INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3]....INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].展开更多
AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabet...AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS： Forty Sprague-Dawley rats were divided into 4 groups： control, diabetes mellitus （DM）, candesartan- treated DM, and enalapril-treated DM （each group, n---10）. After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/（kg · d）] and enalapril [ACEI, 10 mg/（kg · d）] were administered to rats orally for 4Wko Vascular endothelial growth factor （VEGF） and angiotensin II （Ang II） concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor （ATIR） levels were assessed at week 4 by Western blotting. RESULTS： Vitreous Ang II levels were significantly higher in the DM group and candesartan-treated DM group than in the control （P=0.04 and 0.005, respectively）. Vitreous ATIR increased significantly in DM compared to the other three groups （P〈0.007）. Candesartan-treated DM rats showed higher vitreal ATIR concentration than the enalapril-treated DM group and control （P〈0.001 and P=0.005, respectively）. No difference in vitreous Ang II and ATIR concentration was found between the enalapril- treated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups. CONCLUSION： Increased Ang II and ATIR in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB.展开更多
AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All th...AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH.展开更多
Introduction: Despite progress in universal health coverage, maternal mortality remains a concern for developing countries, including Mali. The problem is not due only to a lack of health services but to a combination...Introduction: Despite progress in universal health coverage, maternal mortality remains a concern for developing countries, including Mali. The problem is not due only to a lack of health services but to a combination of factors that need to be identified to give hope to women of childbearing age. Objective: Determine the factors associated with maternal mortality in the Timbuktu region of Mali. Methodology: Retrospective, descriptive, cross-sectional and analytical study from January 1, 2018 to December 31, 2022 using a questionnaire and an interview guide to determine the factors associated with maternal mortality in the Timbuktu region of Mali. Results: A total of 112 maternal deaths were recorded between 2018 and 2022. The average age of the women who died was 26 years (standard deviation 7.6 years). The 14 – 23-year-old age group is the most affected (43.8%). 66.1% of women came from rural areas. Illiteracy (77.7%), lack of ANC (54.5%), distance of households from health facilities (76%) and insecurity (52.7%) have been identified as factors contributing to maternal mortality. Conclusion: This study reported a high prevalence of maternal mortality rates that may be associated with women’s socioeconomic conditions. Actions must be developed to integrate CPN into an advanced strategy for women living in rural areas in Mali.展开更多
目的:综合评价虚拟现实体育活动对脑卒中患者上肢功能康复的影响。方法:通过PubMed、Cochrane Library、Web of Science、Medline、中国知网(CNKI)等数据库检索自建库至2024年2月的相关文献,采用Sata17.0、RevMan5.3统计软件进行Meta分...目的:综合评价虚拟现实体育活动对脑卒中患者上肢功能康复的影响。方法:通过PubMed、Cochrane Library、Web of Science、Medline、中国知网(CNKI)等数据库检索自建库至2024年2月的相关文献,采用Sata17.0、RevMan5.3统计软件进行Meta分析。结果:共纳入10项研究,共涉及676名受试者,总体方法学质量较高,无明显发表偏倚。在虚拟现实体育活动干预下,与对照组相比,可有效改善Fugl-Meyer量表(FMA)评分(WMD=4.85,95%CI:4.29~5.41,P<0.001),改善Box and Block实验(BBT)评分(WMD=4.21,95%CI:-1.61~10.02,P=0.156),提高上肢运动速度(WMD=3.23,95%CI:0.44~6.02,P=0.023),间接提高功能独立性量表(FIM)评分(WMD=8.54,95%CI:5.30~11.79,P<0.001),但对提升上肢力量(SMD=0.02,95%CI:-0.53-0.57,P=0.944)和手功能(WMD=-0.74,95%CI:-1.28~-0.20,P=0.007)没有改善作用,对上肢活动频率和活动度改善情况尚不清楚。结论:虚拟现实技术应用在脑卒中上肢运动康复训练中,能有效改善上肢活动能力,提高运动量和运动质量,改善功能独立性,但在力量和活动度方面未产生积极影响,虚拟现实作为一种新兴临床干预手段,对于心血管疾病的预防和改善是一种有效的方法。展开更多
Better understanding of the immunological mechanisms implying the insemination and the infertility of some menand women is needed and crucial to the development of an effective immunocontraceptive method. To provide g...Better understanding of the immunological mechanisms implying the insemination and the infertility of some menand women is needed and crucial to the development of an effective immunocontraceptive method. To provide goodprotection against conception or infection, and avoid any possible and unexpected comlications which immunocontra-ceptive 'vaccine' may arise of , it seems the right time for scientists to create a virtually new thinking for this extremelyurgent and important issue. This conceptual article describes our original thoughts of the future development of im-munocntraceptives, preferably, based on immunoglobulins rather than vaccines, against human sperm specific antigensand seminal plasma immunosuppressive factors. Its general correctness, advantages and feasibility for fertility regula-tion and prevention of infection are discussed. (Asian J Androl 1999 Sep; 1: 87-93)展开更多
Lee SM, Jung JW, Park SW, Lee JE, Byon IS. Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye. Int J Ophthalmo12017; 10（6）： 1019-1020
