"针刺临床试验干预措施报告标准"(Standards,for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照试验检查清单及解释的形式供作者和期刊编辑使用,旨在..."针刺临床试验干预措施报告标准"(Standards,for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照试验检查清单及解释的形式供作者和期刊编辑使用,旨在提高针刺临床试验报告的质量,尤其是对其中干预措施的报告,因而有助于对这些试验的解释和重复。随后对STRICTA的应用及影响的述评都强调了STRICTA的价值,也提出了改进和修订的建议。为使修订过程顺利进地,STRICTA工作组、CONSORT工作组和中国Cochrane中心于2008年开始合作,召集成立的包含47名成员的专家小组对清单的修改稿提出了电子版反馈意见。在后来于弗莱堡(Freiburg)召开的见面会上,由21名专家组成的工作组进一步修订了STRICTA对照检查清单,并计划如何对其进行发布。新的STRICTA对照检查清单作为CONSORT的正式扩展版,包含6项条目及17条二级条目。这些条目为报告针刺治疗的合理性、针刺的细节、治疗方案、其他干预措施、治疗师的背景以及对照或对照干预提供了指南。而且,作为修订工作的一部分,对每一条目作了详尽解释,并针对每一条目给出了良好报告的实例。此外,STRICTA中的"对照"(controlled)一词被替换成了"临床"(clinical),以示STRICTA适用于更广泛的各类临床评价设计,包括非对照结局研究和病例报道。修订的STRICTA对照检查清单有望与CONSORT声明及其非药物治疗扩展版一起共同提高针刺临床试验的报告质量。展开更多
序言
本文件在美国心血管造影和介入治疗学会（Society for Cardiovascular Angiography and Interventions，SCAI）、血管医学和生物学学会（Society for Vascular Medicine and Biology,SVMB）、介入放射学学会（Society of Interven...序言
本文件在美国心血管造影和介入治疗学会（Society for Cardiovascular Angiography and Interventions，SCAI）、血管医学和生物学学会（Society for Vascular Medicine and Biology,SVMB）、介入放射学学会（Society of Interventional Radiology，SIR）、美国介入与治疗神经放射学学会（American Society of Interventional ＆ Therapeutic Neuroradiology,ASITN）共同倡导下，展开更多
"针刺临床试验干预措施报告标准"(STandards for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照检查清单及解释的形式供作者和期刊编辑使用,旨在提高..."针刺临床试验干预措施报告标准"(STandards for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照检查清单及解释的形式供作者和期刊编辑使用,旨在提高针刺临床试验报告的质量,尤其是对其中干预措施的报告,因而有助于对这些试验的解释和重复。随后对STRICTA的应用及影响的述评都强调了STRICTA的价值,也提出了改进和修订的建议。为使修订过程顺利进行,STRICTA工作组、CONSORT工作组和中国Cochrane中心于2008年开始合作。召集成立的有47名成员的专家组对清单的修改稿提出了电子版反馈意见。在后来于弗莱堡(Freiburg)召开的见面会上,由21名专家组成的工作组进一步修订了STRICTA对照检查清单,并计划如何对其进行发布。新的STRICTA对照检查清单作为CONSORT的正式扩展版,包含6项条目及17条二级条目。这些条目为报告针刺治疗的合理性、针刺的细节、治疗方案、其他干预措施、治疗师的背景以及对照或对照干预提供了指南。而且,作为修订工作的一部分,对每一条目作了详尽解释,并针对每一条目给出了报告良好的实例。此外,STRICTA中的"对照"(controlled)一词被替换成了"临床"(clinical),以示STRICTA适用于更广泛的各类临床评价设计,包括非对照结局研究和病例报道。修订的STRICTA对照检查清单有望与CONSORT声明及其非药物治疗扩展版一起共同提高针刺临床试验的报告质量。展开更多
