Introduction: This study investigates the Experimental and Theoretical Investigation of Steel and Glass Fiber Reinforced Polymer (GFRP) Reinforced Slab Incorporating Alccofine and M-sand. Objective: Specific objective...Introduction: This study investigates the Experimental and Theoretical Investigation of Steel and Glass Fiber Reinforced Polymer (GFRP) Reinforced Slab Incorporating Alccofine and M-sand. Objective: Specific objectives include evaluating the mechanical properties and structural behaviour of steel and GFRP-reinforced one-way slabs and comparing experimental and theoretical predictions. Methods: Four different mix proportions were arrived at, comprising both conventional concrete and Alccofine-based concrete. In each formulation, a combination of normal river sand and M-sand was utilized. Results: Concrete with Alccofine exhibits superior mechanical properties, while M-sand incorporation minimally affects strength but reduces reliance on natural sand. GFRP-reinforced slabs display distinct brittle behaviour with significant deflections post-cracking, contrasting steel-reinforced slabs’ gradual, ductile failure. Discrepancies between experimental data and design recommendations underscore the need for guideline refinement. Conclusion: Alccofine and M-sand enhance concrete properties, but reinforcement type significantly influences slab behaviour. GFRP-reinforced slabs, though exhibiting lower values than steel, offer advantages in harsh environments, warranting further optimization.展开更多
Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to...Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.展开更多
Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psori...Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract(100 and 200 mg/kg b.w.) and isolated flavonoid quercetin(25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results:The isolated flavonoid quercetin from the rhizome of S.china produced significant orthokeratosis(P<0.01) in the mouse tail test.In epidermal thickness,a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract(200 mg/kg) and isolated flavonoid quercetin(50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition(P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin(IC_(50),62.42± 10.20 μg/mL).Conclusions:From the above data,the flavonoid quercetin shows significant orthokeratosis,anti-inflammatory and maximum antiproliferant activities.To our knowledge,this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.展开更多
Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privileg...Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in "low-risk" settings. Furthermore, although corneal graft survival in "lowrisk" recipients is favourable, the prognosis in "high-risk" recipients for corneal graft is poor. In "high-risk" grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of "high-risk" recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in "high-risk" recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both "low-risk" and "hi展开更多
Bamboo shoots can be harvested at different ages but the data on the changes in nutritional composition with age are scanty. We standardized harvesting age of bamboo shoots in central India to obtain best quality prod...Bamboo shoots can be harvested at different ages but the data on the changes in nutritional composition with age are scanty. We standardized harvesting age of bamboo shoots in central India to obtain best quality produce with respect to nutritional composition. The shoots harvested on different days （2–20 days after emergence from ground） were analyzed for their nutritional （dietary fibres, carbohydrates, proteins, total phenols, ascorbic acid, sodium, potassium, phosphorus, calcium, magnesium and phenolic acids） and anti nutritional （cyanogen） constituents. A significant variation （at p ≤ 0.5） was observed in the nutritional composition of shoots of Dendrocalamus asper, D. strictus and Bambusa tulda harvested at different days. An overall decrease was observed in proteins and total phenols while dietary fibres and carbohydrates increased with ages. Significant variation （at p ≤ 0.5） was also observed in phenolic acids while minerals did not vary significantly. Results revealed that the optimum harvesting age for D. asper, D. strictus and B. tulda was on 10–14 days, 6–10 days and 10–16 days （after emergence from the ground） respectively. These results can be used to obtain quality bamboo shoots.展开更多
Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 7...Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 h.The microstructure,microhardness and tensile strength were studied for all the three conditions and four routes.Significant improvement in hardness(HV 184 after five passes) and strength(602 MPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route Bc.Microstructure evolution was reasonably equiaxed in route Bc with aspect ratio of 1.6.Solutionised and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.展开更多
Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic acti...Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.展开更多
