The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK...The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification.Moreover,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals.Based on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data collection.The estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.展开更多
Cancer poses a major public health burden worldwide,with approximately 18,094,716 newly diagnosed cases and 9,894,402 cancer-related deaths in 2020[1].Infections such as sepsis are among the leading causes of death in...Cancer poses a major public health burden worldwide,with approximately 18,094,716 newly diagnosed cases and 9,894,402 cancer-related deaths in 2020[1].Infections such as sepsis are among the leading causes of death in this population after cancer itself[2].展开更多
目的系统评价庆大霉素封管液预防血透患者中心静脉导管相关感染的效果。方法检索Cochrane Library、PubMed、Web of Science、Joanna Briggs Institute Library、CINAHL Complete、中国知网、万方及维普数据库,选择血透患者单独应用庆...目的系统评价庆大霉素封管液预防血透患者中心静脉导管相关感染的效果。方法检索Cochrane Library、PubMed、Web of Science、Joanna Briggs Institute Library、CINAHL Complete、中国知网、万方及维普数据库,选择血透患者单独应用庆大霉素或肝素封管液的随机对照试验。根据Cochrane Reviewer′s Handbook 5.0推荐标准进行质量评价,由2位研究者筛选文献,采用RevMan5.3软件进行Meta分析。结果本研究共纳入11项随机对照试验。Meta分析结果显示,单独应用庆大霉素封管的血透患者中心静脉导管相关感染发生率低于单独应用肝素封管(OR=0.34,95%CI:0.23~0.51,I^(2)=18%,P<0.001)。单独应用庆大霉素封管的血透患者中心静脉导管内血栓形成发生率低于单独肝素封管(OR=0.16,95%CI:0.10~0.27,I2=18%,P<0.001)。结论本研究结果提示,庆大霉素封管液可降低血透患者的中心静脉导管相关感染发生率以及导管内血栓形成的风险,对临床工作具有一定的参考价值。展开更多
目的探讨应用加速康复外科(enhanced recovery after surgery,ERAS)理念对老年股骨转子间骨折患者进行围手术期管理的临床疗效。方法对2016年1月-2017年12月四川大学华西医院收治的64例老年股骨转子间骨折患者的临床资料进行回顾性分析...目的探讨应用加速康复外科(enhanced recovery after surgery,ERAS)理念对老年股骨转子间骨折患者进行围手术期管理的临床疗效。方法对2016年1月-2017年12月四川大学华西医院收治的64例老年股骨转子间骨折患者的临床资料进行回顾性分析。其中2017年1月-12月入院的32例患者为ERAS组,2016年1月-12月入院的32例患者为对照组。对照组采用常规骨科围手术期管理措施,ERAS组则在常规治疗措施的基础上结合ERAS理念进行围手术期管理。比较两组患者的围手术期并发症发生率、视觉模拟评分法得分、改良Barthel指数量表评分、住院满意度及住院时长。结果两组患者年龄、性别、美国麻醉师协会分级、合并疾病、入院时改良Barthel指数量表和视觉模拟评分法得分、受伤至手术的时间的差异无统计学意义(P>0.05)。ERAS组围手术期并发症总发生率(12.5%vs.37.5%)和住院时长[(8.09±2.33)vs.(10.41±3.63)d]均低于对照组,差异有统计学意义(P<0.05)。术前、术后第1天和第3天两组患者的视觉模拟评分法得分均较入院时降低(P<0.05)。各时间点两组间比较显示,术前、术后第1天和第3天ERAS组患者视觉模拟评分法得分均低于对照组,差异有统计学意义(P<0.05)。术后第3天及第1、3、6个月两组患者改良Barthel指数量表评分均随时间延长呈不断上升趋势。ERAS组患者的改良Barthel指数量表评分在术后第3天、第1个月和第3个月优于对照组(P<0.05),而术后6个月两组间比较差异无统计学意义(P>0.05)。ERAS组患者住院满意度评分为(95.56±5.12)分,高于对照组(92.84±5.62)分,差异有统计学意义(P<0.05)。结论对老年股骨转子间骨折患者实施ERAS围手术期管理模式可能减少围手术期并发症的发生,减轻患者疼痛,促进患者生活自理能力短期恢复,提升患者住院满意度并缩短住院时长。展开更多
基金supported by the Chinese Academy of Sciencesthe National Key R&D Program of China+22 种基金the CAS Center for Excellence in Particle PhysicsWuyi Universitythe Tsung-Dao Lee Institute of Shanghai Jiao Tong University in Chinathe Institut National de Physique Nucléaire et de Physique de Particules (IN2P3) in Francethe Istituto Nazionale di Fisica Nucleare (INFN) in Italythe Italian-Chinese collaborative research program MAECI-NSFCthe Fond de la Recherche Scientifique (F.R.S-FNRS)FWO under the "Excellence of Science-EOS" in Belgiumthe Conselho Nacional de Desenvolvimento Científico e Tecnològico in Brazilthe Agencia Nacional de Investigacion y Desarrollo in Chilethe Charles University Research Centrethe Ministry of Education,Youth,and Sports in Czech Republicthe Deutsche Forschungsgemeinschaft (DFG)the Helmholtz Associationthe Cluster of Excellence PRISMA+ in Germanythe Joint Institute of Nuclear Research (JINR)Lomonosov Moscow State University in Russiathe joint Russian Science Foundation (RSF)National Natural Science Foundation of China (NSFC) research programthe MOST and MOE in Taiwan,Chinathe Chulalongkorn UniversitySuranaree University of Technology in Thailandthe University of California at Irvine in USA
文摘The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification.Moreover,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals.Based on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data collection.The estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.