以田间试验为基础,对所建立的简化土壤水氮联合运移模型进行了验证。将条件模拟方法所得到的表层土壤饱和导水率(Ks)的随机场与该联合模型相结合,随机地模拟了冬小麦地1999年3月15日至6月10日这一时段的硝酸盐淋失情况。在总来水量为353...以田间试验为基础,对所建立的简化土壤水氮联合运移模型进行了验证。将条件模拟方法所得到的表层土壤饱和导水率(Ks)的随机场与该联合模型相结合,随机地模拟了冬小麦地1999年3月15日至6月10日这一时段的硝酸盐淋失情况。在总来水量为353.8 mm、施N量为86.25 kg hm-2的情况下,2 m土体硝酸盐淋失量最小值为N 15.04 kg hm-2,最大值为N 26.04 kg hm-2,分别占此段施肥量的17.4%和30.2%。以传统方法(Ks平均值)所得到硝酸盐淋失量作为对照,发现硝酸盐淋失量超过该值且概率大于70%的面积约占到田块总面积的20%左右。说明由于田间空间变异的作用,造成了硝酸盐淋失的巨大差异,故不能用传统的方法来代替,因为这样做就掩盖了地下水可能造成硝酸盐污染的风险性。展开更多
Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years w...Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human "-omes" including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies.展开更多
Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(...Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.展开更多
作为EMSLAB电磁感应国际合作计划的一部分,通过对海底观测的三分量变化地磁场的分析,构制了横跨Juan de Fuca洋脊、Juan de Fuca板块到板块俯冲带的三条地磁转换函数剖面,计算了各个测点的地磁场感应矢量。结果表明,Juan de Fuca板块的...作为EMSLAB电磁感应国际合作计划的一部分,通过对海底观测的三分量变化地磁场的分析,构制了横跨Juan de Fuca洋脊、Juan de Fuca板块到板块俯冲带的三条地磁转换函数剖面,计算了各个测点的地磁场感应矢量。结果表明,Juan de Fuca板块的东、西两部分的浅部电性结构是有差异的,近海岸线的东区更导电;而深部电性结构是相对均匀的。这一结果与由大地电磁资料计算得到的二维模型剖面是一致的。展开更多
Carbide-derived carbon （CDC） is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the rearrangement o...Carbide-derived carbon （CDC） is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the rearrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tribological performance. CDC coatings are distinguished by their low friction coefficients and high wear resistance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail.展开更多
文摘"针刺临床试验干预措施报告标准"(Standards,for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照试验检查清单及解释的形式供作者和期刊编辑使用,旨在提高针刺临床试验报告的质量,尤其是对其中干预措施的报告,因而有助于对这些试验的解释和重复。随后对STRICTA的应用及影响的述评都强调了STRICTA的价值,也提出了改进和修订的建议。为使修订过程顺利进地,STRICTA工作组、CONSORT工作组和中国Cochrane中心于2008年开始合作,召集成立的包含47名成员的专家小组对清单的修改稿提出了电子版反馈意见。在后来于弗莱堡(Freiburg)召开的见面会上,由21名专家组成的工作组进一步修订了STRICTA对照检查清单,并计划如何对其进行发布。新的STRICTA对照检查清单作为CONSORT的正式扩展版,包含6项条目及17条二级条目。这些条目为报告针刺治疗的合理性、针刺的细节、治疗方案、其他干预措施、治疗师的背景以及对照或对照干预提供了指南。而且,作为修订工作的一部分,对每一条目作了详尽解释,并针对每一条目给出了良好报告的实例。此外,STRICTA中的"对照"(controlled)一词被替换成了"临床"(clinical),以示STRICTA适用于更广泛的各类临床评价设计,包括非对照结局研究和病例报道。修订的STRICTA对照检查清单有望与CONSORT声明及其非药物治疗扩展版一起共同提高针刺临床试验的报告质量。
文摘序言
本文件在美国心血管造影和介入治疗学会（Society for Cardiovascular Angiography and Interventions，SCAI）、血管医学和生物学学会（Society for Vascular Medicine and Biology,SVMB）、介入放射学学会（Society of Interventional Radiology，SIR）、美国介入与治疗神经放射学学会（American Society of Interventional ＆ Therapeutic Neuroradiology,ASITN）共同倡导下，