The present investigation was aimed to understand the physiological and biochemical basis of water-deficit stress tolerance in pearl millet [Pennisetum glaucum (L.) R. Br.] hybrid ICMH 356 and its parents ICMR 356 (♂...The present investigation was aimed to understand the physiological and biochemical basis of water-deficit stress tolerance in pearl millet [Pennisetum glaucum (L.) R. Br.] hybrid ICMH 356 and its parents ICMR 356 (♂) and ICMB 88004 (♀) in response to and recovery from drought stress and also to comprehend crop adaptation under dryland conditions. A field experiment was conducted in a split plot design with moisture levels as the main plot and genotypes as the sub plots. A comparative analysis of hybrid and parents under well-watered and water-deficit stress conditions revealed that the hybrid was superior over the parents in terms of leaf water relations, excised leaf water retention capacity, accumulation of compatible solutes, photosynthesis, membrane stability index and antioxidative enzyme viz., superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), ascorbate peroxidase (APX) and guaiacol peroxidase (GPOX) activities. ANOVA for these parameters was also found to be significant for genotypes, treatments and their interactions at 0.01% level. Maintenance of superiority in terms of these physiological and biochemical parameters coupled with better recovery ability upon stress relief are crucial physiological mechanisms contributing to water deficit stress tolerance in pearl millet. Simple correlation coefficient analysis revealed significant positive association of yield at 0.01% level with relative water content, leaf water potential, stomatal conductance, photosynthesis, proline, total soluble sugars, free amino acids, membrane stability index, leaf area index and total biomass, while a significant negative association with solute potential and malondialdehyde content, under water-deficit stress clearly indicated that such relationships can be positively attributed to drought tolerance.展开更多
Recent advancement in low-cost cameras has facilitated surveillance in various developing towns in India.The video obtained from such surveillance are of low quality.Still counting vehicles from such videos are necess...Recent advancement in low-cost cameras has facilitated surveillance in various developing towns in India.The video obtained from such surveillance are of low quality.Still counting vehicles from such videos are necessity to avoid traf-fic congestion and allows drivers to plan their routes more precisely.On the other hand,detecting vehicles from such low quality videos are highly challenging with vision based methodologies.In this research a meticulous attempt is made to access low-quality videos to describe traffic in Salem town in India,which is mostly an un-attempted entity by most available sources.In this work profound Detection Transformer(DETR)model is used for object(vehicle)detection.Here vehicles are anticipated in a rush-hour traffic video using a set of loss functions that carry out bipartite coordinating among estimated and information acquired on real attributes.Every frame in the traffic footage has its date and time which is detected and retrieved using Tesseract Optical Character Recognition.The date and time extricated and perceived from the input image are incorporated with the length of the recognized objects acquired from the DETR model.This furnishes the vehicles report with timestamp.Transformer Timeseries Prediction Model(TTPM)is proposed to predict the density of the vehicle for future prediction,here the regular NLP layers have been removed and the encoding temporal layer has been modified.The proposed TTPM error rate outperforms the existing models with RMSE of 4.313 and MAE of 3.812.展开更多
The periodic outbreak of mosquito-borne diseases like dengue fever,zika fever,and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological system.Due to the l...The periodic outbreak of mosquito-borne diseases like dengue fever,zika fever,and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological system.Due to the lack of therapeutic measures,preventive treatments or vaccines against pathogens,insecticide resistance eventually lead the research focus towards novel technological applications in mosquito management.Nanomaterials with ovicidal,larvicidal,adulticidal,and repellent properties for controlling mosquito vectors are under research.A literature search was carried out for advancements in nanomaterials,insecticides,and mosquito control in PubMed/MEDLINE,Scopus,Google Scholar,ScienceDirect,and Web of Science.This paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases,in vivo and in vitro toxicity evaluation against mosquito species,mode of action,effect on non-target organisms,and ecological risks.Organic and inorganic materials that provide controlled release,target delivery,less dosage,prolonged efficacy,a reduction in the use of organic solvents and emulsifiers,and minimum pollution to the environment have already been explored.Indeed,further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.展开更多
Preserving biodiversity and maintaining ecological balance is essential in current environmental conditions.It is challenging to determine vegetation using traditional map classification approaches.The primary issue i...Preserving biodiversity and maintaining ecological balance is essential in current environmental conditions.It is challenging to determine vegetation using traditional map classification approaches.The primary issue in detecting vegetation pattern is that it appears with complex spatial structures and similar spectral properties.It is more demandable to determine the multiple spectral ana-lyses for improving the accuracy of vegetation mapping through remotely sensed images.The proposed framework is developed with the idea of ensembling three effective strategies to produce a robust architecture for vegetation mapping.The architecture