为了提高支持向量机(SVM)对航空发动机气路故障诊断的准确率以及在诊断过程中的可靠性,引入量子自适应粒子群优化算法(QAPSO)对其惩罚因子、核函数参数以及松弛变量进行寻优,并利用优化后的支持向量机对航空发动机气路故障进行诊断。以P...为了提高支持向量机(SVM)对航空发动机气路故障诊断的准确率以及在诊断过程中的可靠性,引入量子自适应粒子群优化算法(QAPSO)对其惩罚因子、核函数参数以及松弛变量进行寻优,并利用优化后的支持向量机对航空发动机气路故障进行诊断。以PW4056发动机的EHM(Equipment Health Monitoring)状态监控系统为例,将QAPSO-SVM算法、QPSO-SVM、PSO-SVM、SVM、BP和Elman神经网络用于航空发动机气路故障诊断中,从发动机故障诊断的性能参数、抗噪能力、训练时间以及诊断精度四方面进行综合比较分析。仿真结果表明:QAPSO-SVM方法在多种故障模式的诊断中准确度都要优于其他两种优化的SVM以及BP与Elman神经网络;QAPSO-SVM的平均诊断准确度与抗噪能力也要优于其他方法,并且在故障诊断性能参数不同的情况下,也能够很好地对其进行诊断,展现出较强适应能力。展开更多
Objective To investigate the attenuating effect of curcumin, an anti-inflammatory compound derived from dietary spice turmeric （Curcuma longa） on the pro-inflammatory insulin-resistant state in 3T3-L1 adipocytes. Me...Objective To investigate the attenuating effect of curcumin, an anti-inflammatory compound derived from dietary spice turmeric （Curcuma longa） on the pro-inflammatory insulin-resistant state in 3T3-L1 adipocytes. Methods Glucose uptake rate was determined with the [3H] 2-deoxyglucose uptake method. Expressions of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were measured by quantitative RT-PCR analysis and ELISA. Nuclear transcription factor kappaB p65 （NF-r,B p65） and mitogen-activated protein kinase （MAPKs） were detected by Western blot assay. Results The basal glucose uptake was not altered, and curcumin increased the insulin-stimulated glucose uptake in 3T3-L1 cells. Curcumin suppressed the transcription and secretion of TNF-α and IL-6 induced by palmitate in a concentration-dependent manner. Palmitate induced nuclear translocation of NF-kB. The activities of Jun NH2-terminal kinase ONK）, extracellular signal-regulated kinasel/2 （ERKI/2） and p38MAPK decreased in the presence of curcumin. Moreover, pretreatment with SP600125 （inhibitor of JNK） instead of PD98059 or SB203580 （inhibitor of ERKI/2 or p38MAPK, respectively） decreased the up-regulation of TNF-α induced by palmitate. Conelusion Curcumin reverses palmitate-induced insulin resistance state in 3T3-L1 adipocytes through the NF-kB and JNK pathway.展开更多
目的:探讨复方血栓通(cFXST)对玻璃体腔注射雷珠单抗(IVR)治疗湿性老年性黄斑变性(wet-AMD)的辅助治疗作用。方法:纳入湿性老年性黄斑变性患者38例,以1:1的比例随机纳入Lucentis组(单独玻璃体腔注射雷珠单抗,19例)和cFXST组(玻璃体腔注...目的:探讨复方血栓通(cFXST)对玻璃体腔注射雷珠单抗(IVR)治疗湿性老年性黄斑变性(wet-AMD)的辅助治疗作用。方法:纳入湿性老年性黄斑变性患者38例,以1:1的比例随机纳入Lucentis组(单独玻璃体腔注射雷珠单抗,19例)和cFXST组(玻璃体腔注射雷珠单抗联合复方血栓通,19例)。Lucentis组患者每月行玻璃体腔注射雷珠单抗(IVR),共计3次;cFXST组患者除IVR外,每日口服cFXST。分别在基线、玻璃体腔注射Lucentis后1个月、3个月记录最佳矫正视力(BCVA)和光学相干断层扫描(OCT)影像上视网膜新生血干至色素上皮下厚度(CNV-PED)。结果:cFXST组CNV-PED厚度在1月和3月分别降低31.7%和36.1%,高于Lucentis组的19.7%(P=0.021)、24.2%(P=0.018)。3个月后,cFXST组BCVA变化(P=0.045)及视力提高显著的患者比例(16/16 vs 8/17,P=0.001)明显高于Lucentis组。结论:每日口服cFXST治疗可提高抗VEGF治疗老年wet-AMD的短期疗效。展开更多