基金White RoseHealth Innovation Partnership Enterprise and Innovation Office+7 种基金 Charles Thackrah Building 101 Clarendon RoadLeeds LS2 9LJLeeds UK提供资金支持UK National Institute for Health Research的一项Career Scientist Award资助Cancer Research UK资助University of Ottawa Research Chair资助
文摘"针刺临床试验干预措施报告标准"(STandards for Reporting Interventions in Clinical Trials of Acupuncture,STRICTA)于2001年和2002年在5种期刊上发表。该指南以对照检查清单及解释的形式供作者和期刊编辑使用,旨在提高针刺临床试验报告的质量,尤其是对其中干预措施的报告,因而有助于对这些试验的解释和重复。随后对STRICTA的应用及影响的述评都强调了STRICTA的价值,也提出了改进和修订的建议。为使修订过程顺利进行,STRICTA工作组、CONSORT工作组和中国Cochrane中心于2008年开始合作。召集成立的有47名成员的专家组对清单的修改稿提出了电子版反馈意见。在后来于弗莱堡(Freiburg)召开的见面会上,由21名专家组成的工作组进一步修订了STRICTA对照检查清单,并计划如何对其进行发布。新的STRICTA对照检查清单作为CONSORT的正式扩展版,包含6项条目及17条二级条目。这些条目为报告针刺治疗的合理性、针刺的细节、治疗方案、其他干预措施、治疗师的背景以及对照或对照干预提供了指南。而且,作为修订工作的一部分,对每一条目作了详尽解释,并针对每一条目给出了报告良好的实例。此外,STRICTA中的"对照"(controlled)一词被替换成了"临床"(clinical),以示STRICTA适用于更广泛的各类临床评价设计,包括非对照结局研究和病例报道。修订的STRICTA对照检查清单有望与CONSORT声明及其非药物治疗扩展版一起共同提高针刺临床试验的报告质量。
文摘以田间试验为基础,对所建立的简化土壤水氮联合运移模型进行了验证。将条件模拟方法所得到的表层土壤饱和导水率(Ks)的随机场与该联合模型相结合,随机地模拟了冬小麦地1999年3月15日至6月10日这一时段的硝酸盐淋失情况。在总来水量为353.8 mm、施N量为86.25 kg hm-2的情况下,2 m土体硝酸盐淋失量最小值为N 15.04 kg hm-2,最大值为N 26.04 kg hm-2,分别占此段施肥量的17.4%和30.2%。以传统方法(Ks平均值)所得到硝酸盐淋失量作为对照,发现硝酸盐淋失量超过该值且概率大于70%的面积约占到田块总面积的20%左右。说明由于田间空间变异的作用,造成了硝酸盐淋失的巨大差异,故不能用传统的方法来代替,因为这样做就掩盖了地下水可能造成硝酸盐污染的风险性。
文摘Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human "-omes" including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies.
文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.
基金supported by the National Natural Science Foundation of China(50773009)Science and Technology Commission of Shanghai Municipality,China(08JC1400600)~~
文摘作为EMSLAB电磁感应国际合作计划的一部分,通过对海底观测的三分量变化地磁场的分析,构制了横跨Juan de Fuca洋脊、Juan de Fuca板块到板块俯冲带的三条地磁转换函数剖面,计算了各个测点的地磁场感应矢量。结果表明,Juan de Fuca板块的东、西两部分的浅部电性结构是有差异的,近海岸线的东区更导电;而深部电性结构是相对均匀的。这一结果与由大地电磁资料计算得到的二维模型剖面是一致的。
文摘Carbide-derived carbon （CDC） is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the rearrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tribological performance. CDC coatings are distinguished by their low friction coefficients and high wear resistance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail.
