BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed.AIM To develop a precise noninvasive test to stage liver fibrosis and c...BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed.AIM To develop a precise noninvasive test to stage liver fibrosis and cirrhosis.METHODS With liver biopsy as the gold standard,we established a new index,[alkaline phosphatase(U/L)+gamma-glutamyl transpeptidase(U/L)/platelet(109/L)(AGPR)],to predict liver fibrosis and cirrhosis.In addition,we compared the area under the receiver operating characteristic curve(AUROC)of AGPR,gammaglutamyl transpeptidase to platelet ratio,aspartate transaminase to platelet ratio index,and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis.RESULTS Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage(P<0.001).In the training cohort,the AUROC of AGPR was 0.83(95%CI:0.78-0.87)for predicting fibrosis(≥F2),0.84(95%CI:0.79-0.88)for predicting extensive fibrosis(≥F3),and 0.87(95%CI:0.83-0.91)for predicting cirrhosis(F4).In the validation cohort,the AUROCs of AGPR to predict≥F2,≥F3 and F4 were 0.83(95%CI:0.77-0.88),0.83(95%CI:0.77-0.89),and 0.84(95%CI:0.78-0.89),respectively.CONCLUSION The AGPR index should become a new,simple,accurate,and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients.展开更多
BACKGROUND Radical resection remains an effective strategy for patients with hepatocellular carcinoma(HCC).Unfortunately,the postoperative early recurrence(recurrence within 2 years)rate is still high.AIM To develop a...BACKGROUND Radical resection remains an effective strategy for patients with hepatocellular carcinoma(HCC).Unfortunately,the postoperative early recurrence(recurrence within 2 years)rate is still high.AIM To develop a radiomics model based on preoperative contrast-enhanced computed tomography(CECT)to evaluate early recurrence in HCC patients with a single tumour.METHODS We enrolled a total of 402 HCC patients from two centres who were diagnosed with a single tumour and underwent radical resection.First,the features from the portal venous and arterial phases of CECT were extracted based on the region of interest,and the early recurrence-related radiomics features were selected via the least absolute shrinkage and selection operator proportional hazards model(LASSO Cox)to determine radiomics scores for each patient.Then,the clinicopathologic data were combined to develop a model to predict early recurrence by Cox regression.Finally,we evaluated the prediction performance of this model by multiple methods.RESULTS A total of 1915 radiomics features were extracted from CECT images,and 31 of them were used to determine the radiomics scores,which showed a significant difference between the early recurrence and nonearly recurrence groups.Univariate and multivariate Cox regression analyses showed that radiomics scores and serum alphafetoprotein were independent indicators,and they were used to develop a combined model to predict early recurrence.The area under the receiver operating characteristic curve values for the training and validation cohorts were 0.77 and 0.74,respectively,while the C-indices were 0.712 and 0.674,respectively.The calibration curves and decision curve analysis showed satisfactory accuracy and clinical utilities.Kaplan-Meier curves based on recurrence-free survival and overall survival showed significant differences.CONCLUSION The preoperative radiomics model was shown to be effective for predicting early recurrence among HCC patients with a single tumour.展开更多
Based on the 1 550 nm all-fiber pulsed laser Doppler vibrometer(LDV) system independently developed by our laboratory, empirical mode decomposition(EMD) and optimally modified Log-spectral amplitude estimator(OM-LSA) ...Based on the 1 550 nm all-fiber pulsed laser Doppler vibrometer(LDV) system independently developed by our laboratory, empirical mode decomposition(EMD) and optimally modified Log-spectral amplitude estimator(OM-LSA) algorithms are associated to separate the speech micro-vibration from the target macro motion. This combined algorithm compensates for the weakness of the EMD algorithm in denoising and the inability of the OM-LSA algorithm on signal separation, achieving separation and simultaneous acquisition of the macro motion and speech micro-vibration of a target. The experimental results indicate that using this combined algorithm, the LDV system can functionally operate within 30 m and gain a 4.21 d B promotion in the signal-to-noise ratio(SNR) relative to a traditional OM-LSA algorithm.展开更多
Diffusion bonding is a near net shape forming process that can join dissimilar materials through atomic diffusion under a high pressure at a high temperature.Titanium alloy TC4（Ti-6 Al-4 V）and 4 J29 Kovar alloy（Fe-...Diffusion bonding is a near net shape forming process that can join dissimilar materials through atomic diffusion under a high pressure at a high temperature.Titanium alloy TC4（Ti-6 Al-4 V）and 4 J29 Kovar alloy（Fe-29 Ni-17 Co）were diffusely bonded by a vacuum hot-press sintering process in the temperature range of 700-850°C and bonding time of 120 min,under a pressure of 34.66 MPa.Interfacial microstructures and intermetallic compounds of the diffusion-bonded joints were characterized by optical microscopy,scanning electron microscopy,X-ray diffraction（XRD）and energy dispersive spectroscopy（EDS）.The elemental diffusion across the interface was revealed by electron probe microanalysis.Mechanical properties of joints were investigated by micro Vickers hardness and tensile strength.Results of EDS and XRD indicated that（Fe,Co,Ni）-Ti,TiNi,Ti_2Ni,TiNi_2,Fe_2 Ti,Ti_（17） Mn_3 and Al_6 Ti_（19） were formed at the interface.When the bonding temperature was raised from 700 to 850°C,the voids of interface were reduced and intermetallic layers were widened.Maximum tensile strength of joints at 53.5 MPa was recorded by the sintering process at 850°C for 120 min.Fracture surface of the joint indicated brittle nature,and failure took place through interface of intermetallic compounds.Based on the mechanical properties and microstructure of the diffusion-bonded joints,diffusion mechanisms between Ti-6 Al-4 Vtitanium and Fe-29 Ni-17 Co Kovar alloys were analyzed in terms of elemental diffusion,nucleation and growth of grains,plastic deformation and formation of intermetallic compounds near the interface.展开更多