基金supported by the National Natural Science Foundation of China(52105576,22105106,22005151,62288102)the Open Project Program of the State Key Laboratory of Digital Manufacturing Equipment and Technology(DMETKF2021010)+3 种基金the open research fund of the National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology(KFJJ20210201)the general project of Natural Science Research in Colleges and Universities of Jiangsu Province(21KJB460017)the Natural Science Foundation of Jiangsu Province of China(BK20210603)the Start-up Funding sponsored by Nanjing University of Posts and Telecommunications(NY221003,NY220124)。
基金supported by CAMS Innovation Fund for Medical Sciences(2021-I2M-1-062)the National Key Research and Development Program of China(2022YFC2304601,2021YFC2500801)+1 种基金National High Level Hospital Clinical Research Funding(2022-PUMCH-D-005,2022-PUMCH-D-1112022-PUMCH-B-126)National Key Clinical Specialty Construction Projects。
文摘Cancer poses a major public health burden worldwide,with approximately 18,094,716 newly diagnosed cases and 9,894,402 cancer-related deaths in 2020[1].Infections such as sepsis are among the leading causes of death in this population after cancer itself[2].
文摘目的探讨应用加速康复外科(enhanced recovery after surgery,ERAS)理念对老年股骨转子间骨折患者进行围手术期管理的临床疗效。方法对2016年1月-2017年12月四川大学华西医院收治的64例老年股骨转子间骨折患者的临床资料进行回顾性分析。其中2017年1月-12月入院的32例患者为ERAS组,2016年1月-12月入院的32例患者为对照组。对照组采用常规骨科围手术期管理措施,ERAS组则在常规治疗措施的基础上结合ERAS理念进行围手术期管理。比较两组患者的围手术期并发症发生率、视觉模拟评分法得分、改良Barthel指数量表评分、住院满意度及住院时长。结果两组患者年龄、性别、美国麻醉师协会分级、合并疾病、入院时改良Barthel指数量表和视觉模拟评分法得分、受伤至手术的时间的差异无统计学意义(P>0.05)。ERAS组围手术期并发症总发生率(12.5%vs.37.5%)和住院时长[(8.09±2.33)vs.(10.41±3.63)d]均低于对照组,差异有统计学意义(P<0.05)。术前、术后第1天和第3天两组患者的视觉模拟评分法得分均较入院时降低(P<0.05)。各时间点两组间比较显示,术前、术后第1天和第3天ERAS组患者视觉模拟评分法得分均低于对照组,差异有统计学意义(P<0.05)。术后第3天及第1、3、6个月两组患者改良Barthel指数量表评分均随时间延长呈不断上升趋势。ERAS组患者的改良Barthel指数量表评分在术后第3天、第1个月和第3个月优于对照组(P<0.05),而术后6个月两组间比较差异无统计学意义(P>0.05)。ERAS组患者住院满意度评分为(95.56±5.12)分,高于对照组(92.84±5.62)分,差异有统计学意义(P<0.05)。结论对老年股骨转子间骨折患者实施ERAS围手术期管理模式可能减少围手术期并发症的发生,减轻患者疼痛,促进患者生活自理能力短期恢复,提升患者住院满意度并缩短住院时长。
