Quasicrystals （QCs） are sensitive to the piezoelectric （PE） effect. This paper studies static deformation of a multilayered one-dimensional （1D） hexagonal QC plate with the PE effect. The exact closed-form solut...Quasicrystals （QCs） are sensitive to the piezoelectric （PE） effect. This paper studies static deformation of a multilayered one-dimensional （1D） hexagonal QC plate with the PE effect. The exact closed-form solutions of the extended displacement and traction for a homogeneous piezoelectric quasicrystal （PQC）plate are derived from an eigensystem. The general solutions for multilayered PQC plates are then obtained using the propagator matrix method when mechanical and electrical loads are applied on the top surface of the plate. Numerical examples for several sandwich plates made up of PQC, PE, and QC materials are provided to show the effect of stacking sequence on phonon, phason, and electric fields under mechanical and electrical loads, which is useful in designing new composites for engineering structures.展开更多
A mathematical model for nonlocal vibration and buckling of embedded two-dimensional(2 D) decagonal quasicrystal(QC) layered nanoplates is proposed. The Pasternak-type foundation is used to simulate the interaction be...A mathematical model for nonlocal vibration and buckling of embedded two-dimensional(2 D) decagonal quasicrystal(QC) layered nanoplates is proposed. The Pasternak-type foundation is used to simulate the interaction between the nanoplates and the elastic medium. The exact solutions of the nonlocal vibration frequency and buckling critical load of the 2 D decagonal QC layered nanoplates are obtained by solving the eigensystem and using the propagator matrix method. The present three-dimensional(3 D) exact solution can predict correctly the nature frequencies and critical loads of the nanoplates as compared with previous thin-plate and medium-thick-plate theories.Numerical examples are provided to display the effects of the quasiperiodic direction,length-to-width ratio, thickness of the nanoplates, nonlocal parameter, stacking sequence,and medium elasticity on the vibration frequency and critical buckling load of the 2 D decagonal QC nanoplates. The results show that the effects of the quasiperiodic direction on the vibration frequency and critical buckling load depend on the length-to-width ratio of the nanoplates. The thickness of the nanoplate and the elasticity of the surrounding medium can be adjusted for optimal frequency and critical buckling load of the nanoplate.This feature is useful since the frequency and critical buckling load of the 2 D decagonal QCs as coating materials of plate structures can now be tuned as one desire.展开更多
Host-less lithium metal anode generally suffers from large volume changes and serious dendrite growth during cycling,which poses challenges for its practical application.Interpenetrating phase composites with continuo...Host-less lithium metal anode generally suffers from large volume changes and serious dendrite growth during cycling,which poses challenges for its practical application.Interpenetrating phase composites with continuous architectures offer a solution to enhance mechanical properties of materials.Herein,a robust composite Li anode(LBN)material is fabricated through the metallurgical reaction between Li and hexagonal boron nitride(h-BN)with the formation of interpenetrating LiB/Li_(3)BN_(2)phases.As LiB fibers are anchored by Li_(3)BN_(2)granules,the collapse and slippage of LiB fibers are suppressed whilst the mechanical strength and structural stability of LBN are reinforced.By rolling,ultrathin(15μm),freestanding,and electrochemically stable LBN foil can be obtained.The LBN anode exhibits a high average Coulombic efficiency of 99.69%(1 mA cm^(-2),3 mAh cm^(-2))and a long lifespan of 2500 h(1 mA cm^(-2),1 m Ah cm^(-2)).Notably,the LiCoO_(2)(with double-sided load 40 mg cm^(-2))|LBN pouch cell can operate over450 cycles with a capacity retention of 90.1%.The exceptional cycling stability of LBN can be ascribed to the interpenetrating reinforcement architectures and synergistic electronic/ionic conductivity of the LiB/Li_(3)BN_(2)dual-lithiophilic-phases.This work provides a new methodology for thin Li strip processing and reinforced-architecture design,with implications beyond battery applications.展开更多
