TCM in modulating its activity.
基金This work was supported by grants from the National Natural Science Foundation of China （No. 81470074）, and the Clinical funding from Beijing Municipal Science and Technology Committee （No.Z141107002514117）.
文摘INTRODUCTION Fatal familial insomnia （FFI） is a serious and rare prion disease, which was first reported by Lugaresi et al. in 1986.Early diagnosis of FFI might be important for early and sufficient counseling of patients and their relatives, also concerning the risk of inheritance, and potentially also for treatment studies. However, the diagnosis of FFI might be difficult because of the heterogeneity of clinical features, low sensitivity of diagnostic tests, and absence of family history. The aim of the present study was to develop a clinical scheme and diagnostic criteria for FFI based on our research and expert consensus.
文摘城市不同区域网约车供需缺口预测可为车辆调度策略提供支持,从而提高车辆运行效率和乘客服务水平.为实现网约车供需缺口短时预测,提出一种基于时空数据挖掘的深度学习预测模型(Spatio-Temporal Deep Learning Model, S-TDL).该模型由时空变量模型、空间属性变量模型和环境变量模型3个子模型融合而成,可捕捉时空关联性、区域差异性和环境变化对供需缺口的影响.同时,提出特征聚类—最大信息系数两阶段特征选择方法,筛选与供需缺口相关性强的特征变量,提高训练效率,减少过拟合.滴滴出行实例分析证明,特征选择后的STDL模型预测精度显著优于BP神经网络、长短期记忆网络和卷积神经网络.
