Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biol...Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins.展开更多
为了实现农产品低湿节能干燥,分析了典型转轮除湿干燥模式,基于能耗高、结构不合理等问题,开展转轮热泵联合除湿干燥系统优化设计与试验研究,研制出转轮除湿热泵干燥机。为了检验并提高转轮除湿热泵干燥机的作业性能,该文以杏鲍菇为研...为了实现农产品低湿节能干燥,分析了典型转轮除湿干燥模式,基于能耗高、结构不合理等问题,开展转轮热泵联合除湿干燥系统优化设计与试验研究,研制出转轮除湿热泵干燥机。为了检验并提高转轮除湿热泵干燥机的作业性能,该文以杏鲍菇为研究对象,以降低杏鲍菇色差、除湿能耗比,提高复水性为目标,运用Box-Benhnken中心组合试验设计理论,对再生温度、干燥温度、转换点相对湿度影响其干燥品质与能耗的因素开展响应面试验。通过数据分析,建立了响应面模型,结合四维渲染图分析了上述3个考察指标受3个试验因素取值变化的影响机制,同时对各影响因素进行了综合优化与试验验证。结果表明,3个模型的R2均大于0.98,试验因素对干燥品质及能耗有较大影响,当再生温度87℃,干燥温度50℃,转换点相对湿度45%时,杏鲍菇复水比4.028,色差22.89,除湿能耗比(specific power consumption,SPC)2 633 k J/kg,与预测绝对值误差均低于6个百分点。该研究为转轮除湿热泵干燥设备的设计及干燥工艺优化提供参考。展开更多
The q24 band of chromosome 8 （8q24） is frequently amplified in human cancers including breast cancer, and several SNPs （single nucleotide polymorphisms） at 8q24, including rs13281615, have been identified for thei...The q24 band of chromosome 8 （8q24） is frequently amplified in human cancers including breast cancer, and several SNPs （single nucleotide polymorphisms） at 8q24, including rs13281615, have been identified for their association with cancer risks. These SNPs are in a ＂gene desert＂ region, and their functions in cancer development remain to be illustrated, although several of the SNPs appear to influence the genes in the ＂desert＂ in a long-range manner, including the v-myc avian myelocytomatosis viral oncogene homolog （MYC） and the non- protein coding plasmacytoma variant translocation 1 （PVT1）, both of which have been implicated in human cancers. In the current study, we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer. In addition to confirming the association of the GG genotype of rs 13281615 with breast cancer risk, we found that germline GG genotype was significantly associated with estrogen receptor （ER） positivity, higher tumor grade and higher proliferation index. We also found frequent somatic mutations （22/121 or 18.2%） of this SNP in breast cancer. Interestingly, the majority of the mutations （17/22 or 77%） involved a G→ A change, resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers. Furthermore, PVT1 expression was increased in cancers, and the increase was associated with the GG genotype of rs13281615. These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression, and that during oncogenesis, ＂protective＂ mutations could occur.展开更多
The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the...The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.展开更多
A series of blade tip geometries, including original plain tip, rounded tip on the pressure side and diverging tip towards the suction side, were adopted to investigate the effect of blade geometry on tip leakage vort...A series of blade tip geometries, including original plain tip, rounded tip on the pressure side and diverging tip towards the suction side, were adopted to investigate the effect of blade geometry on tip leakage vortex dynamics and cavitation pattern in an axial-flow pump. On the basis of the computation, it clearly shows the flow structure in the clearance for different tip configurations by the detailed data of axial velocity and turbulent kinetic energy. The in-plain trajectory, in aspects of the angle between the blade suction side and vortex core and the initial point of tip leakage vortex, was presented using the maximum swirling strength method. The most striking feature is that the inception location of tip leakage vortex is delayed for chamfered tip due to the change of blade loading on suction side. Some significant non-dimensional parameters, such as pressure, swirling strength and turbulent kinetic energy, were used to depict the characteristics of tip vortex core. By the distribution of circumferential vorticity which dominates the vortical flows near the tip region, it is observed that the endwall detachment as the leakage flow meets the mainstream varies considerably for tested cases. The present study also indicates that the shear layer feeds the turbulence into tip leakage vortex core, but the way is different. For the chamfered tip, high turbulence level in vortex core is mainly from the tip clearance where large turbulent kinetic energy emerges, while it is almost from a layer extending from the suction side corner for rounded tip. At last, the visualized observations show that tip clearance cavitation is eliminated dramatically for rounded tip but more intensive for chamfered tip, which can be associated with the vortex structure in the clearance.展开更多