In order to demonstrate the relationship between methylation of fragile histidine triad(FHIT)and T-cadherin/H-cadherin(CDH13)genes and liver cancer,the methylation status of FHIT and CDH13 was detected in healthy indi...In order to demonstrate the relationship between methylation of fragile histidine triad(FHIT)and T-cadherin/H-cadherin(CDH13)genes and liver cancer,the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer.The phenol-chloroform method was used to extract genomic DNA.The methylation specific polymerase chain reaction method was applied to detect the methylation status of FHIT and CDH13.The relationship between smoking and alcohol consumption and gene(FHIT and CDH13)methylation was analyzed.There was significant difference in methylation rate of FHIT(72.67%,34.67%)and CDH13(72.0%,28.0%)between liver cancer patients and healthy individuals of Mongolian descent(P<0.05),as well as that of FHIT(68%,30.67%)and CDH13(64%,26%)between liver cancer patients and healthy individuals of Han individuals(P<0.05).There was also a relationship between smoking and drinking and the methylation of FHIT and CDH13(P<0.05).Thus,the methylation of FHIT and CDH13 had a relationship with liver cancer incidence.Smoking and alcohol ingestion may promote the methylation of FHIT and CDH13.展开更多
The practical application of Li metal anodes(LMAs)is limited by uncontrolled dendrite growth and side reactions.Herein,we propose a new friction-induced strategy to produce high-performance thin Li anode(Li@CFO).By vi...The practical application of Li metal anodes(LMAs)is limited by uncontrolled dendrite growth and side reactions.Herein,we propose a new friction-induced strategy to produce high-performance thin Li anode(Li@CFO).By virtue of the in situ friction reaction between fluoropolymer grease and Li strips during rolling,a robust organic/inorganic hybrid interlayer(lithiophilic LiF/LiC_(6)framework hybridized-CF_(2)-O-CF_(2)-chains)was formed atop Li metal.The derived interface contributes to reversible Li plating/stripping behaviors by mitigating side reactions and decreasing the solvation degree at the interface.The Li@CFO||Li@CFO symmetrical cell exhibits a remarkable lifespan for 5,600 h(1.0 mA cm^(-2)and 1.0 mAh cm^(-2))and 1,350 cycles even at a harsh condition(18.0 mA cm^(-2)and 3.0 mAh cm^(-2)).When paired with high-loading LiFePO4 cathodes,the full cell lasts over 450 cycles at 1C with a high-capacity retention of 99.9%.This work provides a new friction-induced strategy for producing high-performance thin LMAs.展开更多
The modified couple stress theory has been applied in many nanomaterials except for nano-quasicrystals.In this paper,the modified couple stress theory is firstly adopted to analyze the static bending deformation of mu...The modified couple stress theory has been applied in many nanomaterials except for nano-quasicrystals.In this paper,the modified couple stress theory is firstly adopted to analyze the static bending deformation of multilayered one-dimensional(ID)hexagonal quasicrystal(QC)nanoplates under surface loadings.The general solutions for the extended displacement and traction vectors in a simply supported and homogeneous QC nanoplate are derived by solving an eigenvalue problem reduced from the governing equations.Utilizing the propagator matrix method,the analytical solutions of multilayered ID QC nanoplates are then obtained by assuming that the layer interfaces are continuous.Numerical examples for some kinds of nanoplates made up of QC and crystal(BaTiOa)are provided to illustrate the effects of the material length parameter,the number of layers and the stacking sequence of nanoplates on the phonon and phason fields,which is helpful for the application of QCs to surface coating and solar energy selective absorber.展开更多
OBJECTIVE We aimed identification of cell surface molecules, which might serve as diagnostic biomarkers or useful targets for therapies, in breast cancer. METHODS We developed unique DNA microarray coupled with spheri...OBJECTIVE We aimed identification of cell surface molecules, which might serve as diagnostic biomarkers or useful targets for therapies, in breast cancer. METHODS We developed unique DNA microarray coupled with spherical self-organizing map （sSOM） analysis to characterize cells and tissues by the cell surface markers. In the microarray 1,797 probes for human genes coding membrane bound proteins were spotted. With this microarray the gene expression profiles of eight breast carcinoma cell lines were compared to identify the genes that were commonly expressed in breast carcinomas but not in normal cells. RESULTS The gene expression profiles of