Research that addresses male reproductive health should assist in the development of reproductive healthprogrammes and policy; identify and test new leads in male contraceptive technology; establish effective maleinvo...Research that addresses male reproductive health should assist in the development of reproductive healthprogrammes and policy; identify and test new leads in male contraceptive technology; establish effective maleinvolvement initiatives which are likely to have a positive impact on the reproductive health of men and women; guidethe allocation of health care resources to ensure cost-effectiveness of interventions; generate new knowledge, developdiagnostic technology in reproductive health and offer optimal treatment/care regimens. In considering the needs and demands of male reproductive health research in Asia and the Pacific, the followingsix research topics are recommended as the priority research areas: male contraceptive technology; male reproductivehealth behaviour and male adolescent reproductive health; male reproductive aging including male menopause and otherdiseases; male RTIs, STDs, HIV/AIDS; prevalence, management and prevention of male infertility; environment andsemen quality and other male reproductive problems. One of the major challenges now facing us is the elaboration of a comprehensive, yet realistic male reproductivehealth research agenda that reflect the needs and demands of Asian developing countries. To this end, to make use of aninterdisciplinary approach is of strategic importance. The most creative insights and productive leads are likely toemerge from a research team that is interdisciplinary especially in the field of reproductive health.展开更多
Objective To determine the relation between infant feeding practices (and other factors) and the duration of postpartum amenorrhoea in a sample of Chinese women Subjects &. Methods Infant feeding and the return of...Objective To determine the relation between infant feeding practices (and other factors) and the duration of postpartum amenorrhoea in a sample of Chinese women Subjects &. Methods Infant feeding and the return of menses were measured longitudinally in 541 mothers and their infants in Pengxian County, Sichuan Province. The durations of breastfeeding and of lactational amenorrhoea were estimated through survival analysis. Cox's non-parametric hazards regression analysis was performed to determine the variables associated with the duration of lactational amenorrhoea. Results Mothers breastfed frequently per day, the mean frequency ranging from 6. 4 per day at 3 weeks postpartum to 5. 4 per day at 6 months. They breastfed for over 18. 3 months on average. The median duration of lactational amenorrhoea was 9. 5 months. The period from birth until the first breastfeed was a significant determinant of the duration of lactational amenorrhoea, P = 0. 038. Compared with women who ended full breastfeeding earlier, those who ceased full breastfeeding at 120 to 24C days returned to menses significantly sooner (risk ratio = 1. 34; 95% CI = 1. 06-1. 69). This finding is probably spurious since no relationship between full breastfeeding duration and the return of menses was found among women -who ended full breastfeeding after 240 days. Conclusion The most important determinant of the return of menses was the delay in the first breastfeed after birth, suggesting that the Ten Steps to Successful Breastfeeding should be more precisely implemented.展开更多
基金This study was supported by the research grant from Administration of Key Disciplines for"Project 211"of Sun Yat-Sen University of Medical Sciences,Grant No.98097.
文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].
基金Supported by Biomedical Research Institute Grant(PNU-2013-0373),Pusan National University Hospital
文摘AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS： Forty Sprague-Dawley rats were divided into 4 groups： control, diabetes mellitus （DM）, candesartan- treated DM, and enalapril-treated DM （each group, n---10）. After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/（kg · d）] and enalapril [ACEI, 10 mg/（kg · d）] were administered to rats orally for 4Wko Vascular endothelial growth factor （VEGF） and angiotensin II （Ang II） concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor （ATIR） levels were assessed at week 4 by Western blotting. RESULTS： Vitreous Ang II levels were significantly higher in the DM group and candesartan-treated DM group than in the control （P=0.04 and 0.005, respectively）. Vitreous ATIR increased significantly in DM compared to the other three groups （P〈0.007）. Candesartan-treated DM rats showed higher vitreal ATIR concentration than the enalapril-treated DM group and control （P〈0.001 and P=0.005, respectively）. No difference in vitreous Ang II and ATIR concentration was found between the enalapril- treated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups. CONCLUSION： Increased Ang II and ATIR in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB.
基金International Medical University Authorities for Providing Research Grant (No. IMU 127/2006)
文摘AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH.
文摘Introduction: Despite progress in universal health coverage, maternal mortality remains a concern for developing countries, including Mali. The problem is not due only to a lack of health services but to a combination of factors that need to be identified to give hope to women of childbearing age. Objective: Determine the factors associated with maternal mortality in the Timbuktu region of Mali. Methodology: Retrospective, descriptive, cross-sectional and analytical study from January 1, 2018 to December 31, 2022 using a questionnaire and an interview guide to determine the factors associated with maternal mortality in the Timbuktu region of Mali. Results: A total of 112 maternal deaths were recorded between 2018 and 2022. The average age of the women who died was 26 years (standard deviation 7.6 years). The 14 – 23-year-old age group is the most affected (43.8%). 66.1% of women came from rural areas. Illiteracy (77.7%), lack of ANC (54.5%), distance of households from health facilities (76%) and insecurity (52.7%) have been identified as factors contributing to maternal mortality. Conclusion: This study reported a high prevalence of maternal mortality rates that may be associated with women’s socioeconomic conditions. Actions must be developed to integrate CPN into an advanced strategy for women living in rural areas in Mali.
