To the Editor： Pseudohypoaldosteronism Type 11 （PHAII）, also known as Gordon syndrome, is a rare autosomal disease, caused by mutations in WNK1, WNK4, CUL3, or KLHL3 genes. Hitherto, about 200 individuals and famil...To the Editor： Pseudohypoaldosteronism Type 11 （PHAII）, also known as Gordon syndrome, is a rare autosomal disease, caused by mutations in WNK1, WNK4, CUL3, or KLHL3 genes. Hitherto, about 200 individuals and families have been reported with PHAII; of these, 26 were caused by CUL3 mutation.[1,2] In pediatrics, hyperkalemia-complicated hypertension is rare, and PHAII should be considered in this condition.展开更多
文摘To the Editor： Pseudohypoaldosteronism Type 11 （PHAII）, also known as Gordon syndrome, is a rare autosomal disease, caused by mutations in WNK1, WNK4, CUL3, or KLHL3 genes. Hitherto, about 200 individuals and families have been reported with PHAII; of these, 26 were caused by CUL3 mutation.[1,2] In pediatrics, hyperkalemia-complicated hypertension is rare, and PHAII should be considered in this condition.