sSOM from the eight breast carcinoma cell lines were successfully distinguished from that of normal breast tissue derived cells suggesting the presence of genes of interest, sSOMon the data extensively filtered revealed several candidate genes, of which expression was significant in carcinoma cells but low in normal cells. Finally, TM9SF2 was nominated through validations of PCR procedures together with CD24 and ErbB3, which are known breast carcinoma markers. TMgSF2 expression was further confirmed by immunological staining. Interestingly, TMgSF2 was found to be expressed in all the cell lines evaluated while CD24 and ErbB3 were not in all of the carcinoma cells, supporting their relationship in sSOM. Although physiological significance of TMgSF2 is unknown yet, siRNA treatment significantly inhibited the growth of MDA- MB-231 cells. CONCLUSION We propose TM9SF2 as a novel and useful diagnostic marker as well as a potential molecular target specific to breast carcinoma cells covering wide range of breast cancer.展开更多
目的探讨酒精性肝硬化(alcoholic cirrhosis,AC)与乙型肝炎后肝硬化(hepatitis B cirrhosis,HBC)及酒精合并乙型肝炎后肝硬化(AC+HBC)在临床表现、实验室检查结果及并发症等方面的差异。方法收集2013年1月至2017年12月于大连医科大学附...目的探讨酒精性肝硬化(alcoholic cirrhosis,AC)与乙型肝炎后肝硬化(hepatitis B cirrhosis,HBC)及酒精合并乙型肝炎后肝硬化(AC+HBC)在临床表现、实验室检查结果及并发症等方面的差异。方法收集2013年1月至2017年12月于大连医科大学附属第一医院住院首次诊断的356例肝硬化患者的临床资料,其中男292例,女64例,年龄(56.33±10.89)岁。按病因分为AC组81例,HBC组220例,AC+HBC组55例。分析比较三组肝硬化患者一般情况、临床表现、肝功能指标及并发症发生情况。结果AC组患者腹胀、肝掌、蜘蛛痣、黄疸、腹水、腹壁静脉曲张的发生率均高于HBC组,而右上腹痛的发生率低于HBC组(P<0.05)。AC+HBC组患者腹水、腹壁静脉曲张的发生率均低于AC组(P<0.05)。AC+HBC组患者蜘蛛痣、黄疸的发生率均高于HBC组(P<0.05)。AC组和AC+HBC组患者的天冬氨酸转移酶(AST)、γ-谷氨酰转移酶(GGT)、总胆红素(TBIL)、总胆汁酸(TBA)及天冬氨酸转移酶/丙氨酸转移酶(AST/ALT)比值均较HBC组高,而白蛋白(ALB)均较HBC组低(P<0.05)。AC+HBC组患者AST较AC组高(P<0.05)。AC组患者上消化道出血的发生率高于HBC组(P<0.05),HBC组和AC+HBC组患者肝细胞癌的发生率均高于AC组(P<0.05)。结论AC和HBC患者在临床表现、肝功能指标等方面均存在一定差异,应该根据各自的特点采取相应的防治措施。展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.11502123 and11262012)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(No.2015JQ01)
文摘Quasicrystals （QCs） are sensitive to the piezoelectric （PE） effect. This paper studies static deformation of a multilayered one-dimensional （1D） hexagonal QC plate with the PE effect. The exact closed-form solutions of the extended displacement and traction for a homogeneous piezoelectric quasicrystal （PQC）plate are derived from an eigensystem. The general solutions for multilayered PQC plates are then obtained using the propagator matrix method when mechanical and electrical loads are applied on the top surface of the plate. Numerical examples for several sandwich plates made up of PQC, PE, and QC materials are provided to show the effect of stacking sequence on phonon, phason, and electric fields under mechanical and electrical loads, which is useful in designing new composites for engineering structures.
基金the National Natural Science Foundation of China(Nos.12072166 and 11862021)the Program for Science and Technology of Inner Mongolia Autonomous Region of China(No.2021GG0254)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(No.2020MS01006)。
文摘A mathematical model for nonlocal vibration and buckling of embedded two-dimensional(2 D) decagonal quasicrystal(QC) layered nanoplates is proposed. The Pasternak-type foundation is used to simulate the interaction between the nanoplates and the elastic medium. The exact solutions of the nonlocal vibration frequency and buckling critical load of the 2 D decagonal QC layered nanoplates are obtained by solving the eigensystem and using the propagator matrix method. The present three-dimensional(3 D) exact solution can predict correctly the nature frequencies and critical loads of the nanoplates as compared with previous thin-plate and medium-thick-plate theories.Numerical examples are provided to display the effects of the quasiperiodic direction,length-to-width ratio, thickness of the nanoplates, nonlocal parameter, stacking sequence,and medium elasticity on the vibration frequency and critical buckling load of the 2 D decagonal QC nanoplates. The results show that the effects of the quasiperiodic direction on the vibration frequency and critical buckling load depend on the length-to-width ratio of the nanoplates. The thickness of the nanoplate and the elasticity of the surrounding medium can be adjusted for optimal frequency and critical buckling load of the nanoplate.This feature is useful since the frequency and critical buckling load of the 2 D decagonal QCs as coating materials of plate structures can now be tuned as one desire.
