Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron minutiflorum.The chemical structures of all the isolates were determined by spectroscopic...Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron minutiflorum.The chemical structures of all the isolates were determined by spectroscopic methods,and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses.Compounds 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures.Biologi-cally,compounds 2,5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid(Diaphorina citri)with LD_(50) values 27.15,17.02 and 16.20 mg/L,respectively.These values were comparable to the positive control matrine(LD_(50)=11.86 mg/L),which were calculated using observations on day 6.Meanwhile,compound 4 hadα-glucosidase inhibitory activity with IC_(50) value of 17.87±0.74μM.展开更多
基金The Natural Science Foundation of China(32160109,31800294)the Natural Science Foundation of Guangxi Province of China(2018GXNSFBA138006,2019AC20231)+2 种基金Educational Department of Guangxi(2018KY0089)the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2017-A07,2020-A09)Joint cultivation base of biology and medicine graduate student between Guangxi Normal University and Guilin Pharma Company.
文摘Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron minutiflorum.The chemical structures of all the isolates were determined by spectroscopic methods,and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses.Compounds 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures.Biologi-cally,compounds 2,5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid(Diaphorina citri)with LD_(50) values 27.15,17.02 and 16.20 mg/L,respectively.These values were comparable to the positive control matrine(LD_(50)=11.86 mg/L),which were calculated using observations on day 6.Meanwhile,compound 4 hadα-glucosidase inhibitory activity with IC_(50) value of 17.87±0.74μM.