comprises three approaches,feature-based approach,region-based approach,and texture-based approach for classifying the vegetation area.The novel Deep Meta fusion model(DMFM)is created with a unique fusion frame-work of residual stacking of convolution layers with Unique covariate features(UCF),Intensity features(IF),and Colour features(CF).The overhead issues in GPU utilization during Convolution neural network(CNN)models are reduced here with a lightweight architecture.The system considers detailing feature areas to improve classification accuracy and reduce processing time.The proposed DMFM model achieved 99%accuracy,with a maximum processing time of 130 s.The training,testing,and validation losses are degraded to a significant level that shows the performance quality with the DMFM model.The system acts as a standard analysis platform for dynamic datasets since all three different fea-tures,such as Unique covariate features(UCF),Intensity features(IF),and Colour features(CF),are considered very well.展开更多
The Internet of Things(IoT)is converting today’s physical world into a complex and sophisticated network of connected devices on an enormous scale.The existing malicious node detection mechanism in traditional approa...The Internet of Things(IoT)is converting today’s physical world into a complex and sophisticated network of connected devices on an enormous scale.The existing malicious node detection mechanism in traditional approaches lacks in transparency,availability,or traceability of the detection phase.To overcome these concerns,we provide a decentralized technique using blockchain technology.Despite the fact that blockchain technology is applicable to create that type of models,existing harmony set of instructions are susceptible to do violence to such as DoS and Sybil,making blockchain systems unfeasible.Here,a new Proof-of-Improved-Participation(PoIP)harmony instruction was suggested that benefits the participation rules to select honest peers for mining while limiting malicious peers.Under an evaluation the PoIP outperforms the Proof-of-Work(PoW)instructions are demonstrated,Proof of Stake(PoS)instructions in terms of energy consumption,accuracy,and bandwidth.To compare the three consensus protocols with respect to efficiency,we build a lightweight mining model andfind that PoIP consensus has greater efficiency than PoW and PoS.PoIP has 25%lower attack risk than existing consensus.As a consequence,our suggested methodology can provide the needed security with minimal attack risk and high accuracy,according to the analysis results.As a result,suggested consensus is more efficient than existing methods in terms of block generation time.Hence we suggest that suggested consensus is very suitable for IoT-based applications especially in healthcare.展开更多
Safflower is an important, traditional, multipurpose oil crop. This was to investigate the effect of different salinity levels on morphological, physiological, biochemical and antioxidant response of two safflower cul...Safflower is an important, traditional, multipurpose oil crop. This was to investigate the effect of different salinity levels on morphological, physiological, biochemical and antioxidant response of two safflower cultivars (Carthamus tinctorius L. cultivar TSF1 and cultivar SM) differing in salt tolerance. Salinity stress (0.0%, 1.0%, 1.5% and 2.0% of NaCl) was induced to safflower plants after 19 days of vegetative growth. After 12 days of stress impositions, plants were harvested and analysed for various parameters. The results revealed that cultivar TSF1 showed maximum growth, dry weight, cell membrane stability and more water content in both root and leaf tissues at higher salinity levels than cultivar SM. Salt stress resulted an accumulation of more soluble sugars, amino acids, proline and glycine betaine at high salinity level confers the tolerance potential of cultivar TSF1 over cultivar SM. Salt stress induces more increase in the enzyme activity of superoxide dismutase, ascorbate peroxidase, guaiacol peroxidase and catalase in tolerant cultivar than sensitive one. The results indicate that each cultivar adopt specific strategy at distinct salinity level for resistance against salinity. The possible conclusion is that improved tolerance in cultivar TSF1 to salinity may be accomplished by better management of growth, physiological attributes and antioxidative defence mechanisms.展开更多
Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based ...Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based epidemiological studies in survivors of atomic bombs and after occupational and medical low dose radiation exposures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was previously thought. This has raised the concern of a cardiovascular disease risk from exposure to space radiation during long-distance space travel. Groundbased studies with animal and cell culture models play an important role in estimating health risks from space radiation exposure. Charged particle space radiation has dense ionization characteristics and may induce unique biological responses,appropriate simulation of the space radiation environment and careful consideration of the choice of the experimental model are critical. Recent studies have addressed cardiovascular effects of space radiation using such models and provided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could potentially be administered pharmacological countermeasures against adverse effects of space radiation,and research is focused on the development of such compounds. Because the cardiovascular response to space radiation has not yet been clearly defined,the identification of potential pharmacological countermeasures against cardiovascular effects is still in its infancy.展开更多