Copper is a moderately incompatible chalcophile element.Its behavior is strongly controlled by sulfides.The speciation of sulfur is controlled by oxygen fugacity.Therefore,porphyry Cu deposits are usually oxidized(wit...Copper is a moderately incompatible chalcophile element.Its behavior is strongly controlled by sulfides.The speciation of sulfur is controlled by oxygen fugacity.Therefore,porphyry Cu deposits are usually oxidized(with oxygen fugacities > AFMQ +2)(Mungall 2002;Sun et al.2015).The problem is that while most of the magmas at convergent margins are highly oxidized,porphyry Cu deposits are very rare,suggesting that high oxygen fugacity alone is not sufficient.Partial melting of mantle peridotite even at very high oxygen fugacities forms arc magmas with initial Cu contents too low to form porphyry Cu deposits directly(Lee et al.2012;Wilkinson 2013).Here we show that partial melting of subducted young oceanic slabs at high oxygen fugacity(>AFMQ +2) may form magmas with initial Cu contents up to >500 ppm,favorable for porphyry mineralization.Pre-enrichment of Cu through sulfide saturation and accumulation is not necessarily beneficial to porphyry Cu mineralization.In contrast,remelting of porphyritic hydrothermal sulfide associated with iron oxides may have major contributions to porphyry deposits.Thick overriding continental crust reduces the "leakage" of hydrothermal fluids,thereby promoting porphyry mineralization.Nevertheless,it is also more difficult for ore forming fluids to penetrate the thick continental crust to reach the depths of 2—4 km where porphyry deposits form.展开更多
基金This work was supported by the National Key Research and Development Program of China(2016YFB1001300)the National Natural Science Foundation of China(No.11527901)the Fundamental Research Funds for the Central Universities.
文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins.
文摘为了实现农产品低湿节能干燥,分析了典型转轮除湿干燥模式,基于能耗高、结构不合理等问题,开展转轮热泵联合除湿干燥系统优化设计与试验研究,研制出转轮除湿热泵干燥机。为了检验并提高转轮除湿热泵干燥机的作业性能,该文以杏鲍菇为研究对象,以降低杏鲍菇色差、除湿能耗比,提高复水性为目标,运用Box-Benhnken中心组合试验设计理论,对再生温度、干燥温度、转换点相对湿度影响其干燥品质与能耗的因素开展响应面试验。通过数据分析,建立了响应面模型,结合四维渲染图分析了上述3个考察指标受3个试验因素取值变化的影响机制,同时对各影响因素进行了综合优化与试验验证。结果表明,3个模型的R2均大于0.98,试验因素对干燥品质及能耗有较大影响,当再生温度87℃,干燥温度50℃,转换点相对湿度45%时,杏鲍菇复水比4.028,色差22.89,除湿能耗比(specific power consumption,SPC)2 633 k J/kg,与预测绝对值误差均低于6个百分点。该研究为转轮除湿热泵干燥设备的设计及干燥工艺优化提供参考。
基金supported by the National Nature Science Foundation of China (Nos.30870980,31171250,and 30625032)the National Basic Research Program of China (No.2007CB914802)
文摘The q24 band of chromosome 8 （8q24） is frequently amplified in human cancers including breast cancer, and several SNPs （single nucleotide polymorphisms） at 8q24, including rs13281615, have been identified for their association with cancer risks. These SNPs are in a ＂gene desert＂ region, and their functions in cancer development remain to be illustrated, although several of the SNPs appear to influence the genes in the ＂desert＂ in a long-range manner, including the v-myc avian myelocytomatosis viral oncogene homolog （MYC） and the non- protein coding plasmacytoma variant translocation 1 （PVT1）, both of which have been implicated in human cancers. In the current study, we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer. In addition to confirming the association of the GG genotype of rs 13281615 with breast cancer risk, we found that germline GG genotype was significantly associated with estrogen receptor （ER） positivity, higher tumor grade and higher proliferation index. We also found frequent somatic mutations （22/121 or 18.2%） of this SNP in breast cancer. Interestingly, the majority of the mutations （17/22 or 77%） involved a G→ A change, resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers. Furthermore, PVT1 expression was increased in cancers, and the increase was associated with the GG genotype of rs13281615. These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression, and that during oncogenesis, ＂protective＂ mutations could occur.
