To the Editor： Drug-induced pancreatitis （DIP） is a rare cause. According to a German retrospective study, the incidence of pancreatitis caused by drugs was 1.4%.[1] A nationwide survey conducted by Japan showed th...To the Editor： Drug-induced pancreatitis （DIP） is a rare cause. According to a German retrospective study, the incidence of pancreatitis caused by drugs was 1.4%.[1] A nationwide survey conducted by Japan showed that 1.2% of all cases of acute pancreatitis were caused by drugs.[2] The DIP is caused due to the drug itself or its metabolites, or organism-specific reactions caused by the introduction of hypersensitivity during pancreatic injury. Despite appropriate treatment, it demonstrated severe complications and high mortality.[3] Valproate （sodium valproate and divalproex sodium forms） is a commonly used medication that is approved by the U.S. Food and Drug Administration for the treatment of epilepsy, migraine, and bipolar disorders. Adverse effects associated with valproate are typically benign, but there are more serious effects that are less frequently observed. These effects include hepatotoxicity, teratogenicity, possible polycystic ovaries with a potential sterile effect, and acute pancreatitis.[4] Even though acute pancreatitis is an adverse effect of very low frequency, it is very important to be noted due to a high mortality rate of patients with acute pancreatitis as a consequence of the use of valproate.展开更多
基金This study was supported by a grant from The Natural Science Foundation of Shaanxi Province （No. 2017JM8007）.
文摘To the Editor： Drug-induced pancreatitis （DIP） is a rare cause. According to a German retrospective study, the incidence of pancreatitis caused by drugs was 1.4%.[1] A nationwide survey conducted by Japan showed that 1.2% of all cases of acute pancreatitis were caused by drugs.[2] The DIP is caused due to the drug itself or its metabolites, or organism-specific reactions caused by the introduction of hypersensitivity during pancreatic injury. Despite appropriate treatment, it demonstrated severe complications and high mortality.[3] Valproate （sodium valproate and divalproex sodium forms） is a commonly used medication that is approved by the U.S. Food and Drug Administration for the treatment of epilepsy, migraine, and bipolar disorders. Adverse effects associated with valproate are typically benign, but there are more serious effects that are less frequently observed. These effects include hepatotoxicity, teratogenicity, possible polycystic ovaries with a potential sterile effect, and acute pancreatitis.[4] Even though acute pancreatitis is an adverse effect of very low frequency, it is very important to be noted due to a high mortality rate of patients with acute pancreatitis as a consequence of the use of valproate.