AIM： To investigate if cisplatin alters vitamin status and if VR modulates cisplatin induced intestinal apoptosis and oxidative stress in Wistar/NIN （WNIN） male rats.METHODS： Weanling, WNIN male rats （n = 12 per ...AIM： To investigate if cisplatin alters vitamin status and if VR modulates cisplatin induced intestinal apoptosis and oxidative stress in Wistar/NIN （WNIN） male rats.METHODS： Weanling, WNIN male rats （n = 12 per group） received adlibitum for 17 wk： control diet （20% protein） or the same with 50% vitamin restriction. They were then sub-divided into two groups of six rats each and administered cisplatin （2.61 mg/kg bodyweight） once a week for three wk or PBS （vehicle control）. Intestinal epithelial cell （IEC） apoptosis was monitored by morphometry, Annexin-V binding, M30 cytodeath assay and DNA fragmentation. Structural and functional integrity of the villus were assessed by villus height / crypt depth ratio and activities of alkaline phosphatase, lys, ala-dipeptidyl amino-peptidase, respectively. To assess the probable mechanism（s） of altered apoptosis, oxidative stress parameters, caspase-3 activity, and expression of Bcl-2 and Bax were determined.RESULTS： Cisplatin per se decreased plasma vitamin levels and they were the lowest in VR animals treated with cisplatin. As expected VR increased only villus apoptosis, whereas cisplatin increased stem cell apoptosis in the crypt. However, cisplatin treatment of VR rats increased apoptosis both in villus and crypt regions and was associated with higher levels of TBARS, protein carbonyls and caspase-3 activity, but lower GSH concentrations. VR induced decrease in Bcl-2 expression was further lowered by cisplatin. Bax expression, unaffected by VR was increased on cisplatin treatment. Mucosal functional integrity was severely compromised in cisplatin treated VR-rats.CONCLUSION： Low intake of vitamins increases the sensitivity of rats to cisplatin and promotes intestinal epithelial cell apoptosis.展开更多
To increase the thermotolerance of improved White Ponni（IWP）, two quantitative trait loci（QTLs）, q HTSF1.1 and q HTSF4.1, controlling spikelet fertility under high-temperature stress, were introgressed from Nagina...To increase the thermotolerance of improved White Ponni（IWP）, two quantitative trait loci（QTLs）, q HTSF1.1 and q HTSF4.1, controlling spikelet fertility under high-temperature stress, were introgressed from Nagina 22 into IWP through marker-assisted breeding. The progenies were subjected to foreground selection of target QTLs using simple sequence repent markers RM431 and RM5757 linked to q HTSF1.1 and q HTSF4.1, respectively. At each generation, foreground selection with single target QTL or both QTLs was done together. The QTL-positive plants were forwarded to next generation by selfing. The F2：3 progenies were subjected to phenotypic analyses under high-temperature stress at the flowering stage. Chlorophyll stability index, malondialdehyde content, grain yield, and yield-related components of the F2：3 progenies were measured. The progenies IWP-295, IWP-277 and IWP-246 harboring both q HTSF1.1 and q HTSF4.1 showed higher fertility percentages under high-temperature stress at the flowering stage. These QTLs were responsible for maintaining membrane integrity and yield under elevated temperature conditions.展开更多
In the present investigation,an analytical analysis has been carried out to study theinfluence of chemical reaction on MHD flow of a nanofluid in an expanding or contractingporous pipe in the presence of heat sourcels...In the present investigation,an analytical analysis has been carried out to study theinfluence of chemical reaction on MHD flow of a nanofluid in an expanding or contractingporous pipe in the presence of heat sourcelsink.The pipe wall expands or contracts uniformlyat a time dependent rate.Similarity transfomations have been invoked to reduce the governingflow equations into coupled nonlinear ordinary differential equations.An analytical approach,namely the homotopy analysis method(HAM)is employed to obtain the analytical solutions ofthe ordinary differential equations.The convergence of the obtained series solutions isanalyzed.The effects of various physical parameters such as wall expansion ratio,Brownianmotion parameter,thermophoresis parameter,Lewis number,chemical reaction parameter andheat sourcelsink parameter on flow variables have been discussed.Further,for the case ofhydrodynamic viscous fluid,we find a good agreement between the HAM solutions andsolutions already reported in the literature.展开更多