We present an ameliorated arctangent algorithm based on phase-locked loop for digital Doppler signal processing,utilized within the heterodyne detection system. We define the error gain factor given by the approximati...We present an ameliorated arctangent algorithm based on phase-locked loop for digital Doppler signal processing,utilized within the heterodyne detection system. We define the error gain factor given by the approximation of Taylor expansion by means of a comparison of the measured values and true values. Exact expressions are derived for the amplitude error of two in-phase & quadrature signals and the frequency error of the acousto-optic modulator. Numerical simulation results and experimental results make it clear that the dynamic instability of the intermediate frequency signals leads to cumulative errors, which will spiral upward. An improved arctangent algorithm for the heterodyne detection is proposed to eliminate the cumulative errors and harmonic components. Depending on the narrow-band filter, our experiments were performed to realize the detectable displacement of 20 nm at a detection distance of 20 m. The aim of this paper is the demonstration of the optimized arctangent algorithm as a powerful approach to the demodulation algorithm, which will advance the signal-to-noise ratio and measurement accuracy of the heterodyne detection system.展开更多
基金Supported by the National Natural Science Foundation of China,No.81372163the Natural Science Foundation of Guangxi,No.2018GXNSFDA138001+2 种基金the Science and Technology Planning Project of Guilin,No.20190218-1the Opening Project of Key laboratory of High-Incidence-Tumor Prevention&Treatment(Guangxi Medical University),Ministry of Education,No.GKE-KF202101the Program of Guangxi Zhuang Autonomous Region Health and Family Planning Commission,No.Z20210706 and No.Z20190665。
文摘BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed.AIM To develop a precise noninvasive test to stage liver fibrosis and cirrhosis.METHODS With liver biopsy as the gold standard,we established a new index,[alkaline phosphatase(U/L)+gamma-glutamyl transpeptidase(U/L)/platelet(109/L)(AGPR)],to predict liver fibrosis and cirrhosis.In addition,we compared the area under the receiver operating characteristic curve(AUROC)of AGPR,gammaglutamyl transpeptidase to platelet ratio,aspartate transaminase to platelet ratio index,and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis.RESULTS Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage(P<0.001).In the training cohort,the AUROC of AGPR was 0.83(95%CI:0.78-0.87)for predicting fibrosis(≥F2),0.84(95%CI:0.79-0.88)for predicting extensive fibrosis(≥F3),and 0.87(95%CI:0.83-0.91)for predicting cirrhosis(F4).In the validation cohort,the AUROCs of AGPR to predict≥F2,≥F3 and F4 were 0.83(95%CI:0.77-0.88),0.83(95%CI:0.77-0.89),and 0.84(95%CI:0.78-0.89),respectively.CONCLUSION The AGPR index should become a new,simple,accurate,and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients.
基金National Natural Science Foundation of China,No.81773148Natural Science Foundation of Guangxi,No.2018GXNSFDA138001+3 种基金Program of Guangxi Zhuang Autonomous Region Health and Family Planning Commission,No.Z20210706Guangxi Medical and Healthcare Appropriate Technology Development and Promotion and Application Projects,No.S2022132Guangxi Natural Science Foundation,No.2022JJA140009Guangxi Zhuang Autonomous Region Health and Family Planning Commission Self-funded of Scientific Research Project,No.Z20170812.
文摘BACKGROUND Radical resection remains an effective strategy for patients with hepatocellular carcinoma(HCC).Unfortunately,the postoperative early recurrence(recurrence within 2 years)rate is still high.AIM To develop a radiomics model based on preoperative contrast-enhanced computed tomography(CECT)to evaluate early recurrence in HCC patients with a single tumour.METHODS We enrolled a total of 402 HCC patients from two centres who were diagnosed with a single tumour and underwent radical resection.First,the features from the portal venous and arterial phases of CECT were extracted based on the region of interest,and the early recurrence-related radiomics features were selected via the least absolute shrinkage and selection operator proportional hazards model(LASSO Cox)to determine radiomics scores for each patient.Then,the clinicopathologic data were combined to develop a model to predict early recurrence by Cox regression.Finally,we evaluated the prediction performance of this model by multiple methods.RESULTS A total of 1915 radiomics features were extracted from CECT images,and 31 of them were used to determine the radiomics scores,which showed a significant difference between the early recurrence and nonearly recurrence groups.Univariate and multivariate Cox regression analyses showed that radiomics scores and serum alphafetoprotein were independent indicators,and they were used to develop a combined model to predict early recurrence.The area under the receiver operating characteristic curve values for the training and validation cohorts were 0.77 and 0.74,respectively,while the C-indices were 0.712 and 0.674,respectively.The calibration curves and decision curve analysis showed satisfactory accuracy and clinical utilities.Kaplan-Meier curves based on recurrence-free survival and overall survival showed significant differences.CONCLUSION The preoperative radiomics model was shown to be effective for predicting early recurrence among HCC patients with a single tumour.