基金supported by the National Natural Science Foundation of China(92372117 and U22A20141)the National Key Research and Development Program of China(2023YFC3905904)+2 种基金Natural Science Foundation of Hunan Province(2022JJ20068)Natural Science Foundation of Changsha City(kq2208258)Innovation-Driven Project of Central South University(2023CXQD024)。
文摘Host-less lithium metal anode generally suffers from large volume changes and serious dendrite growth during cycling,which poses challenges for its practical application.Interpenetrating phase composites with continuous architectures offer a solution to enhance mechanical properties of materials.Herein,a robust composite Li anode(LBN)material is fabricated through the metallurgical reaction between Li and hexagonal boron nitride(h-BN)with the formation of interpenetrating LiB/Li_(3)BN_(2)phases.As LiB fibers are anchored by Li_(3)BN_(2)granules,the collapse and slippage of LiB fibers are suppressed whilst the mechanical strength and structural stability of LBN are reinforced.By rolling,ultrathin(15μm),freestanding,and electrochemically stable LBN foil can be obtained.The LBN anode exhibits a high average Coulombic efficiency of 99.69%(1 mA cm^(-2),3 mAh cm^(-2))and a long lifespan of 2500 h(1 mA cm^(-2),1 m Ah cm^(-2)).Notably,the LiCoO_(2)(with double-sided load 40 mg cm^(-2))|LBN pouch cell can operate over450 cycles with a capacity retention of 90.1%.The exceptional cycling stability of LBN can be ascribed to the interpenetrating reinforcement architectures and synergistic electronic/ionic conductivity of the LiB/Li_(3)BN_(2)dual-lithiophilic-phases.This work provides a new methodology for thin Li strip processing and reinforced-architecture design,with implications beyond battery applications.
基金This work was supported by grants from the Major Scientific Project of the Affiliated Hospital of Inner Mongolia Medical University(No.NYFY ZD009)National Natural Science Foundation of China(No.81760676).
文摘In order to demonstrate the relationship between methylation of fragile histidine triad(FHIT)and T-cadherin/H-cadherin(CDH13)genes and liver cancer,the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer.The phenol-chloroform method was used to extract genomic DNA.The methylation specific polymerase chain reaction method was applied to detect the methylation status of FHIT and CDH13.The relationship between smoking and alcohol consumption and gene(FHIT and CDH13)methylation was analyzed.There was significant difference in methylation rate of FHIT(72.67%,34.67%)and CDH13(72.0%,28.0%)between liver cancer patients and healthy individuals of Mongolian descent(P<0.05),as well as that of FHIT(68%,30.67%)and CDH13(64%,26%)between liver cancer patients and healthy individuals of Han individuals(P<0.05).There was also a relationship between smoking and drinking and the methylation of FHIT and CDH13(P<0.05).Thus,the methylation of FHIT and CDH13 had a relationship with liver cancer incidence.Smoking and alcohol ingestion may promote the methylation of FHIT and CDH13.
基金This work was supported by the National Natural Science Foundation of China(U1904216 and U22A20141)the Natural Science Foundation of Changsha City(kq2208258).
文摘The practical application of Li metal anodes(LMAs)is limited by uncontrolled dendrite growth and side reactions.Herein,we propose a new friction-induced strategy to produce high-performance thin Li anode(Li@CFO).By virtue of the in situ friction reaction between fluoropolymer grease and Li strips during rolling,a robust organic/inorganic hybrid interlayer(lithiophilic LiF/LiC_(6)framework hybridized-CF_(2)-O-CF_(2)-chains)was formed atop Li metal.The derived interface contributes to reversible Li plating/stripping behaviors by mitigating side reactions and decreasing the solvation degree at the interface.The Li@CFO||Li@CFO symmetrical cell exhibits a remarkable lifespan for 5,600 h(1.0 mA cm^(-2)and 1.0 mAh cm^(-2))and 1,350 cycles even at a harsh condition(18.0 mA cm^(-2)and 3.0 mAh cm^(-2)).When paired with high-loading LiFePO4 cathodes,the full cell lasts over 450 cycles at 1C with a high-capacity retention of 99.9%.This work provides a new friction-induced strategy for producing high-performance thin LMAs.