The state of art pertaining to vertical handover decisions in next-generation wireless networks provides a detailed overview of vertical handover studies.This paper classifies the research initiatives under the vertic...The state of art pertaining to vertical handover decisions in next-generation wireless networks provides a detailed overview of vertical handover studies.This paper classifies the research initiatives under the vertical handover decision mechanism for heterogeneous wireless networks.A fair comparison of traditional and recent techniques is drafted to obtain direction of the vertical handover decision.Several issues related to seamless support on mobility management techniques have been described in the literature.The next-generation wireless network promises to offer enhanced data services compared to other networks in mobile communication.Since all next generation network(NGN)is an IP-based network,challenges drive toward providing quality of service in the handover process.The necessity of handover process is a seamless connection.The handover operations that minimize or even target the elimination of delay in new network connection establishment are most welcomed.However,frequent disconnection and inefficient seamless handovers result in handover operation failures.Most of the existing methods on handover decisions are based on mobile-controlled handovers.Here,the decisions are in-corporate in the mobile devices.Several mobile-controlled handovers take a single parameter or two or more additional parameters as a combination to evaluate the policy decision.These approaches are carefully studied and classified.展开更多
文摘Introduction: This study investigates the Experimental and Theoretical Investigation of Steel and Glass Fiber Reinforced Polymer (GFRP) Reinforced Slab Incorporating Alccofine and M-sand. Objective: Specific objectives include evaluating the mechanical properties and structural behaviour of steel and GFRP-reinforced one-way slabs and comparing experimental and theoretical predictions. Methods: Four different mix proportions were arrived at, comprising both conventional concrete and Alccofine-based concrete. In each formulation, a combination of normal river sand and M-sand was utilized. Results: Concrete with Alccofine exhibits superior mechanical properties, while M-sand incorporation minimally affects strength but reduces reliance on natural sand. GFRP-reinforced slabs display distinct brittle behaviour with significant deflections post-cracking, contrasting steel-reinforced slabs’ gradual, ductile failure. Discrepancies between experimental data and design recommendations underscore the need for guideline refinement. Conclusion: Alccofine and M-sand enhance concrete properties, but reinforcement type significantly influences slab behaviour. GFRP-reinforced slabs, though exhibiting lower values than steel, offer advantages in harsh environments, warranting further optimization.
文摘Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.
基金financially supported by Vels University,Tamilnadu,India
文摘Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract(100 and 200 mg/kg b.w.) and isolated flavonoid quercetin(25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results:The isolated flavonoid quercetin from the rhizome of S.china produced significant orthokeratosis(P<0.01) in the mouse tail test.In epidermal thickness,a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract(200 mg/kg) and isolated flavonoid quercetin(50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition(P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin(IC_(50),62.42± 10.20 μg/mL).Conclusions:From the above data,the flavonoid quercetin shows significant orthokeratosis,anti-inflammatory and maximum antiproliferant activities.To our knowledge,this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.
基金Supported by Saving Sight in Grampian,Development Trust of University of Aberdeen,United KingdomAction Medical Research United Kingdom(grant SP4328)Link?ping University,Sweden
文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in "low-risk" settings. Furthermore, although corneal graft survival in "lowrisk" recipients is favourable, the prognosis in "high-risk" recipients for corneal graft is poor. In "high-risk" grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of "high-risk" recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in "high-risk" recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both "low-risk" and "hi
基金funded by National Bamboo Mission,Govt. of India
文摘Bamboo shoots can be harvested at different ages but the data on the changes in nutritional composition with age are scanty. We standardized harvesting age of bamboo shoots in central India to obtain best quality produce with respect to nutritional composition. The shoots harvested on different days （2–20 days after emergence from ground） were analyzed for their nutritional （dietary fibres, carbohydrates, proteins, total phenols, ascorbic acid, sodium, potassium, phosphorus, calcium, magnesium and phenolic acids） and anti nutritional （cyanogen） constituents. A significant variation （at p ≤ 0.5） was observed in the nutritional composition of shoots of Dendrocalamus asper, D. strictus and Bambusa tulda harvested at different days. An overall decrease was observed in proteins and total phenols while dietary fibres and carbohydrates increased with ages. Significant variation （at p ≤ 0.5） was also observed in phenolic acids while minerals did not vary significantly. Results revealed that the optimum harvesting age for D. asper, D. strictus and B. tulda was on 10–14 days, 6–10 days and 10–16 days （after emergence from the ground） respectively. These results can be used to obtain quality bamboo shoots.
文摘Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 h.The microstructure,microhardness and tensile strength were studied for all the three conditions and four routes.Significant improvement in hardness(HV 184 after five passes) and strength(602 MPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route Bc.Microstructure evolution was reasonably equiaxed in route Bc with aspect ratio of 1.6.Solutionised and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.
文摘Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.