基金supported by the National Natural Science Foundation of China (No.61805234)the Key Research Program of Frontier Science,CAS (No.QYZDB-SSWSLH014)the Foundation of State Key Laboratory of Laser Interaction with Matter (No.SKLLIM1704)。
文摘Based on the 1 550 nm all-fiber pulsed laser Doppler vibrometer(LDV) system independently developed by our laboratory, empirical mode decomposition(EMD) and optimally modified Log-spectral amplitude estimator(OM-LSA) algorithms are associated to separate the speech micro-vibration from the target macro motion. This combined algorithm compensates for the weakness of the EMD algorithm in denoising and the inability of the OM-LSA algorithm on signal separation, achieving separation and simultaneous acquisition of the macro motion and speech micro-vibration of a target. The experimental results indicate that using this combined algorithm, the LDV system can functionally operate within 30 m and gain a 4.21 d B promotion in the signal-to-noise ratio(SNR) relative to a traditional OM-LSA algorithm.
基金supported by National Natural Science Foundation of China(No.51201143)Fundamental Research Funds for the Central Universities (No.2682015CX001)+5 种基金China Postdoctoral Science Foundation(No.2015M570794)Key Laboratory of Infrared Imaging Materials and Detectors,Shanghai Institute of Technical Physics,Chinese Academy of Sciences(No.IIMDKFJJ-14-04)Sichuan Science and Technology Support Program(No.2016FZ0079)R&D Projects Funding from the Research Council of Norway(No.263875/H30)supported by the U.S. National Science Foundation No.1436120supported by DoD W911NF14-1-0060
文摘Diffusion bonding is a near net shape forming process that can join dissimilar materials through atomic diffusion under a high pressure at a high temperature.Titanium alloy TC4（Ti-6 Al-4 V）and 4 J29 Kovar alloy（Fe-29 Ni-17 Co）were diffusely bonded by a vacuum hot-press sintering process in the temperature range of 700-850°C and bonding time of 120 min,under a pressure of 34.66 MPa.Interfacial microstructures and intermetallic compounds of the diffusion-bonded joints were characterized by optical microscopy,scanning electron microscopy,X-ray diffraction（XRD）and energy dispersive spectroscopy（EDS）.The elemental diffusion across the interface was revealed by electron probe microanalysis.Mechanical properties of joints were investigated by micro Vickers hardness and tensile strength.Results of EDS and XRD indicated that（Fe,Co,Ni）-Ti,TiNi,Ti_2Ni,TiNi_2,Fe_2 Ti,Ti_（17） Mn_3 and Al_6 Ti_（19） were formed at the interface.When the bonding temperature was raised from 700 to 850°C,the voids of interface were reduced and intermetallic layers were widened.Maximum tensile strength of joints at 53.5 MPa was recorded by the sintering process at 850°C for 120 min.Fracture surface of the joint indicated brittle nature,and failure took place through interface of intermetallic compounds.Based on the mechanical properties and microstructure of the diffusion-bonded joints,diffusion mechanisms between Ti-6 Al-4 Vtitanium and Fe-29 Ni-17 Co Kovar alloys were analyzed in terms of elemental diffusion,nucleation and growth of grains,plastic deformation and formation of intermetallic compounds near the interface.
基金supported by Key Research Program of Frontier Science,Chinese Academy of Sciences(Grant No.QYZDB-SSW-SLH014)the Yong Scientists Fund of the National Natural Science Foundation of China(Grant No.61205143)
文摘We present an ameliorated arctangent algorithm based on phase-locked loop for digital Doppler signal processing,utilized within the heterodyne detection system. We define the error gain factor given by the approximation of Taylor expansion by means of a comparison of the measured values and true values. Exact expressions are derived for the amplitude error of two in-phase & quadrature signals and the frequency error of the acousto-optic modulator. Numerical simulation results and experimental results make it clear that the dynamic instability of the intermediate frequency signals leads to cumulative errors, which will spiral upward. An improved arctangent algorithm for the heterodyne detection is proposed to eliminate the cumulative errors and harmonic components. Depending on the narrow-band filter, our experiments were performed to realize the detectable displacement of 20 nm at a detection distance of 20 m. The aim of this paper is the demonstration of the optimized arctangent algorithm as a powerful approach to the demodulation algorithm, which will advance the signal-to-noise ratio and measurement accuracy of the heterodyne detection system.