基金supported by the National Natural Science Foundation of China(NSFC)under Grants 11825301,12003016,12073077the National Key R&D Program of China No.2021YFA0718600+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences with the Grant No.XDA15018400the Youth Innovation Promotion Association of CAS(2023061)。
文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.
基金the National Natural Science Foundation of China(Grant No.51479083)prospective Joint Research Proj ectofJiangsu Province(Grant No.BY2015064-08)+1 种基金Primary Research&Development Plan of Jiangsu Province(Grant Nos.BE2015001-3 and BE2015146)333Project of Jiangsu Province and Six Talent Peaks Project in Jiangsu Province(Grant No.HYGC-008)
文摘A series of blade tip geometries, including original plain tip, rounded tip on the pressure side and diverging tip towards the suction side, were adopted to investigate the effect of blade geometry on tip leakage vortex dynamics and cavitation pattern in an axial-flow pump. On the basis of the computation, it clearly shows the flow structure in the clearance for different tip configurations by the detailed data of axial velocity and turbulent kinetic energy. The in-plain trajectory, in aspects of the angle between the blade suction side and vortex core and the initial point of tip leakage vortex, was presented using the maximum swirling strength method. The most striking feature is that the inception location of tip leakage vortex is delayed for chamfered tip due to the change of blade loading on suction side. Some significant non-dimensional parameters, such as pressure, swirling strength and turbulent kinetic energy, were used to depict the characteristics of tip vortex core. By the distribution of circumferential vorticity which dominates the vortical flows near the tip region, it is observed that the endwall detachment as the leakage flow meets the mainstream varies considerably for tested cases. The present study also indicates that the shear layer feeds the turbulence into tip leakage vortex core, but the way is different. For the chamfered tip, high turbulence level in vortex core is mainly from the tip clearance where large turbulent kinetic energy emerges, while it is almost from a layer extending from the suction side corner for rounded tip. At last, the visualized observations show that tip clearance cavitation is eliminated dramatically for rounded tip but more intensive for chamfered tip, which can be associated with the vortex structure in the clearance.
基金No.IS-2308 from GIGCAS,which is supported by the NSFC(No.91328204,41090374,41121002)the Chinese Academy of Sciences(KZCXl-YW-15)
文摘Copper is a moderately incompatible chalcophile element.Its behavior is strongly controlled by sulfides.The speciation of sulfur is controlled by oxygen fugacity.Therefore,porphyry Cu deposits are usually oxidized(with oxygen fugacities > AFMQ +2)(Mungall 2002;Sun et al.2015).The problem is that while most of the magmas at convergent margins are highly oxidized,porphyry Cu deposits are very rare,suggesting that high oxygen fugacity alone is not sufficient.Partial melting of mantle peridotite even at very high oxygen fugacities forms arc magmas with initial Cu contents too low to form porphyry Cu deposits directly(Lee et al.2012;Wilkinson 2013).Here we show that partial melting of subducted young oceanic slabs at high oxygen fugacity(>AFMQ +2) may form magmas with initial Cu contents up to >500 ppm,favorable for porphyry mineralization.Pre-enrichment of Cu through sulfide saturation and accumulation is not necessarily beneficial to porphyry Cu mineralization.In contrast,remelting of porphyritic hydrothermal sulfide associated with iron oxides may have major contributions to porphyry deposits.Thick overriding continental crust reduces the "leakage" of hydrothermal fluids,thereby promoting porphyry mineralization.Nevertheless,it is also more difficult for ore forming fluids to penetrate the thick continental crust to reach the depths of 2—4 km where porphyry deposits form.