文摘目的:综合评价虚拟现实体育活动对脑卒中患者上肢功能康复的影响。方法:通过PubMed、Cochrane Library、Web of Science、Medline、中国知网(CNKI)等数据库检索自建库至2024年2月的相关文献,采用Sata17.0、RevMan5.3统计软件进行Meta分析。结果:共纳入10项研究,共涉及676名受试者,总体方法学质量较高,无明显发表偏倚。在虚拟现实体育活动干预下,与对照组相比,可有效改善Fugl-Meyer量表(FMA)评分(WMD=4.85,95%CI:4.29~5.41,P<0.001),改善Box and Block实验(BBT)评分(WMD=4.21,95%CI:-1.61~10.02,P=0.156),提高上肢运动速度(WMD=3.23,95%CI:0.44~6.02,P=0.023),间接提高功能独立性量表(FIM)评分(WMD=8.54,95%CI:5.30~11.79,P<0.001),但对提升上肢力量(SMD=0.02,95%CI:-0.53-0.57,P=0.944)和手功能(WMD=-0.74,95%CI:-1.28~-0.20,P=0.007)没有改善作用,对上肢活动频率和活动度改善情况尚不清楚。结论:虚拟现实技术应用在脑卒中上肢运动康复训练中,能有效改善上肢活动能力,提高运动量和运动质量,改善功能独立性,但在力量和活动度方面未产生积极影响,虚拟现实作为一种新兴临床干预手段,对于心血管疾病的预防和改善是一种有效的方法。
文摘Better understanding of the immunological mechanisms implying the insemination and the infertility of some menand women is needed and crucial to the development of an effective immunocontraceptive method. To provide goodprotection against conception or infection, and avoid any possible and unexpected comlications which immunocontra-ceptive 'vaccine' may arise of , it seems the right time for scientists to create a virtually new thinking for this extremelyurgent and important issue. This conceptual article describes our original thoughts of the future development of im-munocntraceptives, preferably, based on immunoglobulins rather than vaccines, against human sperm specific antigensand seminal plasma immunosuppressive factors. Its general correctness, advantages and feasibility for fertility regula-tion and prevention of infection are discussed. (Asian J Androl 1999 Sep; 1: 87-93)
文摘Lee SM, Jung JW, Park SW, Lee JE, Byon IS. Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye. Int J Ophthalmo12017; 10（6）： 1019-1020
文摘Research that addresses male reproductive health should assist in the development of reproductive healthprogrammes and policy; identify and test new leads in male contraceptive technology; establish effective maleinvolvement initiatives which are likely to have a positive impact on the reproductive health of men and women; guidethe allocation of health care resources to ensure cost-effectiveness of interventions; generate new knowledge, developdiagnostic technology in reproductive health and offer optimal treatment/care regimens. In considering the needs and demands of male reproductive health research in Asia and the Pacific, the followingsix research topics are recommended as the priority research areas: male contraceptive technology; male reproductivehealth behaviour and male adolescent reproductive health; male reproductive aging including male menopause and otherdiseases; male RTIs, STDs, HIV/AIDS; prevalence, management and prevention of male infertility; environment andsemen quality and other male reproductive problems. One of the major challenges now facing us is the elaboration of a comprehensive, yet realistic male reproductivehealth research agenda that reflect the needs and demands of Asian developing countries. To this end, to make use of aninterdisciplinary approach is of strategic importance. The most creative insights and productive leads are likely toemerge from a research team that is interdisciplinary especially in the field of reproductive health.
基金This study was supported by the UNDP/UNFPA/WHO/World Bank Special Programme of Research,Development and Research Training in Human ReproductionWorld Health Organization
文摘Objective To determine the relation between infant feeding practices (and other factors) and the duration of postpartum amenorrhoea in a sample of Chinese women Subjects &. Methods Infant feeding and the return of menses were measured longitudinally in 541 mothers and their infants in Pengxian County, Sichuan Province. The durations of breastfeeding and of lactational amenorrhoea were estimated through survival analysis. Cox's non-parametric hazards regression analysis was performed to determine the variables associated with the duration of lactational amenorrhoea. Results Mothers breastfed frequently per day, the mean frequency ranging from 6. 4 per day at 3 weeks postpartum to 5. 4 per day at 6 months. They breastfed for over 18. 3 months on average. The median duration of lactational amenorrhoea was 9. 5 months. The period from birth until the first breastfeed was a significant determinant of the duration of lactational amenorrhoea, P = 0. 038. Compared with women who ended full breastfeeding earlier, those who ceased full breastfeeding at 120 to 24C days returned to menses significantly sooner (risk ratio = 1. 34; 95% CI = 1. 06-1. 69). This finding is probably spurious since no relationship between full breastfeeding duration and the return of menses was found among women -who ended full breastfeeding after 240 days. Conclusion The most important determinant of the return of menses was the delay in the first breastfeed after birth, suggesting that the Ten Steps to Successful Breastfeeding should be more precisely implemented.