文摘The present investigation was aimed to understand the physiological and biochemical basis of water-deficit stress tolerance in pearl millet [Pennisetum glaucum (L.) R. Br.] hybrid ICMH 356 and its parents ICMR 356 (♂) and ICMB 88004 (♀) in response to and recovery from drought stress and also to comprehend crop adaptation under dryland conditions. A field experiment was conducted in a split plot design with moisture levels as the main plot and genotypes as the sub plots. A comparative analysis of hybrid and parents under well-watered and water-deficit stress conditions revealed that the hybrid was superior over the parents in terms of leaf water relations, excised leaf water retention capacity, accumulation of compatible solutes, photosynthesis, membrane stability index and antioxidative enzyme viz., superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), ascorbate peroxidase (APX) and guaiacol peroxidase (GPOX) activities. ANOVA for these parameters was also found to be significant for genotypes, treatments and their interactions at 0.01% level. Maintenance of superiority in terms of these physiological and biochemical parameters coupled with better recovery ability upon stress relief are crucial physiological mechanisms contributing to water deficit stress tolerance in pearl millet. Simple correlation coefficient analysis revealed significant positive association of yield at 0.01% level with relative water content, leaf water potential, stomatal conductance, photosynthesis, proline, total soluble sugars, free amino acids, membrane stability index, leaf area index and total biomass, while a significant negative association with solute potential and malondialdehyde content, under water-deficit stress clearly indicated that such relationships can be positively attributed to drought tolerance.
文摘Recent advancement in low-cost cameras has facilitated surveillance in various developing towns in India.The video obtained from such surveillance are of low quality.Still counting vehicles from such videos are necessity to avoid traf-fic congestion and allows drivers to plan their routes more precisely.On the other hand,detecting vehicles from such low quality videos are highly challenging with vision based methodologies.In this research a meticulous attempt is made to access low-quality videos to describe traffic in Salem town in India,which is mostly an un-attempted entity by most available sources.In this work profound Detection Transformer(DETR)model is used for object(vehicle)detection.Here vehicles are anticipated in a rush-hour traffic video using a set of loss functions that carry out bipartite coordinating among estimated and information acquired on real attributes.Every frame in the traffic footage has its date and time which is detected and retrieved using Tesseract Optical Character Recognition.The date and time extricated and perceived from the input image are incorporated with the length of the recognized objects acquired from the DETR model.This furnishes the vehicles report with timestamp.Transformer Timeseries Prediction Model(TTPM)is proposed to predict the density of the vehicle for future prediction,here the regular NLP layers have been removed and the encoding temporal layer has been modified.The proposed TTPM error rate outperforms the existing models with RMSE of 4.313 and MAE of 3.812.
文摘The periodic outbreak of mosquito-borne diseases like dengue fever,zika fever,and yellow fever all over the world highlights the need for effective mosquito control methods targeting the biological system.Due to the lack of therapeutic measures,preventive treatments or vaccines against pathogens,insecticide resistance eventually lead the research focus towards novel technological applications in mosquito management.Nanomaterials with ovicidal,larvicidal,adulticidal,and repellent properties for controlling mosquito vectors are under research.A literature search was carried out for advancements in nanomaterials,insecticides,and mosquito control in PubMed/MEDLINE,Scopus,Google Scholar,ScienceDirect,and Web of Science.This paper aims to provide insights into various nanomaterials relevant to mosquito-borne diseases,in vivo and in vitro toxicity evaluation against mosquito species,mode of action,effect on non-target organisms,and ecological risks.Organic and inorganic materials that provide controlled release,target delivery,less dosage,prolonged efficacy,a reduction in the use of organic solvents and emulsifiers,and minimum pollution to the environment have already been explored.Indeed,further research on the ecological risk and economic feasibility of nanomaterials in mosquitocidal applications should be done prior to commercialization.
文摘Preserving biodiversity and maintaining ecological balance is essential in current environmental conditions.It is challenging to determine vegetation using traditional map classification approaches.The primary issue in detecting vegetation pattern is that it appears with complex spatial structures and similar spectral properties.It is more demandable to determine the multiple spectral ana-lyses for improving the accuracy of vegetation mapping through remotely sensed images.The proposed framework is developed with the idea of ensembling three effective strategies to produce a robust architecture for vegetation mapping.The architecture comprises three approaches,feature-based approach,region-based approach,and texture-based approach for classifying the vegetation area.The novel Deep Meta fusion model(DMFM)is created with a unique fusion frame-work of residual stacking of convolution layers with Unique covariate features(UCF),Intensity features(IF),and Colour features(CF).The overhead issues in GPU utilization during Convolution neural network(CNN)models are reduced here with a lightweight architecture.The system considers detailing feature areas to improve classification accuracy and reduce processing time.The proposed DMFM model achieved 99%accuracy,with a maximum processing time of 130 s.The training,testing,and validation losses are degraded to a significant level that shows the performance quality with the DMFM model.The system acts as a standard analysis platform for dynamic datasets since all three different fea-tures,such as Unique covariate features(UCF),Intensity features(IF),and Colour features(CF),are considered very well.
