<strong>Background</strong>: The aim at this study is to establish the effectiveness of case management (CM) compared to care as usual (CAU) in patients with schizophrenia. <strong>Methods</strong...<strong>Background</strong>: The aim at this study is to establish the effectiveness of case management (CM) compared to care as usual (CAU) in patients with schizophrenia. <strong>Methods</strong>: 128 patients with schizophrenia were recruited from the community of Haidian District (Beijing, China), 68 patients in the CM group and 60 patients in the CAU group. Efficacy and safety information were assessed at one year follow-up. The relapse rate was similar in both groups after 12 months followed up (7% and 5%). The withdraw rate was significant lower in CM group compared with CAU group (10% and 36%). <strong>Results</strong>: There is no significant difference in PANSS, PSP and SSMI score between 2 groups at each visit. Between endpoint and baseline, there is a significant improvement on PANSS negative score and PSP in patients treated with CM, while CAU group was not significantly changed. <strong>Conclusions</strong>: There is a possible effectiveness of CM group of improving negative symptoms and social function in schizophrenia clients.展开更多
目的探讨酸性环境对高磷诱导的大鼠血管平滑肌细胞(VSMCs)钙化的影响及其机制。方法体外分离培养大鼠VSMCs,采用免疫细胞化学法鉴定。将VSMCs按随机数字表法分为正常对照组、高磷+p H 7.4组、高磷+p H 7.1组。刺激4 d后,采用逆转录聚合...目的探讨酸性环境对高磷诱导的大鼠血管平滑肌细胞(VSMCs)钙化的影响及其机制。方法体外分离培养大鼠VSMCs,采用免疫细胞化学法鉴定。将VSMCs按随机数字表法分为正常对照组、高磷+p H 7.4组、高磷+p H 7.1组。刺激4 d后,采用逆转录聚合酶链反应和Western blot检测活化T细胞核因子c1(NFATc1)、Runt相关转录因子2(Runx2)基因和蛋白的表达。刺激14 d后,对各组细胞进行钙化染色、钙含量和碱性磷酸酶(ALP)活性测定。结果与正常对照组比较,高磷+p H 7.4组的钙含量、ALP活性、Runx2和NFATc1表达升高(P<0.05);与高磷+p H 7.4组比较,高磷+p H 7.1组的钙含量、ALP活性、Runx2和NFATc1表达降低(P<0.05)。相关性分析发现,NFATc1蛋白表达水平与ALP活性、Runx2蛋白表达水平呈正相关(P<0.05)。结论酸性环境可以抑制高磷诱导的大鼠VSMCs钙化,其机制可能是通过降低NFATc1表达,抑制VSMCs表型转化来实现的。展开更多
文摘<strong>Background</strong>: The aim at this study is to establish the effectiveness of case management (CM) compared to care as usual (CAU) in patients with schizophrenia. <strong>Methods</strong>: 128 patients with schizophrenia were recruited from the community of Haidian District (Beijing, China), 68 patients in the CM group and 60 patients in the CAU group. Efficacy and safety information were assessed at one year follow-up. The relapse rate was similar in both groups after 12 months followed up (7% and 5%). The withdraw rate was significant lower in CM group compared with CAU group (10% and 36%). <strong>Results</strong>: There is no significant difference in PANSS, PSP and SSMI score between 2 groups at each visit. Between endpoint and baseline, there is a significant improvement on PANSS negative score and PSP in patients treated with CM, while CAU group was not significantly changed. <strong>Conclusions</strong>: There is a possible effectiveness of CM group of improving negative symptoms and social function in schizophrenia clients.
文摘目的探讨酸性环境对高磷诱导的大鼠血管平滑肌细胞(VSMCs)钙化的影响及其机制。方法体外分离培养大鼠VSMCs,采用免疫细胞化学法鉴定。将VSMCs按随机数字表法分为正常对照组、高磷+p H 7.4组、高磷+p H 7.1组。刺激4 d后,采用逆转录聚合酶链反应和Western blot检测活化T细胞核因子c1(NFATc1)、Runt相关转录因子2(Runx2)基因和蛋白的表达。刺激14 d后,对各组细胞进行钙化染色、钙含量和碱性磷酸酶(ALP)活性测定。结果与正常对照组比较,高磷+p H 7.4组的钙含量、ALP活性、Runx2和NFATc1表达升高(P<0.05);与高磷+p H 7.4组比较,高磷+p H 7.1组的钙含量、ALP活性、Runx2和NFATc1表达降低(P<0.05)。相关性分析发现,NFATc1蛋白表达水平与ALP活性、Runx2蛋白表达水平呈正相关(P<0.05)。结论酸性环境可以抑制高磷诱导的大鼠VSMCs钙化,其机制可能是通过降低NFATc1表达,抑制VSMCs表型转化来实现的。