基金supported by the National Natural Science Foundation of China(Grant Nos.11862021,11502123,and 11262012)Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT-19-A06)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2015JQ01).
文摘The modified couple stress theory has been applied in many nanomaterials except for nano-quasicrystals.In this paper,the modified couple stress theory is firstly adopted to analyze the static bending deformation of multilayered one-dimensional(ID)hexagonal quasicrystal(QC)nanoplates under surface loadings.The general solutions for the extended displacement and traction vectors in a simply supported and homogeneous QC nanoplate are derived by solving an eigenvalue problem reduced from the governing equations.Utilizing the propagator matrix method,the analytical solutions of multilayered ID QC nanoplates are then obtained by assuming that the layer interfaces are continuous.Numerical examples for some kinds of nanoplates made up of QC and crystal(BaTiOa)are provided to illustrate the effects of the material length parameter,the number of layers and the stacking sequence of nanoplates on the phonon and phason fields,which is helpful for the application of QCs to surface coating and solar energy selective absorber.
基金supported by the Grantin-Aid for scientific research(B)No.18300164"Screening of carcinoma cell surface markers and its application in molecular targeting with bionanocapsules"Japan Society for the Promotion of Science(JSPS).
文摘OBJECTIVE We aimed identification of cell surface molecules, which might serve as diagnostic biomarkers or useful targets for therapies, in breast cancer. METHODS We developed unique DNA microarray coupled with spherical self-organizing map （sSOM） analysis to characterize cells and tissues by the cell surface markers. In the microarray 1,797 probes for human genes coding membrane bound proteins were spotted. With this microarray the gene expression profiles of eight breast carcinoma cell lines were compared to identify the genes that were commonly expressed in breast carcinomas but not in normal cells. RESULTS The gene expression profiles of sSOM from the eight breast carcinoma cell lines were successfully distinguished from that of normal breast tissue derived cells suggesting the presence of genes of interest, sSOMon the data extensively filtered revealed several candidate genes, of which expression was significant in carcinoma cells but low in normal cells. Finally, TM9SF2 was nominated through validations of PCR procedures together with CD24 and ErbB3, which are known breast carcinoma markers. TMgSF2 expression was further confirmed by immunological staining. Interestingly, TMgSF2 was found to be expressed in all the cell lines evaluated while CD24 and ErbB3 were not in all of the carcinoma cells, supporting their relationship in sSOM. Although physiological significance of TMgSF2 is unknown yet, siRNA treatment significantly inhibited the growth of MDA- MB-231 cells. CONCLUSION We propose TM9SF2 as a novel and useful diagnostic marker as well as a potential molecular target specific to breast carcinoma cells covering wide range of breast cancer.
文摘目的探讨酒精性肝硬化(alcoholic cirrhosis,AC)与乙型肝炎后肝硬化(hepatitis B cirrhosis,HBC)及酒精合并乙型肝炎后肝硬化(AC+HBC)在临床表现、实验室检查结果及并发症等方面的差异。方法收集2013年1月至2017年12月于大连医科大学附属第一医院住院首次诊断的356例肝硬化患者的临床资料,其中男292例,女64例,年龄(56.33±10.89)岁。按病因分为AC组81例,HBC组220例,AC+HBC组55例。分析比较三组肝硬化患者一般情况、临床表现、肝功能指标及并发症发生情况。结果AC组患者腹胀、肝掌、蜘蛛痣、黄疸、腹水、腹壁静脉曲张的发生率均高于HBC组,而右上腹痛的发生率低于HBC组(P<0.05)。AC+HBC组患者腹水、腹壁静脉曲张的发生率均低于AC组(P<0.05)。AC+HBC组患者蜘蛛痣、黄疸的发生率均高于HBC组(P<0.05)。AC组和AC+HBC组患者的天冬氨酸转移酶(AST)、γ-谷氨酰转移酶(GGT)、总胆红素(TBIL)、总胆汁酸(TBA)及天冬氨酸转移酶/丙氨酸转移酶(AST/ALT)比值均较HBC组高,而白蛋白(ALB)均较HBC组低(P<0.05)。AC+HBC组患者AST较AC组高(P<0.05)。AC组患者上消化道出血的发生率高于HBC组(P<0.05),HBC组和AC+HBC组患者肝细胞癌的发生率均高于AC组(P<0.05)。结论AC和HBC患者在临床表现、肝功能指标等方面均存在一定差异,应该根据各自的特点采取相应的防治措施。