文摘The Internet of Things(IoT)is converting today’s physical world into a complex and sophisticated network of connected devices on an enormous scale.The existing malicious node detection mechanism in traditional approaches lacks in transparency,availability,or traceability of the detection phase.To overcome these concerns,we provide a decentralized technique using blockchain technology.Despite the fact that blockchain technology is applicable to create that type of models,existing harmony set of instructions are susceptible to do violence to such as DoS and Sybil,making blockchain systems unfeasible.Here,a new Proof-of-Improved-Participation(PoIP)harmony instruction was suggested that benefits the participation rules to select honest peers for mining while limiting malicious peers.Under an evaluation the PoIP outperforms the Proof-of-Work(PoW)instructions are demonstrated,Proof of Stake(PoS)instructions in terms of energy consumption,accuracy,and bandwidth.To compare the three consensus protocols with respect to efficiency,we build a lightweight mining model andfind that PoIP consensus has greater efficiency than PoW and PoS.PoIP has 25%lower attack risk than existing consensus.As a consequence,our suggested methodology can provide the needed security with minimal attack risk and high accuracy,according to the analysis results.As a result,suggested consensus is more efficient than existing methods in terms of block generation time.Hence we suggest that suggested consensus is very suitable for IoT-based applications especially in healthcare.
文摘Safflower is an important, traditional, multipurpose oil crop. This was to investigate the effect of different salinity levels on morphological, physiological, biochemical and antioxidant response of two safflower cultivars (Carthamus tinctorius L. cultivar TSF1 and cultivar SM) differing in salt tolerance. Salinity stress (0.0%, 1.0%, 1.5% and 2.0% of NaCl) was induced to safflower plants after 19 days of vegetative growth. After 12 days of stress impositions, plants were harvested and analysed for various parameters. The results revealed that cultivar TSF1 showed maximum growth, dry weight, cell membrane stability and more water content in both root and leaf tissues at higher salinity levels than cultivar SM. Salt stress resulted an accumulation of more soluble sugars, amino acids, proline and glycine betaine at high salinity level confers the tolerance potential of cultivar TSF1 over cultivar SM. Salt stress induces more increase in the enzyme activity of superoxide dismutase, ascorbate peroxidase, guaiacol peroxidase and catalase in tolerant cultivar than sensitive one. The results indicate that each cultivar adopt specific strategy at distinct salinity level for resistance against salinity. The possible conclusion is that improved tolerance in cultivar TSF1 to salinity may be accomplished by better management of growth, physiological attributes and antioxidative defence mechanisms.
基金Supported by The National Space Biomedical Research Institute(RE03701)through NCC 9-58the National Institutes of Health(CA148679 and P20 GM109005)
文摘Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based epidemiological studies in survivors of atomic bombs and after occupational and medical low dose radiation exposures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was previously thought. This has raised the concern of a cardiovascular disease risk from exposure to space radiation during long-distance space travel. Groundbased studies with animal and cell culture models play an important role in estimating health risks from space radiation exposure. Charged particle space radiation has dense ionization characteristics and may induce unique biological responses,appropriate simulation of the space radiation environment and careful consideration of the choice of the experimental model are critical. Recent studies have addressed cardiovascular effects of space radiation using such models and provided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could potentially be administered pharmacological countermeasures against adverse effects of space radiation,and research is focused on the development of such compounds. Because the cardiovascular response to space radiation has not yet been clearly defined,the identification of potential pharmacological countermeasures against cardiovascular effects is still in its infancy.