文摘为了提高支持向量机(SVM)对航空发动机气路故障诊断的准确率以及在诊断过程中的可靠性,引入量子自适应粒子群优化算法(QAPSO)对其惩罚因子、核函数参数以及松弛变量进行寻优,并利用优化后的支持向量机对航空发动机气路故障进行诊断。以PW4056发动机的EHM(Equipment Health Monitoring)状态监控系统为例,将QAPSO-SVM算法、QPSO-SVM、PSO-SVM、SVM、BP和Elman神经网络用于航空发动机气路故障诊断中,从发动机故障诊断的性能参数、抗噪能力、训练时间以及诊断精度四方面进行综合比较分析。仿真结果表明:QAPSO-SVM方法在多种故障模式的诊断中准确度都要优于其他两种优化的SVM以及BP与Elman神经网络;QAPSO-SVM的平均诊断准确度与抗噪能力也要优于其他方法,并且在故障诊断性能参数不同的情况下,也能够很好地对其进行诊断,展现出较强适应能力。
基金supported by the Projects in the National Science & Technology Pillar Program during the Eleventh Five-year Plan Period:Research and Industrialization of Functional Foods in Reducing Blood Lipid,Pressure and Glucose(2006-2010.No.2006BAD27B05).
文摘Objective To investigate the attenuating effect of curcumin, an anti-inflammatory compound derived from dietary spice turmeric （Curcuma longa） on the pro-inflammatory insulin-resistant state in 3T3-L1 adipocytes. Methods Glucose uptake rate was determined with the [3H] 2-deoxyglucose uptake method. Expressions of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were measured by quantitative RT-PCR analysis and ELISA. Nuclear transcription factor kappaB p65 （NF-r,B p65） and mitogen-activated protein kinase （MAPKs） were detected by Western blot assay. Results The basal glucose uptake was not altered, and curcumin increased the insulin-stimulated glucose uptake in 3T3-L1 cells. Curcumin suppressed the transcription and secretion of TNF-α and IL-6 induced by palmitate in a concentration-dependent manner. Palmitate induced nuclear translocation of NF-kB. The activities of Jun NH2-terminal kinase ONK）, extracellular signal-regulated kinasel/2 （ERKI/2） and p38MAPK decreased in the presence of curcumin. Moreover, pretreatment with SP600125 （inhibitor of JNK） instead of PD98059 or SB203580 （inhibitor of ERKI/2 or p38MAPK, respectively） decreased the up-regulation of TNF-α induced by palmitate. Conelusion Curcumin reverses palmitate-induced insulin resistance state in 3T3-L1 adipocytes through the NF-kB and JNK pathway.
文摘目的:探讨复方血栓通(cFXST)对玻璃体腔注射雷珠单抗(IVR)治疗湿性老年性黄斑变性(wet-AMD)的辅助治疗作用。方法:纳入湿性老年性黄斑变性患者38例,以1:1的比例随机纳入Lucentis组(单独玻璃体腔注射雷珠单抗,19例)和cFXST组(玻璃体腔注射雷珠单抗联合复方血栓通,19例)。Lucentis组患者每月行玻璃体腔注射雷珠单抗(IVR),共计3次;cFXST组患者除IVR外,每日口服cFXST。分别在基线、玻璃体腔注射Lucentis后1个月、3个月记录最佳矫正视力(BCVA)和光学相干断层扫描(OCT)影像上视网膜新生血干至色素上皮下厚度(CNV-PED)。结果:cFXST组CNV-PED厚度在1月和3月分别降低31.7%和36.1%,高于Lucentis组的19.7%(P=0.021)、24.2%(P=0.018)。3个月后,cFXST组BCVA变化(P=0.045)及视力提高显著的患者比例(16/16 vs 8/17,P=0.001)明显高于Lucentis组。结论:每日口服cFXST治疗可提高抗VEGF治疗老年wet-AMD的短期疗效。