基金Supported by The Indian Council of Medical Research
文摘AIM： To investigate if cisplatin alters vitamin status and if VR modulates cisplatin induced intestinal apoptosis and oxidative stress in Wistar/NIN （WNIN） male rats.METHODS： Weanling, WNIN male rats （n = 12 per group） received adlibitum for 17 wk： control diet （20% protein） or the same with 50% vitamin restriction. They were then sub-divided into two groups of six rats each and administered cisplatin （2.61 mg/kg bodyweight） once a week for three wk or PBS （vehicle control）. Intestinal epithelial cell （IEC） apoptosis was monitored by morphometry, Annexin-V binding, M30 cytodeath assay and DNA fragmentation. Structural and functional integrity of the villus were assessed by villus height / crypt depth ratio and activities of alkaline phosphatase, lys, ala-dipeptidyl amino-peptidase, respectively. To assess the probable mechanism（s） of altered apoptosis, oxidative stress parameters, caspase-3 activity, and expression of Bcl-2 and Bax were determined.RESULTS： Cisplatin per se decreased plasma vitamin levels and they were the lowest in VR animals treated with cisplatin. As expected VR increased only villus apoptosis, whereas cisplatin increased stem cell apoptosis in the crypt. However, cisplatin treatment of VR rats increased apoptosis both in villus and crypt regions and was associated with higher levels of TBARS, protein carbonyls and caspase-3 activity, but lower GSH concentrations. VR induced decrease in Bcl-2 expression was further lowered by cisplatin. Bax expression, unaffected by VR was increased on cisplatin treatment. Mucosal functional integrity was severely compromised in cisplatin treated VR-rats.CONCLUSION： Low intake of vitamins increases the sensitivity of rats to cisplatin and promotes intestinal epithelial cell apoptosis.
基金supported by the Department of Biotechnology,New Delhi(Grant No.BT/PR10593/AG2 II/106/936/2014)
文摘To increase the thermotolerance of improved White Ponni（IWP）, two quantitative trait loci（QTLs）, q HTSF1.1 and q HTSF4.1, controlling spikelet fertility under high-temperature stress, were introgressed from Nagina 22 into IWP through marker-assisted breeding. The progenies were subjected to foreground selection of target QTLs using simple sequence repent markers RM431 and RM5757 linked to q HTSF1.1 and q HTSF4.1, respectively. At each generation, foreground selection with single target QTL or both QTLs was done together. The QTL-positive plants were forwarded to next generation by selfing. The F2：3 progenies were subjected to phenotypic analyses under high-temperature stress at the flowering stage. Chlorophyll stability index, malondialdehyde content, grain yield, and yield-related components of the F2：3 progenies were measured. The progenies IWP-295, IWP-277 and IWP-246 harboring both q HTSF1.1 and q HTSF4.1 showed higher fertility percentages under high-temperature stress at the flowering stage. These QTLs were responsible for maintaining membrane integrity and yield under elevated temperature conditions.
基金The authors gratefully acknowledge National Board forHigher Mathematics,India for sanctioning a major researchproject under the Grant no.2/48(19)/2012/NBHM(R.P.)/R&D II/9137.The authors thank all the three anonymousreviewers for their constructive comments and suggestions.
文摘In the present investigation,an analytical analysis has been carried out to study theinfluence of chemical reaction on MHD flow of a nanofluid in an expanding or contractingporous pipe in the presence of heat sourcelsink.The pipe wall expands or contracts uniformlyat a time dependent rate.Similarity transfomations have been invoked to reduce the governingflow equations into coupled nonlinear ordinary differential equations.An analytical approach,namely the homotopy analysis method(HAM)is employed to obtain the analytical solutions ofthe ordinary differential equations.The convergence of the obtained series solutions isanalyzed.The effects of various physical parameters such as wall expansion ratio,Brownianmotion parameter,thermophoresis parameter,Lewis number,chemical reaction parameter andheat sourcelsink parameter on flow variables have been discussed.Further,for the case ofhydrodynamic viscous fluid,we find a good agreement between the HAM solutions andsolutions already reported in the literature.
文摘The state of art pertaining to vertical handover decisions in next-generation wireless networks provides a detailed overview of vertical handover studies.This paper classifies the research initiatives under the vertical handover decision mechanism for heterogeneous wireless networks.A fair comparison of traditional and recent techniques is drafted to obtain direction of the vertical handover decision.Several issues related to seamless support on mobility management techniques have been described in the literature.The next-generation wireless network promises to offer enhanced data services compared to other networks in mobile communication.Since all next generation network(NGN)is an IP-based network,challenges drive toward providing quality of service in the handover process.The necessity of handover process is a seamless connection.The handover operations that minimize or even target the elimination of delay in new network connection establishment are most welcomed.However,frequent disconnection and inefficient seamless handovers result in handover operation failures.Most of the existing methods on handover decisions are based on mobile-controlled handovers.Here,the decisions are in-corporate in the mobile devices.Several mobile-controlled handovers take a single parameter or two or more additional parameters as a combination to evaluate the policy decision.These approaches are carefully studied and classified.
